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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SLC4A8
Full Name:
Electroneutral sodium bicarbonate exchanger 1
Alias:
Electroneutral Na+- driven Cl-HCO3 exchanger; K-NBC3; NBC; NBC3; NDCBE1; S4A8; Solute carrier family 4 member 8; Solute carrier family 4, sodium bicarbonate cotransporter, member 8
Type:
Membrane, Integral membrane protein
Mass (Da):
122938
Number AA:
1093
UniProt ID:
Q2Y0W8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005452
GO:0031402
PhosphoSite+
KinaseNET
Biological Process:
GO:0006820
GO:0006814
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
P
A
A
G
S
N
E
P
D
G
V
L
Site 2
S14
N
E
P
D
G
V
L
S
Y
Q
R
P
D
E
E
Site 3
Y15
E
P
D
G
V
L
S
Y
Q
R
P
D
E
E
A
Site 4
Y37
S
T
I
L
N
I
H
Y
E
K
E
E
L
E
G
Site 5
T47
E
E
L
E
G
H
R
T
L
Y
V
G
V
R
M
Site 6
Y49
L
E
G
H
R
T
L
Y
V
G
V
R
M
P
L
Site 7
S81
R
G
R
G
K
G
A
S
Q
G
E
E
G
L
E
Site 8
T94
L
E
A
L
A
H
D
T
P
S
Q
R
V
Q
F
Site 9
T136
E
D
A
E
W
K
E
T
A
R
W
L
K
F
E
Site 10
S154
E
D
G
G
E
R
W
S
K
P
Y
V
A
T
L
Site 11
Y157
G
E
R
W
S
K
P
Y
V
A
T
L
S
L
H
Site 12
T160
W
S
K
P
Y
V
A
T
L
S
L
H
S
L
F
Site 13
S186
L
L
D
M
H
A
N
S
I
E
E
I
S
D
L
Site 14
S207
L
S
S
D
L
N
D
S
M
R
V
K
V
R
E
Site 15
S237
N
L
I
P
I
V
R
S
F
A
E
V
G
K
K
Site 16
S246
A
E
V
G
K
K
Q
S
D
P
H
L
M
D
K
Site 17
T257
L
M
D
K
H
G
Q
T
V
S
P
Q
S
V
P
Site 18
S259
D
K
H
G
Q
T
V
S
P
Q
S
V
P
T
T
Site 19
S262
G
Q
T
V
S
P
Q
S
V
P
T
T
N
L
E
Site 20
T266
S
P
Q
S
V
P
T
T
N
L
E
V
K
N
G
Site 21
S279
N
G
V
N
C
E
H
S
P
V
D
L
S
K
V
Site 22
S284
E
H
S
P
V
D
L
S
K
V
D
L
H
F
M
Site 23
S301
I
P
T
G
A
E
A
S
N
V
L
V
G
E
V
Site 24
Y353
P
V
G
K
G
Q
Q
Y
H
E
I
G
R
S
M
Site 25
Y374
E
I
F
H
D
V
A
Y
K
A
K
E
R
D
D
Site 26
T394
D
E
F
L
D
Q
V
T
V
L
P
P
G
E
W
Site 27
S404
P
P
G
E
W
D
P
S
I
R
I
E
P
P
K
Site 28
S415
E
P
P
K
N
V
P
S
Q
E
K
R
K
M
P
Site 29
T448
S
G
P
E
L
Q
R
T
G
R
L
F
G
G
L
Site 30
Y466
I
K
R
K
A
P
W
Y
W
S
D
Y
R
D
A
Site 31
Y470
A
P
W
Y
W
S
D
Y
R
D
A
L
S
L
Q
Site 32
S475
S
D
Y
R
D
A
L
S
L
Q
C
L
A
S
F
Site 33
S509
E
A
T
E
G
R
I
S
A
I
E
S
L
F
G
Site 34
Y588
D
A
S
S
L
V
C
Y
I
T
R
F
T
E
E
Site 35
Y620
L
I
H
L
A
E
T
Y
P
I
H
M
H
S
Q
Site 36
S626
T
Y
P
I
H
M
H
S
Q
L
D
H
L
S
L
Site 37
Y634
Q
L
D
H
L
S
L
Y
Y
C
R
C
T
L
P
Site 38
Y635
L
D
H
L
S
L
Y
Y
C
R
C
T
L
P
E
Site 39
T668
E
V
H
W
A
N
L
T
V
S
E
C
Q
E
M
Site 40
T691
C
G
H
H
G
P
Y
T
P
D
V
L
F
W
S
Site 41
T714
I
L
S
S
T
L
K
T
F
K
T
S
R
Y
F
Site 42
T717
S
T
L
K
T
F
K
T
S
R
Y
F
P
T
R
Site 43
T723
K
T
S
R
Y
F
P
T
R
V
R
S
M
V
S
Site 44
S759
S
P
K
L
Q
V
P
S
V
F
K
P
T
R
D
Site 45
S856
L
S
I
T
H
V
N
S
L
K
L
E
S
E
C
Site 46
S861
V
N
S
L
K
L
E
S
E
C
S
A
P
G
E
Site 47
S864
L
K
L
E
S
E
C
S
A
P
G
E
Q
P
K
Site 48
Y943
K
H
Q
P
D
F
I
Y
L
R
H
V
P
L
R
Site 49
S997
K
V
M
D
L
C
F
S
K
R
E
L
S
W
L
Site 50
S1002
C
F
S
K
R
E
L
S
W
L
D
D
L
M
P
Site 51
S1011
L
D
D
L
M
P
E
S
K
K
K
K
L
D
D
Site 52
S1044
G
D
K
F
P
L
E
S
R
K
L
L
S
S
P
Site 53
S1049
L
E
S
R
K
L
L
S
S
P
G
K
N
I
S
Site 54
S1050
E
S
R
K
L
L
S
S
P
G
K
N
I
S
C
Site 55
S1056
S
S
P
G
K
N
I
S
C
R
C
D
P
S
E
Site 56
S1062
I
S
C
R
C
D
P
S
E
I
N
I
S
D
E
Site 57
S1067
D
P
S
E
I
N
I
S
D
E
M
P
K
T
T
Site 58
T1073
I
S
D
E
M
P
K
T
T
V
W
K
A
L
S
Site 59
T1074
S
D
E
M
P
K
T
T
V
W
K
A
L
S
M
Site 60
S1080
T
T
V
W
K
A
L
S
M
N
S
G
N
A
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation