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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SV2C
Full Name:
Synaptic vesicle glycoprotein 2C
Alias:
KIAA1054; Synaptic vesicle protein 2C
Type:
Membrane, Synapse, Cytoplasmic vesicle, Cell junction, Integral membrane, Synaptic vesicle protein
Mass (Da):
82342
Number AA:
727
UniProt ID:
Q496J9
International Prot ID:
IPI00173947
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0016021
GO:0030141
Uniprot
OncoNet
Molecular Function:
GO:0005215
PhosphoSite+
KinaseNET
Biological Process:
GO:0006836
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
E
D
S
Y
K
D
R
T
S
L
M
K
G
A
K
Site 2
S10
D
S
Y
K
D
R
T
S
L
M
K
G
A
K
D
Site 3
Y41
V
D
R
A
Q
D
E
Y
T
Q
R
S
Y
S
R
Site 4
T42
D
R
A
Q
D
E
Y
T
Q
R
S
Y
S
R
F
Site 5
S45
Q
D
E
Y
T
Q
R
S
Y
S
R
F
Q
D
E
Site 6
Y46
D
E
Y
T
Q
R
S
Y
S
R
F
Q
D
E
E
Site 7
S47
E
Y
T
Q
R
S
Y
S
R
F
Q
D
E
E
D
Site 8
Y58
D
E
E
D
D
D
D
Y
Y
P
A
G
E
T
Y
Site 9
Y59
E
E
D
D
D
D
Y
Y
P
A
G
E
T
Y
N
Site 10
S75
E
A
N
D
D
E
G
S
S
E
A
T
E
G
H
Site 11
S76
A
N
D
D
E
G
S
S
E
A
T
E
G
H
D
Site 12
Y89
H
D
E
D
D
E
I
Y
E
G
E
Y
Q
G
I
Site 13
Y93
D
E
I
Y
E
G
E
Y
Q
G
I
P
S
M
N
Site 14
S105
S
M
N
Q
A
K
D
S
I
V
S
V
G
Q
P
Site 15
Y117
G
Q
P
K
G
D
E
Y
K
D
R
R
E
L
E
Site 16
S125
K
D
R
R
E
L
E
S
E
R
R
A
D
E
E
Site 17
S188
T
D
L
C
I
P
N
S
G
S
G
W
L
G
S
Site 18
Y314
S
F
S
M
G
S
A
Y
Q
F
H
S
W
R
V
Site 19
T379
G
Q
P
E
K
V
F
T
V
N
K
I
K
T
P
Site 20
T385
F
T
V
N
K
I
K
T
P
K
Q
I
D
E
L
Site 21
S397
D
E
L
I
E
I
E
S
D
T
G
T
W
Y
R
Site 22
Y403
E
S
D
T
G
T
W
Y
R
R
C
F
V
R
I
Site 23
T433
N
Y
P
V
R
D
N
T
I
K
L
T
I
V
W
Site 24
S463
D
V
I
K
P
L
Q
S
D
E
Y
A
L
L
T
Site 25
Y466
K
P
L
Q
S
D
E
Y
A
L
L
T
R
N
V
Site 26
Y478
R
N
V
E
R
D
K
Y
A
N
F
T
I
N
F
Site 27
Y497
Q
I
H
T
G
M
E
Y
D
N
G
R
F
I
G
Site 28
T511
G
V
K
F
K
S
V
T
F
K
D
S
V
F
K
Site 29
S515
K
S
V
T
F
K
D
S
V
F
K
S
C
T
F
Site 30
S519
F
K
D
S
V
F
K
S
C
T
F
E
D
V
T
Site 31
T521
D
S
V
F
K
S
C
T
F
E
D
V
T
S
V
Site 32
T526
S
C
T
F
E
D
V
T
S
V
N
T
Y
F
K
Site 33
T572
N
K
T
G
C
Q
I
T
F
D
D
D
Y
S
A
Site 34
Y577
Q
I
T
F
D
D
D
Y
S
A
Y
W
I
Y
F
Site 35
T658
W
N
S
L
D
V
V
T
V
E
L
Y
P
T
D
Site 36
Y662
D
V
V
T
V
E
L
Y
P
T
D
R
R
A
T
Site 37
T664
V
T
V
E
L
Y
P
T
D
R
R
A
T
G
F
Site 38
T669
Y
P
T
D
R
R
A
T
G
F
G
F
L
N
A
Site 39
S698
S
L
V
S
I
T
K
S
I
P
I
L
L
A
S
Site 40
T706
I
P
I
L
L
A
S
T
V
L
V
C
G
G
L
Site 41
T721
V
G
L
C
L
P
D
T
R
T
Q
V
L
M
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation