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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLA2G4E
Full Name:
Cytosolic phospholipase A2 epsilon
Alias:
EC 3.1.1.4; PA24E
Type:
Mass (Da):
95687
Number AA:
838
UniProt ID:
Q3MJ16
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005764
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0004623
PhosphoSite+
KinaseNET
Biological Process:
GO:0009395
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
R
Q
M
H
A
R
V
S
H
S
L
P
D
P
C
Site 2
S13
M
H
A
R
V
S
H
S
L
P
D
P
C
Q
A
Site 3
S23
D
P
C
Q
A
E
D
S
R
P
S
A
T
C
A
Site 4
S26
Q
A
E
D
S
R
P
S
A
T
C
A
L
K
A
Site 5
T36
C
A
L
K
A
P
Q
T
S
W
D
G
L
L
R
Site 6
S69
V
R
Q
A
D
M
L
S
Q
T
D
C
F
V
S
Site 7
S83
S
L
W
L
P
T
A
S
Q
K
K
L
R
T
R
Site 8
T89
A
S
Q
K
K
L
R
T
R
T
I
S
N
C
P
Site 9
T91
Q
K
K
L
R
T
R
T
I
S
N
C
P
N
P
Site 10
S93
K
L
R
T
R
T
I
S
N
C
P
N
P
E
W
Site 11
T125
L
S
V
C
D
E
D
T
V
T
P
D
D
H
L
Site 12
T127
V
C
D
E
D
T
V
T
P
D
D
H
L
L
T
Site 13
T134
T
P
D
D
H
L
L
T
V
L
Y
D
L
T
K
Site 14
T148
K
L
C
F
R
K
K
T
H
V
K
F
P
L
N
Site 15
S171
V
E
F
L
L
E
E
S
P
S
P
P
E
T
L
Site 16
S173
F
L
L
E
E
S
P
S
P
P
E
T
L
V
T
Site 17
T177
E
S
P
S
P
P
E
T
L
V
T
N
G
V
L
Site 18
T180
S
P
P
E
T
L
V
T
N
G
V
L
V
S
R
Site 19
S195
G
H
G
W
L
L
L
S
G
E
Q
D
Q
G
R
Site 20
T220
V
N
E
S
F
E
N
T
Q
R
V
R
P
C
L
Site 21
Y239
P
T
S
A
C
F
H
Y
P
K
Y
F
Q
S
Q
Site 22
S264
S
C
G
L
C
C
R
S
R
K
K
G
P
I
S
Site 23
S271
S
R
K
K
G
P
I
S
Q
P
L
D
C
L
S
Site 24
S278
S
Q
P
L
D
C
L
S
D
G
Q
V
M
T
L
Site 25
S292
L
P
V
G
G
G
E
S
L
G
S
P
E
T
L
Site 26
S295
G
G
G
E
S
L
G
S
P
E
T
L
D
V
R
Site 27
T298
E
S
L
G
S
P
E
T
L
D
V
R
L
G
F
Site 28
S355
A
T
G
G
G
T
R
S
M
T
S
M
Y
G
H
Site 29
T357
G
G
G
T
R
S
M
T
S
M
Y
G
H
L
L
Site 30
S358
G
G
T
R
S
M
T
S
M
Y
G
H
L
L
G
Site 31
Y360
T
R
S
M
T
S
M
Y
G
H
L
L
G
L
Q
Site 32
Y392
T
W
T
M
A
T
L
Y
R
D
P
D
W
S
S
Site 33
S398
L
Y
R
D
P
D
W
S
S
K
N
L
E
P
A
Site 34
S399
Y
R
D
P
D
W
S
S
K
N
L
E
P
A
I
Site 35
S437
Q
E
E
L
R
Q
R
S
Q
E
G
Y
R
V
T
Site 36
Y441
R
Q
R
S
Q
E
G
Y
R
V
T
F
T
D
F
Site 37
T444
S
Q
E
G
Y
R
V
T
F
T
D
F
W
G
L
Site 38
S467
E
R
N
E
C
K
L
S
D
Q
R
A
A
L
S
Site 39
S474
S
D
Q
R
A
A
L
S
C
G
Q
N
P
L
P
Site 40
Y483
G
Q
N
P
L
P
I
Y
L
T
I
N
V
K
D
Site 41
S493
I
N
V
K
D
D
V
S
N
Q
D
F
R
E
W
Site 42
S504
F
R
E
W
F
E
F
S
P
Y
E
V
G
L
Q
Site 43
Y506
E
W
F
E
F
S
P
Y
E
V
G
L
Q
K
Y
Site 44
Y513
Y
E
V
G
L
Q
K
Y
G
A
F
I
P
S
E
Site 45
S519
K
Y
G
A
F
I
P
S
E
L
F
G
S
E
F
Site 46
S562
L
L
D
A
W
N
L
S
H
T
S
E
E
F
F
Site 47
T573
E
E
F
F
H
R
W
T
R
E
K
V
Q
D
I
Site 48
S611
P
G
S
W
L
S
N
S
F
R
E
I
L
T
H
Site 49
T617
N
S
F
R
E
I
L
T
H
R
S
F
V
S
E
Site 50
S620
R
E
I
L
T
H
R
S
F
V
S
E
F
H
N
Site 51
Y638
G
L
Q
L
H
T
N
Y
L
Q
N
G
Q
F
S
Site 52
T650
Q
F
S
R
W
K
D
T
V
L
D
G
F
P
N
Site 53
T660
D
G
F
P
N
Q
L
T
E
S
A
N
H
L
C
Site 54
Y679
A
F
F
V
N
S
S
Y
P
P
L
L
R
P
E
Site 55
Y697
D
L
I
I
H
L
N
Y
C
A
G
S
Q
T
K
Site 56
S701
H
L
N
Y
C
A
G
S
Q
T
K
P
L
K
Q
Site 57
Y712
P
L
K
Q
T
C
E
Y
C
T
V
Q
N
I
P
Site 58
Y723
Q
N
I
P
F
P
K
Y
E
L
P
D
E
N
E
Site 59
T758
F
F
P
L
I
N
D
T
F
R
K
Y
K
A
P
Site 60
Y762
I
N
D
T
F
R
K
Y
K
A
P
G
V
E
R
Site 61
S770
K
A
P
G
V
E
R
S
P
E
E
L
E
Q
G
Site 62
Y782
E
Q
G
Q
V
D
I
Y
G
P
K
T
P
Y
A
Site 63
T786
V
D
I
Y
G
P
K
T
P
Y
A
T
K
E
L
Site 64
Y788
I
Y
G
P
K
T
P
Y
A
T
K
E
L
T
Y
Site 65
T796
A
T
K
E
L
T
Y
T
E
A
T
F
D
K
L
Site 66
T799
E
L
T
Y
T
E
A
T
F
D
K
L
V
K
L
Site 67
T817
N
I
L
N
N
K
D
T
L
L
Q
A
L
R
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation