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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
C10orf137
Full Name:
Erythroid differentiation-related factor 1
Alias:
chromosome 10 open reading frame 137; DKFZp586F1019; EDRF1; FLJ21617
Type:
Unknown function
Mass (Da):
138530
Number AA:
UniProt ID:
Q3B7T1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
A
A
A
R
G
G
L
S
L
L
S
Q
G
E
S
Site 2
S26
R
G
G
L
S
L
L
S
Q
G
E
S
E
E
S
Site 3
S30
S
L
L
S
Q
G
E
S
E
E
S
S
A
Q
G
Site 4
S33
S
Q
G
E
S
E
E
S
S
A
Q
G
S
A
L
Site 5
S34
Q
G
E
S
E
E
S
S
A
Q
G
S
A
L
F
Site 6
S38
E
E
S
S
A
Q
G
S
A
L
F
L
G
G
N
Site 7
S49
L
G
G
N
E
V
K
S
R
A
V
V
K
Y
S
Site 8
Y55
K
S
R
A
V
V
K
Y
S
S
A
P
P
R
T
Site 9
S57
R
A
V
V
K
Y
S
S
A
P
P
R
T
A
F
Site 10
T71
F
A
R
L
E
E
K
T
D
L
K
L
P
P
A
Site 11
S84
P
A
N
W
L
R
E
S
A
K
L
G
P
A
G
Site 12
S98
G
T
T
I
L
G
N
S
K
K
S
K
P
F
S
Site 13
S101
I
L
G
N
S
K
K
S
K
P
F
S
S
F
G
Site 14
S105
S
K
K
S
K
P
F
S
S
F
G
M
A
Y
D
Site 15
S106
K
K
S
K
P
F
S
S
F
G
M
A
Y
D
F
Site 16
S125
G
N
D
V
D
V
V
S
D
S
E
N
I
K
K
Site 17
S127
D
V
D
V
V
S
D
S
E
N
I
K
K
L
L
Site 18
S139
K
L
L
K
I
P
Y
S
K
S
H
V
S
M
A
Site 19
S141
L
K
I
P
Y
S
K
S
H
V
S
M
A
V
H
Site 20
S144
P
Y
S
K
S
H
V
S
M
A
V
H
R
I
G
Site 21
Y181
W
T
W
L
K
E
F
Y
Q
R
L
I
D
Q
K
Site 22
Y200
K
K
S
K
E
H
W
Y
Q
K
A
I
L
S
K
Site 23
S223
D
G
A
A
Q
P
V
S
S
T
A
E
Q
Q
E
Site 24
S231
S
T
A
E
Q
Q
E
S
S
S
S
D
Q
T
N
Site 25
S232
T
A
E
Q
Q
E
S
S
S
S
D
Q
T
N
D
Site 26
S234
E
Q
Q
E
S
S
S
S
D
Q
T
N
D
S
E
Site 27
T237
E
S
S
S
S
D
Q
T
N
D
S
E
G
A
S
Site 28
S240
S
S
D
Q
T
N
D
S
E
G
A
S
W
P
A
Site 29
S244
T
N
D
S
E
G
A
S
W
P
A
P
F
E
M
Site 30
S253
P
A
P
F
E
M
P
S
S
V
S
E
D
P
S
Site 31
S254
A
P
F
E
M
P
S
S
V
S
E
D
P
S
A
Site 32
S256
F
E
M
P
S
S
V
S
E
D
P
S
A
S
S
Site 33
S260
S
S
V
S
E
D
P
S
A
S
S
Q
G
S
E
Site 34
S262
V
S
E
D
P
S
A
S
S
Q
G
S
E
P
L
Site 35
S263
S
E
D
P
S
A
S
S
Q
G
S
E
P
L
E
Site 36
S266
P
S
A
S
S
Q
G
S
E
P
L
E
P
S
Y
Site 37
S272
G
S
E
P
L
E
P
S
Y
I
V
G
H
V
A
Site 38
Y273
S
E
P
L
E
P
S
Y
I
V
G
H
V
A
S
Site 39
S280
Y
I
V
G
H
V
A
S
A
P
K
E
Q
N
L
Site 40
S297
L
F
N
D
G
E
H
S
Q
G
L
K
N
D
F
Site 41
S335
G
G
R
Y
P
A
V
S
L
R
L
R
D
N
N
Site 42
Y378
V
N
G
I
V
Q
K
Y
E
M
I
K
T
E
E
Site 43
T383
Q
K
Y
E
M
I
K
T
E
E
I
P
N
L
E
Site 44
S392
E
I
P
N
L
E
N
S
N
F
S
T
K
V
I
Site 45
T396
L
E
N
S
N
F
S
T
K
V
I
K
D
I
A
Site 46
S412
N
I
L
S
F
L
K
S
N
C
T
K
E
G
H
Site 47
Y421
C
T
K
E
G
H
T
Y
W
L
F
K
A
S
G
Site 48
S429
W
L
F
K
A
S
G
S
D
I
V
K
L
Y
D
Site 49
T439
V
K
L
Y
D
L
T
T
L
C
E
E
T
E
D
Site 50
Y448
C
E
E
T
E
D
K
Y
Q
N
P
F
T
M
P
Site 51
T453
D
K
Y
Q
N
P
F
T
M
P
V
A
I
L
L
Site 52
T480
Q
N
K
K
H
Y
G
T
I
R
T
L
L
L
N
Site 53
S495
C
L
K
L
L
D
K
S
R
H
P
Q
I
I
A
Site 54
S503
R
H
P
Q
I
I
A
S
A
N
Y
M
L
S
E
Site 55
S525
K
K
E
E
N
S
E
S
P
L
N
E
N
S
D
Site 56
S531
E
S
P
L
N
E
N
S
D
E
S
Y
S
E
E
Site 57
S534
L
N
E
N
S
D
E
S
Y
S
E
E
E
E
E
Site 58
Y535
N
E
N
S
D
E
S
Y
S
E
E
E
E
E
M
Site 59
S536
E
N
S
D
E
S
Y
S
E
E
E
E
E
M
P
Site 60
S545
E
E
E
E
M
P
D
S
D
E
N
G
S
Y
S
Site 61
S550
P
D
S
D
E
N
G
S
Y
S
T
S
S
D
P
Site 62
Y551
D
S
D
E
N
G
S
Y
S
T
S
S
D
P
S
Site 63
S552
S
D
E
N
G
S
Y
S
T
S
S
D
P
S
D
Site 64
S554
E
N
G
S
Y
S
T
S
S
D
P
S
D
D
S
Site 65
S555
N
G
S
Y
S
T
S
S
D
P
S
D
D
S
K
Site 66
S558
Y
S
T
S
S
D
P
S
D
D
S
K
A
V
A
Site 67
S561
S
S
D
P
S
D
D
S
K
A
V
A
I
I
K
Site 68
S574
I
K
S
V
G
E
L
S
V
P
E
K
Y
K
S
Site 69
Y579
E
L
S
V
P
E
K
Y
K
S
I
H
Q
I
R
Site 70
S581
S
V
P
E
K
Y
K
S
I
H
Q
I
R
P
S
Site 71
T597
A
F
P
V
C
H
D
T
E
E
R
C
R
L
V
Site 72
S614
Y
V
L
E
G
L
K
S
V
D
S
S
I
K
K
Site 73
S617
E
G
L
K
S
V
D
S
S
I
K
K
E
S
D
Site 74
S618
G
L
K
S
V
D
S
S
I
K
K
E
S
D
L
Site 75
S623
D
S
S
I
K
K
E
S
D
L
P
A
A
D
P
Site 76
S631
D
L
P
A
A
D
P
S
T
P
I
P
L
K
Y
Site 77
T632
L
P
A
A
D
P
S
T
P
I
P
L
K
Y
E
Site 78
Y638
S
T
P
I
P
L
K
Y
E
D
E
S
S
R
G
Site 79
S642
P
L
K
Y
E
D
E
S
S
R
G
G
P
E
G
Site 80
S643
L
K
Y
E
D
E
S
S
R
G
G
P
E
G
L
Site 81
S663
L
F
L
D
K
M
G
S
L
Q
K
G
N
Y
S
Site 82
Y669
G
S
L
Q
K
G
N
Y
S
S
Q
S
G
M
I
Site 83
S671
L
Q
K
G
N
Y
S
S
Q
S
G
M
I
P
G
Site 84
S673
K
G
N
Y
S
S
Q
S
G
M
I
P
G
S
W
Site 85
Y696
I
L
K
S
S
K
A
Y
Y
V
L
S
D
A
A
Site 86
Y697
L
K
S
S
K
A
Y
Y
V
L
S
D
A
A
M
Site 87
S705
V
L
S
D
A
A
M
S
L
Q
K
Y
G
R
A
Site 88
Y709
A
A
M
S
L
Q
K
Y
G
R
A
L
R
Y
I
Site 89
Y715
K
Y
G
R
A
L
R
Y
I
K
L
A
L
Q
S
Site 90
Y771
A
H
L
E
E
F
H
Y
Q
T
K
E
D
Q
E
Site 91
S782
E
D
Q
E
I
L
H
S
L
H
R
E
S
S
C
Site 92
S788
H
S
L
H
R
E
S
S
C
Q
G
F
A
W
A
Site 93
S799
F
A
W
A
T
D
L
S
T
D
L
E
S
Q
L
Site 94
T800
A
W
A
T
D
L
S
T
D
L
E
S
Q
L
S
Site 95
S804
D
L
S
T
D
L
E
S
Q
L
S
V
S
C
K
Site 96
S807
T
D
L
E
S
Q
L
S
V
S
C
K
C
Y
E
Site 97
S823
A
N
E
I
L
Q
F
S
D
L
K
S
Q
N
P
Site 98
S827
L
Q
F
S
D
L
K
S
Q
N
P
E
H
Y
V
Site 99
Y833
K
S
Q
N
P
E
H
Y
V
Q
V
L
K
R
M
Site 100
S860
N
Q
A
A
A
L
Q
S
E
R
L
V
S
K
S
Site 101
S865
L
Q
S
E
R
L
V
S
K
S
V
S
A
A
E
Site 102
S867
S
E
R
L
V
S
K
S
V
S
A
A
E
Q
Q
Site 103
S869
R
L
V
S
K
S
V
S
A
A
E
Q
Q
L
W
Site 104
S929
D
E
L
K
R
E
F
S
P
E
E
G
L
Y
Y
Site 105
Y935
F
S
P
E
E
G
L
Y
Y
N
K
A
I
D
Y
Site 106
Y936
S
P
E
E
G
L
Y
Y
N
K
A
I
D
Y
Y
Site 107
Y942
Y
Y
N
K
A
I
D
Y
Y
L
K
A
L
R
S
Site 108
Y943
Y
N
K
A
I
D
Y
Y
L
K
A
L
R
S
L
Site 109
S949
Y
Y
L
K
A
L
R
S
L
G
T
R
D
I
H
Site 110
Y971
N
W
E
L
S
T
T
Y
F
T
M
A
T
L
Q
Site 111
Y981
M
A
T
L
Q
Q
D
Y
A
P
L
S
R
K
A
Site 112
S985
Q
Q
D
Y
A
P
L
S
R
K
A
Q
E
Q
I
Site 113
S997
E
Q
I
E
K
E
V
S
E
A
M
M
K
S
L
Site 114
S1003
V
S
E
A
M
M
K
S
L
K
Y
C
D
V
D
Site 115
Y1006
A
M
M
K
S
L
K
Y
C
D
V
D
S
V
S
Site 116
S1011
L
K
Y
C
D
V
D
S
V
S
A
R
Q
P
L
Site 117
Y1021
A
R
Q
P
L
C
Q
Y
R
A
A
T
I
H
H
Site 118
T1025
L
C
Q
Y
R
A
A
T
I
H
H
R
L
A
S
Site 119
Y1034
H
H
R
L
A
S
M
Y
H
S
C
L
R
N
Q
Site 120
S1036
R
L
A
S
M
Y
H
S
C
L
R
N
Q
V
G
Site 121
T1092
A
F
A
E
F
Q
M
T
S
Q
N
S
N
V
G
Site 122
S1093
F
A
E
F
Q
M
T
S
Q
N
S
N
V
G
K
Site 123
S1134
E
E
F
G
Q
P
K
S
G
D
A
A
A
A
A
Site 124
S1144
A
A
A
A
A
D
A
S
P
S
L
N
R
E
E
Site 125
S1146
A
A
A
D
A
S
P
S
L
N
R
E
E
V
M
Site 126
S1175
L
Q
S
I
K
L
L
S
S
T
K
K
K
T
S
Site 127
S1176
Q
S
I
K
L
L
S
S
T
K
K
K
T
S
N
Site 128
T1189
S
N
N
I
E
D
D
T
I
L
K
T
N
K
H
Site 129
T1193
E
D
D
T
I
L
K
T
N
K
H
I
Y
S
Q
Site 130
S1199
K
T
N
K
H
I
Y
S
Q
L
L
R
A
T
A
Site 131
T1205
Y
S
Q
L
L
R
A
T
A
N
K
T
A
T
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation