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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HSF5
Full Name:
Heat shock factor protein 5
Alias:
Heat shock transcription factor 5
Type:
Mass (Da):
65278
Number AA:
596
UniProt ID:
Q4G112
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
E
A
L
L
S
T
P
I
N
P
N
N
F
Site 2
S24
K
L
W
R
L
V
N
S
P
R
Y
R
S
I
R
Site 3
Y27
R
L
V
N
S
P
R
Y
R
S
I
R
W
D
G
Site 4
S29
V
N
S
P
R
Y
R
S
I
R
W
D
G
R
G
Site 5
S76
P
E
L
F
K
T
T
S
F
T
S
F
I
R
Q
Site 6
S79
F
K
T
T
S
F
T
S
F
I
R
Q
L
N
L
Site 7
T131
L
V
H
L
K
R
L
T
S
A
N
K
A
K
L
Site 8
S132
V
H
L
K
R
L
T
S
A
N
K
A
K
L
A
Site 9
S194
A
V
G
Q
F
H
R
S
F
R
R
D
S
L
S
Site 10
S199
H
R
S
F
R
R
D
S
L
S
P
Y
S
C
V
Site 11
S201
S
F
R
R
D
S
L
S
P
Y
S
C
V
S
T
Site 12
Y203
R
R
D
S
L
S
P
Y
S
C
V
S
T
P
S
Site 13
S204
R
D
S
L
S
P
Y
S
C
V
S
T
P
S
H
Site 14
S207
L
S
P
Y
S
C
V
S
T
P
S
H
D
H
S
Site 15
T208
S
P
Y
S
C
V
S
T
P
S
H
D
H
S
T
Site 16
S210
Y
S
C
V
S
T
P
S
H
D
H
S
T
Y
P
Site 17
S214
S
T
P
S
H
D
H
S
T
Y
P
L
K
G
L
Site 18
T215
T
P
S
H
D
H
S
T
Y
P
L
K
G
L
D
Site 19
Y216
P
S
H
D
H
S
T
Y
P
L
K
G
L
D
R
Site 20
T224
P
L
K
G
L
D
R
T
P
V
P
H
R
I
W
Site 21
S245
H
P
G
Q
V
E
T
S
P
T
F
S
D
K
G
Site 22
T247
G
Q
V
E
T
S
P
T
F
S
D
K
G
V
P
Site 23
S249
V
E
T
S
P
T
F
S
D
K
G
V
P
F
P
Site 24
T263
P
V
L
Q
R
F
P
T
E
V
T
Y
T
L
Q
Site 25
T268
F
P
T
E
V
T
Y
T
L
Q
P
S
T
T
S
Site 26
T284
H
V
Q
Q
G
P
Q
T
M
V
S
S
S
Q
K
Site 27
S287
Q
G
P
Q
T
M
V
S
S
S
Q
K
Y
S
N
Site 28
S288
G
P
Q
T
M
V
S
S
S
Q
K
Y
S
N
Y
Site 29
S289
P
Q
T
M
V
S
S
S
Q
K
Y
S
N
Y
T
Site 30
Y292
M
V
S
S
S
Q
K
Y
S
N
Y
T
P
S
A
Site 31
S293
V
S
S
S
Q
K
Y
S
N
Y
T
P
S
A
Q
Site 32
Y295
S
S
Q
K
Y
S
N
Y
T
P
S
A
Q
Y
S
Site 33
T296
S
Q
K
Y
S
N
Y
T
P
S
A
Q
Y
S
Q
Site 34
S298
K
Y
S
N
Y
T
P
S
A
Q
Y
S
Q
A
Y
Site 35
S302
Y
T
P
S
A
Q
Y
S
Q
A
Y
Y
P
T
A
Site 36
Y306
A
Q
Y
S
Q
A
Y
Y
P
T
A
V
L
Q
C
Site 37
S347
Q
N
P
S
M
Q
S
S
Y
P
V
E
F
L
P
Site 38
Y348
N
P
S
M
Q
S
S
Y
P
V
E
F
L
P
S
Site 39
S360
L
P
S
N
W
P
C
S
T
T
D
E
N
T
K
Site 40
T368
T
T
D
E
N
T
K
T
E
V
N
L
E
A
V
Site 41
S385
I
V
D
E
L
H
S
S
P
K
L
E
M
V
K
Site 42
S403
V
E
N
Q
C
P
T
S
P
S
Y
R
G
Q
H
Site 43
S405
N
Q
C
P
T
S
P
S
Y
R
G
Q
H
I
L
Site 44
S415
G
Q
H
I
L
A
N
S
N
N
S
N
P
C
S
Site 45
S418
I
L
A
N
S
N
N
S
N
P
C
S
A
S
Q
Site 46
S422
S
N
N
S
N
P
C
S
A
S
Q
A
S
Q
L
Site 47
S424
N
S
N
P
C
S
A
S
Q
A
S
Q
L
E
P
Site 48
S453
T
E
Q
A
V
A
C
S
L
P
Q
S
P
E
Y
Site 49
Y460
S
L
P
Q
S
P
E
Y
I
Y
T
I
H
T
A
Site 50
T463
Q
S
P
E
Y
I
Y
T
I
H
T
A
Q
P
V
Site 51
T466
E
Y
I
Y
T
I
H
T
A
Q
P
V
E
N
S
Site 52
S473
T
A
Q
P
V
E
N
S
T
I
Q
E
S
A
A
Site 53
S497
E
H
L
N
H
N
P
S
P
S
S
V
V
F
V
Site 54
S499
L
N
H
N
P
S
P
S
S
V
V
F
V
Q
E
Site 55
S500
N
H
N
P
S
P
S
S
V
V
F
V
Q
E
G
Site 56
S511
V
Q
E
G
P
P
F
S
T
H
Q
V
D
A
N
Site 57
S524
A
N
I
K
C
Q
T
S
S
R
E
N
I
L
P
Site 58
S525
N
I
K
C
Q
T
S
S
R
E
N
I
L
P
S
Site 59
S532
S
R
E
N
I
L
P
S
E
Q
M
G
F
L
I
Site 60
S540
E
Q
M
G
F
L
I
S
E
M
G
P
A
S
K
Site 61
S546
I
S
E
M
G
P
A
S
K
P
S
E
D
T
G
Site 62
T556
S
E
D
T
G
L
A
T
P
A
R
Y
R
E
H
Site 63
S565
A
R
Y
R
E
H
R
S
N
S
Q
Q
G
K
S
Site 64
S567
Y
R
E
H
R
S
N
S
Q
Q
G
K
S
P
D
Site 65
S572
S
N
S
Q
Q
G
K
S
P
D
L
H
L
L
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation