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Updated November 2019
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Protein Info
Short Name:
LRRK1
Full Name:
Leucine-rich repeat serine/threonine-protein kinase 1
Alias:
EC 2.7.11.1; KIAA1790
Type:
Protein-serine kinase, TKL group, LRRK family, N/A subfamily
Mass (Da):
227843
Number AA:
2038
UniProt ID:
Q38SD2
International Prot ID:
IPI00748651
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005525
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
GO:0007264
Phosida
TranscriptoNet
STRING
Kinexus Products
LRRKSubtide - LRRK1 protein kinase substrate peptide - Powder PE-01BHX95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BHX95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
S
Q
R
P
P
S
M
Y
W
C
V
G
P
E
E
Site 2
S39
G
D
T
G
G
K
P
S
T
R
G
G
D
P
A
Site 3
S49
G
G
D
P
A
A
R
S
R
R
T
E
G
I
R
Site 4
T52
P
A
A
R
S
R
R
T
E
G
I
R
A
A
Y
Site 5
Y59
T
E
G
I
R
A
A
Y
R
R
G
D
R
G
G
Site 6
S80
E
A
C
D
Q
C
A
S
Q
L
E
K
G
Q
L
Site 7
S89
L
E
K
G
Q
L
L
S
I
P
A
A
Y
G
D
Site 8
S171
E
S
L
P
G
P
C
S
P
Q
R
L
L
N
W
Site 9
S205
T
H
G
A
D
P
E
S
Y
A
V
R
K
N
E
Site 10
Y206
H
G
A
D
P
E
S
Y
A
V
R
K
N
E
F
Site 11
S245
R
H
G
A
Y
F
C
S
Y
I
L
L
D
S
P
Site 12
S251
C
S
Y
I
L
L
D
S
P
D
P
S
K
H
L
Site 13
S255
L
L
D
S
P
D
P
S
K
H
L
L
R
K
Y
Site 14
Y262
S
K
H
L
L
R
K
Y
F
I
E
A
S
P
L
Site 15
S267
R
K
Y
F
I
E
A
S
P
L
P
S
S
Y
P
Site 16
S271
I
E
A
S
P
L
P
S
S
Y
P
G
K
T
A
Site 17
S272
E
A
S
P
L
P
S
S
Y
P
G
K
T
A
L
Site 18
Y273
A
S
P
L
P
S
S
Y
P
G
K
T
A
L
R
Site 19
T277
P
S
S
Y
P
G
K
T
A
L
R
V
K
W
S
Site 20
S333
N
L
R
K
L
N
L
S
D
N
H
L
G
E
L
Site 21
S345
G
E
L
P
G
V
Q
S
S
D
E
I
I
C
S
Site 22
S346
E
L
P
G
V
Q
S
S
D
E
I
I
C
S
R
Site 23
S360
R
L
L
E
I
D
I
S
S
N
K
L
S
H
L
Site 24
S361
L
L
E
I
D
I
S
S
N
K
L
S
H
L
P
Site 25
S365
D
I
S
S
N
K
L
S
H
L
P
P
G
F
L
Site 26
S375
P
P
G
F
L
H
L
S
K
L
Q
K
L
T
A
Site 27
T397
L
F
E
E
E
N
A
T
N
W
I
G
L
R
K
Site 28
S411
K
L
Q
E
L
D
I
S
D
N
K
L
T
E
L
Site 29
S431
H
S
F
K
S
L
N
S
L
N
V
S
R
N
N
Site 30
S435
S
L
N
S
L
N
V
S
R
N
N
L
K
V
F
Site 31
T524
W
T
C
R
Q
L
K
T
L
D
L
S
R
N
Q
Site 32
S528
Q
L
K
T
L
D
L
S
R
N
Q
L
G
K
N
Site 33
T541
K
N
E
D
G
L
K
T
K
R
I
A
F
F
T
Site 34
T548
T
K
R
I
A
F
F
T
T
R
G
R
Q
R
S
Site 35
S555
T
T
R
G
R
Q
R
S
G
T
E
A
A
S
V
Site 36
T557
R
G
R
Q
R
S
G
T
E
A
A
S
V
L
E
Site 37
T585
L
N
D
N
H
L
D
T
V
P
P
S
V
C
L
Site 38
Y600
L
K
S
L
S
E
L
Y
L
G
N
N
P
G
L
Site 39
T625
G
N
L
W
Q
L
D
T
E
D
L
T
I
S
N
Site 40
T629
Q
L
D
T
E
D
L
T
I
S
N
V
P
A
E
Site 41
S647
E
G
P
K
A
M
L
S
Y
L
R
A
Q
L
R
Site 42
Y648
G
P
K
A
M
L
S
Y
L
R
A
Q
L
R
K
Site 43
S675
G
P
P
R
Q
G
K
S
T
L
L
E
I
L
Q
Site 44
T676
P
P
R
Q
G
K
S
T
L
L
E
I
L
Q
T
Site 45
T699
G
E
A
T
I
R
T
T
K
W
E
L
Q
R
P
Site 46
S715
G
S
R
A
K
V
E
S
V
E
F
N
V
W
D
Site 47
S807
Y
V
L
A
L
C
R
S
P
S
G
S
R
A
T
Site 48
S809
L
A
L
C
R
S
P
S
G
S
R
A
T
G
F
Site 49
S811
L
C
R
S
P
S
G
S
R
A
T
G
F
P
D
Site 50
T814
S
P
S
G
S
R
A
T
G
F
P
D
I
T
F
Site 51
T820
A
T
G
F
P
D
I
T
F
K
H
L
H
E
I
Site 52
S831
L
H
E
I
S
C
K
S
L
E
G
Q
E
G
L
Site 53
S869
A
G
R
L
I
P
R
S
Y
L
S
L
Q
E
A
Site 54
Y870
G
R
L
I
P
R
S
Y
L
S
L
Q
E
A
V
Site 55
S885
L
A
E
Q
Q
R
R
S
R
D
D
D
V
Q
Y
Site 56
Y892
S
R
D
D
D
V
Q
Y
L
T
D
R
Q
L
E
Site 57
T894
D
D
D
V
Q
Y
L
T
D
R
Q
L
E
Q
L
Site 58
T905
L
E
Q
L
V
E
Q
T
P
D
N
D
I
K
D
Site 59
Y913
P
D
N
D
I
K
D
Y
E
D
L
Q
S
A
I
Site 60
S918
K
D
Y
E
D
L
Q
S
A
I
S
F
L
I
E
Site 61
T935
T
L
L
H
F
P
D
T
S
H
G
L
R
N
L
Site 62
S965
F
N
I
K
G
S
R
S
V
A
K
N
G
V
I
Site 63
Y994
T
Q
Q
T
E
E
Q
Y
F
Q
F
L
A
K
F
Site 64
S1020
L
L
P
H
L
L
P
S
K
P
G
L
D
T
H
Site 65
T1026
P
S
K
P
G
L
D
T
H
G
M
R
H
P
T
Site 66
T1033
T
H
G
M
R
H
P
T
A
N
T
I
Q
R
V
Site 67
S1078
E
N
K
K
N
T
K
S
R
N
R
K
V
T
I
Site 68
T1084
K
S
R
N
R
K
V
T
I
Y
S
F
T
G
N
Site 69
Y1086
R
N
R
K
V
T
I
Y
S
F
T
G
N
Q
R
Site 70
S1087
N
R
K
V
T
I
Y
S
F
T
G
N
Q
R
N
Site 71
S1097
G
N
Q
R
N
R
C
S
T
F
R
V
K
R
N
Site 72
T1098
N
Q
R
N
R
C
S
T
F
R
V
K
R
N
Q
Site 73
T1106
F
R
V
K
R
N
Q
T
I
Y
W
Q
E
G
L
Site 74
Y1108
V
K
R
N
Q
T
I
Y
W
Q
E
G
L
L
V
Site 75
S1123
T
F
D
G
G
Y
L
S
V
E
S
S
D
V
N
Site 76
S1127
G
Y
L
S
V
E
S
S
D
V
N
W
K
K
K
Site 77
S1145
G
M
K
I
V
C
Q
S
E
V
R
D
F
S
A
Site 78
S1151
Q
S
E
V
R
D
F
S
A
M
A
F
I
T
D
Site 79
T1172
D
Q
W
F
P
A
L
T
A
T
E
S
D
G
T
Site 80
S1176
P
A
L
T
A
T
E
S
D
G
T
P
L
M
E
Site 81
T1179
T
A
T
E
S
D
G
T
P
L
M
E
Q
Y
V
Site 82
Y1210
E
K
S
E
D
V
Q
Y
F
D
M
E
D
C
V
Site 83
S1227
A
I
E
R
D
F
I
S
C
P
R
H
P
D
L
Site 84
S1259
A
R
L
F
L
E
N
S
K
L
E
H
S
E
D
Site 85
S1264
E
N
S
K
L
E
H
S
E
D
E
G
S
V
L
Site 86
S1269
E
H
S
E
D
E
G
S
V
L
G
Q
G
G
S
Site 87
T1278
L
G
Q
G
G
S
G
T
V
I
Y
R
A
R
Y
Site 88
Y1281
G
G
S
G
T
V
I
Y
R
A
R
Y
Q
G
Q
Site 89
Y1285
T
V
I
Y
R
A
R
Y
Q
G
Q
P
V
A
V
Site 90
T1318
M
L
R
H
L
R
A
T
D
A
M
K
N
F
S
Site 91
S1325
T
D
A
M
K
N
F
S
E
F
R
Q
E
A
S
Site 92
T1367
A
P
L
S
S
L
N
T
V
L
S
E
N
A
R
Site 93
S1370
S
S
L
N
T
V
L
S
E
N
A
R
D
S
S
Site 94
S1376
L
S
E
N
A
R
D
S
S
F
I
P
L
G
H
Site 95
S1377
S
E
N
A
R
D
S
S
F
I
P
L
G
H
M
Site 96
S1419
S
D
N
I
L
V
W
S
L
D
V
K
E
H
I
Site 97
S1431
E
H
I
N
I
K
L
S
D
Y
G
I
S
R
Q
Site 98
Y1433
I
N
I
K
L
S
D
Y
G
I
S
R
Q
S
F
Site 99
S1439
D
Y
G
I
S
R
Q
S
F
H
E
G
A
L
G
Site 100
T1450
G
A
L
G
V
E
G
T
P
G
Y
Q
A
P
E
Site 101
Y1453
G
V
E
G
T
P
G
Y
Q
A
P
E
I
R
P
Site 102
Y1464
E
I
R
P
R
I
V
Y
D
E
K
V
D
M
F
Site 103
S1538
E
K
R
P
L
A
L
S
V
V
S
Q
M
K
D
Site 104
T1561
E
L
C
C
G
K
Q
T
A
F
F
S
S
Q
G
Site 105
S1566
K
Q
T
A
F
F
S
S
Q
G
Q
E
Y
T
V
Site 106
Y1571
F
S
S
Q
G
Q
E
Y
T
V
V
F
W
D
G
Site 107
T1572
S
S
Q
G
Q
E
Y
T
V
V
F
W
D
G
K
Site 108
Y1585
G
K
E
E
S
R
N
Y
T
V
V
N
T
E
K
Site 109
T1586
K
E
E
S
R
N
Y
T
V
V
N
T
E
K
G
Site 110
S1616
C
Q
L
Q
V
Q
R
S
L
W
T
A
T
E
D
Site 111
Y1629
E
D
Q
K
I
Y
I
Y
T
L
K
G
M
C
P
Site 112
T1639
K
G
M
C
P
L
N
T
P
Q
Q
A
L
D
T
Site 113
T1684
V
F
P
V
V
R
G
T
P
K
D
S
C
S
Y
Site 114
S1688
V
R
G
T
P
K
D
S
C
S
Y
L
C
S
H
Site 115
S1690
G
T
P
K
D
S
C
S
Y
L
C
S
H
T
A
Site 116
Y1691
T
P
K
D
S
C
S
Y
L
C
S
H
T
A
N
Site 117
S1694
D
S
C
S
Y
L
C
S
H
T
A
N
R
S
K
Site 118
T1696
C
S
Y
L
C
S
H
T
A
N
R
S
K
F
S
Site 119
Y1714
E
D
A
R
Q
N
P
Y
P
V
K
A
M
E
V
Site 120
S1724
K
A
M
E
V
V
N
S
G
S
E
V
W
Y
S
Site 121
S1726
M
E
V
V
N
S
G
S
E
V
W
Y
S
N
G
Site 122
Y1730
N
S
G
S
E
V
W
Y
S
N
G
P
G
L
L
Site 123
S1731
S
G
S
E
V
W
Y
S
N
G
P
G
L
L
V
Site 124
S1765
M
V
T
S
V
V
C
S
S
E
G
R
G
E
E
Site 125
S1766
V
T
S
V
V
C
S
S
E
G
R
G
E
E
V
Site 126
S1783
C
L
D
D
K
A
N
S
L
V
M
Y
H
S
T
Site 127
Y1787
K
A
N
S
L
V
M
Y
H
S
T
T
Y
Q
L
Site 128
S1804
R
Y
F
C
G
V
P
S
P
L
R
D
M
F
P
Site 129
T1817
F
P
V
R
P
L
D
T
E
P
P
A
A
S
H
Site 130
S1823
D
T
E
P
P
A
A
S
H
T
A
N
P
K
V
Site 131
T1825
E
P
P
A
A
S
H
T
A
N
P
K
V
P
E
Site 132
S1835
P
K
V
P
E
G
D
S
I
A
D
V
S
I
M
Site 133
S1840
G
D
S
I
A
D
V
S
I
M
Y
S
E
E
L
Site 134
T1859
L
I
H
Q
E
S
L
T
D
Y
C
S
M
S
S
Site 135
Y1861
H
Q
E
S
L
T
D
Y
C
S
M
S
S
Y
S
Site 136
S1863
E
S
L
T
D
Y
C
S
M
S
S
Y
S
S
S
Site 137
S1865
L
T
D
Y
C
S
M
S
S
Y
S
S
S
P
P
Site 138
S1866
T
D
Y
C
S
M
S
S
Y
S
S
S
P
P
R
Site 139
Y1867
D
Y
C
S
M
S
S
Y
S
S
S
P
P
R
Q
Site 140
S1868
Y
C
S
M
S
S
Y
S
S
S
P
P
R
Q
A
Site 141
S1869
C
S
M
S
S
Y
S
S
S
P
P
R
Q
A
A
Site 142
S1870
S
M
S
S
Y
S
S
S
P
P
R
Q
A
A
R
Site 143
S1878
P
P
R
Q
A
A
R
S
P
S
S
L
P
S
S
Site 144
S1880
R
Q
A
A
R
S
P
S
S
L
P
S
S
P
A
Site 145
S1881
Q
A
A
R
S
P
S
S
L
P
S
S
P
A
S
Site 146
S1884
R
S
P
S
S
L
P
S
S
P
A
S
S
S
S
Site 147
S1885
S
P
S
S
L
P
S
S
P
A
S
S
S
S
V
Site 148
S1888
S
L
P
S
S
P
A
S
S
S
S
V
P
F
S
Site 149
S1889
L
P
S
S
P
A
S
S
S
S
V
P
F
S
T
Site 150
S1890
P
S
S
P
A
S
S
S
S
V
P
F
S
T
D
Site 151
S1891
S
S
P
A
S
S
S
S
V
P
F
S
T
D
C
Site 152
S1895
S
S
S
S
V
P
F
S
T
D
C
E
D
S
D
Site 153
T1896
S
S
S
V
P
F
S
T
D
C
E
D
S
D
M
Site 154
S1901
F
S
T
D
C
E
D
S
D
M
L
H
T
P
G
Site 155
T1906
E
D
S
D
M
L
H
T
P
G
A
A
S
D
R
Site 156
S1911
L
H
T
P
G
A
A
S
D
R
S
E
H
D
L
Site 157
S1914
P
G
A
A
S
D
R
S
E
H
D
L
T
P
M
Site 158
T1919
D
R
S
E
H
D
L
T
P
M
D
G
E
T
F
Site 159
T1925
L
T
P
M
D
G
E
T
F
S
Q
H
L
Q
A
Site 160
S1927
P
M
D
G
E
T
F
S
Q
H
L
Q
A
V
K
Site 161
S1960
V
I
G
L
E
K
D
S
G
A
Q
R
G
R
V
Site 162
T1996
A
K
D
T
V
V
C
T
F
E
N
E
N
T
E
Site 163
Y2021
A
R
E
F
D
I
F
Y
Q
S
Y
E
E
L
G
Site 164
S2023
E
F
D
I
F
Y
Q
S
Y
E
E
L
G
R
L
Site 165
Y2024
F
D
I
F
Y
Q
S
Y
E
E
L
G
R
L
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation