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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLEKHN1
Full Name:
Pleckstrin homology domain-containing family N member 1
Alias:
DKFZp434H2010; PKHN1; pleckstrin domain-containing family N 1; pleckstriny domain containing, family N member 1
Type:
Unknown function
Mass (Da):
71790
Number AA:
UniProt ID:
Q494U1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
A
P
R
R
L
R
A
S
F
S
R
K
P
S
L
Site 2
S19
R
R
L
R
A
S
F
S
R
K
P
S
L
K
G
Site 3
S23
A
S
F
S
R
K
P
S
L
K
G
N
R
E
D
Site 4
S31
L
K
G
N
R
E
D
S
A
R
M
S
A
G
L
Site 5
S35
R
E
D
S
A
R
M
S
A
G
L
P
G
P
E
Site 6
S46
P
G
P
E
A
A
R
S
G
D
A
A
A
N
K
Site 7
S79
N
L
E
Q
P
F
L
S
V
F
K
K
G
R
R
Site 8
S109
V
Q
L
R
F
Q
H
S
Q
D
V
S
D
C
Y
Site 9
Y116
S
Q
D
V
S
D
C
Y
L
E
L
F
P
A
H
Site 10
Y125
E
L
F
P
A
H
L
Y
F
Q
A
H
G
S
E
Site 11
S131
L
Y
F
Q
A
H
G
S
E
G
L
T
F
Q
G
Site 12
S167
I
T
G
V
W
D
A
S
R
A
P
R
G
T
P
Site 13
T173
A
S
R
A
P
R
G
T
P
D
P
G
L
G
E
Site 14
Y223
A
E
L
D
R
W
L
Y
H
L
E
K
Q
T
A
Site 15
S240
G
G
P
R
R
C
H
S
A
P
P
Q
G
S
C
Site 16
S246
H
S
A
P
P
Q
G
S
C
G
D
E
L
P
W
Site 17
T254
C
G
D
E
L
P
W
T
L
Q
R
R
L
T
R
Site 18
T260
W
T
L
Q
R
R
L
T
R
L
R
T
A
S
G
Site 19
T264
R
R
L
T
R
L
R
T
A
S
G
H
E
P
G
Site 20
S266
L
T
R
L
R
T
A
S
G
H
E
P
G
G
S
Site 21
S273
S
G
H
E
P
G
G
S
A
V
C
A
S
R
V
Site 22
S336
E
K
E
K
Q
I
R
S
F
L
I
E
G
P
L
Site 23
S381
P
P
L
P
G
A
E
S
F
P
G
S
Q
V
M
Site 24
S385
G
A
E
S
F
P
G
S
Q
V
M
G
S
G
R
Site 25
S390
P
G
S
Q
V
M
G
S
G
R
G
S
L
S
S
Site 26
S394
V
M
G
S
G
R
G
S
L
S
S
G
G
Q
T
Site 27
S396
G
S
G
R
G
S
L
S
S
G
G
Q
T
S
W
Site 28
S397
S
G
R
G
S
L
S
S
G
G
Q
T
S
W
D
Site 29
T401
S
L
S
S
G
G
Q
T
S
W
D
S
G
C
L
Site 30
S402
L
S
S
G
G
Q
T
S
W
D
S
G
C
L
A
Site 31
S405
G
G
Q
T
S
W
D
S
G
C
L
A
P
P
S
Site 32
S412
S
G
C
L
A
P
P
S
T
R
T
S
H
S
L
Site 33
T413
G
C
L
A
P
P
S
T
R
T
S
H
S
L
P
Site 34
S416
A
P
P
S
T
R
T
S
H
S
L
P
E
S
S
Site 35
S418
P
S
T
R
T
S
H
S
L
P
E
S
S
V
P
Site 36
S422
T
S
H
S
L
P
E
S
S
V
P
S
T
V
G
Site 37
S423
S
H
S
L
P
E
S
S
V
P
S
T
V
G
C
Site 38
S426
L
P
E
S
S
V
P
S
T
V
G
C
S
S
Q
Site 39
T427
P
E
S
S
V
P
S
T
V
G
C
S
S
Q
H
Site 40
S432
P
S
T
V
G
C
S
S
Q
H
T
P
D
Q
A
Site 41
T435
V
G
C
S
S
Q
H
T
P
D
Q
A
N
S
D
Site 42
S441
H
T
P
D
Q
A
N
S
D
R
A
S
I
G
R
Site 43
S445
Q
A
N
S
D
R
A
S
I
G
R
R
R
T
E
Site 44
T451
A
S
I
G
R
R
R
T
E
L
R
R
S
G
S
Site 45
S456
R
R
T
E
L
R
R
S
G
S
S
R
S
P
G
Site 46
S458
T
E
L
R
R
S
G
S
S
R
S
P
G
S
K
Site 47
S459
E
L
R
R
S
G
S
S
R
S
P
G
S
K
A
Site 48
S461
R
R
S
G
S
S
R
S
P
G
S
K
A
R
A
Site 49
S464
G
S
S
R
S
P
G
S
K
A
R
A
E
G
R
Site 50
T475
A
E
G
R
G
P
V
T
P
L
H
L
D
L
T
Site 51
T482
T
P
L
H
L
D
L
T
Q
L
H
R
L
S
L
Site 52
S488
L
T
Q
L
H
R
L
S
L
E
S
S
P
D
A
Site 53
S491
L
H
R
L
S
L
E
S
S
P
D
A
P
D
H
Site 54
S492
H
R
L
S
L
E
S
S
P
D
A
P
D
H
T
Site 55
T499
S
P
D
A
P
D
H
T
S
E
T
S
H
S
P
Site 56
S500
P
D
A
P
D
H
T
S
E
T
S
H
S
P
L
Site 57
T502
A
P
D
H
T
S
E
T
S
H
S
P
L
Y
A
Site 58
S503
P
D
H
T
S
E
T
S
H
S
P
L
Y
A
D
Site 59
S505
H
T
S
E
T
S
H
S
P
L
Y
A
D
P
Y
Site 60
Y508
E
T
S
H
S
P
L
Y
A
D
P
Y
T
P
P
Site 61
Y512
S
P
L
Y
A
D
P
Y
T
P
P
A
T
S
H
Site 62
T513
P
L
Y
A
D
P
Y
T
P
P
A
T
S
H
R
Site 63
S518
P
Y
T
P
P
A
T
S
H
R
R
V
T
D
V
Site 64
T523
A
T
S
H
R
R
V
T
D
V
R
G
L
E
E
Site 65
S533
R
G
L
E
E
F
L
S
A
M
Q
S
A
R
G
Site 66
S537
E
F
L
S
A
M
Q
S
A
R
G
P
T
P
S
Site 67
T542
M
Q
S
A
R
G
P
T
P
S
S
P
L
P
S
Site 68
S544
S
A
R
G
P
T
P
S
S
P
L
P
S
V
P
Site 69
S545
A
R
G
P
T
P
S
S
P
L
P
S
V
P
V
Site 70
S553
P
L
P
S
V
P
V
S
V
P
A
S
D
P
R
Site 71
S557
V
P
V
S
V
P
A
S
D
P
R
S
C
S
S
Site 72
S561
V
P
A
S
D
P
R
S
C
S
S
G
P
A
G
Site 73
S563
A
S
D
P
R
S
C
S
S
G
P
A
G
P
Y
Site 74
S564
S
D
P
R
S
C
S
S
G
P
A
G
P
Y
L
Site 75
Y570
S
S
G
P
A
G
P
Y
L
L
S
K
K
G
A
Site 76
S573
P
A
G
P
Y
L
L
S
K
K
G
A
L
Q
S
Site 77
S580
S
K
K
G
A
L
Q
S
R
A
A
Q
R
H
R
Site 78
S589
A
A
Q
R
H
R
G
S
A
K
D
G
G
P
Q
Site 79
S605
P
D
A
P
Q
L
V
S
S
A
R
E
G
S
P
Site 80
S606
D
A
P
Q
L
V
S
S
A
R
E
G
S
P
E
Site 81
S611
V
S
S
A
R
E
G
S
P
E
P
W
L
P
L
Site 82
T619
P
E
P
W
L
P
L
T
D
G
R
S
P
R
R
Site 83
S623
L
P
L
T
D
G
R
S
P
R
R
S
R
D
P
Site 84
S627
D
G
R
S
P
R
R
S
R
D
P
G
Y
D
H
Site 85
Y632
R
R
S
R
D
P
G
Y
D
H
L
W
D
E
T
Site 86
T639
Y
D
H
L
W
D
E
T
L
S
S
S
H
Q
K
Site 87
S641
H
L
W
D
E
T
L
S
S
S
H
Q
K
C
P
Site 88
S642
L
W
D
E
T
L
S
S
S
H
Q
K
C
P
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation