KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SMTNL2
Full Name:
Smoothelin-like protein 2
Alias:
Smoothelin-like 2; Smtl2; Smtnl2
Type:
Mass (Da):
50196
Number AA:
461
UniProt ID:
Q2TAL5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
P
D
A
Q
E
A
R
T
V
R
E
A
L
G
R
Site 2
T59
L
A
G
P
L
A
R
T
V
A
D
L
Q
R
D
Site 3
T78
Q
A
Q
L
E
R
L
T
R
Q
V
E
A
L
G
Site 4
T96
G
M
S
P
V
P
G
T
P
G
T
P
S
P
P
Site 5
T99
P
V
P
G
T
P
G
T
P
S
P
P
P
A
P
Site 6
S101
P
G
T
P
G
T
P
S
P
P
P
A
P
G
V
Site 7
S117
D
R
A
P
R
L
G
S
A
R
F
A
S
H
A
Site 8
T125
A
R
F
A
S
H
A
T
F
S
L
S
G
R
G
Site 9
S127
F
A
S
H
A
T
F
S
L
S
G
R
G
Q
S
Site 10
S129
S
H
A
T
F
S
L
S
G
R
G
Q
S
L
D
Site 11
S134
S
L
S
G
R
G
Q
S
L
D
H
D
E
A
S
Site 12
S141
S
L
D
H
D
E
A
S
E
S
E
M
R
K
T
Site 13
S143
D
H
D
E
A
S
E
S
E
M
R
K
T
S
N
Site 14
T148
S
E
S
E
M
R
K
T
S
N
S
C
I
M
E
Site 15
S149
E
S
E
M
R
K
T
S
N
S
C
I
M
E
N
Site 16
S176
P
E
I
A
Q
N
F
S
A
P
D
P
P
R
P
Site 17
S187
P
P
R
P
R
P
V
S
L
S
L
R
L
P
H
Site 18
S189
R
P
R
P
V
S
L
S
L
R
L
P
H
Q
P
Site 19
T198
R
L
P
H
Q
P
V
T
A
I
T
R
V
S
D
Site 20
S204
V
T
A
I
T
R
V
S
D
R
F
S
G
E
T
Site 21
S208
T
R
V
S
D
R
F
S
G
E
T
S
A
A
A
Site 22
T211
S
D
R
F
S
G
E
T
S
A
A
A
L
S
P
Site 23
S212
D
R
F
S
G
E
T
S
A
A
A
L
S
P
M
Site 24
S230
T
L
G
G
L
N
P
S
P
S
E
V
I
T
P
Site 25
S232
G
G
L
N
P
S
P
S
E
V
I
T
P
W
T
Site 26
T236
P
S
P
S
E
V
I
T
P
W
T
P
S
P
S
Site 27
T239
S
E
V
I
T
P
W
T
P
S
P
S
E
K
N
Site 28
S241
V
I
T
P
W
T
P
S
P
S
E
K
N
S
S
Site 29
S243
T
P
W
T
P
S
P
S
E
K
N
S
S
F
T
Site 30
S247
P
S
P
S
E
K
N
S
S
F
T
W
S
V
P
Site 31
S248
S
P
S
E
K
N
S
S
F
T
W
S
V
P
S
Site 32
T250
S
E
K
N
S
S
F
T
W
S
V
P
S
S
G
Site 33
S252
K
N
S
S
F
T
W
S
V
P
S
S
G
Y
G
Site 34
T262
S
S
G
Y
G
A
V
T
A
S
K
H
S
N
S
Site 35
S264
G
Y
G
A
V
T
A
S
K
H
S
N
S
P
P
Site 36
S267
A
V
T
A
S
K
H
S
N
S
P
P
L
V
T
Site 37
S269
T
A
S
K
H
S
N
S
P
P
L
V
T
P
P
Site 38
T274
S
N
S
P
P
L
V
T
P
P
Q
S
P
V
S
Site 39
S278
P
L
V
T
P
P
Q
S
P
V
S
P
Q
P
P
Site 40
S281
T
P
P
Q
S
P
V
S
P
Q
P
P
A
I
T
Site 41
S303
R
R
R
E
L
V
R
S
Q
T
L
P
R
T
S
Site 42
T305
R
E
L
V
R
S
Q
T
L
P
R
T
S
E
A
Site 43
S310
S
Q
T
L
P
R
T
S
E
A
Q
A
R
K
A
Site 44
S342
A
R
A
R
L
K
R
S
Q
S
F
G
V
A
S
Site 45
S344
A
R
L
K
R
S
Q
S
F
G
V
A
S
A
S
Site 46
S349
S
Q
S
F
G
V
A
S
A
S
S
I
K
Q
I
Site 47
S377
H
V
D
L
Q
N
F
S
S
S
W
S
D
G
M
Site 48
S378
V
D
L
Q
N
F
S
S
S
W
S
D
G
M
A
Site 49
S379
D
L
Q
N
F
S
S
S
W
S
D
G
M
A
F
Site 50
Y400
F
F
P
D
A
F
D
Y
N
S
L
S
P
T
Q
Site 51
S402
P
D
A
F
D
Y
N
S
L
S
P
T
Q
R
Q
Site 52
S404
A
F
D
Y
N
S
L
S
P
T
Q
R
Q
K
N
Site 53
T406
D
Y
N
S
L
S
P
T
Q
R
Q
K
N
F
E
Site 54
T417
K
N
F
E
L
A
F
T
M
A
E
N
L
A
N
Site 55
Y454
F
T
Y
V
Q
S
L
Y
N
H
L
R
R
F
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation