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Updated November 2019
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Protein Info
Short Name:
FER1L6
Full Name:
Fer-1-like protein 6
Alias:
C8orfk23; C8orfk23 protein; Fer1l6; Fer-1-like 6 (c. elegans); Fr1l6
Type:
Mass (Da):
209297
Number AA:
1857
UniProt ID:
Q2WGJ9
International Prot ID:
IPI00333405
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
A
N
K
A
A
K
D
S
Q
G
D
T
E
A
L
Site 2
T31
A
K
D
S
Q
G
D
T
E
A
L
Q
E
E
P
Site 3
S39
E
A
L
Q
E
E
P
S
H
Q
E
G
P
R
G
Site 4
S60
A
S
I
F
P
V
P
S
A
S
P
K
R
R
S
Site 5
S62
I
F
P
V
P
S
A
S
P
K
R
R
S
K
L
Site 6
S67
S
A
S
P
K
R
R
S
K
L
L
T
K
I
H
Site 7
T71
K
R
R
S
K
L
L
T
K
I
H
D
G
E
V
Site 8
S115
I
G
D
E
K
K
Q
S
T
V
K
E
G
T
N
Site 9
T121
Q
S
T
V
K
E
G
T
N
S
P
F
Y
N
E
Site 10
S123
T
V
K
E
G
T
N
S
P
F
Y
N
E
Y
F
Site 11
Y126
E
G
T
N
S
P
F
Y
N
E
Y
F
V
F
D
Site 12
Y129
N
S
P
F
Y
N
E
Y
F
V
F
D
F
I
G
Site 13
T170
S
F
K
V
D
L
G
T
V
Y
N
Q
P
G
H
Site 14
Y172
K
V
D
L
G
T
V
Y
N
Q
P
G
H
Q
F
Site 15
T194
T
D
P
G
D
I
R
T
G
T
K
G
Y
L
K
Site 16
T196
P
G
D
I
R
T
G
T
K
G
Y
L
K
C
D
Site 17
T215
G
K
G
D
V
L
K
T
S
P
K
T
S
D
T
Site 18
S216
K
G
D
V
L
K
T
S
P
K
T
S
D
T
E
Site 19
S220
L
K
T
S
P
K
T
S
D
T
E
E
P
I
E
Site 20
T222
T
S
P
K
T
S
D
T
E
E
P
I
E
K
N
Site 21
Y246
E
R
P
W
A
R
F
Y
V
R
L
Y
K
A
E
Site 22
Y250
A
R
F
Y
V
R
L
Y
K
A
E
G
L
P
K
Site 23
S260
E
G
L
P
K
M
N
S
S
I
M
A
N
V
T
Site 24
S274
T
K
A
F
V
G
D
S
K
D
L
V
D
P
F
Site 25
T294
A
G
Q
M
G
R
T
T
V
Q
K
N
C
A
D
Site 26
T359
G
D
K
G
F
L
P
T
F
G
P
A
W
I
N
Site 27
Y368
G
P
A
W
I
N
L
Y
G
S
P
R
N
H
S
Site 28
S375
Y
G
S
P
R
N
H
S
L
M
D
D
Y
Q
E
Site 29
Y380
N
H
S
L
M
D
D
Y
Q
E
M
N
E
G
F
Site 30
S407
E
I
A
V
E
I
L
S
G
R
A
Q
E
S
K
Site 31
S413
L
S
G
R
A
Q
E
S
K
F
S
K
A
L
K
Site 32
S426
L
K
E
L
K
L
P
S
K
D
K
D
S
K
S
Site 33
S431
L
P
S
K
D
K
D
S
K
S
S
K
G
K
D
Site 34
S433
S
K
D
K
D
S
K
S
S
K
G
K
D
K
A
Site 35
T443
G
K
D
K
A
D
K
T
E
D
G
K
S
Q
Q
Site 36
S448
D
K
T
E
D
G
K
S
Q
Q
A
S
N
K
T
Site 37
S452
D
G
K
S
Q
Q
A
S
N
K
T
N
S
T
E
Site 38
S457
Q
A
S
N
K
T
N
S
T
E
V
E
V
E
S
Site 39
S464
S
T
E
V
E
V
E
S
F
D
V
P
P
E
I
Site 40
S501
K
I
G
D
K
P
I
S
F
E
V
S
I
G
N
Site 41
S517
G
N
L
I
D
G
G
S
H
Y
G
S
K
K
S
Site 42
Y519
L
I
D
G
G
S
H
Y
G
S
K
K
S
A
E
Site 43
S521
D
G
G
S
H
Y
G
S
K
K
S
A
E
S
A
Site 44
S524
S
H
Y
G
S
K
K
S
A
E
S
A
E
E
D
Site 45
T555
P
I
P
M
A
S
T
T
H
P
E
K
P
L
V
Site 46
Y569
V
T
E
G
N
R
N
Y
N
Y
L
P
F
E
A
Site 47
Y571
E
G
N
R
N
Y
N
Y
L
P
F
E
A
K
K
Site 48
Y582
E
A
K
K
P
C
V
Y
F
I
S
S
W
G
D
Site 49
T631
A
P
E
E
K
M
K
T
V
L
S
D
F
I
S
Site 50
S634
E
K
M
K
T
V
L
S
D
F
I
S
R
S
S
Site 51
S641
S
D
F
I
S
R
S
S
A
F
I
S
E
A
E
Site 52
S645
S
R
S
S
A
F
I
S
E
A
E
K
K
P
K
Site 53
T665
T
L
D
K
K
R
L
T
L
C
W
Q
E
L
E
Site 54
S690
Q
Q
Q
K
K
K
L
S
V
D
E
M
I
H
E
Site 55
Y732
S
N
N
R
R
V
A
Y
A
R
I
A
S
K
D
Site 56
Y742
I
A
S
K
D
L
L
Y
S
P
V
A
G
Q
M
Site 57
S743
A
S
K
D
L
L
Y
S
P
V
A
G
Q
M
G
Site 58
T758
K
H
C
G
K
I
K
T
H
F
L
K
P
P
G
Site 59
S772
G
K
R
P
A
G
W
S
V
Q
A
K
V
D
V
Site 60
S805
V
G
Y
E
A
E
M
S
S
K
G
A
G
T
N
Site 61
T811
M
S
S
K
G
A
G
T
N
H
P
P
S
N
L
Site 62
S816
A
G
T
N
H
P
P
S
N
L
L
Y
Q
E
Q
Site 63
Y820
H
P
P
S
N
L
L
Y
Q
E
Q
H
V
F
Q
Site 64
S843
R
G
L
I
A
A
D
S
N
G
L
S
D
P
F
Site 65
S847
A
A
D
S
N
G
L
S
D
P
F
A
K
V
T
Site 66
T854
S
D
P
F
A
K
V
T
F
L
S
H
C
Q
T
Site 67
T861
T
F
L
S
H
C
Q
T
T
K
I
I
S
Q
T
Site 68
S866
C
Q
T
T
K
I
I
S
Q
T
L
S
P
T
W
Site 69
T868
T
T
K
I
I
S
Q
T
L
S
P
T
W
N
Q
Site 70
S870
K
I
I
S
Q
T
L
S
P
T
W
N
Q
M
L
Site 71
S905
V
V
V
E
L
Y
D
S
D
A
V
G
K
P
E
Site 72
Y930
V
K
L
A
D
Q
D
Y
E
P
P
R
L
C
Y
Site 73
Y937
Y
E
P
P
R
L
C
Y
H
P
I
F
C
G
N
Site 74
S962
E
L
L
Q
V
P
P
S
G
L
Q
G
L
P
P
Site 75
T976
P
V
E
P
P
D
I
T
Q
I
Y
P
V
P
A
Site 76
Y979
P
P
D
I
T
Q
I
Y
P
V
P
A
N
I
R
Site 77
S1011
M
K
K
V
Q
L
L
S
V
D
R
P
Q
A
L
Site 78
S1074
D
W
R
A
F
G
R
S
T
L
V
G
T
Y
T
Site 79
T1100
R
E
P
L
A
P
I
T
Q
V
D
G
T
Q
P
Site 80
T1105
P
I
T
Q
V
D
G
T
Q
P
G
H
D
I
S
Site 81
S1112
T
Q
P
G
H
D
I
S
D
S
L
T
A
T
E
Site 82
S1114
P
G
H
D
I
S
D
S
L
T
A
T
E
S
S
Site 83
T1116
H
D
I
S
D
S
L
T
A
T
E
S
S
G
A
Site 84
T1118
I
S
D
S
L
T
A
T
E
S
S
G
A
H
S
Site 85
S1120
D
S
L
T
A
T
E
S
S
G
A
H
S
S
S
Site 86
S1121
S
L
T
A
T
E
S
S
G
A
H
S
S
S
Q
Site 87
S1125
T
E
S
S
G
A
H
S
S
S
Q
D
P
P
A
Site 88
S1126
E
S
S
G
A
H
S
S
S
Q
D
P
P
A
D
Site 89
S1127
S
S
G
A
H
S
S
S
Q
D
P
P
A
D
H
Site 90
Y1136
D
P
P
A
D
H
I
Y
V
D
V
E
P
P
P
Site 91
T1144
V
D
V
E
P
P
P
T
V
V
P
D
S
A
Q
Site 92
S1149
P
P
T
V
V
P
D
S
A
Q
A
Q
P
A
I
Site 93
S1163
I
L
V
D
V
P
D
S
S
P
M
L
E
P
E
Site 94
S1164
L
V
D
V
P
D
S
S
P
M
L
E
P
E
H
Site 95
T1172
P
M
L
E
P
E
H
T
P
V
A
Q
E
P
P
Site 96
S1191
P
K
D
P
R
K
P
S
R
R
S
T
K
R
R
Site 97
S1194
P
R
K
P
S
R
R
S
T
K
R
R
K
R
T
Site 98
T1195
R
K
P
S
R
R
S
T
K
R
R
K
R
T
I
Site 99
T1201
S
T
K
R
R
K
R
T
I
A
D
E
S
A
E
Site 100
Y1217
V
I
D
W
W
S
K
Y
Y
A
S
L
K
K
A
Site 101
S1286
I
Y
D
G
D
L
E
S
E
F
N
N
F
E
D
Site 102
T1297
N
F
E
D
W
V
K
T
F
E
L
F
R
G
K
Site 103
S1305
F
E
L
F
R
G
K
S
T
E
D
D
H
G
L
Site 104
Y1328
F
K
G
S
F
C
I
Y
K
S
P
Q
D
S
S
Site 105
S1330
G
S
F
C
I
Y
K
S
P
Q
D
S
S
S
E
Site 106
S1334
I
Y
K
S
P
Q
D
S
S
S
E
D
S
G
Q
Site 107
S1335
Y
K
S
P
Q
D
S
S
S
E
D
S
G
Q
L
Site 108
S1336
K
S
P
Q
D
S
S
S
E
D
S
G
Q
L
R
Site 109
S1339
Q
D
S
S
S
E
D
S
G
Q
L
R
I
Q
Q
Site 110
S1377
P
A
D
P
D
G
K
S
D
P
Y
I
V
I
K
Site 111
Y1380
P
D
G
K
S
D
P
Y
I
V
I
K
L
G
K
Site 112
Y1396
E
I
K
D
R
D
K
Y
I
P
K
Q
L
N
P
Site 113
T1414
R
S
F
E
I
Q
A
T
F
P
K
E
S
L
L
Site 114
S1422
F
P
K
E
S
L
L
S
I
L
I
Y
D
H
D
Site 115
Y1449
I
D
L
E
N
R
F
Y
S
K
H
R
A
I
C
Site 116
S1460
R
A
I
C
G
L
Q
S
Q
Y
E
I
E
G
Y
Site 117
Y1462
I
C
G
L
Q
S
Q
Y
E
I
E
G
Y
N
A
Site 118
Y1467
S
Q
Y
E
I
E
G
Y
N
A
W
R
D
T
S
Site 119
T1473
G
Y
N
A
W
R
D
T
S
K
P
T
E
I
L
Site 120
S1474
Y
N
A
W
R
D
T
S
K
P
T
E
I
L
T
Site 121
Y1493
D
N
K
L
D
G
P
Y
F
H
P
G
K
I
Q
Site 122
T1517
T
I
F
T
E
E
D
T
D
E
T
V
E
S
Y
Site 123
T1520
T
E
E
D
T
D
E
T
V
E
S
Y
E
H
L
Site 124
S1523
D
T
D
E
T
V
E
S
Y
E
H
L
A
L
K
Site 125
T1552
L
V
P
E
H
I
E
T
R
P
L
Y
H
K
D
Site 126
Y1556
H
I
E
T
R
P
L
Y
H
K
D
K
P
G
M
Site 127
S1589
P
G
P
P
V
D
I
S
P
R
R
P
K
G
Y
Site 128
Y1596
S
P
R
R
P
K
G
Y
E
L
R
V
T
I
W
Site 129
T1601
K
G
Y
E
L
R
V
T
I
W
N
T
E
D
V
Site 130
T1617
L
E
D
E
N
I
F
T
G
Q
K
S
S
D
I
Site 131
S1621
N
I
F
T
G
Q
K
S
S
D
I
Y
V
K
G
Site 132
Y1625
G
Q
K
S
S
D
I
Y
V
K
G
W
L
K
G
Site 133
Y1644
K
Q
E
T
D
V
H
Y
N
S
L
T
G
E
G
Site 134
S1646
E
T
D
V
H
Y
N
S
L
T
G
E
G
N
F
Site 135
T1648
D
V
H
Y
N
S
L
T
G
E
G
N
F
N
W
Site 136
Y1663
R
F
L
F
P
F
Q
Y
L
P
A
E
K
Q
M
Site 137
S1680
T
K
R
E
N
I
F
S
L
E
K
M
E
C
K
Site 138
S1703
V
W
D
F
E
R
L
S
S
D
D
F
L
G
T
Site 139
S1704
W
D
F
E
R
L
S
S
D
D
F
L
G
T
L
Site 140
T1710
S
S
D
D
F
L
G
T
L
E
M
N
L
N
S
Site 141
S1717
T
L
E
M
N
L
N
S
F
P
R
A
A
K
S
Site 142
S1743
A
S
E
E
T
K
I
S
I
F
Q
Q
K
R
V
Site 143
S1757
V
R
G
W
W
P
F
S
K
S
K
E
L
T
G
Site 144
S1759
G
W
W
P
F
S
K
S
K
E
L
T
G
K
V
Site 145
T1763
F
S
K
S
K
E
L
T
G
K
V
E
A
E
F
Site 146
T1801
A
K
P
N
R
P
D
T
S
F
S
W
F
M
S
Site 147
S1802
K
P
N
R
P
D
T
S
F
S
W
F
M
S
P
Site 148
S1804
N
R
P
D
T
S
F
S
W
F
M
S
P
F
K
Site 149
Y1815
S
P
F
K
C
L
Y
Y
L
I
W
K
N
Y
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation