KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
AAK1
Full Name:
AP2-associated protein kinase 1
Alias:
Adaptor-associated kinase 1; AP2 associated kinase 1; DKFZp686K16132; EC 2.7.11.1; KIAA1048; Kinase AAK1
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; EC 2.7.11.-; Other group; NAK family
Mass (Da):
93578
Number AA:
863
UniProt ID:
Q2M2I8
International Prot ID:
IPI00479760
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005905
GO:0019898
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
AP2-associated protein kinase 1 S637 phosphosite-specific antibody AB-PK503#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK503#AP2-associated protein kinase 1 (R634-T640, human) pS637 phosphopeptide - Powder PE-04ALP99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ALP99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
K
K
F
F
D
S
R
R
E
Q
G
G
S
Site 2
S14
S
R
R
E
Q
G
G
S
G
L
G
S
G
S
S
Site 3
S18
Q
G
G
S
G
L
G
S
G
S
S
G
G
G
G
Site 4
S20
G
S
G
L
G
S
G
S
S
G
G
G
G
S
T
Site 5
S21
S
G
L
G
S
G
S
S
G
G
G
G
S
T
S
Site 6
S26
G
S
S
G
G
G
G
S
T
S
G
L
G
S
G
Site 7
T27
S
S
G
G
G
G
S
T
S
G
L
G
S
G
Y
Site 8
S28
S
G
G
G
G
S
T
S
G
L
G
S
G
Y
I
Site 9
Y34
T
S
G
L
G
S
G
Y
I
G
R
V
F
G
I
Site 10
T47
G
I
G
R
Q
Q
V
T
V
D
E
V
L
A
E
Site 11
S98
I
Q
I
M
R
D
L
S
G
H
K
N
I
V
G
Site 12
Y106
G
H
K
N
I
V
G
Y
I
D
S
S
I
N
N
Site 13
S109
N
I
V
G
Y
I
D
S
S
I
N
N
V
S
S
Site 14
T144
L
M
N
Q
R
L
Q
T
G
F
T
E
N
E
V
Site 15
T170
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
Site 16
Y190
L
L
H
D
R
G
H
Y
V
L
C
D
F
G
S
Site 17
Y220
V
E
D
E
I
K
K
Y
T
T
L
S
Y
R
A
Site 18
T221
E
D
E
I
K
K
Y
T
T
L
S
Y
R
A
P
Site 19
T222
D
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
Site 20
S224
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
V
Site 21
Y225
K
K
Y
T
T
L
S
Y
R
A
P
E
M
V
N
Site 22
Y234
A
P
E
M
V
N
L
Y
S
G
K
I
I
T
T
Site 23
S235
P
E
M
V
N
L
Y
S
G
K
I
I
T
T
K
Site 24
Y253
W
A
L
G
C
L
L
Y
K
L
C
Y
F
T
L
Site 25
Y292
D
M
H
C
L
I
R
Y
M
L
E
P
D
P
D
Site 26
Y305
P
D
K
R
P
D
I
Y
Q
V
S
Y
F
S
F
Site 27
S308
R
P
D
I
Y
Q
V
S
Y
F
S
F
K
L
L
Site 28
Y309
P
D
I
Y
Q
V
S
Y
F
S
F
K
L
L
K
Site 29
S311
I
Y
Q
V
S
Y
F
S
F
K
L
L
K
K
E
Site 30
S327
P
I
P
N
V
Q
N
S
P
I
P
A
K
L
P
Site 31
T347
S
E
A
A
A
K
K
T
Q
P
K
A
R
L
T
Site 32
T354
T
Q
P
K
A
R
L
T
D
P
I
P
T
T
E
Site 33
T359
R
L
T
D
P
I
P
T
T
E
T
S
I
A
P
Site 34
T360
L
T
D
P
I
P
T
T
E
T
S
I
A
P
R
Site 35
T362
D
P
I
P
T
T
E
T
S
I
A
P
R
Q
R
Site 36
T389
L
P
I
Q
P
A
L
T
P
R
K
R
A
T
V
Site 37
T395
L
T
P
R
K
R
A
T
V
Q
P
P
P
Q
A
Site 38
S405
P
P
P
Q
A
A
G
S
S
N
Q
P
G
L
L
Site 39
S406
P
P
Q
A
A
G
S
S
N
Q
P
G
L
L
A
Site 40
S414
N
Q
P
G
L
L
A
S
V
P
Q
P
K
P
Q
Site 41
S425
P
K
P
Q
A
P
P
S
Q
P
L
P
Q
T
Q
Site 42
T431
P
S
Q
P
L
P
Q
T
Q
A
K
Q
P
Q
A
Site 43
T441
K
Q
P
Q
A
P
P
T
P
Q
Q
T
P
S
T
Site 44
T445
A
P
P
T
P
Q
Q
T
P
S
T
Q
A
Q
G
Site 45
S447
P
T
P
Q
Q
T
P
S
T
Q
A
Q
G
L
P
Site 46
T448
T
P
Q
Q
T
P
S
T
Q
A
Q
G
L
P
A
Site 47
T460
L
P
A
Q
A
Q
A
T
P
Q
H
Q
Q
Q
L
Site 48
T488
A
Q
Q
Q
P
A
G
T
F
Y
Q
Q
Q
Q
A
Site 49
T507
F
Q
A
V
H
P
A
T
Q
K
P
A
I
A
Q
Site 50
S519
I
A
Q
F
P
V
V
S
Q
G
G
S
Q
Q
Q
Site 51
S523
P
V
V
S
Q
G
G
S
Q
Q
Q
L
M
Q
N
Site 52
Y532
Q
Q
L
M
Q
N
F
Y
Q
Q
Q
Q
Q
Q
Q
Site 53
T605
R
Q
Q
P
K
V
Q
T
T
P
P
P
A
V
Q
Site 54
T606
Q
Q
P
K
V
Q
T
T
P
P
P
A
V
Q
G
Site 55
S618
V
Q
G
Q
K
V
G
S
L
T
P
P
S
S
P
Site 56
T620
G
Q
K
V
G
S
L
T
P
P
S
S
P
K
T
Site 57
S623
V
G
S
L
T
P
P
S
S
P
K
T
Q
R
A
Site 58
S624
G
S
L
T
P
P
S
S
P
K
T
Q
R
A
G
Site 59
T627
T
P
P
S
S
P
K
T
Q
R
A
G
H
R
R
Site 60
S637
A
G
H
R
R
I
L
S
D
V
T
H
S
A
V
AP2-associated protein kinase 1 S637 phosphosite-specific antibody AB-PK503#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK503#AP2-associated protein kinase 1 (R634-T640, human) pS637 phosphopeptide - Powder PE-04ALP99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ALP99
Site 61
T640
R
R
I
L
S
D
V
T
H
S
A
V
F
G
V
Site 62
S642
I
L
S
D
V
T
H
S
A
V
F
G
V
P
A
Site 63
S650
A
V
F
G
V
P
A
S
K
S
T
Q
L
L
Q
Site 64
S652
F
G
V
P
A
S
K
S
T
Q
L
L
Q
A
A
Site 65
T653
G
V
P
A
S
K
S
T
Q
L
L
Q
A
A
A
Site 66
S664
Q
A
A
A
A
E
A
S
L
N
K
S
K
S
A
Site 67
S668
A
E
A
S
L
N
K
S
K
S
A
T
T
T
P
Site 68
S670
A
S
L
N
K
S
K
S
A
T
T
T
P
S
G
Site 69
T672
L
N
K
S
K
S
A
T
T
T
P
S
G
S
P
Site 70
T674
K
S
K
S
A
T
T
T
P
S
G
S
P
R
T
Site 71
S676
K
S
A
T
T
T
P
S
G
S
P
R
T
S
Q
Site 72
S678
A
T
T
T
P
S
G
S
P
R
T
S
Q
Q
N
Site 73
T681
T
P
S
G
S
P
R
T
S
Q
Q
N
V
Y
N
Site 74
S682
P
S
G
S
P
R
T
S
Q
Q
N
V
Y
N
P
Site 75
Y687
R
T
S
Q
Q
N
V
Y
N
P
S
E
G
S
T
Site 76
S690
Q
Q
N
V
Y
N
P
S
E
G
S
T
W
N
P
Site 77
T694
Y
N
P
S
E
G
S
T
W
N
P
F
D
D
D
Site 78
S731
H
P
E
K
L
G
G
S
A
E
S
L
I
P
G
Site 79
S734
K
L
G
G
S
A
E
S
L
I
P
G
F
Q
S
Site 80
T749
T
Q
G
D
A
F
A
T
T
S
F
S
A
G
T
Site 81
T750
Q
G
D
A
F
A
T
T
S
F
S
A
G
T
A
Site 82
S751
G
D
A
F
A
T
T
S
F
S
A
G
T
A
E
Site 83
T765
E
K
R
K
G
G
Q
T
V
D
S
G
L
P
L
Site 84
S797
K
L
I
E
G
L
K
S
P
D
T
S
L
L
L
Site 85
T800
E
G
L
K
S
P
D
T
S
L
L
L
P
D
L
Site 86
T811
L
P
D
L
L
P
M
T
D
P
F
G
S
T
S
Site 87
S816
P
M
T
D
P
F
G
S
T
S
D
A
V
I
G
Site 88
S818
T
D
P
F
G
S
T
S
D
A
V
I
G
K
V
Site 89
Y845
A
C
F
K
N
D
K
Y
L
V
N
Q
S
L
G
Site 90
S850
D
K
Y
L
V
N
Q
S
L
G
N
S
P
A
T
Site 91
S854
V
N
Q
S
L
G
N
S
P
A
T
P
E
A
K
Site 92
T857
S
L
G
N
S
P
A
T
P
E
A
K
A
I
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation