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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RFX4
Full Name:
Transcription factor RFX4
Alias:
Regulatory factor X 4; Regulatory factor X, 4 (influences HLA class II expression); Testis development protein NYD-SP10
Type:
Unknown function
Mass (Da):
83400
Number AA:
UniProt ID:
Q33E94
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
L
E
E
P
D
M
D
S
T
E
S
W
I
E
R
Site 2
T14
E
E
P
D
M
D
S
T
E
S
W
I
E
R
C
Site 3
S25
I
E
R
C
L
N
E
S
E
N
K
R
Y
S
S
Site 4
Y30
N
E
S
E
N
K
R
Y
S
S
H
T
S
L
G
Site 5
S31
E
S
E
N
K
R
Y
S
S
H
T
S
L
G
N
Site 6
S32
S
E
N
K
R
Y
S
S
H
T
S
L
G
N
V
Site 7
T34
N
K
R
Y
S
S
H
T
S
L
G
N
V
S
N
Site 8
S35
K
R
Y
S
S
H
T
S
L
G
N
V
S
N
D
Site 9
S53
E
K
E
N
N
R
A
S
K
P
H
S
T
P
A
Site 10
S57
N
R
A
S
K
P
H
S
T
P
A
T
L
Q
W
Site 11
T58
R
A
S
K
P
H
S
T
P
A
T
L
Q
W
L
Site 12
T61
K
P
H
S
T
P
A
T
L
Q
W
L
E
E
N
Site 13
Y69
L
Q
W
L
E
E
N
Y
E
I
A
E
G
V
C
Site 14
Y86
R
S
A
L
Y
M
H
Y
L
D
F
C
E
K
N
Site 15
T95
D
F
C
E
K
N
D
T
Q
P
V
N
A
A
S
Site 16
S102
T
Q
P
V
N
A
A
S
F
G
K
I
I
R
Q
Site 17
T115
R
Q
Q
F
P
Q
L
T
T
R
R
L
G
T
R
Site 18
T121
L
T
T
R
R
L
G
T
R
G
Q
S
K
Y
H
Site 19
S125
R
L
G
T
R
G
Q
S
K
Y
H
Y
Y
G
I
Site 20
Y127
G
T
R
G
Q
S
K
Y
H
Y
Y
G
I
A
V
Site 21
Y129
R
G
Q
S
K
Y
H
Y
Y
G
I
A
V
K
E
Site 22
Y130
G
Q
S
K
Y
H
Y
Y
G
I
A
V
K
E
S
Site 23
Y140
A
V
K
E
S
S
Q
Y
Y
D
V
M
Y
S
K
Site 24
Y141
V
K
E
S
S
Q
Y
Y
D
V
M
Y
S
K
K
Site 25
Y145
S
Q
Y
Y
D
V
M
Y
S
K
K
G
A
A
W
Site 26
S154
K
K
G
A
A
W
V
S
E
T
G
K
K
E
V
Site 27
T165
K
K
E
V
S
K
Q
T
V
A
Y
S
P
R
S
Site 28
Y168
V
S
K
Q
T
V
A
Y
S
P
R
S
K
L
G
Site 29
S169
S
K
Q
T
V
A
Y
S
P
R
S
K
L
G
T
Site 30
S172
T
V
A
Y
S
P
R
S
K
L
G
T
L
L
P
Site 31
T176
S
P
R
S
K
L
G
T
L
L
P
E
F
P
N
Site 32
S192
K
D
L
N
L
P
A
S
L
P
E
E
K
V
S
Site 33
S199
S
L
P
E
E
K
V
S
T
F
I
M
M
Y
R
Site 34
T200
L
P
E
E
K
V
S
T
F
I
M
M
Y
R
T
Site 35
Y205
V
S
T
F
I
M
M
Y
R
T
H
C
Q
R
I
Site 36
T215
H
C
Q
R
I
L
D
T
V
I
R
A
N
F
D
Site 37
T280
Q
A
L
P
D
S
L
T
Q
V
I
R
K
F
A
Site 38
S313
R
N
I
K
F
E
L
S
R
R
F
S
Q
I
L
Site 39
S317
F
E
L
S
R
R
F
S
Q
I
L
R
R
Q
T
Site 40
T324
S
Q
I
L
R
R
Q
T
S
L
N
H
L
C
Q
Site 41
S325
Q
I
L
R
R
Q
T
S
L
N
H
L
C
Q
A
Site 42
S333
L
N
H
L
C
Q
A
S
R
T
V
I
H
S
A
Site 43
Y364
S
I
T
K
Q
T
L
Y
T
M
E
D
S
R
D
Site 44
S369
T
L
Y
T
M
E
D
S
R
D
E
H
R
K
L
Site 45
Y381
R
K
L
I
T
Q
L
Y
Q
E
F
D
H
L
L
Site 46
S392
D
H
L
L
E
E
Q
S
P
I
E
S
Y
I
E
Site 47
S396
E
E
Q
S
P
I
E
S
Y
I
E
W
L
D
T
Site 48
S419
V
A
A
K
R
Q
G
S
L
K
K
V
A
Q
Q
Site 49
T443
T
R
V
I
R
D
M
T
L
H
S
A
P
S
F
Site 50
S446
I
R
D
M
T
L
H
S
A
P
S
F
G
S
F
Site 51
S508
E
A
A
A
P
T
P
S
P
V
P
S
F
S
P
Site 52
S512
P
T
P
S
P
V
P
S
F
S
P
A
K
S
A
Site 53
S514
P
S
P
V
P
S
F
S
P
A
K
S
A
T
S
Site 54
S518
P
S
F
S
P
A
K
S
A
T
S
V
E
V
P
Site 55
S521
S
P
A
K
S
A
T
S
V
E
V
P
P
P
S
Site 56
S528
S
V
E
V
P
P
P
S
S
P
V
S
N
P
S
Site 57
S529
V
E
V
P
P
P
S
S
P
V
S
N
P
S
P
Site 58
S532
P
P
P
S
S
P
V
S
N
P
S
P
E
Y
T
Site 59
S535
S
S
P
V
S
N
P
S
P
E
Y
T
G
L
S
Site 60
Y538
V
S
N
P
S
P
E
Y
T
G
L
S
T
T
G
Site 61
T539
S
N
P
S
P
E
Y
T
G
L
S
T
T
G
A
Site 62
S542
S
P
E
Y
T
G
L
S
T
T
G
A
M
Q
S
Site 63
S549
S
T
T
G
A
M
Q
S
Y
T
W
S
L
T
Y
Site 64
T551
T
G
A
M
Q
S
Y
T
W
S
L
T
Y
T
V
Site 65
T555
Q
S
Y
T
W
S
L
T
Y
T
V
T
T
A
A
Site 66
S564
T
V
T
T
A
A
G
S
P
A
E
N
S
Q
Q
Site 67
S569
A
G
S
P
A
E
N
S
Q
Q
L
P
C
M
R
Site 68
T578
Q
L
P
C
M
R
N
T
H
V
P
S
S
S
V
Site 69
S583
R
N
T
H
V
P
S
S
S
V
T
H
R
I
P
Site 70
S584
N
T
H
V
P
S
S
S
V
T
H
R
I
P
V
Site 71
T586
H
V
P
S
S
S
V
T
H
R
I
P
V
Y
P
Site 72
Y592
V
T
H
R
I
P
V
Y
P
H
R
E
E
H
G
Site 73
Y600
P
H
R
E
E
H
G
Y
T
G
S
Y
N
Y
G
Site 74
T601
H
R
E
E
H
G
Y
T
G
S
Y
N
Y
G
S
Site 75
S603
E
E
H
G
Y
T
G
S
Y
N
Y
G
S
Y
G
Site 76
Y604
E
H
G
Y
T
G
S
Y
N
Y
G
S
Y
G
N
Site 77
Y606
G
Y
T
G
S
Y
N
Y
G
S
Y
G
N
Q
H
Site 78
Y609
G
S
Y
N
Y
G
S
Y
G
N
Q
H
P
H
P
Site 79
Y621
P
H
P
M
Q
S
Q
Y
P
A
L
P
H
D
T
Site 80
T628
Y
P
A
L
P
H
D
T
A
I
S
G
P
L
H
Site 81
Y639
G
P
L
H
Y
A
P
Y
H
R
S
S
A
Q
Y
Site 82
S643
Y
A
P
Y
H
R
S
S
A
Q
Y
P
F
N
S
Site 83
Y646
Y
H
R
S
S
A
Q
Y
P
F
N
S
P
T
S
Site 84
S650
S
A
Q
Y
P
F
N
S
P
T
S
R
M
E
P
Site 85
T652
Q
Y
P
F
N
S
P
T
S
R
M
E
P
C
L
Site 86
S661
R
M
E
P
C
L
M
S
S
T
P
R
L
H
P
Site 87
S662
M
E
P
C
L
M
S
S
T
P
R
L
H
P
T
Site 88
T663
E
P
C
L
M
S
S
T
P
R
L
H
P
T
P
Site 89
T669
S
T
P
R
L
H
P
T
P
V
T
P
R
W
P
Site 90
T672
R
L
H
P
T
P
V
T
P
R
W
P
E
V
P
Site 91
Y685
V
P
S
A
N
T
C
Y
T
N
P
S
V
H
S
Site 92
T686
P
S
A
N
T
C
Y
T
N
P
S
V
H
S
A
Site 93
S692
Y
T
N
P
S
V
H
S
A
R
Y
G
N
S
S
Site 94
Y695
P
S
V
H
S
A
R
Y
G
N
S
S
D
M
Y
Site 95
S699
S
A
R
Y
G
N
S
S
D
M
Y
T
P
L
T
Site 96
Y702
Y
G
N
S
S
D
M
Y
T
P
L
T
T
R
R
Site 97
T703
G
N
S
S
D
M
Y
T
P
L
T
T
R
R
N
Site 98
T706
S
D
M
Y
T
P
L
T
T
R
R
N
S
E
Y
Site 99
T707
D
M
Y
T
P
L
T
T
R
R
N
S
E
Y
E
Site 100
S711
P
L
T
T
R
R
N
S
E
Y
E
H
M
Q
H
Site 101
Y713
T
T
R
R
N
S
E
Y
E
H
M
Q
H
F
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation