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Updated November 2019
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Protein Info
Short Name:
NBPF8
Full Name:
Neuroblastoma breakpoint family member 8
Alias:
Type:
Mass (Da):
99215
Number AA:
869
UniProt ID:
Q3BBV2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
V
V
S
A
G
P
W
S
S
E
K
A
E
M
N
Site 2
S10
V
S
A
G
P
W
S
S
E
K
A
E
M
N
I
Site 3
S45
L
K
E
M
F
S
N
S
T
G
R
L
P
G
Q
Site 4
T54
G
R
L
P
G
Q
P
T
E
E
I
Q
Q
Y
K
Site 5
Y60
P
T
E
E
I
Q
Q
Y
K
V
L
V
H
S
Q
Site 6
S66
Q
Y
K
V
L
V
H
S
Q
E
R
E
L
T
Q
Site 7
T72
H
S
Q
E
R
E
L
T
Q
L
K
E
K
L
R
Site 8
S85
L
R
E
G
R
D
A
S
R
S
L
N
E
H
L
Site 9
S87
E
G
R
D
A
S
R
S
L
N
E
H
L
Q
A
Site 10
T97
E
H
L
Q
A
L
L
T
L
D
E
P
D
K
S
Site 11
S104
T
L
D
E
P
D
K
S
Q
G
Q
D
L
Q
E
Site 12
S128
Q
H
L
V
Q
K
L
S
P
E
N
D
E
D
E
Site 13
S151
D
E
K
V
L
E
S
S
A
P
R
E
V
Q
K
Site 14
S168
E
S
K
V
P
E
D
S
L
E
E
C
A
I
T
Site 15
T175
S
L
E
E
C
A
I
T
C
S
N
S
H
G
P
Site 16
T195
P
H
K
N
I
K
I
T
F
E
E
D
K
V
N
Site 17
S204
E
E
D
K
V
N
S
S
L
V
V
D
R
E
S
Site 18
S211
S
L
V
V
D
R
E
S
S
H
D
G
C
Q
D
Site 19
S212
L
V
V
D
R
E
S
S
H
D
G
C
Q
D
A
Site 20
S245
V
V
S
A
G
P
L
S
S
E
K
A
E
M
N
Site 21
S246
V
S
A
G
P
L
S
S
E
K
A
E
M
N
I
Site 22
S273
E
K
K
Q
Q
F
R
S
L
K
E
K
C
F
V
Site 23
Y294
L
A
K
Q
Q
N
K
Y
K
Y
E
E
C
K
D
Site 24
Y296
K
Q
Q
N
K
Y
K
Y
E
E
C
K
D
L
I
Site 25
S305
E
C
K
D
L
I
K
S
M
L
R
N
E
R
Q
Site 26
Y331
Q
A
E
E
L
R
Q
Y
K
V
L
V
H
S
Q
Site 27
T343
H
S
Q
E
R
E
L
T
Q
L
R
E
K
L
R
Site 28
T368
E
H
L
Q
A
L
L
T
P
D
E
P
D
K
S
Site 29
S375
T
P
D
E
P
D
K
S
Q
G
Q
D
L
Q
E
Site 30
S399
Q
H
L
V
Q
K
L
S
P
E
N
D
N
D
D
Site 31
S421
V
A
E
K
V
Q
K
S
S
S
P
R
E
M
Q
Site 32
S422
A
E
K
V
Q
K
S
S
S
P
R
E
M
Q
K
Site 33
S423
E
K
V
Q
K
S
S
S
P
R
E
M
Q
K
A
Site 34
S439
E
K
E
V
P
E
D
S
L
E
E
C
A
I
T
Site 35
Y454
C
S
N
S
H
G
P
Y
D
S
N
Q
P
H
R
Site 36
S456
N
S
H
G
P
Y
D
S
N
Q
P
H
R
K
T
Site 37
T463
S
N
Q
P
H
R
K
T
K
I
T
F
E
E
D
Site 38
T466
P
H
R
K
T
K
I
T
F
E
E
D
K
V
D
Site 39
S474
F
E
E
D
K
V
D
S
T
L
I
G
S
S
S
Site 40
T475
E
E
D
K
V
D
S
T
L
I
G
S
S
S
H
Site 41
S481
S
T
L
I
G
S
S
S
H
V
E
W
E
D
A
Site 42
S509
E
E
E
K
G
P
V
S
P
R
N
L
Q
E
S
Site 43
S516
S
P
R
N
L
Q
E
S
E
E
E
E
V
P
Q
Site 44
S525
E
E
E
V
P
Q
E
S
W
D
E
G
Y
S
T
Site 45
Y530
Q
E
S
W
D
E
G
Y
S
T
L
S
I
P
P
Site 46
S531
E
S
W
D
E
G
Y
S
T
L
S
I
P
P
E
Site 47
T532
S
W
D
E
G
Y
S
T
L
S
I
P
P
E
R
Site 48
S534
D
E
G
Y
S
T
L
S
I
P
P
E
R
L
A
Site 49
S542
I
P
P
E
R
L
A
S
Y
Q
S
Y
S
S
T
Site 50
Y543
P
P
E
R
L
A
S
Y
Q
S
Y
S
S
T
F
Site 51
S545
E
R
L
A
S
Y
Q
S
Y
S
S
T
F
H
S
Site 52
Y546
R
L
A
S
Y
Q
S
Y
S
S
T
F
H
S
L
Site 53
S547
L
A
S
Y
Q
S
Y
S
S
T
F
H
S
L
E
Site 54
S548
A
S
Y
Q
S
Y
S
S
T
F
H
S
L
E
E
Site 55
T549
S
Y
Q
S
Y
S
S
T
F
H
S
L
E
E
Q
Site 56
S552
S
Y
S
S
T
F
H
S
L
E
E
Q
Q
V
C
Site 57
S585
E
A
T
G
P
R
L
S
R
E
L
L
D
E
K
Site 58
S600
G
P
E
V
L
Q
D
S
L
D
R
C
Y
S
T
Site 59
Y605
Q
D
S
L
D
R
C
Y
S
T
P
S
G
C
L
Site 60
S606
D
S
L
D
R
C
Y
S
T
P
S
G
C
L
E
Site 61
T607
S
L
D
R
C
Y
S
T
P
S
G
C
L
E
L
Site 62
S609
D
R
C
Y
S
T
P
S
G
C
L
E
L
T
D
Site 63
T615
P
S
G
C
L
E
L
T
D
S
C
Q
P
Y
R
Site 64
S617
G
C
L
E
L
T
D
S
C
Q
P
Y
R
S
A
Site 65
Y621
L
T
D
S
C
Q
P
Y
R
S
A
F
Y
I
L
Site 66
Y645
D
M
D
E
I
E
K
Y
Q
E
V
E
E
D
Q
Site 67
S655
V
E
E
D
Q
D
P
S
C
P
R
L
S
R
E
Site 68
S660
D
P
S
C
P
R
L
S
R
E
L
L
D
E
K
Site 69
S675
E
P
E
V
L
Q
D
S
L
D
R
C
Y
S
T
Site 70
Y680
Q
D
S
L
D
R
C
Y
S
T
P
S
G
Y
L
Site 71
S681
D
S
L
D
R
C
Y
S
T
P
S
G
Y
L
E
Site 72
T682
S
L
D
R
C
Y
S
T
P
S
G
Y
L
E
L
Site 73
Y696
L
P
D
L
G
Q
P
Y
S
S
A
V
Y
S
L
Site 74
S697
P
D
L
G
Q
P
Y
S
S
A
V
Y
S
L
E
Site 75
S698
D
L
G
Q
P
Y
S
S
A
V
Y
S
L
E
E
Site 76
S702
P
Y
S
S
A
V
Y
S
L
E
E
Q
Y
L
G
Site 77
S735
G
P
P
C
P
R
L
S
R
E
L
L
E
V
V
Site 78
Y755
Q
D
S
L
D
R
C
Y
S
T
P
S
S
C
L
Site 79
S756
D
S
L
D
R
C
Y
S
T
P
S
S
C
L
E
Site 80
T757
S
L
D
R
C
Y
S
T
P
S
S
C
L
E
Q
Site 81
S760
R
C
Y
S
T
P
S
S
C
L
E
Q
P
D
S
Site 82
S767
S
C
L
E
Q
P
D
S
C
Q
P
Y
G
S
S
Site 83
Y771
Q
P
D
S
C
Q
P
Y
G
S
S
F
Y
A
L
Site 84
S774
S
C
Q
P
Y
G
S
S
F
Y
A
L
E
E
K
Site 85
S786
E
E
K
H
V
G
F
S
L
D
V
G
E
I
E
Site 86
S806
K
I
G
R
G
R
R
S
K
K
K
R
R
R
G
Site 87
S830
P
P
C
P
R
L
N
S
V
L
M
E
V
E
E
Site 88
Y849
Q
D
S
L
D
R
C
Y
S
T
P
S
M
Y
C
Site 89
S850
D
S
L
D
R
C
Y
S
T
P
S
M
Y
C
E
Site 90
T851
S
L
D
R
C
Y
S
T
P
S
M
Y
C
E
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation