KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PARP6
Full Name:
Poly [ADP-ribose] polymerase 6
Alias:
Type:
Mass (Da):
71115
Number AA:
630
UniProt ID:
Q2NL67
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
Q
F
W
N
D
D
D
S
E
G
D
N
E
S
E
Site 2
S19
D
S
E
G
D
N
E
S
E
E
F
L
Y
G
V
Site 3
Y24
N
E
S
E
E
F
L
Y
G
V
Q
G
S
C
A
Site 4
Y35
G
S
C
A
A
D
L
Y
R
H
P
Q
L
D
A
Site 5
S52
E
A
V
K
E
I
Y
S
E
N
S
V
S
I
R
Site 6
S55
K
E
I
Y
S
E
N
S
V
S
I
R
E
Y
G
Site 7
S57
I
Y
S
E
N
S
V
S
I
R
E
Y
G
T
I
Site 8
Y61
N
S
V
S
I
R
E
Y
G
T
I
D
D
V
D
Site 9
S83
S
F
L
D
E
E
V
S
T
A
W
K
V
L
R
Site 10
T84
F
L
D
E
E
V
S
T
A
W
K
V
L
R
T
Site 11
S101
I
V
L
R
L
R
F
S
L
S
Q
Y
L
D
G
Site 12
S103
L
R
L
R
F
S
L
S
Q
Y
L
D
G
P
E
Site 13
Y105
L
R
F
S
L
S
Q
Y
L
D
G
P
E
P
S
Site 14
S112
Y
L
D
G
P
E
P
S
I
E
V
F
Q
P
S
Site 15
S119
S
I
E
V
F
Q
P
S
N
K
E
G
F
G
L
Site 16
T152
L
S
N
D
F
L
K
T
Q
Q
E
K
R
H
S
Site 17
S159
T
Q
Q
E
K
R
H
S
W
F
K
A
S
G
T
Site 18
T166
S
W
F
K
A
S
G
T
I
K
K
F
R
A
G
Site 19
S175
K
K
F
R
A
G
L
S
I
F
S
P
I
P
K
Site 20
S178
R
A
G
L
S
I
F
S
P
I
P
K
S
P
S
Site 21
S185
S
P
I
P
K
S
P
S
F
P
I
I
Q
D
S
Site 22
S212
V
G
R
L
M
N
R
S
I
S
C
T
M
K
N
Site 23
S214
R
L
M
N
R
S
I
S
C
T
M
K
N
P
K
Site 24
T216
M
N
R
S
I
S
C
T
M
K
N
P
K
V
E
Site 25
Y227
P
K
V
E
V
F
G
Y
P
P
S
P
Q
A
G
Site 26
T249
G
L
P
P
P
A
R
T
S
P
L
V
S
G
H
Site 27
S250
L
P
P
P
A
R
T
S
P
L
V
S
G
H
C
Site 28
S254
A
R
T
S
P
L
V
S
G
H
C
K
N
I
P
Site 29
T281
Y
A
E
Q
R
I
P
T
L
N
E
Y
C
V
V
Site 30
Y285
R
I
P
T
L
N
E
Y
C
V
V
C
D
E
Q
Site 31
S348
M
C
R
A
A
L
E
S
P
R
K
S
I
I
F
Site 32
S352
A
L
E
S
P
R
K
S
I
I
F
E
P
Y
P
Site 33
Y358
K
S
I
I
F
E
P
Y
P
S
V
V
D
P
T
Site 34
S360
I
I
F
E
P
Y
P
S
V
V
D
P
T
D
P
Site 35
T365
Y
P
S
V
V
D
P
T
D
P
K
T
L
A
F
Site 36
T369
V
D
P
T
D
P
K
T
L
A
F
N
P
K
K
Site 37
Y379
F
N
P
K
K
K
N
Y
E
R
L
Q
K
A
L
Site 38
S388
R
L
Q
K
A
L
D
S
V
M
S
I
R
E
M
Site 39
S391
K
A
L
D
S
V
M
S
I
R
E
M
T
Q
G
Site 40
T396
V
M
S
I
R
E
M
T
Q
G
S
Y
L
E
I
Site 41
Y400
R
E
M
T
Q
G
S
Y
L
E
I
K
K
Q
M
Site 42
T442
S
R
L
K
F
M
H
T
S
H
Q
F
L
L
L
Site 43
S443
R
L
K
F
M
H
T
S
H
Q
F
L
L
L
S
Site 44
S450
S
H
Q
F
L
L
L
S
S
P
P
A
K
E
A
Site 45
S451
H
Q
F
L
L
L
S
S
P
P
A
K
E
A
R
Site 46
T461
A
K
E
A
R
F
R
T
A
K
K
L
Y
G
S
Site 47
Y466
F
R
T
A
K
K
L
Y
G
S
T
F
A
F
H
Site 48
S468
T
A
K
K
L
Y
G
S
T
F
A
F
H
G
S
Site 49
T469
A
K
K
L
Y
G
S
T
F
A
F
H
G
S
H
Site 50
S482
S
H
I
E
N
W
H
S
I
L
R
N
G
L
V
Site 51
Y493
N
G
L
V
N
A
S
Y
T
K
L
Q
L
H
G
Site 52
S520
S
S
I
S
F
G
Y
S
G
M
G
K
G
Q
H
Site 53
S531
K
G
Q
H
R
M
P
S
K
D
E
L
V
Q
R
Site 54
Y539
K
D
E
L
V
Q
R
Y
N
R
M
N
T
I
P
Site 55
T544
Q
R
Y
N
R
M
N
T
I
P
Q
T
R
S
I
Site 56
T548
R
M
N
T
I
P
Q
T
R
S
I
Q
S
R
F
Site 57
Y598
C
T
R
F
F
F
V
Y
E
D
G
Q
V
G
D
Site 58
T610
V
G
D
A
N
I
N
T
Q
D
P
K
I
Q
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation