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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LEPRE1
Full Name:
Prolyl 3-hydroxylase 1
Alias:
Leucine- and proline-enriched proteoglycan 1
Type:
Mass (Da):
83376
Number AA:
736
UniProt ID:
Q32P28
International Prot ID:
IPI00163381
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
GO:0005578
GO:0005783
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0005488
GO:0005506
PhosphoSite+
KinaseNET
Biological Process:
GO:0008152
GO:0008285
GO:0019538
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S26
A
S
Q
A
E
V
E
S
E
A
G
W
G
M
V
Site 2
Y46
F
A
E
G
T
A
A
Y
A
R
G
D
W
P
G
Site 3
S57
D
W
P
G
V
V
L
S
M
E
R
A
L
R
S
Site 4
S64
S
M
E
R
A
L
R
S
R
A
A
L
R
A
L
Site 5
T77
A
L
R
L
R
C
R
T
Q
C
A
A
D
F
P
Site 6
S92
W
E
L
D
P
D
W
S
P
S
P
A
Q
A
S
Site 7
S94
L
D
P
D
W
S
P
S
P
A
Q
A
S
G
A
Site 8
S99
S
P
S
P
A
Q
A
S
G
A
A
A
L
R
D
Site 9
S131
L
G
P
P
A
A
H
S
L
S
E
E
M
E
L
Site 10
S133
P
P
A
A
H
S
L
S
E
E
M
E
L
E
F
Site 11
S144
E
L
E
F
R
K
R
S
P
Y
N
Y
L
Q
V
Site 12
Y146
E
F
R
K
R
S
P
Y
N
Y
L
Q
V
A
Y
Site 13
Y148
R
K
R
S
P
Y
N
Y
L
Q
V
A
Y
F
K
Site 14
Y153
Y
N
Y
L
Q
V
A
Y
F
K
I
N
K
L
E
Site 15
Y185
E
M
Q
Q
N
L
D
Y
Y
Q
T
M
S
G
V
Site 16
Y186
M
Q
Q
N
L
D
Y
Y
Q
T
M
S
G
V
K
Site 17
S190
L
D
Y
Y
Q
T
M
S
G
V
K
E
A
D
F
Site 18
T202
A
D
F
K
D
L
E
T
Q
P
H
M
Q
E
F
Site 19
Y216
F
R
L
G
V
R
L
Y
S
E
E
Q
P
Q
E
Site 20
S217
R
L
G
V
R
L
Y
S
E
E
Q
P
Q
E
A
Site 21
Y250
R
A
L
C
E
G
P
Y
D
Y
D
G
Y
N
Y
Site 22
Y252
L
C
E
G
P
Y
D
Y
D
G
Y
N
Y
L
E
Site 23
Y255
G
P
Y
D
Y
D
G
Y
N
Y
L
E
Y
N
A
Site 24
Y260
D
G
Y
N
Y
L
E
Y
N
A
D
L
F
Q
A
Site 25
Y306
F
L
P
S
H
Y
N
Y
L
Q
F
A
Y
Y
N
Site 26
Y311
Y
N
Y
L
Q
F
A
Y
Y
N
I
G
N
Y
T
Site 27
Y312
N
Y
L
Q
F
A
Y
Y
N
I
G
N
Y
T
Q
Site 28
Y344
M
N
Q
N
L
A
Y
Y
A
A
M
L
G
E
E
Site 29
S355
L
G
E
E
H
T
R
S
I
G
P
R
E
S
A
Site 30
S361
R
S
I
G
P
R
E
S
A
K
E
Y
R
Q
R
Site 31
Y365
P
R
E
S
A
K
E
Y
R
Q
R
S
L
L
E
Site 32
S369
A
K
E
Y
R
Q
R
S
L
L
E
K
E
L
L
Site 33
S392
I
P
F
V
D
P
D
S
W
T
P
E
E
V
I
Site 34
T394
F
V
D
P
D
S
W
T
P
E
E
V
I
P
K
Site 35
S409
R
L
Q
E
K
Q
K
S
E
R
E
T
A
V
R
Site 36
T413
K
Q
K
S
E
R
E
T
A
V
R
I
S
Q
E
Site 37
S418
R
E
T
A
V
R
I
S
Q
E
I
G
N
L
M
Site 38
T436
E
T
L
V
E
E
K
T
K
E
S
L
D
V
S
Site 39
S439
V
E
E
K
T
K
E
S
L
D
V
S
R
L
T
Site 40
S443
T
K
E
S
L
D
V
S
R
L
T
R
E
G
G
Site 41
T446
S
L
D
V
S
R
L
T
R
E
G
G
P
L
L
Site 42
Y454
R
E
G
G
P
L
L
Y
E
G
I
S
L
T
M
Site 43
S469
N
S
K
L
L
N
G
S
Q
R
V
V
M
D
G
Site 44
T490
C
Q
E
L
Q
R
L
T
N
V
A
A
T
S
G
Site 45
T495
R
L
T
N
V
A
A
T
S
G
D
G
Y
R
G
Site 46
Y500
A
A
T
S
G
D
G
Y
R
G
Q
T
S
P
H
Site 47
T504
G
D
G
Y
R
G
Q
T
S
P
H
T
P
N
E
Site 48
S505
D
G
Y
R
G
Q
T
S
P
H
T
P
N
E
K
Site 49
T508
R
G
Q
T
S
P
H
T
P
N
E
K
F
Y
G
Site 50
Y538
P
L
Q
S
A
H
L
Y
Y
N
V
T
E
K
V
Site 51
S551
K
V
R
R
I
M
E
S
Y
F
R
L
D
T
P
Site 52
Y552
V
R
R
I
M
E
S
Y
F
R
L
D
T
P
L
Site 53
T557
E
S
Y
F
R
L
D
T
P
L
Y
F
S
Y
S
Site 54
S583
Q
A
E
R
K
D
D
S
H
P
V
H
V
D
N
Site 55
Y607
C
V
K
E
P
P
A
Y
T
F
R
D
Y
S
A
Site 56
T608
V
K
E
P
P
A
Y
T
F
R
D
Y
S
A
I
Site 57
Y612
P
A
Y
T
F
R
D
Y
S
A
I
L
Y
L
N
Site 58
S613
A
Y
T
F
R
D
Y
S
A
I
L
Y
L
N
G
Site 59
Y617
R
D
Y
S
A
I
L
Y
L
N
G
D
F
D
G
Site 60
Y628
D
F
D
G
G
N
F
Y
F
T
E
L
D
A
K
Site 61
T636
F
T
E
L
D
A
K
T
V
T
A
E
V
Q
P
Site 62
S652
C
G
R
A
V
G
F
S
S
G
T
E
N
P
H
Site 63
S653
G
R
A
V
G
F
S
S
G
T
E
N
P
H
G
Site 64
T655
A
V
G
F
S
S
G
T
E
N
P
H
G
V
K
Site 65
S683
F
T
L
D
P
R
H
S
E
R
D
R
V
Q
A
Site 66
S699
D
L
V
K
M
L
F
S
P
E
E
M
D
L
S
Site 67
S706
S
P
E
E
M
D
L
S
Q
E
Q
P
L
D
A
Site 68
S724
P
P
E
P
A
Q
E
S
L
S
G
S
E
S
K
Site 69
S726
E
P
A
Q
E
S
L
S
G
S
E
S
K
P
K
Site 70
S728
A
Q
E
S
L
S
G
S
E
S
K
P
K
D
E
Site 71
S730
E
S
L
S
G
S
E
S
K
P
K
D
E
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation