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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FAM135B
Full Name:
Protein FAM135B
Alias:
C8orfK32; f135b; loc51059; mgc126009; mgc126010; mgc33221
Type:
Uncharacterized protein
Mass (Da):
155770
Number AA:
1406
UniProt ID:
Q49AJ0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y18
S
V
E
L
H
K
F
Y
N
V
D
L
F
Q
R
Site 2
Y27
V
D
L
F
Q
R
G
Y
Y
Q
I
R
V
T
L
Site 3
Y28
D
L
F
Q
R
G
Y
Y
Q
I
R
V
T
L
K
Site 4
T33
G
Y
Y
Q
I
R
V
T
L
K
V
S
S
R
I
Site 5
S37
I
R
V
T
L
K
V
S
S
R
I
P
H
R
L
Site 6
S45
S
R
I
P
H
R
L
S
A
S
I
A
G
Q
T
Site 7
S47
I
P
H
R
L
S
A
S
I
A
G
Q
T
E
S
Site 8
T52
S
A
S
I
A
G
Q
T
E
S
S
S
L
H
S
Site 9
S54
S
I
A
G
Q
T
E
S
S
S
L
H
S
A
C
Site 10
S56
A
G
Q
T
E
S
S
S
L
H
S
A
C
V
H
Site 11
S59
T
E
S
S
S
L
H
S
A
C
V
H
D
S
T
Site 12
T66
S
A
C
V
H
D
S
T
V
H
S
R
V
F
Q
Site 13
Y76
S
R
V
F
Q
I
L
Y
R
N
E
E
V
P
I
Site 14
S105
E
R
M
E
D
A
L
S
E
V
D
F
Q
L
K
Site 15
S120
V
D
L
H
F
T
D
S
E
Q
Q
L
R
D
V
Site 16
S181
A
L
Q
Q
P
L
I
S
F
T
R
P
G
R
G
Site 17
T183
Q
Q
P
L
I
S
F
T
R
P
G
R
G
S
W
Site 18
S189
F
T
R
P
G
R
G
S
W
L
G
K
G
G
P
Site 19
T198
L
G
K
G
G
P
D
T
G
Q
E
Q
S
I
I
Site 20
Y216
N
L
V
F
G
A
G
Y
C
K
P
T
S
S
E
Site 21
T220
G
A
G
Y
C
K
P
T
S
S
E
G
S
F
Y
Site 22
S221
A
G
Y
C
K
P
T
S
S
E
G
S
F
Y
I
Site 23
S222
G
Y
C
K
P
T
S
S
E
G
S
F
Y
I
T
Site 24
S225
K
P
T
S
S
E
G
S
F
Y
I
T
S
E
N
Site 25
Y227
T
S
S
E
G
S
F
Y
I
T
S
E
N
C
M
Site 26
T282
E
A
L
A
V
E
E
T
L
S
Q
L
C
S
E
Site 27
S288
E
T
L
S
Q
L
C
S
E
L
Q
M
L
N
N
Site 28
T326
T
Q
F
L
D
T
V
T
L
H
S
Q
V
T
T
Site 29
Y334
L
H
S
Q
V
T
T
Y
L
T
Q
E
H
H
T
Site 30
T336
S
Q
V
T
T
Y
L
T
Q
E
H
H
T
L
R
Site 31
T341
Y
L
T
Q
E
H
H
T
L
R
V
R
R
F
S
Site 32
S348
T
L
R
V
R
R
F
S
E
A
F
F
Y
M
E
Site 33
Y353
R
F
S
E
A
F
F
Y
M
E
H
Q
K
L
A
Site 34
T363
H
Q
K
L
A
V
L
T
F
Q
E
N
L
I
Q
Site 35
S373
E
N
L
I
Q
T
H
S
Q
L
S
L
D
I
R
Site 36
S376
I
Q
T
H
S
Q
L
S
L
D
I
R
N
S
E
Site 37
S382
L
S
L
D
I
R
N
S
E
Y
L
T
S
M
P
Site 38
Y384
L
D
I
R
N
S
E
Y
L
T
S
M
P
P
L
Site 39
T386
I
R
N
S
E
Y
L
T
S
M
P
P
L
P
A
Site 40
S387
R
N
S
E
Y
L
T
S
M
P
P
L
P
A
E
Site 41
T404
D
I
D
G
D
W
N
T
L
P
V
I
F
E
D
Site 42
Y413
P
V
I
F
E
D
R
Y
V
D
C
P
A
T
G
Site 43
T419
R
Y
V
D
C
P
A
T
G
H
N
L
S
V
Y
Site 44
S424
P
A
T
G
H
N
L
S
V
Y
P
N
F
D
V
Site 45
Y426
T
G
H
N
L
S
V
Y
P
N
F
D
V
P
V
Site 46
S463
F
R
E
D
L
V
L
S
T
I
K
P
S
Q
M
Site 47
T464
R
E
D
L
V
L
S
T
I
K
P
S
Q
M
D
Site 48
S468
V
L
S
T
I
K
P
S
Q
M
D
S
D
E
E
Site 49
S472
I
K
P
S
Q
M
D
S
D
E
E
V
I
R
C
Site 50
Y501
M
C
S
E
S
Q
V
Y
I
S
I
G
E
F
Q
Site 51
T528
G
Q
T
S
D
A
G
T
Y
P
V
A
D
V
D
Site 52
Y529
Q
T
S
D
A
G
T
Y
P
V
A
D
V
D
T
Site 53
T536
Y
P
V
A
D
V
D
T
S
R
R
S
P
G
P
Site 54
S537
P
V
A
D
V
D
T
S
R
R
S
P
G
P
E
Site 55
S540
D
V
D
T
S
R
R
S
P
G
P
E
D
G
Q
Site 56
T552
D
G
Q
A
P
V
L
T
Y
I
D
V
K
S
S
Site 57
Y553
G
Q
A
P
V
L
T
Y
I
D
V
K
S
S
N
Site 58
S558
L
T
Y
I
D
V
K
S
S
N
K
N
P
S
R
Site 59
S564
K
S
S
N
K
N
P
S
R
A
E
P
L
V
A
Site 60
S578
A
F
N
A
Q
H
E
S
R
S
S
R
D
K
Y
Site 61
S580
N
A
Q
H
E
S
R
S
S
R
D
K
Y
G
L
Site 62
S581
A
Q
H
E
S
R
S
S
R
D
K
Y
G
L
D
Site 63
Y585
S
R
S
S
R
D
K
Y
G
L
D
R
T
G
L
Site 64
S600
S
K
V
V
V
G
G
S
H
Q
N
A
I
S
S
Site 65
S606
G
S
H
Q
N
A
I
S
S
D
K
T
T
L
H
Site 66
S607
S
H
Q
N
A
I
S
S
D
K
T
T
L
H
E
Site 67
T610
N
A
I
S
S
D
K
T
T
L
H
E
L
S
T
Site 68
T611
A
I
S
S
D
K
T
T
L
H
E
L
S
T
L
Site 69
S616
K
T
T
L
H
E
L
S
T
L
G
K
G
I
D
Site 70
S638
L
S
L
K
L
T
P
S
E
P
C
D
P
L
S
Site 71
S645
S
E
P
C
D
P
L
S
S
T
L
R
E
P
L
Site 72
S646
E
P
C
D
P
L
S
S
T
L
R
E
P
L
D
Site 73
T647
P
C
D
P
L
S
S
T
L
R
E
P
L
D
I
Site 74
S656
R
E
P
L
D
I
R
S
S
L
K
D
S
H
T
Site 75
S657
E
P
L
D
I
R
S
S
L
K
D
S
H
T
E
Site 76
S661
I
R
S
S
L
K
D
S
H
T
E
E
Q
E
E
Site 77
T663
S
S
L
K
D
S
H
T
E
E
Q
E
E
L
S
Site 78
S670
T
E
E
Q
E
E
L
S
V
L
S
G
V
I
K
Site 79
S673
Q
E
E
L
S
V
L
S
G
V
I
K
R
S
S
Site 80
S679
L
S
G
V
I
K
R
S
S
S
I
I
S
D
S
Site 81
S680
S
G
V
I
K
R
S
S
S
I
I
S
D
S
G
Site 82
S684
K
R
S
S
S
I
I
S
D
S
G
I
E
S
E
Site 83
S686
S
S
S
I
I
S
D
S
G
I
E
S
E
P
S
Site 84
S690
I
S
D
S
G
I
E
S
E
P
S
S
V
A
W
Site 85
S693
S
G
I
E
S
E
P
S
S
V
A
W
S
E
A
Site 86
S694
G
I
E
S
E
P
S
S
V
A
W
S
E
A
R
Site 87
S698
E
P
S
S
V
A
W
S
E
A
R
S
R
A
L
Site 88
S702
V
A
W
S
E
A
R
S
R
A
L
E
L
P
S
Site 89
S709
S
R
A
L
E
L
P
S
D
R
E
V
L
H
P
Site 90
S727
R
H
A
L
H
R
N
S
L
E
G
G
H
T
E
Site 91
T733
N
S
L
E
G
G
H
T
E
S
N
T
S
L
P
Site 92
S735
L
E
G
G
H
T
E
S
N
T
S
L
P
S
G
Site 93
T737
G
G
H
T
E
S
N
T
S
L
P
S
G
I
Q
Site 94
S738
G
H
T
E
S
N
T
S
L
P
S
G
I
Q
A
Site 95
S751
Q
A
S
L
T
S
I
S
S
L
P
F
E
E
D
Site 96
S752
A
S
L
T
S
I
S
S
L
P
F
E
E
D
E
Site 97
T765
D
E
R
E
V
A
L
T
K
L
T
K
S
V
S
Site 98
T768
E
V
A
L
T
K
L
T
K
S
V
S
A
P
H
Site 99
S772
T
K
L
T
K
S
V
S
A
P
H
I
S
S
P
Site 100
S777
S
V
S
A
P
H
I
S
S
P
E
E
A
A
E
Site 101
S778
V
S
A
P
H
I
S
S
P
E
E
A
A
E
D
Site 102
T788
E
A
A
E
D
A
D
T
K
Q
Q
D
G
G
F
Site 103
S799
D
G
G
F
A
E
P
S
D
M
H
S
K
S
Q
Site 104
S803
A
E
P
S
D
M
H
S
K
S
Q
G
S
P
G
Site 105
S805
P
S
D
M
H
S
K
S
Q
G
S
P
G
S
C
Site 106
S808
M
H
S
K
S
Q
G
S
P
G
S
C
S
Q
L
Site 107
S811
K
S
Q
G
S
P
G
S
C
S
Q
L
C
G
D
Site 108
S813
Q
G
S
P
G
S
C
S
Q
L
C
G
D
S
G
Site 109
S819
C
S
Q
L
C
G
D
S
G
T
D
A
G
A
D
Site 110
T821
Q
L
C
G
D
S
G
T
D
A
G
A
D
H
P
Site 111
Y844
D
N
Q
Q
G
P
G
Y
I
D
I
P
K
G
K
Site 112
T867
H
C
L
P
D
G
R
T
E
N
T
P
G
V
E
Site 113
T870
P
D
G
R
T
E
N
T
P
G
V
E
T
K
G
Site 114
T893
I
A
L
E
N
P
R
T
R
S
L
H
R
A
L
Site 115
S895
L
E
N
P
R
T
R
S
L
H
R
A
L
E
E
Site 116
T903
L
H
R
A
L
E
E
T
P
K
G
M
P
K
D
Site 117
S919
N
V
G
Q
Q
A
L
S
N
S
G
I
S
E
V
Site 118
S921
G
Q
Q
A
L
S
N
S
G
I
S
E
V
E
G
Site 119
S924
A
L
S
N
S
G
I
S
E
V
E
G
L
S
Q
Site 120
S930
I
S
E
V
E
G
L
S
Q
H
Q
V
P
E
L
Site 121
S938
Q
H
Q
V
P
E
L
S
C
T
S
A
A
D
A
Site 122
S950
A
D
A
I
N
R
N
S
T
G
Q
Q
S
Q
S
Site 123
T951
D
A
I
N
R
N
S
T
G
Q
Q
S
Q
S
G
Site 124
S955
R
N
S
T
G
Q
Q
S
Q
S
G
S
P
C
I
Site 125
S957
S
T
G
Q
Q
S
Q
S
G
S
P
C
I
M
D
Site 126
S959
G
Q
Q
S
Q
S
G
S
P
C
I
M
D
D
T
Site 127
T984
E
A
K
H
K
A
G
T
V
C
P
T
V
T
H
Site 128
T988
K
A
G
T
V
C
P
T
V
T
H
S
V
H
S
Site 129
S1008
Q
E
L
K
A
G
T
S
I
M
G
S
H
L
T
Site 130
S1012
A
G
T
S
I
M
G
S
H
L
T
S
A
E
T
Site 131
T1019
S
H
L
T
S
A
E
T
F
T
L
D
S
L
K
Site 132
S1045
T
A
T
C
L
P
F
S
S
V
P
K
E
T
P
Site 133
S1046
A
T
C
L
P
F
S
S
V
P
K
E
T
P
A
Site 134
T1051
F
S
S
V
P
K
E
T
P
A
R
A
G
F
S
Site 135
S1059
P
A
R
A
G
F
S
S
K
Q
T
L
F
P
I
Site 136
T1062
A
G
F
S
S
K
Q
T
L
F
P
I
T
H
Q
Site 137
T1067
K
Q
T
L
F
P
I
T
H
Q
P
L
G
S
F
Site 138
T1079
G
S
F
G
V
V
S
T
H
S
S
T
L
D
E
Site 139
S1082
G
V
V
S
T
H
S
S
T
L
D
E
E
V
S
Site 140
S1089
S
T
L
D
E
E
V
S
E
R
M
F
S
F
Y
Site 141
S1094
E
V
S
E
R
M
F
S
F
Y
Q
A
K
E
K
Site 142
Y1096
S
E
R
M
F
S
F
Y
Q
A
K
E
K
F
K
Site 143
Y1125
V
L
A
S
D
I
P
Y
F
P
P
E
E
E
E
Site 144
S1176
G
K
L
D
F
L
M
S
E
K
N
Q
M
D
T
Site 145
T1189
D
T
F
A
D
F
D
T
M
T
D
R
L
L
D
Site 146
T1191
F
A
D
F
D
T
M
T
D
R
L
L
D
E
I
Site 147
T1229
I
I
I
R
S
V
L
T
R
P
R
F
R
Y
Y
Site 148
Y1235
L
T
R
P
R
F
R
Y
Y
L
N
K
L
H
T
Site 149
Y1236
T
R
P
R
F
R
Y
Y
L
N
K
L
H
T
F
Site 150
T1242
Y
Y
L
N
K
L
H
T
F
L
S
L
S
G
P
Site 151
S1245
N
K
L
H
T
F
L
S
L
S
G
P
H
L
G
Site 152
T1253
L
S
G
P
H
L
G
T
L
Y
N
N
S
T
L
Site 153
Y1255
G
P
H
L
G
T
L
Y
N
N
S
T
L
V
S
Site 154
T1259
G
T
L
Y
N
N
S
T
L
V
S
T
G
L
W
Site 155
S1274
L
M
Q
K
L
K
K
S
G
S
L
L
Q
L
T
Site 156
S1276
Q
K
L
K
K
S
G
S
L
L
Q
L
T
F
R
Site 157
T1281
S
G
S
L
L
Q
L
T
F
R
D
N
A
D
L
Site 158
Y1294
D
L
R
K
C
F
L
Y
Q
L
S
Q
K
T
G
Site 159
S1297
K
C
F
L
Y
Q
L
S
Q
K
T
G
L
Q
Y
Site 160
S1313
K
N
V
V
L
V
A
S
P
Q
D
R
Y
V
P
Site 161
Y1318
V
A
S
P
Q
D
R
Y
V
P
F
H
S
A
R
Site 162
T1331
A
R
I
E
M
C
K
T
A
L
K
D
R
H
T
Site 163
T1338
T
A
L
K
D
R
H
T
G
P
V
Y
A
E
M
Site 164
Y1342
D
R
H
T
G
P
V
Y
A
E
M
I
N
N
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation