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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HKDC1
Full Name:
Putative hexokinase HKDC1
Alias:
EC 2.7.1.1; FLJ22761; FLJ37767; Hexokinase domain containing 1
Type:
EC 2.7.1.1; Kinase (non-protein)
Mass (Da):
102515
Number AA:
917
UniProt ID:
Q2TB90
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004396
PhosphoSite+
KinaseNET
Biological Process:
GO:0006096
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y27
K
K
V
D
R
F
L
Y
H
M
R
L
S
D
D
Site 2
T35
H
M
R
L
S
D
D
T
L
L
D
I
M
R
R
Site 3
S82
S
E
N
G
E
F
L
S
L
D
L
G
G
S
K
Site 4
Y112
V
Q
M
E
S
Q
F
Y
P
T
P
N
E
I
I
Site 5
T114
M
E
S
Q
F
Y
P
T
P
N
E
I
I
R
G
Site 6
T153
K
K
L
P
L
G
L
T
F
S
F
P
C
R
Q
Site 7
S155
L
P
L
G
L
T
F
S
F
P
C
R
Q
T
K
Site 8
T161
F
S
F
P
C
R
Q
T
K
L
E
E
G
V
L
Site 9
S170
L
E
E
G
V
L
L
S
W
T
K
K
F
K
A
Site 10
T183
K
A
R
G
V
Q
D
T
D
V
V
S
R
L
T
Site 11
T190
T
D
V
V
S
R
L
T
K
A
M
R
R
H
K
Site 12
Y238
G
T
G
T
N
A
C
Y
M
E
D
M
S
N
I
Site 13
T275
G
A
L
E
D
I
R
T
E
F
D
R
E
L
D
Site 14
S285
D
R
E
L
D
L
G
S
L
N
P
G
K
Q
L
Site 15
Y301
E
K
M
I
S
G
L
Y
L
G
E
L
V
R
L
Site 16
S325
L
L
F
G
G
E
K
S
S
A
L
H
T
K
G
Site 17
T330
E
K
S
S
A
L
H
T
K
G
K
I
E
T
R
Site 18
T408
K
K
V
E
R
L
R
T
T
V
G
M
D
G
T
Site 19
T409
K
V
E
R
L
R
T
T
V
G
M
D
G
T
L
Site 20
T415
T
T
V
G
M
D
G
T
L
Y
K
I
H
P
Q
Site 21
Y417
V
G
M
D
G
T
L
Y
K
I
H
P
Q
Y
P
Site 22
Y423
L
Y
K
I
H
P
Q
Y
P
K
R
L
H
K
V
Site 23
S445
C
D
V
R
F
L
L
S
E
S
G
S
T
K
G
Site 24
S461
A
M
V
T
A
V
A
S
R
V
Q
A
Q
R
K
Site 25
Y497
K
M
R
A
E
L
E
Y
G
L
K
K
K
S
H
Site 26
S503
E
Y
G
L
K
K
K
S
H
G
L
A
T
V
R
Site 27
T508
K
K
S
H
G
L
A
T
V
R
M
L
P
T
Y
Site 28
S551
K
I
R
S
G
R
R
S
V
R
M
Y
N
K
I
Site 29
Y555
G
R
R
S
V
R
M
Y
N
K
I
F
A
I
P
Site 30
S609
S
F
P
C
R
Q
M
S
I
D
K
G
T
L
I
Site 31
T614
Q
M
S
I
D
K
G
T
L
I
G
W
T
K
G
Site 32
Y724
I
D
D
I
R
T
R
Y
D
T
E
V
D
E
G
Site 33
T726
D
I
R
T
R
Y
D
T
E
V
D
E
G
S
L
Site 34
S732
D
T
E
V
D
E
G
S
L
N
P
G
K
Q
R
Site 35
Y740
L
N
P
G
K
Q
R
Y
E
K
M
T
S
G
M
Site 36
T744
K
Q
R
Y
E
K
M
T
S
G
M
Y
L
G
E
Site 37
Y748
E
K
M
T
S
G
M
Y
L
G
E
I
V
R
Q
Site 38
S772
L
L
F
R
G
Q
I
S
E
R
L
R
T
R
G
Site 39
T777
Q
I
S
E
R
L
R
T
R
G
I
F
E
T
K
Site 40
T783
R
T
R
G
I
F
E
T
K
F
L
S
Q
I
E
Site 41
S787
I
F
E
T
K
F
L
S
Q
I
E
S
D
R
L
Site 42
S791
K
F
L
S
Q
I
E
S
D
R
L
A
L
L
Q
Site 43
Y864
V
G
V
D
G
T
L
Y
K
L
H
P
H
F
S
Site 44
S871
Y
K
L
H
P
H
F
S
R
I
L
Q
E
T
V
Site 45
T877
F
S
R
I
L
Q
E
T
V
K
E
L
A
P
R
Site 46
S892
C
D
V
T
F
M
L
S
E
D
G
S
G
K
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation