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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Spred3
Full Name:
Sprouty-related, EVH1 domain-containing protein 3
Alias:
Eve-3; Sprouty-related, evh1 domain containing 3
Type:
Plasma membrane protein
Mass (Da):
42670
Number AA:
410
UniProt ID:
Q2MJR0
International Prot ID:
IPI00397716
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0007275
GO:0009966
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
V
M
A
R
D
D
S
S
G
G
W
L
P
V
G
Site 2
Y48
G
G
A
R
Q
G
H
Y
V
I
H
G
E
R
L
Site 3
T60
E
R
L
R
D
Q
K
T
T
L
E
C
T
L
K
Site 4
T61
R
L
R
D
Q
K
T
T
L
E
C
T
L
K
P
Site 5
T65
Q
K
T
T
L
E
C
T
L
K
P
G
L
V
Y
Site 6
Y72
T
L
K
P
G
L
V
Y
N
K
V
N
P
I
F
Site 7
T92
G
D
C
K
F
G
L
T
F
Q
S
P
A
E
A
Site 8
S95
K
F
G
L
T
F
Q
S
P
A
E
A
D
E
F
Site 9
S117
L
A
A
L
G
R
G
S
L
T
P
S
S
S
S
Site 10
T119
A
L
G
R
G
S
L
T
P
S
S
S
S
S
S
Site 11
S121
G
R
G
S
L
T
P
S
S
S
S
S
S
S
S
Site 12
S122
R
G
S
L
T
P
S
S
S
S
S
S
S
S
P
Site 13
S123
G
S
L
T
P
S
S
S
S
S
S
S
S
P
S
Site 14
S124
S
L
T
P
S
S
S
S
S
S
S
S
P
S
Q
Site 15
S125
L
T
P
S
S
S
S
S
S
S
S
P
S
Q
D
Site 16
S126
T
P
S
S
S
S
S
S
S
S
P
S
Q
D
T
Site 17
S127
P
S
S
S
S
S
S
S
S
P
S
Q
D
T
A
Site 18
S128
S
S
S
S
S
S
S
S
P
S
Q
D
T
A
E
Site 19
S130
S
S
S
S
S
S
P
S
Q
D
T
A
E
T
P
Site 20
T136
P
S
Q
D
T
A
E
T
P
C
P
L
T
S
H
Site 21
T141
A
E
T
P
C
P
L
T
S
H
V
D
S
D
S
Site 22
S142
E
T
P
C
P
L
T
S
H
V
D
S
D
S
S
Site 23
S146
P
L
T
S
H
V
D
S
D
S
S
S
S
H
S
Site 24
S148
T
S
H
V
D
S
D
S
S
S
S
H
S
R
Q
Site 25
S149
S
H
V
D
S
D
S
S
S
S
H
S
R
Q
E
Site 26
S150
H
V
D
S
D
S
S
S
S
H
S
R
Q
E
T
Site 27
S151
V
D
S
D
S
S
S
S
H
S
R
Q
E
T
P
Site 28
S153
S
D
S
S
S
S
H
S
R
Q
E
T
P
P
S
Site 29
T157
S
S
H
S
R
Q
E
T
P
P
S
A
A
A
A
Site 30
S160
S
R
Q
E
T
P
P
S
A
A
A
A
P
I
I
Site 31
T178
S
A
S
G
F
G
P
T
T
P
P
Q
R
R
R
Site 32
T179
A
S
G
F
G
P
T
T
P
P
Q
R
R
R
S
Site 33
S186
T
P
P
Q
R
R
R
S
S
A
Q
S
Y
P
P
Site 34
S187
P
P
Q
R
R
R
S
S
A
Q
S
Y
P
P
L
Site 35
S190
R
R
R
S
S
A
Q
S
Y
P
P
L
L
P
F
Site 36
Y191
R
R
S
S
A
Q
S
Y
P
P
L
L
P
F
T
Site 37
T198
Y
P
P
L
L
P
F
T
G
I
P
E
P
S
E
Site 38
S204
F
T
G
I
P
E
P
S
E
P
L
A
G
A
G
Site 39
Y220
L
G
W
G
G
R
G
Y
E
D
Y
R
R
S
G
Site 40
Y223
G
G
R
G
Y
E
D
Y
R
R
S
G
P
P
A
Site 41
S226
G
Y
E
D
Y
R
R
S
G
P
P
A
P
L
A
Site 42
S281
P
P
P
G
P
G
P
S
S
A
P
A
K
A
S
Site 43
S282
P
P
G
P
G
P
S
S
A
P
A
K
A
S
P
Site 44
S288
S
S
A
P
A
K
A
S
P
E
A
E
E
A
A
Site 45
S344
S
L
L
Y
H
C
L
S
D
A
E
G
D
F
S
Site 46
S351
S
D
A
E
G
D
F
S
D
P
C
A
C
E
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation