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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GRAMD1B
Full Name:
GRAM domain-containing protein 1B
Alias:
GRAM domain containing 1B; GRM1B; KIAA1201
Type:
Unknown function
Mass (Da):
85400
Number AA:
738
UniProt ID:
Q3KR37
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
K
G
F
K
L
S
C
T
A
S
N
S
N
Site 2
T9
K
G
F
K
L
S
C
T
A
S
N
S
N
R
S
Site 3
S11
F
K
L
S
C
T
A
S
N
S
N
R
S
T
P
Site 4
S13
L
S
C
T
A
S
N
S
N
R
S
T
P
A
C
Site 5
T17
A
S
N
S
N
R
S
T
P
A
C
S
P
I
L
Site 6
S21
N
R
S
T
P
A
C
S
P
I
L
R
K
R
S
Site 7
S28
S
P
I
L
R
K
R
S
R
S
P
T
P
Q
N
Site 8
S30
I
L
R
K
R
S
R
S
P
T
P
Q
N
Q
D
Site 9
T32
R
K
R
S
R
S
P
T
P
Q
N
Q
D
G
D
Site 10
T40
P
Q
N
Q
D
G
D
T
M
V
E
K
G
S
D
Site 11
S46
D
T
M
V
E
K
G
S
D
H
S
S
D
K
S
Site 12
S49
V
E
K
G
S
D
H
S
S
D
K
S
P
S
T
Site 13
S50
E
K
G
S
D
H
S
S
D
K
S
P
S
T
P
Site 14
S53
S
D
H
S
S
D
K
S
P
S
T
P
E
Q
G
Site 15
S55
H
S
S
D
K
S
P
S
T
P
E
Q
G
V
Q
Site 16
T56
S
S
D
K
S
P
S
T
P
E
Q
G
V
Q
R
Site 17
S64
P
E
Q
G
V
Q
R
S
C
S
S
Q
S
G
R
Site 18
S66
Q
G
V
Q
R
S
C
S
S
Q
S
G
R
S
G
Site 19
S67
G
V
Q
R
S
C
S
S
Q
S
G
R
S
G
G
Site 20
S69
Q
R
S
C
S
S
Q
S
G
R
S
G
G
K
N
Site 21
S72
C
S
S
Q
S
G
R
S
G
G
K
N
S
K
K
Site 22
S77
G
R
S
G
G
K
N
S
K
K
S
Q
S
W
Y
Site 23
S80
G
G
K
N
S
K
K
S
Q
S
W
Y
N
V
L
Site 24
S82
K
N
S
K
K
S
Q
S
W
Y
N
V
L
S
P
Site 25
Y84
S
K
K
S
Q
S
W
Y
N
V
L
S
P
T
Y
Site 26
S88
Q
S
W
Y
N
V
L
S
P
T
Y
K
Q
R
N
Site 27
T108
L
F
K
Q
L
P
D
T
E
R
L
I
V
D
Y
Site 28
Y115
T
E
R
L
I
V
D
Y
S
C
A
L
Q
R
D
Site 29
S116
E
R
L
I
V
D
Y
S
C
A
L
Q
R
D
I
Site 30
T147
S
N
I
F
R
W
E
T
L
L
T
V
R
L
K
Site 31
S158
V
R
L
K
D
I
C
S
M
T
K
E
K
T
A
Site 32
T164
C
S
M
T
K
E
K
T
A
R
L
I
P
N
A
Site 33
S185
S
E
K
H
F
F
T
S
F
G
A
R
D
R
T
Site 34
T192
S
F
G
A
R
D
R
T
Y
M
M
M
F
R
L
Site 35
T229
Y
G
N
E
L
G
L
T
S
D
D
E
D
Y
V
Site 36
Y235
L
T
S
D
D
E
D
Y
V
P
P
D
D
D
F
Site 37
S261
E
E
N
E
V
N
D
S
S
S
K
S
S
I
E
Site 38
S262
E
N
E
V
N
D
S
S
S
K
S
S
I
E
T
Site 39
S263
N
E
V
N
D
S
S
S
K
S
S
I
E
T
K
Site 40
S265
V
N
D
S
S
S
K
S
S
I
E
T
K
P
D
Site 41
S266
N
D
S
S
S
K
S
S
I
E
T
K
P
D
A
Site 42
T269
S
S
K
S
S
I
E
T
K
P
D
A
S
P
Q
Site 43
S274
I
E
T
K
P
D
A
S
P
Q
L
P
K
K
S
Site 44
S281
S
P
Q
L
P
K
K
S
I
T
N
S
T
L
T
Site 45
T283
Q
L
P
K
K
S
I
T
N
S
T
L
T
S
T
Site 46
S285
P
K
K
S
I
T
N
S
T
L
T
S
T
G
S
Site 47
T286
K
K
S
I
T
N
S
T
L
T
S
T
G
S
S
Site 48
T288
S
I
T
N
S
T
L
T
S
T
G
S
S
E
A
Site 49
S289
I
T
N
S
T
L
T
S
T
G
S
S
E
A
P
Site 50
S292
S
T
L
T
S
T
G
S
S
E
A
P
V
S
F
Site 51
S293
T
L
T
S
T
G
S
S
E
A
P
V
S
F
D
Site 52
S298
G
S
S
E
A
P
V
S
F
D
G
L
P
L
E
Site 53
S314
E
A
L
E
G
D
G
S
L
E
K
E
L
A
I
Site 54
S337
E
M
I
A
P
V
N
S
P
S
L
D
F
N
D
Site 55
S339
I
A
P
V
N
S
P
S
L
D
F
N
D
N
E
Site 56
T350
N
D
N
E
D
I
P
T
E
L
S
D
S
S
D
Site 57
S353
E
D
I
P
T
E
L
S
D
S
S
D
T
H
D
Site 58
S355
I
P
T
E
L
S
D
S
S
D
T
H
D
E
G
Site 59
S356
P
T
E
L
S
D
S
S
D
T
H
D
E
G
E
Site 60
Y368
E
G
E
V
Q
A
F
Y
E
D
L
S
G
R
Q
Site 61
S372
Q
A
F
Y
E
D
L
S
G
R
Q
Y
V
N
E
Site 62
Y376
E
D
L
S
G
R
Q
Y
V
N
E
V
F
N
F
Site 63
Y389
N
F
S
V
D
K
L
Y
D
L
L
F
T
N
S
Site 64
T394
K
L
Y
D
L
L
F
T
N
S
P
F
Q
R
D
Site 65
S396
Y
D
L
L
F
T
N
S
P
F
Q
R
D
F
M
Site 66
T442
T
N
P
L
A
P
K
T
A
T
V
R
E
T
Q
Site 67
T444
P
L
A
P
K
T
A
T
V
R
E
T
Q
T
M
Site 68
T448
K
T
A
T
V
R
E
T
Q
T
M
Y
K
A
S
Site 69
S455
T
Q
T
M
Y
K
A
S
Q
E
S
E
C
Y
V
Site 70
T469
V
I
D
A
E
V
L
T
H
D
V
P
Y
H
D
Site 71
Y474
V
L
T
H
D
V
P
Y
H
D
Y
F
Y
T
I
Site 72
Y477
H
D
V
P
Y
H
D
Y
F
Y
T
I
N
R
Y
Site 73
Y479
V
P
Y
H
D
Y
F
Y
T
I
N
R
Y
T
L
Site 74
T485
F
Y
T
I
N
R
Y
T
L
T
R
V
A
R
N
Site 75
S494
T
R
V
A
R
N
K
S
R
L
R
V
S
T
E
Site 76
S499
N
K
S
R
L
R
V
S
T
E
L
R
Y
R
K
Site 77
T500
K
S
R
L
R
V
S
T
E
L
R
Y
R
K
Q
Site 78
Y504
R
V
S
T
E
L
R
Y
R
K
Q
P
W
G
L
Site 79
S522
F
I
E
K
N
F
W
S
G
L
E
D
Y
F
R
Site 80
Y527
F
W
S
G
L
E
D
Y
F
R
H
L
E
S
E
Site 81
S533
D
Y
F
R
H
L
E
S
E
L
A
K
T
E
S
Site 82
T538
L
E
S
E
L
A
K
T
E
S
T
Y
L
A
E
Site 83
S550
L
A
E
M
H
R
Q
S
P
K
E
K
A
S
K
Site 84
S556
Q
S
P
K
E
K
A
S
K
T
T
T
V
R
R
Site 85
T558
P
K
E
K
A
S
K
T
T
T
V
R
R
R
K
Site 86
T560
E
K
A
S
K
T
T
T
V
R
R
R
K
R
P
Site 87
S581
P
H
L
E
E
V
M
S
P
V
T
T
P
T
D
Site 88
T584
E
E
V
M
S
P
V
T
T
P
T
D
E
D
V
Site 89
T585
E
V
M
S
P
V
T
T
P
T
D
E
D
V
G
Site 90
T587
M
S
P
V
T
T
P
T
D
E
D
V
G
H
R
Site 91
T611
T
R
H
I
P
E
D
T
P
N
G
F
H
L
Q
Site 92
S674
L
Q
E
R
L
P
Q
S
Q
T
E
W
A
Q
L
Site 93
T676
E
R
L
P
Q
S
Q
T
E
W
A
Q
L
L
E
Site 94
Y688
L
L
E
S
Q
Q
K
Y
H
D
T
E
L
Q
K
Site 95
T691
S
Q
Q
K
Y
H
D
T
E
L
Q
K
W
R
E
Site 96
S702
K
W
R
E
I
I
K
S
S
V
M
L
L
D
Q
Site 97
S713
L
L
D
Q
M
K
D
S
L
I
N
L
Q
N
G
Site 98
S723
N
L
Q
N
G
I
R
S
R
D
Y
T
S
E
S
Site 99
Y726
N
G
I
R
S
R
D
Y
T
S
E
S
E
E
K
Site 100
T727
G
I
R
S
R
D
Y
T
S
E
S
E
E
K
R
Site 101
S728
I
R
S
R
D
Y
T
S
E
S
E
E
K
R
N
Site 102
S730
S
R
D
Y
T
S
E
S
E
E
K
R
N
R
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation