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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FBX43
Full Name:
F-box only protein 43
Alias:
Endogenous meiotic inhibitor 2; F-box protein 43; Fbx43
Type:
Unknown function
Mass (Da):
78384
Number AA:
708
UniProt ID:
Q4G163
International Prot ID:
IPI00175439
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007126
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
K
D
K
D
E
R
I
S
C
L
E
A
Y
V
T
Site 2
T18
S
C
L
E
A
Y
V
T
L
T
S
K
S
S
R
Site 3
T20
L
E
A
Y
V
T
L
T
S
K
S
S
R
F
T
Site 4
S21
E
A
Y
V
T
L
T
S
K
S
S
R
F
T
D
Site 5
S23
Y
V
T
L
T
S
K
S
S
R
F
T
D
E
T
Site 6
T27
T
S
K
S
S
R
F
T
D
E
T
E
I
L
K
Site 7
T30
S
S
R
F
T
D
E
T
E
I
L
K
M
S
Q
Site 8
S36
E
T
E
I
L
K
M
S
Q
R
H
S
G
Q
A
Site 9
S40
L
K
M
S
Q
R
H
S
G
Q
A
G
T
E
A
Site 10
S53
E
A
G
N
G
A
D
S
P
P
I
V
N
S
K
Site 11
S59
D
S
P
P
I
V
N
S
K
Y
S
T
F
R
D
Site 12
Y61
P
P
I
V
N
S
K
Y
S
T
F
R
D
F
C
Site 13
S62
P
I
V
N
S
K
Y
S
T
F
R
D
F
C
S
Site 14
T63
I
V
N
S
K
Y
S
T
F
R
D
F
C
S
T
Site 15
S69
S
T
F
R
D
F
C
S
T
S
S
F
Q
D
S
Site 16
T70
T
F
R
D
F
C
S
T
S
S
F
Q
D
S
G
Site 17
S71
F
R
D
F
C
S
T
S
S
F
Q
D
S
G
Y
Site 18
S72
R
D
F
C
S
T
S
S
F
Q
D
S
G
Y
N
Site 19
S76
S
T
S
S
F
Q
D
S
G
Y
N
E
L
K
S
Site 20
Y78
S
S
F
Q
D
S
G
Y
N
E
L
K
S
C
S
Site 21
S83
S
G
Y
N
E
L
K
S
C
S
F
D
N
I
D
Site 22
S85
Y
N
E
L
K
S
C
S
F
D
N
I
D
K
E
Site 23
Y93
F
D
N
I
D
K
E
Y
L
G
K
K
E
K
G
Site 24
T102
G
K
K
E
K
G
P
T
L
L
Y
E
H
P
E
Site 25
Y105
E
K
G
P
T
L
L
Y
E
H
P
E
T
S
G
Site 26
T110
L
L
Y
E
H
P
E
T
S
G
L
G
L
T
H
Site 27
S121
G
L
T
H
P
L
E
S
P
T
Q
K
K
K
C
Site 28
T138
P
R
K
E
K
D
K
T
P
E
L
C
E
T
P
Site 29
T144
K
T
P
E
L
C
E
T
P
K
I
S
G
K
K
Site 30
S161
P
R
R
R
L
N
V
S
F
A
L
L
K
G
D
Site 31
S171
L
L
K
G
D
F
E
S
Q
N
S
S
L
E
S
Site 32
S174
G
D
F
E
S
Q
N
S
S
L
E
S
S
I
S
Site 33
S175
D
F
E
S
Q
N
S
S
L
E
S
S
I
S
Q
Site 34
S178
S
Q
N
S
S
L
E
S
S
I
S
Q
V
I
N
Site 35
S179
Q
N
S
S
L
E
S
S
I
S
Q
V
I
N
L
Site 36
S181
S
S
L
E
S
S
I
S
Q
V
I
N
L
E
K
Site 37
S192
N
L
E
K
N
I
P
S
S
A
S
G
F
S
R
Site 38
S193
L
E
K
N
I
P
S
S
A
S
G
F
S
R
A
Site 39
S195
K
N
I
P
S
S
A
S
G
F
S
R
A
N
N
Site 40
S204
F
S
R
A
N
N
F
S
P
L
V
T
S
T
L
Site 41
T208
N
N
F
S
P
L
V
T
S
T
L
K
T
E
E
Site 42
T213
L
V
T
S
T
L
K
T
E
E
V
T
S
C
S
Site 43
S218
L
K
T
E
E
V
T
S
C
S
Q
K
L
R
L
Site 44
S220
T
E
E
V
T
S
C
S
Q
K
L
R
L
N
F
Site 45
S228
Q
K
L
R
L
N
F
S
Q
Q
K
T
S
T
I
Site 46
T232
L
N
F
S
Q
Q
K
T
S
T
I
D
D
S
K
Site 47
S233
N
F
S
Q
Q
K
T
S
T
I
D
D
S
K
D
Site 48
T234
F
S
Q
Q
K
T
S
T
I
D
D
S
K
D
D
Site 49
S238
K
T
S
T
I
D
D
S
K
D
D
C
S
L
F
Site 50
S243
D
D
S
K
D
D
C
S
L
F
E
V
E
C
I
Site 51
S261
Q
G
N
N
F
K
D
S
I
T
H
D
F
S
D
Site 52
T263
N
N
F
K
D
S
I
T
H
D
F
S
D
S
S
Site 53
S267
D
S
I
T
H
D
F
S
D
S
S
L
C
I
N
Site 54
S270
T
H
D
F
S
D
S
S
L
C
I
N
D
E
N
Site 55
S288
E
L
L
G
S
S
V
S
G
T
T
C
G
T
D
Site 56
T290
L
G
S
S
V
S
G
T
T
C
G
T
D
E
D
Site 57
S315
A
N
I
R
F
N
A
S
Q
I
L
S
P
S
P
Site 58
S319
F
N
A
S
Q
I
L
S
P
S
P
E
V
R
G
Site 59
S321
A
S
Q
I
L
S
P
S
P
E
V
R
G
S
I
Site 60
S327
P
S
P
E
V
R
G
S
I
S
T
P
E
D
S
Site 61
S329
P
E
V
R
G
S
I
S
T
P
E
D
S
G
F
Site 62
T330
E
V
R
G
S
I
S
T
P
E
D
S
G
F
N
Site 63
S334
S
I
S
T
P
E
D
S
G
F
N
S
L
S
L
Site 64
S338
P
E
D
S
G
F
N
S
L
S
L
E
K
S
E
Site 65
S340
D
S
G
F
N
S
L
S
L
E
K
S
E
D
S
Site 66
S344
N
S
L
S
L
E
K
S
E
D
S
L
S
D
Q
Site 67
S347
S
L
E
K
S
E
D
S
L
S
D
Q
E
G
S
Site 68
S349
E
K
S
E
D
S
L
S
D
Q
E
G
S
F
Q
Site 69
S354
S
L
S
D
Q
E
G
S
F
Q
E
L
L
Q
K
Site 70
T365
L
L
Q
K
H
K
G
T
P
K
V
G
D
T
I
Site 71
T371
G
T
P
K
V
G
D
T
I
R
K
T
R
H
L
Site 72
T375
V
G
D
T
I
R
K
T
R
H
L
G
R
S
R
Site 73
S381
K
T
R
H
L
G
R
S
R
R
L
S
T
L
R
Site 74
S385
L
G
R
S
R
R
L
S
T
L
R
E
Q
S
S
Site 75
T386
G
R
S
R
R
L
S
T
L
R
E
Q
S
S
Q
Site 76
S391
L
S
T
L
R
E
Q
S
S
Q
S
E
T
E
E
Site 77
S392
S
T
L
R
E
Q
S
S
Q
S
E
T
E
E
E
Site 78
T396
E
Q
S
S
Q
S
E
T
E
E
E
K
Q
I
V
Site 79
S407
K
Q
I
V
H
P
D
S
E
K
R
A
A
A
A
Site 80
S415
E
K
R
A
A
A
A
S
A
I
S
E
G
Q
L
Site 81
S418
A
A
A
A
S
A
I
S
E
G
Q
L
S
S
D
Site 82
S423
A
I
S
E
G
Q
L
S
S
D
E
S
G
D
L
Site 83
S424
I
S
E
G
Q
L
S
S
D
E
S
G
D
L
T
Site 84
S427
G
Q
L
S
S
D
E
S
G
D
L
T
F
S
L
Site 85
T431
S
D
E
S
G
D
L
T
F
S
L
K
N
L
S
Site 86
S433
E
S
G
D
L
T
F
S
L
K
N
L
S
K
T
Site 87
S438
T
F
S
L
K
N
L
S
K
T
P
A
L
Q
L
Site 88
T440
S
L
K
N
L
S
K
T
P
A
L
Q
L
V
H
Site 89
S453
V
H
E
L
F
M
K
S
K
R
K
R
L
Q
E
Site 90
S462
R
K
R
L
Q
E
N
S
G
H
E
F
L
E
Q
Site 91
Y503
D
I
L
T
E
L
K
Y
R
N
L
K
H
I
L
Site 92
S524
L
T
A
E
S
L
C
S
V
W
K
V
S
R
N
Site 93
Y549
A
N
R
R
R
K
F
Y
I
T
Q
L
K
T
D
Site 94
T551
R
R
R
K
F
Y
I
T
Q
L
K
T
D
S
E
Site 95
T569
L
N
V
E
D
A
A
T
R
L
Q
L
L
N
R
Site 96
S577
R
L
Q
L
L
N
R
S
A
L
R
S
V
Q
A
Site 97
S581
L
N
R
S
A
L
R
S
V
Q
A
Q
A
R
I
Site 98
S591
A
Q
A
R
I
P
G
S
Q
R
E
Q
G
S
T
Site 99
S597
G
S
Q
R
E
Q
G
S
T
L
S
P
W
G
E
Site 100
T598
S
Q
R
E
Q
G
S
T
L
S
P
W
G
E
V
Site 101
S600
R
E
Q
G
S
T
L
S
P
W
G
E
V
L
T
Site 102
S613
L
T
P
L
A
S
S
S
V
T
H
L
S
S
K
Site 103
T615
P
L
A
S
S
S
V
T
H
L
S
S
K
Q
E
Site 104
S618
S
S
S
V
T
H
L
S
S
K
Q
E
E
Y
V
Site 105
S619
S
S
V
T
H
L
S
S
K
Q
E
E
Y
V
K
Site 106
Y624
L
S
S
K
Q
E
E
Y
V
K
V
A
K
T
L
Site 107
S645
K
P
C
P
R
C
Q
S
P
A
K
Y
Q
P
Y
Site 108
Y649
R
C
Q
S
P
A
K
Y
Q
P
Y
K
K
R
G
Site 109
Y652
S
P
A
K
Y
Q
P
Y
K
K
R
G
L
C
S
Site 110
S659
Y
K
K
R
G
L
C
S
R
T
A
C
G
F
D
Site 111
T661
K
R
G
L
C
S
R
T
A
C
G
F
D
F
C
Site 112
S682
Y
H
G
S
E
E
C
S
R
G
A
A
K
P
R
Site 113
S698
R
K
D
A
L
P
G
S
A
Q
S
K
R
N
L
Site 114
S701
A
L
P
G
S
A
Q
S
K
R
N
L
K
R
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation