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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CHD9
Full Name:
Chromodomain-helicase-DNA-binding protein 9
Alias:
AD013; ATP-dependent helicase CHD9; BC022889; Chromatin-related mesenchymal modulator; Chromatin-remodeling factor CHROM1; Chromodomain helicase DNA binding protein 9; CReMM; FLJ12178; KIAA0308; KISH2; Kismet homolog 2; Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein; PPAR-alpha-interacting complex protein 320 kDa; PRIC320
Type:
Helicase; DNA binding protein; EC 3.6.1.-
Mass (Da):
326022
Number AA:
2897
UniProt ID:
Q3L8U1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000785
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003677
GO:0003682
PhosphoSite+
KinaseNET
Biological Process:
GO:0006333
GO:0016568
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
G
E
T
L
E
G
L
S
D
D
A
F
V
Q
P
Site 2
S52
F
E
P
L
H
I
D
S
L
N
H
V
Q
G
T
Site 3
T59
S
L
N
H
V
Q
G
T
P
T
H
Q
K
M
T
Site 4
S85
K
F
H
H
V
N
Q
S
F
G
S
P
A
E
H
Site 5
S88
H
V
N
Q
S
F
G
S
P
A
E
H
V
L
S
Site 6
S95
S
P
A
E
H
V
L
S
P
H
S
Q
F
N
C
Site 7
S98
E
H
V
L
S
P
H
S
Q
F
N
C
S
P
I
Site 8
S119
N
G
L
F
P
D
V
S
D
G
S
P
M
W
G
Site 9
S122
F
P
D
V
S
D
G
S
P
M
W
G
H
Q
T
Site 10
S139
T
I
S
N
Q
N
G
S
P
F
H
Q
Q
G
H
Site 11
T172
F
Q
A
N
E
Q
Q
T
Q
C
T
S
L
R
S
Site 12
S176
E
Q
Q
T
Q
C
T
S
L
R
S
Q
Q
N
R
Site 13
S192
N
L
N
P
G
Q
N
S
L
S
Q
S
K
N
F
Site 14
S194
N
P
G
Q
N
S
L
S
Q
S
K
N
F
M
N
Site 15
S196
G
Q
N
S
L
S
Q
S
K
N
F
M
N
V
S
Site 16
S203
S
K
N
F
M
N
V
S
G
P
H
R
V
N
V
Site 17
S220
P
P
Q
M
T
N
A
S
N
S
Q
Q
S
I
S
Site 18
S222
Q
M
T
N
A
S
N
S
Q
Q
S
I
S
M
Q
Site 19
S225
N
A
S
N
S
Q
Q
S
I
S
M
Q
Q
F
S
Site 20
S227
S
N
S
Q
Q
S
I
S
M
Q
Q
F
S
Q
T
Site 21
S232
S
I
S
M
Q
Q
F
S
Q
T
S
N
P
S
A
Site 22
T234
S
M
Q
Q
F
S
Q
T
S
N
P
S
A
H
F
Site 23
S256
E
G
N
F
N
G
P
S
P
N
M
T
S
C
S
Site 24
T260
N
G
P
S
P
N
M
T
S
C
S
V
S
N
S
Site 25
S261
G
P
S
P
N
M
T
S
C
S
V
S
N
S
Q
Site 26
S263
S
P
N
M
T
S
C
S
V
S
N
S
Q
Q
F
Site 27
S265
N
M
T
S
C
S
V
S
N
S
Q
Q
F
S
S
Site 28
S267
T
S
C
S
V
S
N
S
Q
Q
F
S
S
H
Y
Site 29
S271
V
S
N
S
Q
Q
F
S
S
H
Y
S
F
S
S
Site 30
S272
S
N
S
Q
Q
F
S
S
H
Y
S
F
S
S
N
Site 31
Y274
S
Q
Q
F
S
S
H
Y
S
F
S
S
N
H
I
Site 32
S275
Q
Q
F
S
S
H
Y
S
F
S
S
N
H
I
S
Site 33
S277
F
S
S
H
Y
S
F
S
S
N
H
I
S
P
N
Site 34
S278
S
S
H
Y
S
F
S
S
N
H
I
S
P
N
S
Site 35
S282
S
F
S
S
N
H
I
S
P
N
S
L
L
Q
S
Site 36
S285
S
N
H
I
S
P
N
S
L
L
Q
S
S
A
V
Site 37
S289
S
P
N
S
L
L
Q
S
S
A
V
L
A
S
N
Site 38
T301
A
S
N
H
T
N
Q
T
L
S
D
F
T
G
S
Site 39
S303
N
H
T
N
Q
T
L
S
D
F
T
G
S
N
S
Site 40
T306
N
Q
T
L
S
D
F
T
G
S
N
S
F
S
P
Site 41
S308
T
L
S
D
F
T
G
S
N
S
F
S
P
H
R
Site 42
S310
S
D
F
T
G
S
N
S
F
S
P
H
R
G
I
Site 43
S312
F
T
G
S
N
S
F
S
P
H
R
G
I
K
Q
Site 44
T322
R
G
I
K
Q
E
S
T
Q
H
I
L
N
P
N
Site 45
T330
Q
H
I
L
N
P
N
T
S
L
N
S
N
N
F
Site 46
S331
H
I
L
N
P
N
T
S
L
N
S
N
N
F
Q
Site 47
Y349
S
S
H
P
Q
G
N
Y
S
N
S
K
L
S
P
Site 48
S350
S
H
P
Q
G
N
Y
S
N
S
K
L
S
P
V
Site 49
S352
P
Q
G
N
Y
S
N
S
K
L
S
P
V
H
M
Site 50
S355
N
Y
S
N
S
K
L
S
P
V
H
M
N
F
P
Site 51
T369
P
D
P
V
D
S
G
T
Q
M
G
H
F
N
D
Site 52
S385
V
E
T
N
G
F
S
S
L
E
E
N
L
L
H
Site 53
S396
N
L
L
H
Q
V
E
S
Q
T
E
P
F
T
G
Site 54
T422
L
P
H
F
D
E
S
T
F
G
Q
D
N
S
S
Site 55
S428
S
T
F
G
Q
D
N
S
S
H
I
L
D
H
D
Site 56
T441
H
D
L
D
R
Q
F
T
S
H
L
V
T
R
P
Site 57
S442
D
L
D
R
Q
F
T
S
H
L
V
T
R
P
S
Site 58
T446
Q
F
T
S
H
L
V
T
R
P
S
D
M
A
Q
Site 59
S449
S
H
L
V
T
R
P
S
D
M
A
Q
T
Q
L
Site 60
T454
R
P
S
D
M
A
Q
T
Q
L
Q
S
Q
A
R
Site 61
S458
M
A
Q
T
Q
L
Q
S
Q
A
R
S
W
H
S
Site 62
S462
Q
L
Q
S
Q
A
R
S
W
H
S
S
F
S
N
Site 63
S465
S
Q
A
R
S
W
H
S
S
F
S
N
H
Q
H
Site 64
S466
Q
A
R
S
W
H
S
S
F
S
N
H
Q
H
L
Site 65
S487
C
L
Q
R
Q
P
P
S
S
K
K
S
D
G
S
Site 66
S488
L
Q
R
Q
P
P
S
S
K
K
S
D
G
S
G
Site 67
S491
Q
P
P
S
S
K
K
S
D
G
S
G
T
Y
T
Site 68
S494
S
S
K
K
S
D
G
S
G
T
Y
T
K
L
Q
Site 69
T498
S
D
G
S
G
T
Y
T
K
L
Q
N
T
Q
V
Site 70
T503
T
Y
T
K
L
Q
N
T
Q
V
R
V
M
S
E
Site 71
S509
N
T
Q
V
R
V
M
S
E
K
K
Q
R
K
K
Site 72
S519
K
Q
R
K
K
V
E
S
E
S
K
Q
E
K
A
Site 73
S531
E
K
A
N
R
I
I
S
E
A
I
A
K
A
K
Site 74
S550
R
N
I
P
R
V
M
S
P
E
N
F
P
T
A
Site 75
T556
M
S
P
E
N
F
P
T
A
S
V
E
G
K
E
Site 76
S558
P
E
N
F
P
T
A
S
V
E
G
K
E
E
K
Site 77
S572
K
K
G
R
R
M
K
S
K
P
K
D
K
D
S
Site 78
S579
S
K
P
K
D
K
D
S
K
K
T
K
T
C
S
Site 79
T584
K
D
S
K
K
T
K
T
C
S
K
L
K
E
K
Site 80
S586
S
K
K
T
K
T
C
S
K
L
K
E
K
T
K
Site 81
T592
C
S
K
L
K
E
K
T
K
I
G
K
L
I
I
Site 82
T600
K
I
G
K
L
I
I
T
L
G
K
K
Q
K
R
Site 83
S611
K
Q
K
R
K
N
E
S
S
D
E
I
S
D
A
Site 84
S612
Q
K
R
K
N
E
S
S
D
E
I
S
D
A
E
Site 85
S616
N
E
S
S
D
E
I
S
D
A
E
Q
M
P
Q
Site 86
T625
A
E
Q
M
P
Q
H
T
L
K
D
Q
D
S
Q
Site 87
S631
H
T
L
K
D
Q
D
S
Q
K
R
R
S
N
R
Site 88
S636
Q
D
S
Q
K
R
R
S
N
R
Q
I
K
R
K
Site 89
Y645
R
Q
I
K
R
K
K
Y
A
E
D
I
E
G
K
Site 90
S654
E
D
I
E
G
K
Q
S
E
E
E
V
K
G
S
Site 91
S697
A
I
V
D
K
I
L
S
S
R
T
V
K
K
E
Site 92
S706
R
T
V
K
K
E
I
S
P
G
V
M
I
D
T
Site 93
T713
S
P
G
V
M
I
D
T
E
E
F
F
V
K
Y
Site 94
Y720
T
E
E
F
F
V
K
Y
K
N
Y
S
Y
L
H
Site 95
Y725
V
K
Y
K
N
Y
S
Y
L
H
C
E
W
A
T
Site 96
Y772
E
E
P
F
N
P
D
Y
V
E
V
D
R
V
L
Site 97
S782
V
D
R
V
L
E
V
S
F
C
E
D
K
D
T
Site 98
T789
S
F
C
E
D
K
D
T
G
E
P
V
I
Y
Y
Site 99
Y795
D
T
G
E
P
V
I
Y
Y
L
V
K
W
C
S
Site 100
S808
C
S
L
P
Y
E
D
S
T
W
E
L
K
E
D
Site 101
T809
S
L
P
Y
E
D
S
T
W
E
L
K
E
D
V
Site 102
S830
E
F
E
Q
L
Q
A
S
R
P
D
T
R
R
L
Site 103
T834
L
Q
A
S
R
P
D
T
R
R
L
D
R
P
P
Site 104
S842
R
R
L
D
R
P
P
S
N
I
W
K
K
I
D
Site 105
Y854
K
I
D
Q
S
R
D
Y
K
N
G
N
Q
L
R
Site 106
Y863
N
G
N
Q
L
R
E
Y
Q
L
E
G
L
N
W
Site 107
T931
E
R
E
F
R
T
W
T
D
I
N
V
V
V
Y
Site 108
Y951
S
R
Q
M
I
Q
Q
Y
E
M
Y
F
R
D
S
Site 109
Y954
M
I
Q
Q
Y
E
M
Y
F
R
D
S
Q
G
R
Site 110
S958
Y
E
M
Y
F
R
D
S
Q
G
R
I
I
R
G
Site 111
T1027
H
K
V
L
L
T
G
T
P
L
Q
N
T
V
E
Site 112
T1032
T
G
T
P
L
Q
N
T
V
E
E
L
F
S
L
Site 113
S1050
L
E
P
L
R
F
P
S
E
S
T
F
M
Q
E
Site 114
S1052
P
L
R
F
P
S
E
S
T
F
M
Q
E
F
G
Site 115
T1053
L
R
F
P
S
E
S
T
F
M
Q
E
F
G
D
Site 116
T1063
Q
E
F
G
D
L
K
T
E
E
Q
V
Q
K
L
Site 117
T1103
T
I
I
E
V
E
L
T
N
I
Q
K
K
Y
Y
Site 118
Y1109
L
T
N
I
Q
K
K
Y
Y
R
A
I
L
E
K
Site 119
T1128
L
S
K
G
A
G
Q
T
N
V
P
N
L
V
N
Site 120
Y1148
R
K
C
C
N
H
P
Y
L
I
K
G
A
E
E
Site 121
T1164
I
L
G
E
F
R
D
T
Y
N
P
A
A
S
D
Site 122
Y1165
L
G
E
F
R
D
T
Y
N
P
A
A
S
D
F
Site 123
Y1223
D
Y
L
I
H
K
R
Y
L
Y
E
R
I
D
G
Site 124
Y1225
L
I
H
K
R
Y
L
Y
E
R
I
D
G
R
V
Site 125
S1245
Q
A
A
I
D
R
F
S
K
P
D
S
D
R
F
Site 126
S1249
D
R
F
S
K
P
D
S
D
R
F
V
F
L
L
Site 127
T1308
V
K
V
Y
R
L
V
T
R
N
S
Y
E
R
E
Site 128
S1311
Y
R
L
V
T
R
N
S
Y
E
R
E
M
F
D
Site 129
Y1312
R
L
V
T
R
N
S
Y
E
R
E
M
F
D
R
Site 130
S1321
R
E
M
F
D
R
A
S
L
K
L
G
L
D
K
Site 131
S1333
L
D
K
A
V
L
Q
S
M
S
G
R
E
S
N
Site 132
S1335
K
A
V
L
Q
S
M
S
G
R
E
S
N
V
G
Site 133
S1339
Q
S
M
S
G
R
E
S
N
V
G
G
I
Q
Q
Site 134
S1348
V
G
G
I
Q
Q
L
S
K
K
E
I
E
D
L
Site 135
Y1361
D
L
L
R
R
G
A
Y
G
A
I
M
E
E
E
Site 136
S1372
M
E
E
E
D
E
G
S
K
F
C
E
E
D
I
Site 137
T1387
D
Q
I
L
L
R
R
T
K
T
I
T
I
E
S
Site 138
T1389
I
L
L
R
R
T
K
T
I
T
I
E
S
E
G
Site 139
T1391
L
R
R
T
K
T
I
T
I
E
S
E
G
R
G
Site 140
S1394
T
K
T
I
T
I
E
S
E
G
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T
E
Y
S
D
P
S
V
P
T
Site 293
S2311
P
G
A
A
T
E
Y
S
D
P
S
V
P
T
P
Site 294
S2314
A
T
E
Y
S
D
P
S
V
P
T
P
P
G
A
Site 295
T2317
Y
S
D
P
S
V
P
T
P
P
G
A
G
V
K
Site 296
S2330
V
K
E
E
H
D
Q
S
T
Q
M
S
K
V
K
Site 297
T2331
K
E
E
H
D
Q
S
T
Q
M
S
K
V
K
K
Site 298
S2334
H
D
Q
S
T
Q
M
S
K
V
K
K
H
V
R
Site 299
T2346
H
V
R
E
K
E
F
T
V
K
I
K
D
E
G
Site 300
T2358
D
E
G
G
L
K
L
T
F
Q
K
Q
G
L
A
Site 301
Y2382
G
A
L
G
Q
Q
Q
Y
L
T
R
L
R
E
L
Site 302
T2384
L
G
Q
Q
Q
Y
L
T
R
L
R
E
L
Q
S
Site 303
S2391
T
R
L
R
E
L
Q
S
A
S
E
T
S
L
V
Site 304
S2393
L
R
E
L
Q
S
A
S
E
T
S
L
V
N
F
Site 305
T2395
E
L
Q
S
A
S
E
T
S
L
V
N
F
P
K
Site 306
S2396
L
Q
S
A
S
E
T
S
L
V
N
F
P
K
S
Site 307
S2407
F
P
K
S
I
P
V
S
G
T
S
I
Q
P
T
Site 308
S2456
N
K
P
P
N
H
V
S
L
G
L
T
S
S
Q
Site 309
T2460
N
H
V
S
L
G
L
T
S
S
Q
I
S
T
G
Site 310
S2473
T
G
I
N
P
A
L
S
Y
T
Q
P
Q
G
I
Site 311
Y2474
G
I
N
P
A
L
S
Y
T
Q
P
Q
G
I
P
Site 312
T2483
Q
P
Q
G
I
P
D
T
E
S
P
V
P
V
I
Site 313
S2485
Q
G
I
P
D
T
E
S
P
V
P
V
I
N
L
Site 314
Y2519
W
L
K
E
H
P
G
Y
V
E
D
L
G
A
F
Site 315
S2554
P
N
K
L
D
V
N
S
L
T
G
E
E
R
V
Site 316
Y2593
F
L
K
E
N
S
E
Y
G
V
A
P
E
W
G
Site 317
S2612
Q
S
G
F
L
P
E
S
M
Y
E
R
I
L
T
Site 318
Y2614
G
F
L
P
E
S
M
Y
E
R
I
L
T
G
P
Site 319
T2619
S
M
Y
E
R
I
L
T
G
P
V
V
R
E
E
Site 320
S2628
P
V
V
R
E
E
V
S
R
R
G
R
R
P
K
Site 321
S2636
R
R
G
R
R
P
K
S
G
I
A
K
A
T
A
Site 322
T2671
L
P
G
V
D
L
T
T
L
Q
A
L
Q
Q
N
Site 323
S2684
Q
N
L
Q
N
L
Q
S
L
Q
V
T
A
G
L
Site 324
T2732
L
G
M
G
G
L
L
T
K
P
T
E
S
G
T
Site 325
T2735
G
G
L
L
T
K
P
T
E
S
G
T
E
D
K
Site 326
S2745
G
T
E
D
K
K
G
S
D
S
K
E
S
E
G
Site 327
S2747
E
D
K
K
G
S
D
S
K
E
S
E
G
K
T
Site 328
T2754
S
K
E
S
E
G
K
T
E
R
T
E
S
Q
S
Site 329
T2757
S
E
G
K
T
E
R
T
E
S
Q
S
S
E
N
Site 330
S2759
G
K
T
E
R
T
E
S
Q
S
S
E
N
G
G
Site 331
S2761
T
E
R
T
E
S
Q
S
S
E
N
G
G
E
N
Site 332
S2762
E
R
T
E
S
Q
S
S
E
N
G
G
E
N
S
Site 333
S2769
S
E
N
G
G
E
N
S
V
S
S
S
P
S
T
Site 334
S2771
N
G
G
E
N
S
V
S
S
S
P
S
T
S
S
Site 335
S2772
G
G
E
N
S
V
S
S
S
P
S
T
S
S
T
Site 336
S2773
G
E
N
S
V
S
S
S
P
S
T
S
S
T
A
Site 337
S2775
N
S
V
S
S
S
P
S
T
S
S
T
A
A
L
Site 338
T2776
S
V
S
S
S
P
S
T
S
S
T
A
A
L
N
Site 339
S2777
V
S
S
S
P
S
T
S
S
T
A
A
L
N
T
Site 340
S2778
S
S
S
P
S
T
S
S
T
A
A
L
N
T
A
Site 341
T2779
S
S
P
S
T
S
S
T
A
A
L
N
T
A
A
Site 342
T2818
G
L
N
L
H
I
P
T
L
S
Q
S
N
T
F
Site 343
S2820
N
L
H
I
P
T
L
S
Q
S
N
T
F
D
V
Site 344
T2824
P
T
L
S
Q
S
N
T
F
D
V
Q
N
K
N
Site 345
S2832
F
D
V
Q
N
K
N
S
D
L
G
S
S
K
S
Site 346
S2836
N
K
N
S
D
L
G
S
S
K
S
V
E
V
K
Site 347
S2839
S
D
L
G
S
S
K
S
V
E
V
K
E
E
D
Site 348
S2861
D
K
G
G
T
E
P
S
P
L
N
E
N
S
T
Site 349
S2867
P
S
P
L
N
E
N
S
T
D
E
G
S
E
K
Site 350
T2868
S
P
L
N
E
N
S
T
D
E
G
S
E
K
A
Site 351
S2878
G
S
E
K
A
D
A
S
S
G
S
D
S
T
S
Site 352
S2879
S
E
K
A
D
A
S
S
G
S
D
S
T
S
S
Site 353
S2881
K
A
D
A
S
S
G
S
D
S
T
S
S
S
S
Site 354
S2883
D
A
S
S
G
S
D
S
T
S
S
S
S
E
D
Site 355
T2884
A
S
S
G
S
D
S
T
S
S
S
S
E
D
S
Site 356
S2885
S
S
G
S
D
S
T
S
S
S
S
E
D
S
D
Site 357
S2886
S
G
S
D
S
T
S
S
S
S
E
D
S
D
S
Site 358
S2887
G
S
D
S
T
S
S
S
S
E
D
S
D
S
S
Site 359
S2888
S
D
S
T
S
S
S
S
E
D
S
D
S
S
N
Site 360
S2891
T
S
S
S
S
E
D
S
D
S
S
N
E
D
_
Site 361
S2893
S
S
S
E
D
S
D
S
S
N
E
D
_
_
_
Site 362
S2894
S
S
E
D
S
D
S
S
N
E
D
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation