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Updated November 2019
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Protein Info
Short Name:
FHOD3
Full Name:
FH1/FH2 domain-containing protein 3
Alias:
FH1/FH2 domain-containing 3; FHOS2; FLJ22297; FLJ22717; Formactin2; Formactin-2; Formin 2 domain containing 3; Formin overexpressed in spleen 2; Forminy 2 domain containing 3; KIAA1695
Type:
Cytoskeleton protein
Mass (Da):
158628
Number AA:
1422
UniProt ID:
Q2V2M9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
Uniprot
OncoNet
Molecular Function:
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
GO:0030036
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T14
R
V
Q
F
L
D
D
T
D
P
F
N
S
T
N
Site 2
T20
D
T
D
P
F
N
S
T
N
F
P
E
P
S
R
Site 3
S26
S
T
N
F
P
E
P
S
R
P
P
L
F
T
F
Site 4
T32
P
S
R
P
P
L
F
T
F
R
E
D
L
A
L
Site 5
T60
P
H
K
L
D
D
C
T
L
Q
L
S
H
N
G
Site 6
S64
D
D
C
T
L
Q
L
S
H
N
G
A
Y
L
G
Site 7
S97
A
G
R
G
K
K
H
S
I
I
L
R
T
Q
L
Site 8
Y116
H
A
C
I
E
K
L
Y
N
S
S
G
R
D
L
Site 9
S118
C
I
E
K
L
Y
N
S
S
G
R
D
L
R
R
Site 10
S119
I
E
K
L
Y
N
S
S
G
R
D
L
R
R
A
Site 11
S129
D
L
R
R
A
L
F
S
L
K
Q
I
F
Q
D
Site 12
Y164
G
A
E
A
D
Q
N
Y
Q
N
Y
I
L
R
A
Site 13
Y167
A
D
Q
N
Y
Q
N
Y
I
L
R
A
L
G
Q
Site 14
T191
G
V
I
N
R
N
E
T
I
Q
W
L
Y
T
L
Site 15
Y196
N
E
T
I
Q
W
L
Y
T
L
I
G
S
K
F
Site 16
T197
E
T
I
Q
W
L
Y
T
L
I
G
S
K
F
R
Site 17
T237
Q
A
V
T
A
V
D
T
K
R
G
V
K
P
W
Site 18
S245
K
R
G
V
K
P
W
S
N
I
M
E
I
L
E
Site 19
T272
A
M
T
L
V
N
K
T
L
S
G
L
P
D
Q
Site 20
T281
S
G
L
P
D
Q
D
T
F
Y
D
V
V
D
C
Site 21
Y283
L
P
D
Q
D
T
F
Y
D
V
V
D
C
L
E
Site 22
S298
E
L
G
I
A
A
V
S
Q
R
H
L
N
K
K
Site 23
Y318
L
V
E
Q
L
N
I
Y
E
V
A
L
R
H
E
Site 24
T330
R
H
E
D
G
D
E
T
T
E
P
P
P
S
G
Site 25
T331
H
E
D
G
D
E
T
T
E
P
P
P
S
G
C
Site 26
S336
E
T
T
E
P
P
P
S
G
C
R
D
R
R
R
Site 27
S345
C
R
D
R
R
R
A
S
V
C
S
S
G
G
G
Site 28
S348
R
R
R
A
S
V
C
S
S
G
G
G
E
H
R
Site 29
S349
R
R
A
S
V
C
S
S
G
G
G
E
H
R
G
Site 30
S362
R
G
L
D
R
R
R
S
R
R
H
S
V
Q
S
Site 31
S366
R
R
R
S
R
R
H
S
V
Q
S
I
K
S
T
Site 32
S369
S
R
R
H
S
V
Q
S
I
K
S
T
L
S
A
Site 33
S372
H
S
V
Q
S
I
K
S
T
L
S
A
P
T
S
Site 34
T373
S
V
Q
S
I
K
S
T
L
S
A
P
T
S
P
Site 35
S375
Q
S
I
K
S
T
L
S
A
P
T
S
P
C
S
Site 36
S379
S
T
L
S
A
P
T
S
P
C
S
Q
S
A
P
Site 37
S382
S
A
P
T
S
P
C
S
Q
S
A
P
S
F
K
Site 38
S384
P
T
S
P
C
S
Q
S
A
P
S
F
K
P
N
Site 39
S387
P
C
S
Q
S
A
P
S
F
K
P
N
Q
V
R
Site 40
Y400
V
R
D
L
R
E
K
Y
S
N
F
G
N
N
S
Site 41
S401
R
D
L
R
E
K
Y
S
N
F
G
N
N
S
Y
Site 42
S407
Y
S
N
F
G
N
N
S
Y
H
S
S
R
P
S
Site 43
Y408
S
N
F
G
N
N
S
Y
H
S
S
R
P
S
S
Site 44
S410
F
G
N
N
S
Y
H
S
S
R
P
S
S
G
S
Site 45
S411
G
N
N
S
Y
H
S
S
R
P
S
S
G
S
S
Site 46
S414
S
Y
H
S
S
R
P
S
S
G
S
S
V
P
T
Site 47
S415
Y
H
S
S
R
P
S
S
G
S
S
V
P
T
T
Site 48
S417
S
S
R
P
S
S
G
S
S
V
P
T
T
P
T
Site 49
S418
S
R
P
S
S
G
S
S
V
P
T
T
P
T
S
Site 50
T421
S
S
G
S
S
V
P
T
T
P
T
S
S
V
S
Site 51
T422
S
G
S
S
V
P
T
T
P
T
S
S
V
S
P
Site 52
T424
S
S
V
P
T
T
P
T
S
S
V
S
P
P
Q
Site 53
S425
S
V
P
T
T
P
T
S
S
V
S
P
P
Q
E
Site 54
S426
V
P
T
T
P
T
S
S
V
S
P
P
Q
E
A
Site 55
S428
T
T
P
T
S
S
V
S
P
P
Q
E
A
R
W
Site 56
S439
E
A
R
W
E
R
S
S
P
S
G
L
L
T
S
Site 57
S441
R
W
E
R
S
S
P
S
G
L
L
T
S
S
F
Site 58
T445
S
S
P
S
G
L
L
T
S
S
F
R
Q
H
Q
Site 59
S446
S
P
S
G
L
L
T
S
S
F
R
Q
H
Q
E
Site 60
S447
P
S
G
L
L
T
S
S
F
R
Q
H
Q
E
S
Site 61
S454
S
F
R
Q
H
Q
E
S
L
A
A
E
R
E
R
Site 62
Y483
E
E
R
N
K
F
R
Y
K
Y
L
E
Q
L
A
Site 63
Y485
R
N
K
F
R
Y
K
Y
L
E
Q
L
A
A
E
Site 64
S500
E
H
E
K
E
L
R
S
R
S
V
S
R
G
R
Site 65
S502
E
K
E
L
R
S
R
S
V
S
R
G
R
A
D
Site 66
S504
E
L
R
S
R
S
V
S
R
G
R
A
D
L
S
Site 67
S511
S
R
G
R
A
D
L
S
L
D
L
T
S
P
A
Site 68
S527
P
A
C
L
A
P
L
S
H
S
P
S
S
S
D
Site 69
S529
C
L
A
P
L
S
H
S
P
S
S
S
D
S
Q
Site 70
S531
A
P
L
S
H
S
P
S
S
S
D
S
Q
E
A
Site 71
S532
P
L
S
H
S
P
S
S
S
D
S
Q
E
A
L
Site 72
S533
L
S
H
S
P
S
S
S
D
S
Q
E
A
L
T
Site 73
S535
H
S
P
S
S
S
D
S
Q
E
A
L
T
V
S
Site 74
T540
S
D
S
Q
E
A
L
T
V
S
A
S
S
P
G
Site 75
S542
S
Q
E
A
L
T
V
S
A
S
S
P
G
T
P
Site 76
S544
E
A
L
T
V
S
A
S
S
P
G
T
P
H
H
Site 77
S545
A
L
T
V
S
A
S
S
P
G
T
P
H
H
P
Site 78
T548
V
S
A
S
S
P
G
T
P
H
H
P
Q
A
S
Site 79
S563
A
G
D
P
E
P
E
S
E
A
E
P
E
A
E
Site 80
S586
E
A
G
Q
D
I
A
S
A
H
E
G
A
E
T
Site 81
T593
S
A
H
E
G
A
E
T
E
V
E
Q
A
L
E
Site 82
S608
Q
E
P
E
E
R
A
S
L
S
E
K
E
R
Q
Site 83
S610
P
E
E
R
A
S
L
S
E
K
E
R
Q
N
E
Site 84
S626
V
N
E
R
D
N
C
S
A
S
S
V
S
S
S
Site 85
S628
E
R
D
N
C
S
A
S
S
V
S
S
S
S
S
Site 86
S629
R
D
N
C
S
A
S
S
V
S
S
S
S
S
T
Site 87
S631
N
C
S
A
S
S
V
S
S
S
S
S
T
L
E
Site 88
S632
C
S
A
S
S
V
S
S
S
S
S
T
L
E
R
Site 89
S633
S
A
S
S
V
S
S
S
S
S
T
L
E
R
E
Site 90
S635
S
S
V
S
S
S
S
S
T
L
E
R
E
E
K
Site 91
T636
S
V
S
S
S
S
S
T
L
E
R
E
E
K
E
Site 92
S647
E
E
K
E
D
K
L
S
R
D
R
T
T
G
L
Site 93
T651
D
K
L
S
R
D
R
T
T
G
L
W
P
A
G
Site 94
T652
K
L
S
R
D
R
T
T
G
L
W
P
A
G
V
Site 95
Y683
R
F
M
L
D
M
L
Y
A
H
N
R
K
S
P
Site 96
S689
L
Y
A
H
N
R
K
S
P
D
D
E
E
K
G
Site 97
T703
G
D
G
E
A
G
R
T
Q
Q
E
A
E
A
V
Site 98
S712
Q
E
A
E
A
V
A
S
L
A
T
R
I
S
T
Site 99
S718
A
S
L
A
T
R
I
S
T
L
Q
A
N
S
Q
Site 100
T719
S
L
A
T
R
I
S
T
L
Q
A
N
S
Q
T
Site 101
S730
N
S
Q
T
Q
D
E
S
V
R
R
V
D
V
G
Site 102
S744
G
C
L
D
N
R
G
S
V
K
A
F
A
E
K
Site 103
S754
A
F
A
E
K
F
N
S
G
D
L
G
R
G
S
Site 104
S761
S
G
D
L
G
R
G
S
I
S
P
D
A
E
P
Site 105
S763
D
L
G
R
G
S
I
S
P
D
A
E
P
N
D
Site 106
T775
P
N
D
K
V
P
E
T
A
P
V
Q
P
K
T
Site 107
T782
T
A
P
V
Q
P
K
T
E
S
D
Y
I
W
D
Site 108
Y786
Q
P
K
T
E
S
D
Y
I
W
D
Q
L
M
A
Site 109
T806
R
I
Q
D
M
D
F
T
D
L
G
E
E
D
D
Site 110
T836
P
P
P
P
P
P
P
T
F
L
G
L
P
P
P
Site 111
S851
P
P
P
P
L
L
D
S
I
P
P
P
P
V
P
Site 112
S878
A
P
Q
G
L
G
W
S
Q
V
P
R
G
Q
P
Site 113
T886
Q
V
P
R
G
Q
P
T
F
T
K
K
K
K
T
Site 114
T888
P
R
G
Q
P
T
F
T
K
K
K
K
T
I
R
Site 115
T893
T
F
T
K
K
K
K
T
I
R
L
F
W
N
E
Site 116
S920
R
C
R
E
F
L
W
S
K
L
E
P
I
K
V
Site 117
T929
L
E
P
I
K
V
D
T
S
R
L
E
H
L
F
Site 118
S930
E
P
I
K
V
D
T
S
R
L
E
H
L
F
E
Site 119
S938
R
L
E
H
L
F
E
S
K
S
K
E
L
S
V
Site 120
S940
E
H
L
F
E
S
K
S
K
E
L
S
V
S
K
Site 121
S944
E
S
K
S
K
E
L
S
V
S
K
K
T
A
A
Site 122
S963
Q
E
I
I
V
L
D
S
K
R
S
N
A
I
N
Site 123
Y992
A
I
L
N
F
D
E
Y
A
L
N
K
E
G
I
Site 124
T1004
E
G
I
E
K
I
L
T
M
I
P
T
D
E
E
Site 125
Y1056
L
W
A
F
K
M
D
Y
E
T
T
E
K
E
V
Site 126
T1082
D
Q
L
E
N
N
K
T
L
G
F
I
L
S
T
Site 127
S1108
N
A
K
A
F
E
L
S
Y
L
E
K
V
P
E
Site 128
Y1109
A
K
A
F
E
L
S
Y
L
E
K
V
P
E
V
Site 129
T1119
K
V
P
E
V
K
D
T
V
H
K
Q
S
L
L
Site 130
S1140
V
V
E
N
F
P
D
S
S
D
L
Y
S
E
I
Site 131
S1141
V
E
N
F
P
D
S
S
D
L
Y
S
E
I
G
Site 132
Y1144
F
P
D
S
S
D
L
Y
S
E
I
G
A
I
T
Site 133
S1145
P
D
S
S
D
L
Y
S
E
I
G
A
I
T
R
Site 134
S1196
P
V
L
K
Q
R
M
S
E
F
L
K
D
C
A
Site 135
T1256
F
A
L
E
Y
R
T
T
R
E
R
V
L
Q
Q
Site 136
T1276
N
H
R
E
R
N
K
T
R
G
K
M
I
T
D
Site 137
T1282
K
T
R
G
K
M
I
T
D
S
G
K
F
S
G
Site 138
S1284
R
G
K
M
I
T
D
S
G
K
F
S
G
S
S
Site 139
S1288
I
T
D
S
G
K
F
S
G
S
S
P
A
P
P
Site 140
S1290
D
S
G
K
F
S
G
S
S
P
A
P
P
S
Q
Site 141
S1291
S
G
K
F
S
G
S
S
P
A
P
P
S
Q
P
Site 142
S1296
G
S
S
P
A
P
P
S
Q
P
Q
G
L
S
Y
Site 143
S1302
P
S
Q
P
Q
G
L
S
Y
A
E
D
A
A
E
Site 144
T1319
N
M
K
A
V
L
K
T
S
S
P
S
V
E
D
Site 145
S1321
K
A
V
L
K
T
S
S
P
S
V
E
D
A
T
Site 146
S1323
V
L
K
T
S
S
P
S
V
E
D
A
T
P
A
Site 147
T1328
S
P
S
V
E
D
A
T
P
A
L
G
V
R
T
Site 148
S1337
A
L
G
V
R
T
R
S
R
A
S
R
G
S
T
Site 149
S1340
V
R
T
R
S
R
A
S
R
G
S
T
S
S
W
Site 150
S1343
R
S
R
A
S
R
G
S
T
S
S
W
T
M
G
Site 151
T1344
S
R
A
S
R
G
S
T
S
S
W
T
M
G
T
Site 152
S1346
A
S
R
G
S
T
S
S
W
T
M
G
T
D
D
Site 153
S1354
W
T
M
G
T
D
D
S
P
N
V
T
D
D
A
Site 154
T1358
T
D
D
S
P
N
V
T
D
D
A
A
D
E
I
Site 155
S1372
I
M
D
R
I
V
K
S
A
T
Q
V
P
S
Q
Site 156
T1374
D
R
I
V
K
S
A
T
Q
V
P
S
Q
R
V
Site 157
S1378
K
S
A
T
Q
V
P
S
Q
R
V
V
P
R
E
Site 158
S1389
V
P
R
E
R
K
R
S
R
A
N
R
K
S
L
Site 159
S1395
R
S
R
A
N
R
K
S
L
R
R
T
L
K
S
Site 160
T1399
N
R
K
S
L
R
R
T
L
K
S
G
L
T
P
Site 161
S1402
S
L
R
R
T
L
K
S
G
L
T
P
E
E
A
Site 162
T1405
R
T
L
K
S
G
L
T
P
E
E
A
R
A
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation