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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TMEM16D
Full Name:
Anoctamin-4
Alias:
Anoctamin 4; FLJ34221; Flj34221; FLJ34272; Flj34272; FLJ35277; Flj35277; Tm16d; Tmem16d; Tmem16d protein; Transmembrane protein 16d
Type:
Membrane, Integral membrane protein
Mass (Da):
111462
Number AA:
955
UniProt ID:
Q32M45
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0034707
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005254
GO:0031404
PhosphoSite+
KinaseNET
Biological Process:
GO:0006811
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
E
A
S
S
S
G
I
T
N
G
Site 2
S5
_
_
_
M
E
A
S
S
S
G
I
T
N
G
K
Site 3
S6
_
_
M
E
A
S
S
S
G
I
T
N
G
K
T
Site 4
T9
E
A
S
S
S
G
I
T
N
G
K
T
K
V
F
Site 5
T13
S
G
I
T
N
G
K
T
K
V
F
H
P
E
G
Site 6
S40
I
L
P
D
G
P
K
S
D
V
D
F
S
E
I
Site 7
S70
D
E
L
E
A
V
S
S
P
C
K
D
D
D
S
Site 8
S77
S
P
C
K
D
D
D
S
L
L
H
P
G
N
L
Site 9
S86
L
H
P
G
N
L
T
S
T
S
D
D
A
S
R
Site 10
S88
P
G
N
L
T
S
T
S
D
D
A
S
R
L
E
Site 11
S92
T
S
T
S
D
D
A
S
R
L
E
A
G
G
E
Site 12
S107
T
V
P
E
R
N
K
S
N
G
L
Y
F
R
D
Site 13
Y111
R
N
K
S
N
G
L
Y
F
R
D
G
K
C
R
Site 14
Y121
D
G
K
C
R
I
D
Y
I
L
V
Y
R
K
S
Site 15
Y125
R
I
D
Y
I
L
V
Y
R
K
S
N
P
Q
T
Site 16
S128
Y
I
L
V
Y
R
K
S
N
P
Q
T
E
K
R
Site 17
T132
Y
R
K
S
N
P
Q
T
E
K
R
E
V
F
E
Site 18
S154
L
Q
M
E
K
E
S
S
L
I
N
S
D
I
I
Site 19
Y175
P
W
E
V
L
G
R
Y
A
E
Q
M
N
V
R
Site 20
Y190
M
P
F
R
R
K
I
Y
Y
L
P
R
R
Y
K
Site 21
Y191
P
F
R
R
K
I
Y
Y
L
P
R
R
Y
K
F
Site 22
Y196
I
Y
Y
L
P
R
R
Y
K
F
M
S
R
I
D
Site 23
S200
P
R
R
Y
K
F
M
S
R
I
D
K
Q
I
S
Site 24
S207
S
R
I
D
K
Q
I
S
R
F
R
R
W
L
P
Site 25
T224
P
M
R
L
D
K
E
T
L
P
D
L
E
E
N
Site 26
Y234
D
L
E
E
N
D
C
Y
T
A
P
F
S
Q
Q
Site 27
T235
L
E
E
N
D
C
Y
T
A
P
F
S
Q
Q
R
Site 28
Y273
H
I
L
Q
R
I
K
Y
E
E
G
K
N
K
I
Site 29
T287
I
G
L
N
R
L
L
T
N
G
S
Y
E
A
A
Site 30
S290
N
R
L
L
T
N
G
S
Y
E
A
A
F
P
L
Site 31
Y291
R
L
L
T
N
G
S
Y
E
A
A
F
P
L
H
Site 32
S301
A
F
P
L
H
E
G
S
Y
R
S
K
N
S
I
Site 33
Y302
F
P
L
H
E
G
S
Y
R
S
K
N
S
I
R
Site 34
S304
L
H
E
G
S
Y
R
S
K
N
S
I
R
T
H
Site 35
S307
G
S
Y
R
S
K
N
S
I
R
T
H
G
A
E
Site 36
Y321
E
N
H
R
H
L
L
Y
E
C
W
A
S
W
G
Site 37
Y331
W
A
S
W
G
V
W
Y
K
Y
Q
P
L
D
L
Site 38
Y333
S
W
G
V
W
Y
K
Y
Q
P
L
D
L
V
R
Site 39
Y342
P
L
D
L
V
R
R
Y
F
G
E
K
I
G
L
Site 40
S382
G
V
T
T
L
D
H
S
Q
V
S
K
E
V
C
Site 41
Y454
R
R
R
A
V
I
A
Y
D
W
D
L
I
D
W
Site 42
Y476
R
P
Q
F
E
A
K
Y
S
K
K
E
R
M
N
Site 43
S486
K
E
R
M
N
P
I
S
G
K
P
E
P
Y
Q
Site 44
T496
P
E
P
Y
Q
A
F
T
D
K
C
S
R
L
I
Site 45
S546
W
A
L
I
R
N
N
S
Q
V
A
T
T
G
T
Site 46
T584
T
N
L
E
Q
P
R
T
E
S
E
W
E
N
S
Site 47
S586
L
E
Q
P
R
T
E
S
E
W
E
N
S
F
T
Site 48
S591
T
E
S
E
W
E
N
S
F
T
L
K
M
F
L
Site 49
Y625
F
T
G
H
P
G
A
Y
L
R
L
I
N
R
W
Site 50
S691
H
G
P
E
R
K
I
S
F
P
Q
W
E
K
D
Site 51
Y699
F
P
Q
W
E
K
D
Y
N
L
Q
P
M
N
A
Site 52
Y750
I
E
I
R
L
D
A
Y
K
F
V
T
Q
W
R
Site 53
T754
L
D
A
Y
K
F
V
T
Q
W
R
R
P
L
A
Site 54
S762
Q
W
R
R
P
L
A
S
R
A
K
D
I
G
I
Site 55
Y801
D
F
I
P
R
L
V
Y
A
Y
K
Y
G
P
C
Site 56
Y805
R
L
V
Y
A
Y
K
Y
G
P
C
A
G
Q
G
Site 57
S833
S
L
S
V
F
R
I
S
D
F
E
N
R
S
E
Site 58
S839
I
S
D
F
E
N
R
S
E
P
E
S
D
G
S
Site 59
S843
E
N
R
S
E
P
E
S
D
G
S
E
F
S
G
Site 60
S846
S
E
P
E
S
D
G
S
E
F
S
G
T
P
L
Site 61
S849
E
S
D
G
S
E
F
S
G
T
P
L
K
Y
C
Site 62
T851
D
G
S
E
F
S
G
T
P
L
K
Y
C
R
Y
Site 63
Y855
F
S
G
T
P
L
K
Y
C
R
Y
R
D
Y
R
Site 64
Y861
K
Y
C
R
Y
R
D
Y
R
D
P
P
H
S
L
Site 65
S867
D
Y
R
D
P
P
H
S
L
V
P
Y
G
Y
T
Site 66
Y871
P
P
H
S
L
V
P
Y
G
Y
T
L
Q
F
W
Site 67
Y922
D
R
M
R
R
E
K
Y
L
I
Q
E
M
M
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation