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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TBC1D25
Full Name:
TBC1 domain family member 25
Alias:
OATL1; TBC1 domain family, member 25
Type:
Mass (Da):
76357
Number AA:
688
UniProt ID:
Q3MII6
International Prot ID:
IPI00296736
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0044464
Uniprot
OncoNet
Molecular Function:
GO:0005083
GO:0005096
GO:0005097
PhosphoSite+
KinaseNET
Biological Process:
GO:0032313
GO:0032318
GO:0043087
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
A
S
G
A
S
D
L
S
G
S
G
A
P
P
P
Site 2
S13
G
A
S
D
L
S
G
S
G
A
P
P
P
G
V
Site 3
S45
V
R
V
K
K
C
E
S
F
L
P
P
E
F
R
Site 4
S85
G
K
K
N
F
G
I
S
Y
L
G
R
D
R
L
Site 5
Y97
D
R
L
G
Q
E
V
Y
L
S
L
L
S
D
W
Site 6
T108
L
S
D
W
D
L
S
T
A
F
A
T
A
S
K
Site 7
S114
S
T
A
F
A
T
A
S
K
P
Y
L
Q
L
R
Site 8
S127
L
R
V
D
I
R
P
S
E
D
S
P
L
L
E
Site 9
S130
D
I
R
P
S
E
D
S
P
L
L
E
D
W
D
Site 10
S140
L
E
D
W
D
I
I
S
P
K
D
V
I
G
S
Site 11
S147
S
P
K
D
V
I
G
S
D
V
L
L
A
E
K
Site 12
T159
A
E
K
R
S
S
L
T
T
A
A
L
P
F
T
Site 13
T160
E
K
R
S
S
L
T
T
A
A
L
P
F
T
Q
Site 14
T166
T
T
A
A
L
P
F
T
Q
S
I
L
T
Q
V
Site 15
S168
A
A
L
P
F
T
Q
S
I
L
T
Q
V
G
R
Site 16
T171
P
F
T
Q
S
I
L
T
Q
V
G
R
T
L
S
Site 17
S178
T
Q
V
G
R
T
L
S
K
V
Q
Q
V
L
S
Site 18
S185
S
K
V
Q
Q
V
L
S
W
S
Y
G
E
D
V
Site 19
S200
K
P
F
K
P
P
L
S
D
A
E
F
H
T
Y
Site 20
Y207
S
D
A
E
F
H
T
Y
L
N
H
E
G
Q
L
Site 21
S215
L
N
H
E
G
Q
L
S
R
P
E
E
L
R
L
Site 22
Y225
E
E
L
R
L
R
I
Y
H
G
G
V
E
P
S
Site 23
S232
Y
H
G
G
V
E
P
S
L
R
K
V
V
W
R
Site 24
Y240
L
R
K
V
V
W
R
Y
L
L
N
V
Y
P
D
Site 25
Y245
W
R
Y
L
L
N
V
Y
P
D
G
L
T
G
R
Site 26
T250
N
V
Y
P
D
G
L
T
G
R
E
R
M
D
Y
Site 27
Y257
T
G
R
E
R
M
D
Y
M
K
R
K
S
R
E
Site 28
S262
M
D
Y
M
K
R
K
S
R
E
Y
E
Q
L
K
Site 29
Y265
M
K
R
K
S
R
E
Y
E
Q
L
K
S
E
W
Site 30
S270
R
E
Y
E
Q
L
K
S
E
W
A
Q
R
A
N
Site 31
T295
V
L
K
D
V
L
R
T
D
R
A
H
P
Y
Y
Site 32
Y301
R
T
D
R
A
H
P
Y
Y
A
G
P
E
D
G
Site 33
Y302
T
D
R
A
H
P
Y
Y
A
G
P
E
D
G
P
Site 34
T319
R
A
L
H
D
L
L
T
T
Y
A
V
T
H
P
Site 35
Y392
R
H
A
D
P
D
F
Y
Q
Y
L
Q
E
A
G
Site 36
Y394
A
D
P
D
F
Y
Q
Y
L
Q
E
A
G
A
D
Site 37
T430
A
L
R
M
L
E
V
T
W
S
S
L
P
P
D
Site 38
S432
R
M
L
E
V
T
W
S
S
L
P
P
D
P
P
Site 39
S433
M
L
E
V
T
W
S
S
L
P
P
D
P
P
E
Site 40
T455
P
P
S
Q
V
A
D
T
G
F
G
G
H
R
G
Site 41
T480
P
A
G
G
G
G
S
T
F
E
D
A
V
D
H
Site 42
S492
V
D
H
L
A
T
A
S
Q
G
P
G
G
G
G
Site 43
S506
G
R
L
L
R
Q
A
S
L
D
G
L
Q
Q
L
Site 44
S519
Q
L
R
D
N
M
G
S
R
R
D
P
L
V
Q
Site 45
S535
P
H
P
A
A
L
I
S
S
K
S
L
S
E
P
Site 46
S536
H
P
A
A
L
I
S
S
K
S
L
S
E
P
L
Site 47
S540
L
I
S
S
K
S
L
S
E
P
L
L
N
S
P
Site 48
S546
L
S
E
P
L
L
N
S
P
D
P
L
L
S
S
Site 49
S552
N
S
P
D
P
L
L
S
S
F
S
H
P
D
S
Site 50
S553
S
P
D
P
L
L
S
S
F
S
H
P
D
S
P
Site 51
S555
D
P
L
L
S
S
F
S
H
P
D
S
P
S
S
Site 52
S559
S
S
F
S
H
P
D
S
P
S
S
S
S
P
P
Site 53
S561
F
S
H
P
D
S
P
S
S
S
S
P
P
S
T
Site 54
S562
S
H
P
D
S
P
S
S
S
S
P
P
S
T
Q
Site 55
S563
H
P
D
S
P
S
S
S
S
P
P
S
T
Q
E
Site 56
S564
P
D
S
P
S
S
S
S
P
P
S
T
Q
E
A
Site 57
S567
P
S
S
S
S
P
P
S
T
Q
E
A
S
P
T
Site 58
T568
S
S
S
S
P
P
S
T
Q
E
A
S
P
T
G
Site 59
S572
P
P
S
T
Q
E
A
S
P
T
G
D
M
A
V
Site 60
T574
S
T
Q
E
A
S
P
T
G
D
M
A
V
G
S
Site 61
S589
P
L
M
Q
E
V
G
S
P
K
D
P
G
K
S
Site 62
S596
S
P
K
D
P
G
K
S
L
P
P
V
P
P
M
Site 63
Y640
I
M
R
N
G
L
D
Y
N
E
L
A
M
H
F
Site 64
Y670
A
R
A
L
F
A
D
Y
L
Q
S
E
V
W
D
Site 65
S673
L
F
A
D
Y
L
Q
S
E
V
W
D
S
E
E
Site 66
S678
L
Q
S
E
V
W
D
S
E
E
G
A
E
A
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation