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Updated November 2019
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Protein Info
Short Name:
FLJ43906
Full Name:
C2 domain-containing protein 3
Alias:
C2 calcium-dependent domain containing 3; C2CD3; DKFZp434D1219; DKFZP586P0123
Type:
Mass (Da):
260350
Number AA:
UniProt ID:
Q4AC94
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
K
Q
R
K
G
Q
G
S
G
G
S
R
G
R
K
Site 2
S12
K
G
Q
G
S
G
G
S
R
G
R
K
K
R
G
Site 3
S21
G
R
K
K
R
G
L
S
D
I
S
P
S
T
S
Site 4
S24
K
R
G
L
S
D
I
S
P
S
T
S
L
P
P
Site 5
S28
S
D
I
S
P
S
T
S
L
P
P
L
V
E
G
Site 6
T69
R
V
R
W
W
G
E
T
S
D
G
T
L
F
C
Site 7
T73
W
G
E
T
S
D
G
T
L
F
C
P
R
D
A
Site 8
T83
C
P
R
D
A
L
Q
T
E
P
K
A
V
R
T
Site 9
T91
E
P
K
A
V
R
T
T
T
R
Y
A
I
R
C
Site 10
T92
P
K
A
V
R
T
T
T
R
Y
A
I
R
C
G
Site 11
Y94
A
V
R
T
T
T
R
Y
A
I
R
C
G
P
K
Site 12
S138
I
N
G
L
A
Q
L
S
P
T
H
Q
T
N
G
Site 13
T148
H
Q
T
N
G
F
F
T
I
V
S
S
T
S
K
Site 14
S151
N
G
F
F
T
I
V
S
S
T
S
K
K
L
G
Site 15
S152
G
F
F
T
I
V
S
S
T
S
K
K
L
G
E
Site 16
S170
S
L
A
L
E
P
L
S
E
T
Y
D
S
Y
H
Site 17
Y173
L
E
P
L
S
E
T
Y
D
S
Y
H
P
L
P
Site 18
S175
P
L
S
E
T
Y
D
S
Y
H
P
L
P
T
T
Site 19
Y176
L
S
E
T
Y
D
S
Y
H
P
L
P
T
T
D
Site 20
T182
S
Y
H
P
L
P
T
T
D
M
T
E
N
V
L
Site 21
T185
P
L
P
T
T
D
M
T
E
N
V
L
L
S
K
Site 22
S191
M
T
E
N
V
L
L
S
K
Q
G
F
R
E
N
Site 23
T199
K
Q
G
F
R
E
N
T
E
P
S
S
T
Q
F
Site 24
S203
R
E
N
T
E
P
S
S
T
Q
F
Q
V
P
S
Site 25
T204
E
N
T
E
P
S
S
T
Q
F
Q
V
P
S
R
Site 26
S210
S
T
Q
F
Q
V
P
S
R
P
R
D
I
H
T
Site 27
T217
S
R
P
R
D
I
H
T
I
K
I
D
G
K
E
Site 28
S229
G
K
E
L
A
A
N
S
S
R
S
T
T
P
R
Site 29
S230
K
E
L
A
A
N
S
S
R
S
T
T
P
R
G
Site 30
S232
L
A
A
N
S
S
R
S
T
T
P
R
G
K
D
Site 31
T233
A
A
N
S
S
R
S
T
T
P
R
G
K
D
H
Site 32
T234
A
N
S
S
R
S
T
T
P
R
G
K
D
H
V
Site 33
T249
C
F
A
E
N
P
D
T
I
K
D
S
S
F
G
Site 34
S253
N
P
D
T
I
K
D
S
S
F
G
L
Q
H
S
Site 35
S254
P
D
T
I
K
D
S
S
F
G
L
Q
H
S
L
Site 36
S260
S
S
F
G
L
Q
H
S
L
N
S
G
Q
S
L
Site 37
S263
G
L
Q
H
S
L
N
S
G
Q
S
L
E
S
V
Site 38
S266
H
S
L
N
S
G
Q
S
L
E
S
V
T
L
K
Site 39
S269
N
S
G
Q
S
L
E
S
V
T
L
K
G
R
A
Site 40
S282
R
A
P
R
K
Q
M
S
L
L
N
S
S
E
F
Site 41
S286
K
Q
M
S
L
L
N
S
S
E
F
Q
P
Q
I
Site 42
T295
E
F
Q
P
Q
I
R
T
V
A
K
S
H
S
D
Site 43
S299
Q
I
R
T
V
A
K
S
H
S
D
S
C
I
L
Site 44
S301
R
T
V
A
K
S
H
S
D
S
C
I
L
S
S
Site 45
S303
V
A
K
S
H
S
D
S
C
I
L
S
S
N
N
Site 46
S307
H
S
D
S
C
I
L
S
S
N
N
L
P
T
K
Site 47
S318
L
P
T
K
D
L
L
S
A
L
L
E
Q
G
N
Site 48
S334
L
R
N
A
M
V
I
S
A
M
K
S
S
P
E
Site 49
S338
M
V
I
S
A
M
K
S
S
P
E
T
S
M
L
Site 50
T342
A
M
K
S
S
P
E
T
S
M
L
L
D
Q
V
Site 51
S343
M
K
S
S
P
E
T
S
M
L
L
D
Q
V
H
Site 52
S357
H
P
P
I
N
E
D
S
L
R
A
S
T
Q
I
Site 53
S361
N
E
D
S
L
R
A
S
T
Q
I
R
A
F
S
Site 54
T362
E
D
S
L
R
A
S
T
Q
I
R
A
F
S
R
Site 55
S368
S
T
Q
I
R
A
F
S
R
N
R
F
K
D
H
Site 56
T384
E
D
H
L
L
P
S
T
E
N
T
F
W
R
H
Site 57
T387
L
L
P
S
T
E
N
T
F
W
R
H
D
T
K
Site 58
T397
R
H
D
T
K
A
D
T
R
A
I
Q
L
L
L
Site 59
S410
L
L
G
S
A
E
L
S
Q
G
N
F
W
D
G
Site 60
S420
N
F
W
D
G
L
G
S
P
P
D
S
P
S
P
Site 61
S424
G
L
G
S
P
P
D
S
P
S
P
G
S
D
V
Site 62
S426
G
S
P
P
D
S
P
S
P
G
S
D
V
Y
C
Site 63
S429
P
D
S
P
S
P
G
S
D
V
Y
C
I
S
E
Site 64
Y432
P
S
P
G
S
D
V
Y
C
I
S
E
L
N
D
Site 65
S435
G
S
D
V
Y
C
I
S
E
L
N
D
P
Q
Y
Site 66
Y442
S
E
L
N
D
P
Q
Y
D
Q
S
L
L
E
N
Site 67
S445
N
D
P
Q
Y
D
Q
S
L
L
E
N
L
F
Y
Site 68
Y452
S
L
L
E
N
L
F
Y
T
A
P
K
S
D
T
Site 69
T453
L
L
E
N
L
F
Y
T
A
P
K
S
D
T
S
Site 70
S457
L
F
Y
T
A
P
K
S
D
T
S
I
S
D
F
Site 71
S460
T
A
P
K
S
D
T
S
I
S
D
F
L
S
E
Site 72
S462
P
K
S
D
T
S
I
S
D
F
L
S
E
E
D
Site 73
S466
T
S
I
S
D
F
L
S
E
E
D
D
I
V
P
Site 74
S474
E
E
D
D
I
V
P
S
K
K
I
S
Q
S
T
Site 75
S478
I
V
P
S
K
K
I
S
Q
S
T
A
L
A
R
Site 76
S480
P
S
K
K
I
S
Q
S
T
A
L
A
R
S
S
Site 77
S487
S
T
A
L
A
R
S
S
K
V
L
E
S
S
D
Site 78
S493
S
S
K
V
L
E
S
S
D
H
K
L
K
K
R
Site 79
S516
L
V
E
Q
Q
M
L
S
E
T
P
E
D
A
Q
Site 80
T518
E
Q
Q
M
L
S
E
T
P
E
D
A
Q
T
M
Site 81
T524
E
T
P
E
D
A
Q
T
M
T
L
S
V
D
R
Site 82
T526
P
E
D
A
Q
T
M
T
L
S
V
D
R
L
A
Site 83
S554
T
M
G
V
P
P
D
S
P
Q
M
T
P
G
K
Site 84
T558
P
P
D
S
P
Q
M
T
P
G
K
K
S
Y
A
Site 85
S563
Q
M
T
P
G
K
K
S
Y
A
G
P
P
P
K
Site 86
Y564
M
T
P
G
K
K
S
Y
A
G
P
P
P
K
V
Site 87
T578
V
T
T
A
K
K
R
T
F
F
V
E
Y
H
F
Site 88
Y583
K
R
T
F
F
V
E
Y
H
F
P
V
G
F
S
Site 89
S590
Y
H
F
P
V
G
F
S
E
S
G
L
G
K
T
Site 90
S608
T
E
V
V
R
L
A
S
S
K
I
T
D
G
K
Site 91
T612
R
L
A
S
S
K
I
T
D
G
K
V
K
F
Q
Site 92
Y646
S
N
L
T
F
Q
I
Y
V
K
K
T
P
Q
K
Site 93
T650
F
Q
I
Y
V
K
K
T
P
Q
K
K
P
E
V
Site 94
S660
K
K
P
E
V
I
G
S
V
S
L
S
L
R
A
Site 95
S689
V
Q
Q
E
N
G
Q
S
P
F
G
P
L
K
V
Site 96
T708
I
T
D
N
K
D
F
T
G
I
N
T
K
L
S
Site 97
T721
L
S
G
N
T
H
Y
T
P
L
C
A
P
T
S
Site 98
S728
T
P
L
C
A
P
T
S
P
N
K
A
L
P
E
Site 99
T741
P
E
L
N
Q
D
M
T
C
T
K
N
P
Q
N
Site 100
S770
L
V
L
P
N
R
K
S
P
S
P
V
A
P
H
Site 101
S772
L
P
N
R
K
S
P
S
P
V
A
P
H
P
S
Site 102
S787
T
F
V
A
T
P
A
S
H
N
L
V
N
Q
T
Site 103
S819
P
D
G
K
D
F
I
S
G
E
S
E
K
Q
S
Site 104
S822
K
D
F
I
S
G
E
S
E
K
Q
S
P
C
N
Site 105
S826
S
G
E
S
E
K
Q
S
P
C
N
V
Y
L
N
Site 106
Y831
K
Q
S
P
C
N
V
Y
L
N
C
K
L
F
S
Site 107
S845
S
T
E
E
V
T
R
S
V
I
A
W
G
T
T
Site 108
Y870
P
V
S
L
S
S
K
Y
L
E
R
L
K
N
N
Site 109
S889
E
T
W
N
K
V
R
S
P
G
Q
D
K
L
L
Site 110
Y907
K
L
P
L
H
Q
F
Y
M
S
F
K
D
A
K
Site 111
S909
P
L
H
Q
F
Y
M
S
F
K
D
A
K
I
S
Site 112
T971
R
L
K
N
E
E
G
T
L
P
P
F
S
P
R
Site 113
S976
E
G
T
L
P
P
F
S
P
R
P
A
H
F
L
Site 114
Y1033
E
A
D
C
Y
V
Q
Y
Y
F
P
V
Q
H
S
Site 115
Y1034
A
D
C
Y
V
Q
Y
Y
F
P
V
Q
H
S
Q
Site 116
S1040
Y
Y
F
P
V
Q
H
S
Q
S
S
V
L
K
G
Site 117
S1042
F
P
V
Q
H
S
Q
S
S
V
L
K
G
P
E
Site 118
S1043
P
V
Q
H
S
Q
S
S
V
L
K
G
P
E
F
Site 119
T1056
E
F
L
E
N
G
I
T
L
K
P
F
R
T
A
Site 120
T1064
L
K
P
F
R
T
A
T
T
L
C
V
P
D
P
Site 121
S1080
F
N
S
E
H
H
H
S
L
L
L
P
A
E
V
Site 122
T1130
D
Q
K
V
A
K
G
T
L
P
L
S
R
I
C
Site 123
T1152
R
E
D
V
G
I
Q
T
F
N
L
P
L
T
P
Site 124
T1158
Q
T
F
N
L
P
L
T
P
R
I
E
N
R
K
Site 125
S1171
R
K
E
L
R
N
Q
S
S
G
L
L
D
V
G
Site 126
S1172
K
E
L
R
N
Q
S
S
G
L
L
D
V
G
L
Site 127
Y1181
L
L
D
V
G
L
R
Y
R
R
S
P
R
T
A
Site 128
S1184
V
G
L
R
Y
R
R
S
P
R
T
A
E
G
V
Site 129
T1187
R
Y
R
R
S
P
R
T
A
E
G
V
L
A
A
Site 130
S1200
A
A
R
T
V
S
I
S
V
Q
I
I
R
A
C
Site 131
S1240
A
S
V
T
T
H
L
S
F
L
P
Q
G
E
Q
Site 132
T1250
P
Q
G
E
Q
R
R
T
H
P
V
A
C
S
F
Site 133
S1303
V
Y
H
E
N
T
K
S
A
S
D
I
I
S
I
Site 134
S1305
H
E
N
T
K
S
A
S
D
I
I
S
I
E
S
Site 135
S1309
K
S
A
S
D
I
I
S
I
E
S
C
K
E
Y
Site 136
S1333
K
E
L
L
I
K
R
S
G
I
T
G
W
Y
P
Site 137
Y1339
R
S
G
I
T
G
W
Y
P
I
I
L
P
E
D
Site 138
S1368
G
G
L
E
L
S
I
S
F
T
H
R
G
D
R
Site 139
T1370
L
E
L
S
I
S
F
T
H
R
G
D
R
E
R
Site 140
S1388
A
A
E
H
L
G
W
S
F
E
N
S
L
K
D
Site 141
S1392
L
G
W
S
F
E
N
S
L
K
D
F
V
R
M
Site 142
T1406
M
D
E
G
E
P
A
T
V
T
I
S
T
P
R
Site 143
T1408
E
G
E
P
A
T
V
T
I
S
T
P
R
L
W
Site 144
Y1436
I
H
K
N
T
Y
C
Y
L
R
Y
K
F
Y
D
Site 145
T1449
Y
D
H
E
A
F
W
T
P
L
K
K
P
K
E
Site 146
T1466
N
K
K
Q
I
M
V
T
F
K
A
S
K
R
A
Site 147
S1470
I
M
V
T
F
K
A
S
K
R
A
E
V
T
R
Site 148
T1476
A
S
K
R
A
E
V
T
R
G
P
S
L
L
W
Site 149
S1480
A
E
V
T
R
G
P
S
L
L
W
Y
F
R
E
Site 150
Y1484
R
G
P
S
L
L
W
Y
F
R
E
E
R
L
E
Site 151
Y1498
E
I
Q
V
W
R
A
Y
G
N
D
S
V
E
R
Site 152
S1502
W
R
A
Y
G
N
D
S
V
E
R
P
H
Q
T
Site 153
T1509
S
V
E
R
P
H
Q
T
D
S
W
I
G
S
A
Site 154
S1511
E
R
P
H
Q
T
D
S
W
I
G
S
A
Y
V
Site 155
S1515
Q
T
D
S
W
I
G
S
A
Y
V
D
L
A
R
Site 156
S1527
L
A
R
L
G
E
R
S
A
R
T
L
T
V
S
Site 157
T1530
L
G
E
R
S
A
R
T
L
T
V
S
G
V
Y
Site 158
T1532
E
R
S
A
R
T
L
T
V
S
G
V
Y
P
L
Site 159
S1548
G
R
N
A
S
N
L
S
G
A
A
L
R
V
H
Site 160
S1562
H
V
V
L
S
S
L
S
S
H
L
E
P
T
H
Site 161
S1563
V
V
L
S
S
L
S
S
H
L
E
P
T
H
E
Site 162
S1573
E
P
T
H
E
L
D
S
M
D
C
S
S
H
S
Site 163
S1577
E
L
D
S
M
D
C
S
S
H
S
E
S
E
Q
Site 164
S1578
L
D
S
M
D
C
S
S
H
S
E
S
E
Q
L
Site 165
S1580
S
M
D
C
S
S
H
S
E
S
E
Q
L
P
R
Site 166
S1582
D
C
S
S
H
S
E
S
E
Q
L
P
R
R
N
Site 167
S1595
R
N
D
E
V
Q
L
S
P
P
E
V
I
S
C
Site 168
S1601
L
S
P
P
E
V
I
S
C
H
Q
K
S
P
A
Site 169
S1606
V
I
S
C
H
Q
K
S
P
A
S
T
Q
V
P
Site 170
S1609
C
H
Q
K
S
P
A
S
T
Q
V
P
C
S
S
Site 171
T1610
H
Q
K
S
P
A
S
T
Q
V
P
C
S
S
T
Site 172
S1615
A
S
T
Q
V
P
C
S
S
T
T
A
E
V
R
Site 173
S1616
S
T
Q
V
P
C
S
S
T
T
A
E
V
R
L
Site 174
T1624
T
T
A
E
V
R
L
T
Q
E
G
P
A
D
L
Site 175
S1648
V
E
R
A
M
H
L
S
L
K
G
S
P
L
T
Site 176
S1652
M
H
L
S
L
K
G
S
P
L
T
E
R
K
V
Site 177
T1655
S
L
K
G
S
P
L
T
E
R
K
V
S
I
P
Site 178
S1674
S
F
A
T
A
D
E
S
S
P
V
Y
T
Q
V
Site 179
Y1678
A
D
E
S
S
P
V
Y
T
Q
V
V
E
N
T
Site 180
T1679
D
E
S
S
P
V
Y
T
Q
V
V
E
N
T
D
Site 181
S1699
F
Q
Q
Q
S
R
L
S
K
E
L
L
L
D
P
Site 182
S1763
G
Q
I
K
V
A
V
S
P
L
E
S
L
I
H
Site 183
S1784
A
R
R
G
V
E
T
S
K
S
L
I
P
I
Y
Site 184
S1786
R
G
V
E
T
S
K
S
L
I
P
I
Y
S
P
Site 185
Y1791
S
K
S
L
I
P
I
Y
S
P
F
S
F
P
A
Site 186
S1795
I
P
I
Y
S
P
F
S
F
P
A
S
D
T
Y
Site 187
S1799
S
P
F
S
F
P
A
S
D
T
Y
A
A
F
S
Site 188
T1801
F
S
F
P
A
S
D
T
Y
A
A
F
S
S
H
Site 189
Y1802
S
F
P
A
S
D
T
Y
A
A
F
S
S
H
M
Site 190
T1813
S
S
H
M
A
R
Q
T
L
D
Q
L
A
H
A
Site 191
S1828
S
S
K
E
L
D
F
S
S
P
G
R
S
D
T
Site 192
S1829
S
K
E
L
D
F
S
S
P
G
R
S
D
T
T
Site 193
S1833
D
F
S
S
P
G
R
S
D
T
T
R
S
Q
A
Site 194
T1835
S
S
P
G
R
S
D
T
T
R
S
Q
A
S
R
Site 195
T1836
S
P
G
R
S
D
T
T
R
S
Q
A
S
R
H
Site 196
S1838
G
R
S
D
T
T
R
S
Q
A
S
R
H
E
E
Site 197
S1856
N
I
R
R
F
H
E
S
L
H
L
Q
G
E
A
Site 198
T1872
L
P
C
D
D
K
L
T
T
S
P
L
S
S
Q
Site 199
T1873
P
C
D
D
K
L
T
T
S
P
L
S
S
Q
T
Site 200
S1874
C
D
D
K
L
T
T
S
P
L
S
S
Q
T
S
Site 201
S1877
K
L
T
T
S
P
L
S
S
Q
T
S
I
L
T
Site 202
S1878
L
T
T
S
P
L
S
S
Q
T
S
I
L
T
S
Site 203
S1881
S
P
L
S
S
Q
T
S
I
L
T
S
L
R
K
Site 204
S1885
S
Q
T
S
I
L
T
S
L
R
K
N
L
S
E
Site 205
S1891
T
S
L
R
K
N
L
S
E
L
D
Q
I
Q
R
Site 206
Y1899
E
L
D
Q
I
Q
R
Y
F
R
Q
K
L
T
K
Site 207
T1905
R
Y
F
R
Q
K
L
T
K
P
F
L
P
L
S
Site 208
S1912
T
K
P
F
L
P
L
S
P
Q
T
Q
T
A
I
Site 209
S1920
P
Q
T
Q
T
A
I
S
Q
H
Q
E
S
C
R
Site 210
S1925
A
I
S
Q
H
Q
E
S
C
R
D
H
L
G
P
Site 211
S1935
D
H
L
G
P
G
A
S
S
L
D
P
G
S
Q
Site 212
S1936
H
L
G
P
G
A
S
S
L
D
P
G
S
Q
C
Site 213
S1941
A
S
S
L
D
P
G
S
Q
C
I
L
E
K
S
Site 214
T1964
S
L
I
T
D
L
Q
T
I
T
R
D
S
Q
A
Site 215
S1969
L
Q
T
I
T
R
D
S
Q
A
A
L
S
S
H
Site 216
S1974
R
D
S
Q
A
A
L
S
S
H
R
A
R
S
R
Site 217
S1975
D
S
Q
A
A
L
S
S
H
R
A
R
S
R
S
Site 218
S1980
L
S
S
H
R
A
R
S
R
S
N
K
A
T
T
Site 219
S1982
S
H
R
A
R
S
R
S
N
K
A
T
T
L
P
Site 220
T1986
R
S
R
S
N
K
A
T
T
L
P
D
A
Q
D
Site 221
T2002
E
A
L
Q
E
R
C
T
M
P
D
E
P
L
V
Site 222
T2016
V
R
A
P
D
K
G
T
D
S
P
S
P
P
P
Site 223
S2018
A
P
D
K
G
T
D
S
P
S
P
P
P
L
E
Site 224
S2020
D
K
G
T
D
S
P
S
P
P
P
L
E
E
T
Site 225
S2037
G
G
R
M
L
H
E
S
L
R
H
A
V
P
I
Site 226
T2045
L
R
H
A
V
P
I
T
R
M
Q
S
S
E
D
Site 227
S2049
V
P
I
T
R
M
Q
S
S
E
D
T
E
A
G
Site 228
S2050
P
I
T
R
M
Q
S
S
E
D
T
E
A
G
P
Site 229
T2053
R
M
Q
S
S
E
D
T
E
A
G
P
A
Y
S
Site 230
Y2059
D
T
E
A
G
P
A
Y
S
D
E
D
Y
E
E
Site 231
S2060
T
E
A
G
P
A
Y
S
D
E
D
Y
E
E
D
Site 232
Y2064
P
A
Y
S
D
E
D
Y
E
E
D
I
I
E
P
Site 233
T2073
E
D
I
I
E
P
R
T
L
N
E
I
T
T
V
Site 234
T2079
R
T
L
N
E
I
T
T
V
T
D
K
T
S
P
Site 235
T2081
L
N
E
I
T
T
V
T
D
K
T
S
P
W
S
Site 236
T2084
I
T
T
V
T
D
K
T
S
P
W
S
S
V
I
Site 237
S2085
T
T
V
T
D
K
T
S
P
W
S
S
V
I
S
Site 238
S2088
T
D
K
T
S
P
W
S
S
V
I
S
D
T
S
Site 239
S2089
D
K
T
S
P
W
S
S
V
I
S
D
T
S
E
Site 240
S2092
S
P
W
S
S
V
I
S
D
T
S
E
V
I
S
Site 241
T2094
W
S
S
V
I
S
D
T
S
E
V
I
S
P
Q
Site 242
S2095
S
S
V
I
S
D
T
S
E
V
I
S
P
Q
P
Site 243
S2099
S
D
T
S
E
V
I
S
P
Q
P
D
E
V
Q
Site 244
S2111
E
V
Q
R
E
G
P
S
C
P
S
P
G
P
F
Site 245
S2114
R
E
G
P
S
C
P
S
P
G
P
F
C
R
E
Site 246
S2127
R
E
E
L
M
V
K
S
S
F
L
S
S
P
E
Site 247
S2128
E
E
L
M
V
K
S
S
F
L
S
S
P
E
R
Site 248
S2131
M
V
K
S
S
F
L
S
S
P
E
R
A
V
N
Site 249
S2132
V
K
S
S
F
L
S
S
P
E
R
A
V
N
P
Site 250
S2146
P
H
L
P
R
Q
G
S
P
S
Q
S
L
V
A
Site 251
S2148
L
P
R
Q
G
S
P
S
Q
S
L
V
A
C
E
Site 252
S2150
R
Q
G
S
P
S
Q
S
L
V
A
C
E
C
E
Site 253
S2159
V
A
C
E
C
E
A
S
K
A
R
V
G
G
E
Site 254
S2167
K
A
R
V
G
G
E
S
A
S
A
N
P
Q
P
Site 255
S2169
R
V
G
G
E
S
A
S
A
N
P
Q
P
I
P
Site 256
T2179
P
Q
P
I
P
C
P
T
L
S
G
A
Q
Q
S
Site 257
S2181
P
I
P
C
P
T
L
S
G
A
Q
Q
S
S
T
Site 258
S2186
T
L
S
G
A
Q
Q
S
S
T
F
V
G
W
S
Site 259
S2187
L
S
G
A
Q
Q
S
S
T
F
V
G
W
S
S
Site 260
T2188
S
G
A
Q
Q
S
S
T
F
V
G
W
S
S
P
Site 261
S2194
S
T
F
V
G
W
S
S
P
Q
T
D
Q
N
K
Site 262
T2197
V
G
W
S
S
P
Q
T
D
Q
N
K
E
P
K
Site 263
S2205
D
Q
N
K
E
P
K
S
E
A
P
A
E
N
E
Site 264
S2216
A
E
N
E
A
A
T
S
E
L
G
D
S
A
D
Site 265
S2221
A
T
S
E
L
G
D
S
A
D
S
F
K
K
L
Site 266
S2224
E
L
G
D
S
A
D
S
F
K
K
L
P
L
N
Site 267
S2234
K
L
P
L
N
L
A
S
Q
S
R
R
E
N
H
Site 268
S2236
P
L
N
L
A
S
Q
S
R
R
E
N
H
K
G
Site 269
S2249
K
G
P
P
I
D
S
S
D
I
R
Q
R
Q
V
Site 270
T2257
D
I
R
Q
R
Q
V
T
T
G
S
E
T
S
T
Site 271
S2260
Q
R
Q
V
T
T
G
S
E
T
S
T
K
Q
S
Site 272
T2264
T
T
G
S
E
T
S
T
K
Q
S
L
L
L
P
Site 273
S2267
S
E
T
S
T
K
Q
S
L
L
L
P
G
P
I
Site 274
S2289
P
P
Q
Q
L
E
A
S
L
R
M
L
S
L
S
Site 275
S2310
A
T
T
D
Q
D
K
S
E
A
T
R
G
A
L
Site 276
S2318
E
A
T
R
G
A
L
S
Q
R
P
C
R
P
R
Site 277
S2328
P
C
R
P
R
P
N
S
L
P
L
N
L
P
E
Site 278
T2338
L
N
L
P
E
E
E
T
L
R
I
A
R
I
F
Site 279
S2346
L
R
I
A
R
I
F
S
S
Q
Y
S
Q
K
D
Site 280
S2347
R
I
A
R
I
F
S
S
Q
Y
S
Q
K
D
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation