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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ERCC6L
Full Name:
DNA excision repair protein ERCC-6-like
Alias:
ATP-dependent helicase ERCC6-like; DNA excision repair protein ERCC-6-like; Ercc6l; FLJ20105; Hypothetical protein FLJ90238; LOC54821; MGC131695; PICH; Plk1-interacting checkpoint helicase
Type:
DNA binding protein, helicase
Mass (Da):
141103
Number AA:
1250
UniProt ID:
Q2NKX8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000777
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003677
GO:0004386
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0007067
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
F
P
E
A
E
A
L
S
P
E
Q
A
A
H
Y
Site 2
Y21
S
P
E
Q
A
A
H
Y
L
R
Y
V
K
E
A
Site 3
Y24
Q
A
A
H
Y
L
R
Y
V
K
E
A
K
E
A
Site 4
S58
F
P
N
E
K
V
L
S
R
I
Q
K
I
Q
E
Site 5
T79
E
Q
G
D
D
E
F
T
D
V
C
N
S
G
L
Site 6
Y108
K
E
G
I
A
F
L
Y
S
L
Y
R
D
G
R
Site 7
S109
E
G
I
A
F
L
Y
S
L
Y
R
D
G
R
K
Site 8
Y111
I
A
F
L
Y
S
L
Y
R
D
G
R
K
G
G
Site 9
T168
V
K
E
F
I
K
W
T
P
G
M
R
V
K
T
Site 10
T175
T
P
G
M
R
V
K
T
F
H
G
P
S
K
D
Site 11
S180
V
K
T
F
H
G
P
S
K
D
E
R
T
R
N
Site 12
Y224
G
Q
E
F
V
W
D
Y
V
I
L
D
E
A
H
Site 13
T235
D
E
A
H
K
I
K
T
S
S
T
K
S
A
I
Site 14
S236
E
A
H
K
I
K
T
S
S
T
K
S
A
I
C
Site 15
T256
A
S
N
R
L
L
L
T
G
T
P
I
Q
N
N
Site 16
T258
N
R
L
L
L
T
G
T
P
I
Q
N
N
L
Q
Site 17
T282
C
Q
G
S
L
L
G
T
L
K
T
F
K
M
E
Site 18
T285
S
L
L
G
T
L
K
T
F
K
M
E
Y
E
N
Site 19
Y290
L
K
T
F
K
M
E
Y
E
N
P
I
T
R
A
Site 20
T295
M
E
Y
E
N
P
I
T
R
A
R
E
K
D
A
Site 21
T303
R
A
R
E
K
D
A
T
P
G
E
K
A
L
G
Site 22
Y324
L
M
A
I
I
K
P
Y
F
L
R
R
T
K
E
Site 23
T329
K
P
Y
F
L
R
R
T
K
E
D
V
Q
K
K
Site 24
S338
E
D
V
Q
K
K
K
S
S
N
P
E
A
R
L
Site 25
S360
D
A
I
C
E
M
P
S
L
S
R
K
N
D
L
Site 26
Y381
V
P
L
Q
E
E
I
Y
R
K
F
V
S
L
D
Site 27
S386
E
I
Y
R
K
F
V
S
L
D
H
I
K
E
L
Site 28
S431
L
L
N
L
G
T
F
S
A
Q
D
G
N
E
G
Site 29
S441
D
G
N
E
G
E
D
S
P
D
V
D
H
I
D
Site 30
T454
I
D
Q
V
T
D
D
T
L
M
E
E
S
G
K
Site 31
T479
L
R
D
E
G
H
Q
T
L
V
F
S
Q
S
R
Site 32
S483
G
H
Q
T
L
V
F
S
Q
S
R
Q
I
L
N
Site 33
T503
L
K
N
R
H
F
K
T
L
R
I
D
G
T
V
Site 34
T509
K
T
L
R
I
D
G
T
V
T
H
L
L
E
R
Site 35
Y529
L
F
Q
Q
N
K
D
Y
S
V
F
L
L
T
T
Site 36
S530
F
Q
Q
N
K
D
Y
S
V
F
L
L
T
T
Q
Site 37
S557
R
V
V
I
F
D
P
S
W
N
P
A
T
D
A
Site 38
Y571
A
Q
A
V
D
R
V
Y
R
I
G
Q
K
E
N
Site 39
T589
Y
R
L
I
T
C
G
T
V
E
E
K
I
Y
R
Site 40
Y595
G
T
V
E
E
K
I
Y
R
R
Q
V
F
K
D
Site 41
S603
R
R
Q
V
F
K
D
S
L
I
R
Q
T
T
G
Site 42
T608
K
D
S
L
I
R
Q
T
T
G
E
K
K
N
P
Site 43
T609
D
S
L
I
R
Q
T
T
G
E
K
K
N
P
F
Site 44
Y618
E
K
K
N
P
F
R
Y
F
S
K
Q
E
L
R
Site 45
S620
K
N
P
F
R
Y
F
S
K
Q
E
L
R
E
L
Site 46
T638
E
D
L
Q
N
S
V
T
Q
L
Q
L
Q
S
L
Site 47
S652
L
H
A
A
Q
R
K
S
D
I
K
L
D
E
H
Site 48
Y678
I
S
D
H
D
L
M
Y
T
C
D
L
S
V
K
Site 49
T679
S
D
H
D
L
M
Y
T
C
D
L
S
V
K
E
Site 50
Y696
D
V
V
E
E
S
H
Y
I
Q
Q
R
V
Q
K
Site 51
S712
Q
F
L
V
E
F
E
S
Q
N
K
E
F
L
M
Site 52
T724
F
L
M
E
Q
Q
R
T
R
N
E
G
A
W
L
Site 53
S738
L
R
E
P
V
F
P
S
S
T
K
K
K
C
P
Site 54
S739
R
E
P
V
F
P
S
S
T
K
K
K
C
P
K
Site 55
S755
N
K
P
Q
P
Q
P
S
P
L
L
S
T
H
H
Site 56
S759
P
Q
P
S
P
L
L
S
T
H
H
T
Q
E
E
Site 57
T760
Q
P
S
P
L
L
S
T
H
H
T
Q
E
E
D
Site 58
T763
P
L
L
S
T
H
H
T
Q
E
E
D
I
S
S
Site 59
S769
H
T
Q
E
E
D
I
S
S
K
M
A
S
V
V
Site 60
S770
T
Q
E
E
D
I
S
S
K
M
A
S
V
V
I
Site 61
S774
D
I
S
S
K
M
A
S
V
V
I
D
D
L
P
Site 62
S790
E
G
E
K
Q
D
L
S
S
I
K
V
N
V
T
Site 63
T805
T
L
Q
D
G
K
G
T
G
S
A
D
S
I
A
Site 64
S807
Q
D
G
K
G
T
G
S
A
D
S
I
A
T
L
Site 65
S810
K
G
T
G
S
A
D
S
I
A
T
L
P
K
G
Site 66
T813
G
S
A
D
S
I
A
T
L
P
K
G
F
G
S
Site 67
S820
T
L
P
K
G
F
G
S
V
E
E
L
C
T
N
Site 68
T826
G
S
V
E
E
L
C
T
N
S
S
L
G
M
E
Site 69
S828
V
E
E
L
C
T
N
S
S
L
G
M
E
K
S
Site 70
S829
E
E
L
C
T
N
S
S
L
G
M
E
K
S
F
Site 71
S835
S
S
L
G
M
E
K
S
F
A
T
K
N
E
A
Site 72
T847
N
E
A
V
Q
K
E
T
L
Q
E
G
P
K
Q
Site 73
S864
L
Q
E
D
P
L
E
S
F
N
Y
V
L
S
K
Site 74
Y867
D
P
L
E
S
F
N
Y
V
L
S
K
S
T
K
Site 75
S870
E
S
F
N
Y
V
L
S
K
S
T
K
A
D
I
Site 76
S872
F
N
Y
V
L
S
K
S
T
K
A
D
I
G
P
Site 77
S905
I
I
S
I
T
N
E
S
Q
N
A
E
S
N
V
Site 78
S922
I
E
I
A
D
D
L
S
A
S
H
S
A
L
Q
Site 79
S926
D
D
L
S
A
S
H
S
A
L
Q
D
A
Q
A
Site 80
S943
A
K
L
E
E
E
P
S
A
S
S
P
Q
Y
A
Site 81
S945
L
E
E
E
P
S
A
S
S
P
Q
Y
A
C
D
Site 82
S946
E
E
E
P
S
A
S
S
P
Q
Y
A
C
D
F
Site 83
Y949
P
S
A
S
S
P
Q
Y
A
C
D
F
N
L
F
Site 84
S960
F
N
L
F
L
E
D
S
A
D
N
R
Q
N
F
Site 85
S968
A
D
N
R
Q
N
F
S
S
Q
S
L
E
H
V
Site 86
S969
D
N
R
Q
N
F
S
S
Q
S
L
E
H
V
E
Site 87
S971
R
Q
N
F
S
S
Q
S
L
E
H
V
E
K
E
Site 88
S980
E
H
V
E
K
E
N
S
L
C
G
S
A
P
N
Site 89
S984
K
E
N
S
L
C
G
S
A
P
N
S
R
A
G
Site 90
S988
L
C
G
S
A
P
N
S
R
A
G
F
V
H
S
Site 91
S995
S
R
A
G
F
V
H
S
K
T
C
L
S
W
E
Site 92
T997
A
G
F
V
H
S
K
T
C
L
S
W
E
F
S
Site 93
S1000
V
H
S
K
T
C
L
S
W
E
F
S
E
K
D
Site 94
S1004
T
C
L
S
W
E
F
S
E
K
D
D
E
P
E
Site 95
S1021
V
V
K
A
K
I
R
S
K
A
R
R
I
V
S
Site 96
S1028
S
K
A
R
R
I
V
S
D
G
E
D
E
D
D
Site 97
S1036
D
G
E
D
E
D
D
S
F
K
D
T
S
S
I
Site 98
T1040
E
D
D
S
F
K
D
T
S
S
I
N
P
F
N
Site 99
S1041
D
D
S
F
K
D
T
S
S
I
N
P
F
N
T
Site 100
S1042
D
S
F
K
D
T
S
S
I
N
P
F
N
T
S
Site 101
S1049
S
I
N
P
F
N
T
S
L
F
Q
F
S
S
V
Site 102
S1055
T
S
L
F
Q
F
S
S
V
K
Q
F
D
A
S
Site 103
S1062
S
V
K
Q
F
D
A
S
T
P
K
N
D
I
S
Site 104
T1063
V
K
Q
F
D
A
S
T
P
K
N
D
I
S
P
Site 105
S1069
S
T
P
K
N
D
I
S
P
P
G
R
F
F
S
Site 106
S1076
S
P
P
G
R
F
F
S
S
Q
I
P
S
S
V
Site 107
S1077
P
P
G
R
F
F
S
S
Q
I
P
S
S
V
N
Site 108
S1081
F
F
S
S
Q
I
P
S
S
V
N
K
S
M
N
Site 109
S1082
F
S
S
Q
I
P
S
S
V
N
K
S
M
N
S
Site 110
S1086
I
P
S
S
V
N
K
S
M
N
S
R
R
S
L
Site 111
S1089
S
V
N
K
S
M
N
S
R
R
S
L
A
S
R
Site 112
S1092
K
S
M
N
S
R
R
S
L
A
S
R
R
S
L
Site 113
S1095
N
S
R
R
S
L
A
S
R
R
S
L
I
N
M
Site 114
S1098
R
S
L
A
S
R
R
S
L
I
N
M
V
L
D
Site 115
S1117
M
E
E
R
L
D
D
S
S
E
A
K
G
P
E
Site 116
S1118
E
E
R
L
D
D
S
S
E
A
K
G
P
E
D
Site 117
Y1126
E
A
K
G
P
E
D
Y
P
E
E
G
V
E
E
Site 118
S1134
P
E
E
G
V
E
E
S
S
G
E
A
S
K
Y
Site 119
S1135
E
E
G
V
E
E
S
S
G
E
A
S
K
Y
T
Site 120
S1139
E
E
S
S
G
E
A
S
K
Y
T
E
E
D
P
Site 121
Y1141
S
S
G
E
A
S
K
Y
T
E
E
D
P
S
G
Site 122
T1142
S
G
E
A
S
K
Y
T
E
E
D
P
S
G
E
Site 123
S1147
K
Y
T
E
E
D
P
S
G
E
T
L
S
S
E
Site 124
S1152
D
P
S
G
E
T
L
S
S
E
N
K
S
S
W
Site 125
S1153
P
S
G
E
T
L
S
S
E
N
K
S
S
W
L
Site 126
S1157
T
L
S
S
E
N
K
S
S
W
L
M
T
S
K
Site 127
S1158
L
S
S
E
N
K
S
S
W
L
M
T
S
K
P
Site 128
T1162
N
K
S
S
W
L
M
T
S
K
P
S
A
L
A
Site 129
S1163
K
S
S
W
L
M
T
S
K
P
S
A
L
A
Q
Site 130
T1172
P
S
A
L
A
Q
E
T
S
L
G
A
P
E
P
Site 131
S1173
S
A
L
A
Q
E
T
S
L
G
A
P
E
P
L
Site 132
S1181
L
G
A
P
E
P
L
S
G
E
Q
L
V
G
S
Site 133
S1188
S
G
E
Q
L
V
G
S
P
Q
D
K
A
A
E
Site 134
Y1200
A
A
E
A
T
N
D
Y
E
T
L
V
K
R
G
Site 135
T1202
E
A
T
N
D
Y
E
T
L
V
K
R
G
K
E
Site 136
Y1244
M
L
L
T
L
S
L
Y
K
Q
L
N
N
N
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation