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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PTCHD3
Full Name:
Patched domain-containing protein 3
Alias:
Patched-related protein
Type:
Mass (Da):
86890
Number AA:
767
UniProt ID:
Q3KNS1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T19
P
E
Q
K
P
K
L
T
K
P
D
S
A
T
G
Site 2
S23
P
K
L
T
K
P
D
S
A
T
G
P
Q
W
Y
Site 3
Y30
S
A
T
G
P
Q
W
Y
Q
E
S
Q
E
S
E
Site 4
S33
G
P
Q
W
Y
Q
E
S
Q
E
S
E
S
E
G
Site 5
S36
W
Y
Q
E
S
Q
E
S
E
S
E
G
K
Q
P
Site 6
S53
G
P
L
A
P
P
K
S
P
E
P
S
G
P
L
Site 7
S57
P
P
K
S
P
E
P
S
G
P
L
A
S
E
Q
Site 8
S62
E
P
S
G
P
L
A
S
E
Q
D
A
P
L
P
Site 9
S79
D
D
A
P
P
R
P
S
M
L
D
D
A
P
R
Site 10
T101
A
P
L
P
E
E
E
T
P
E
P
T
A
I
C
Site 11
T116
R
H
R
H
R
C
H
T
D
C
L
E
G
L
L
Site 12
T126
L
E
G
L
L
S
R
T
F
Q
W
L
G
W
Q
Site 13
Y158
A
L
G
T
G
F
L
Y
L
P
K
D
E
E
E
Site 14
Y171
E
E
D
L
E
E
H
Y
T
P
V
G
S
P
A
Site 15
T172
E
D
L
E
E
H
Y
T
P
V
G
S
P
A
K
Site 16
S176
E
H
Y
T
P
V
G
S
P
A
K
A
E
R
R
Site 17
T190
R
F
V
Q
G
H
F
T
T
N
D
S
Y
R
F
Site 18
S194
G
H
F
T
T
N
D
S
Y
R
F
S
A
S
R
Site 19
Y195
H
F
T
T
N
D
S
Y
R
F
S
A
S
R
R
Site 20
S198
T
N
D
S
Y
R
F
S
A
S
R
R
S
T
E
Site 21
S200
D
S
Y
R
F
S
A
S
R
R
S
T
E
A
N
Site 22
S203
R
F
S
A
S
R
R
S
T
E
A
N
F
V
S
Site 23
T204
F
S
A
S
R
R
S
T
E
A
N
F
V
S
L
Site 24
Y251
E
K
G
S
Q
I
Q
Y
Q
Q
V
C
A
R
Y
Site 25
Y270
V
P
P
N
P
I
L
Y
A
W
Q
V
N
K
T
Site 26
T277
Y
A
W
Q
V
N
K
T
L
N
L
S
S
I
S
Site 27
S282
N
K
T
L
N
L
S
S
I
S
F
P
A
Y
N
Site 28
S284
T
L
N
L
S
S
I
S
F
P
A
Y
N
H
G
Site 29
Y288
S
S
I
S
F
P
A
Y
N
H
G
R
H
P
L
Site 30
Y296
N
H
G
R
H
P
L
Y
L
T
G
F
F
G
G
Site 31
Y326
A
K
A
M
R
L
L
Y
Y
L
K
T
E
D
P
Site 32
Y327
K
A
M
R
L
L
Y
Y
L
K
T
E
D
P
E
Site 33
T330
R
L
L
Y
Y
L
K
T
E
D
P
E
Y
D
V
Site 34
Y335
L
K
T
E
D
P
E
Y
D
V
Q
S
K
Q
W
Site 35
T368
K
I
E
V
V
H
F
T
S
L
S
R
Q
L
E
Site 36
S369
I
E
V
V
H
F
T
S
L
S
R
Q
L
E
F
Site 37
S371
V
V
H
F
T
S
L
S
R
Q
L
E
F
E
A
Site 38
T469
M
I
S
A
W
H
K
T
N
L
A
D
D
I
R
Site 39
S480
D
D
I
R
E
R
M
S
N
V
Y
S
K
A
A
Site 40
Y483
R
E
R
M
S
N
V
Y
S
K
A
A
V
S
I
Site 41
S484
E
R
M
S
N
V
Y
S
K
A
A
V
S
I
T
Site 42
Y502
I
T
N
I
L
A
L
Y
T
G
I
M
S
S
F
Site 43
T597
D
Y
F
G
P
F
L
T
R
S
E
S
K
Y
F
Site 44
S634
L
D
L
R
N
L
A
S
D
D
S
Y
I
T
P
Site 45
S637
R
N
L
A
S
D
D
S
Y
I
T
P
Y
F
N
Site 46
Y638
N
L
A
S
D
D
S
Y
I
T
P
Y
F
N
V
Site 47
T640
A
S
D
D
S
Y
I
T
P
Y
F
N
V
E
E
Site 48
Y642
D
D
S
Y
I
T
P
Y
F
N
V
E
E
N
Y
Site 49
Y649
Y
F
N
V
E
E
N
Y
F
S
D
Y
G
P
R
Site 50
Y653
E
E
N
Y
F
S
D
Y
G
P
R
V
M
V
I
Site 51
Y667
I
V
T
K
K
V
D
Y
W
D
K
D
V
R
Q
Site 52
Y688
K
I
F
E
K
N
V
Y
V
D
K
N
L
T
E
Site 53
Y701
T
E
F
W
L
D
A
Y
V
Q
Y
L
K
G
N
Site 54
Y704
W
L
D
A
Y
V
Q
Y
L
K
G
N
S
Q
D
Site 55
S709
V
Q
Y
L
K
G
N
S
Q
D
P
N
E
K
N
Site 56
S741
H
D
I
N
I
S
S
S
N
E
I
I
S
S
R
Site 57
S746
S
S
S
N
E
I
I
S
S
R
G
F
I
Q
T
Site 58
S747
S
S
N
E
I
I
S
S
R
G
F
I
Q
T
T
Site 59
T753
S
S
R
G
F
I
Q
T
T
D
V
S
S
S
A
Site 60
T754
S
R
G
F
I
Q
T
T
D
V
S
S
S
A
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation