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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SUV420H1
Full Name:
Histone-lysine N-methyltransferase SUV420H1
Alias:
4-20 homologue 1; CGI85; CGI-85; EC 2.1.1.43; Suppressor of variegation 4-20 homologue 1; SUV41
Type:
Methyltransferase
Mass (Da):
99187
Number AA:
885
UniProt ID:
Q4FZB7
International Prot ID:
IPI00329708
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005694
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006325
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
R
R
N
G
G
K
L
S
N
D
H
Q
Q
N
Q
Site 2
T39
L
Q
H
T
G
K
D
T
L
K
A
G
K
N
A
Site 3
S51
K
N
A
V
E
R
R
S
N
R
C
N
G
N
S
Site 4
S58
S
N
R
C
N
G
N
S
G
F
E
G
Q
S
R
Site 5
S64
N
S
G
F
E
G
Q
S
R
Y
V
P
S
S
G
Site 6
Y66
G
F
E
G
Q
S
R
Y
V
P
S
S
G
M
S
Site 7
S69
G
Q
S
R
Y
V
P
S
S
G
M
S
A
K
E
Site 8
S70
Q
S
R
Y
V
P
S
S
G
M
S
A
K
E
L
Site 9
S73
Y
V
P
S
S
G
M
S
A
K
E
L
C
E
N
Site 10
S86
E
N
D
D
L
A
T
S
L
V
L
D
P
Y
L
Site 11
Y92
T
S
L
V
L
D
P
Y
L
G
F
Q
T
H
K
Site 12
S103
Q
T
H
K
M
N
T
S
A
F
P
S
R
S
S
Site 13
S107
M
N
T
S
A
F
P
S
R
S
S
R
H
F
S
Site 14
S109
T
S
A
F
P
S
R
S
S
R
H
F
S
K
S
Site 15
S110
S
A
F
P
S
R
S
S
R
H
F
S
K
S
D
Site 16
S114
S
R
S
S
R
H
F
S
K
S
D
S
F
S
H
Site 17
S116
S
S
R
H
F
S
K
S
D
S
F
S
H
N
N
Site 18
S118
R
H
F
S
K
S
D
S
F
S
H
N
N
P
V
Site 19
S120
F
S
K
S
D
S
F
S
H
N
N
P
V
R
F
Site 20
Y166
S
G
E
W
A
R
H
Y
F
L
N
K
N
K
M
Site 21
Y203
E
I
L
P
C
N
R
Y
S
S
E
Q
N
G
A
Site 22
S204
I
L
P
C
N
R
Y
S
S
E
Q
N
G
A
K
Site 23
S205
L
P
C
N
R
Y
S
S
E
Q
N
G
A
K
I
Site 24
S251
R
H
G
E
N
D
F
S
V
M
Y
S
T
R
K
Site 25
T284
P
N
C
K
F
V
S
T
G
R
D
T
A
C
V
Site 26
Y306
P
G
E
E
I
S
C
Y
Y
G
D
G
F
F
G
Site 27
Y307
G
E
E
I
S
C
Y
Y
G
D
G
F
F
G
E
Site 28
Y322
N
N
E
F
C
E
C
Y
T
C
E
R
R
G
T
Site 29
T329
Y
T
C
E
R
R
G
T
G
A
F
K
S
R
V
Site 30
S334
R
G
T
G
A
F
K
S
R
V
G
L
P
A
P
Site 31
Y349
A
P
V
I
N
S
K
Y
G
L
R
E
T
D
K
Site 32
T354
S
K
Y
G
L
R
E
T
D
K
R
L
N
R
L
Site 33
S367
R
L
K
K
L
G
D
S
S
K
N
S
D
S
Q
Site 34
S368
L
K
K
L
G
D
S
S
K
N
S
D
S
Q
S
Site 35
S371
L
G
D
S
S
K
N
S
D
S
Q
S
V
S
S
Site 36
S373
D
S
S
K
N
S
D
S
Q
S
V
S
S
N
T
Site 37
S375
S
K
N
S
D
S
Q
S
V
S
S
N
T
D
A
Site 38
S377
N
S
D
S
Q
S
V
S
S
N
T
D
A
D
T
Site 39
S378
S
D
S
Q
S
V
S
S
N
T
D
A
D
T
T
Site 40
T380
S
Q
S
V
S
S
N
T
D
A
D
T
T
Q
E
Site 41
T384
S
S
N
T
D
A
D
T
T
Q
E
K
N
N
A
Site 42
T385
S
N
T
D
A
D
T
T
Q
E
K
N
N
A
T
Site 43
S393
Q
E
K
N
N
A
T
S
N
R
K
S
S
V
G
Site 44
S397
N
A
T
S
N
R
K
S
S
V
G
V
K
K
N
Site 45
S398
A
T
S
N
R
K
S
S
V
G
V
K
K
N
S
Site 46
S405
S
V
G
V
K
K
N
S
K
S
R
T
L
T
R
Site 47
S407
G
V
K
K
N
S
K
S
R
T
L
T
R
Q
S
Site 48
T409
K
K
N
S
K
S
R
T
L
T
R
Q
S
M
S
Site 49
T411
N
S
K
S
R
T
L
T
R
Q
S
M
S
R
I
Site 50
S414
S
R
T
L
T
R
Q
S
M
S
R
I
P
A
S
Site 51
S416
T
L
T
R
Q
S
M
S
R
I
P
A
S
S
N
Site 52
S421
S
M
S
R
I
P
A
S
S
N
S
T
S
S
K
Site 53
S422
M
S
R
I
P
A
S
S
N
S
T
S
S
K
L
Site 54
S424
R
I
P
A
S
S
N
S
T
S
S
K
L
T
H
Site 55
T425
I
P
A
S
S
N
S
T
S
S
K
L
T
H
I
Site 56
S426
P
A
S
S
N
S
T
S
S
K
L
T
H
I
N
Site 57
T430
N
S
T
S
S
K
L
T
H
I
N
N
S
R
V
Site 58
S450
K
P
A
K
P
L
L
S
K
I
K
L
R
N
H
Site 59
Y485
K
E
P
K
V
V
L
Y
K
N
L
P
I
K
K
Site 60
T510
A
V
A
S
G
C
L
T
R
H
A
A
R
E
H
Site 61
S527
N
P
V
R
G
A
H
S
Q
G
E
S
S
P
C
Site 62
S531
G
A
H
S
Q
G
E
S
S
P
C
T
Y
I
T
Site 63
S532
A
H
S
Q
G
E
S
S
P
C
T
Y
I
T
R
Site 64
T535
Q
G
E
S
S
P
C
T
Y
I
T
R
R
S
V
Site 65
Y536
G
E
S
S
P
C
T
Y
I
T
R
R
S
V
R
Site 66
T538
S
S
P
C
T
Y
I
T
R
R
S
V
R
T
R
Site 67
S541
C
T
Y
I
T
R
R
S
V
R
T
R
T
N
L
Site 68
T546
R
R
S
V
R
T
R
T
N
L
K
E
A
S
D
Site 69
S552
R
T
N
L
K
E
A
S
D
I
K
L
E
P
N
Site 70
T560
D
I
K
L
E
P
N
T
L
N
G
Y
K
S
S
Site 71
S566
N
T
L
N
G
Y
K
S
S
V
T
E
P
C
P
Site 72
S567
T
L
N
G
Y
K
S
S
V
T
E
P
C
P
D
Site 73
S575
V
T
E
P
C
P
D
S
G
E
Q
L
Q
P
A
Site 74
S605
G
E
A
K
C
H
K
S
D
T
G
M
S
K
K
Site 75
S610
H
K
S
D
T
G
M
S
K
K
K
S
R
Q
G
Site 76
S614
T
G
M
S
K
K
K
S
R
Q
G
K
L
V
K
Site 77
T630
F
A
K
I
E
E
S
T
P
V
H
D
S
P
G
Site 78
S635
E
S
T
P
V
H
D
S
P
G
K
D
D
A
V
Site 79
S650
P
D
L
M
G
P
H
S
D
Q
G
E
H
S
G
Site 80
T658
D
Q
G
E
H
S
G
T
V
G
V
P
V
S
Y
Site 81
S671
S
Y
T
D
C
A
P
S
P
V
G
C
S
V
V
Site 82
S680
V
G
C
S
V
V
T
S
D
S
F
K
T
K
D
Site 83
S682
C
S
V
V
T
S
D
S
F
K
T
K
D
S
F
Site 84
S688
D
S
F
K
T
K
D
S
F
R
T
A
K
S
K
Site 85
S694
D
S
F
R
T
A
K
S
K
K
K
R
R
I
T
Site 86
T701
S
K
K
K
R
R
I
T
R
Y
D
A
Q
L
I
Site 87
Y703
K
K
R
R
I
T
R
Y
D
A
Q
L
I
L
E
Site 88
T719
N
S
G
I
P
K
L
T
L
R
R
R
H
D
S
Site 89
S726
T
L
R
R
R
H
D
S
S
S
K
T
N
D
Q
Site 90
S727
L
R
R
R
H
D
S
S
S
K
T
N
D
Q
E
Site 91
S728
R
R
R
H
D
S
S
S
K
T
N
D
Q
E
N
Site 92
T730
R
H
D
S
S
S
K
T
N
D
Q
E
N
D
G
Site 93
S741
E
N
D
G
M
N
S
S
K
I
S
I
K
L
S
Site 94
S744
G
M
N
S
S
K
I
S
I
K
L
S
K
D
H
Site 95
S748
S
K
I
S
I
K
L
S
K
D
H
D
N
D
N
Site 96
Y758
H
D
N
D
N
N
L
Y
V
A
K
L
N
N
G
Site 97
S768
K
L
N
N
G
F
N
S
G
S
G
S
S
S
T
Site 98
S770
N
N
G
F
N
S
G
S
G
S
S
S
T
K
L
Site 99
S772
G
F
N
S
G
S
G
S
S
S
T
K
L
K
I
Site 100
S774
N
S
G
S
G
S
S
S
T
K
L
K
I
Q
L
Site 101
S790
R
D
E
E
N
R
G
S
Y
T
E
G
L
H
E
Site 102
Y791
D
E
E
N
R
G
S
Y
T
E
G
L
H
E
N
Site 103
S803
H
E
N
G
V
C
C
S
D
P
L
S
L
L
E
Site 104
S811
D
P
L
S
L
L
E
S
R
M
E
V
D
D
Y
Site 105
Y818
S
R
M
E
V
D
D
Y
S
Q
Y
E
E
E
S
Site 106
S819
R
M
E
V
D
D
Y
S
Q
Y
E
E
E
S
T
Site 107
Y821
E
V
D
D
Y
S
Q
Y
E
E
E
S
T
D
D
Site 108
S825
Y
S
Q
Y
E
E
E
S
T
D
D
S
S
S
S
Site 109
T826
S
Q
Y
E
E
E
S
T
D
D
S
S
S
S
E
Site 110
S829
E
E
E
S
T
D
D
S
S
S
S
E
G
D
E
Site 111
S830
E
E
S
T
D
D
S
S
S
S
E
G
D
E
E
Site 112
S831
E
S
T
D
D
S
S
S
S
E
G
D
E
E
E
Site 113
S832
S
T
D
D
S
S
S
S
E
G
D
E
E
E
D
Site 114
Y841
G
D
E
E
E
D
D
Y
D
D
D
F
E
D
D
Site 115
S872
D
S
I
D
I
D
I
S
S
R
R
R
E
D
Q
Site 116
S873
S
I
D
I
D
I
S
S
R
R
R
E
D
Q
S
Site 117
S880
S
R
R
R
E
D
Q
S
L
R
L
N
A
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation