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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLCH1
Full Name:
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase eta-1
Alias:
DKFZp434C1372; EC 3.1.4.11; KIAA1069; MGC117152; Phospholipase C eta1; Phospholipase C, eta 1; Phospholipase C-eta1a; Phospholipase C-eta1b; Phospholipase C-like 3; PLCeta1; PLCL3
Type:
Membrane, Cytoplasm protein
Mass (Da):
189223
Number AA:
1693
UniProt ID:
Q4KWH8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0004435
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
GO:0016042
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y7
_
M
A
D
L
E
V
Y
K
N
L
S
P
E
K
Site 2
S11
L
E
V
Y
K
N
L
S
P
E
K
V
E
R
C
Site 3
S20
E
K
V
E
R
C
M
S
V
M
Q
S
G
T
Q
Site 4
Y43
K
G
L
V
R
L
F
Y
L
D
E
H
R
T
R
Site 5
S56
T
R
L
R
W
R
P
S
R
K
S
E
K
A
K
Site 6
S59
R
W
R
P
S
R
K
S
E
K
A
K
I
L
I
Site 7
S68
K
A
K
I
L
I
D
S
I
Y
K
V
T
E
G
Site 8
Y70
K
I
L
I
D
S
I
Y
K
V
T
E
G
R
Q
Site 9
S78
K
V
T
E
G
R
Q
S
E
I
F
H
R
Q
A
Site 10
S105
Y
H
G
N
H
M
E
S
L
D
L
I
T
S
N
Site 11
T110
M
E
S
L
D
L
I
T
S
N
P
E
E
A
R
Site 12
S111
E
S
L
D
L
I
T
S
N
P
E
E
A
R
T
Site 13
T118
S
N
P
E
E
A
R
T
W
I
T
G
L
K
Y
Site 14
S131
K
Y
L
M
A
G
I
S
D
E
D
S
L
A
K
Site 15
S135
A
G
I
S
D
E
D
S
L
A
K
R
Q
R
T
Site 16
T142
S
L
A
K
R
Q
R
T
H
D
Q
W
V
K
Q
Site 17
T192
Q
M
F
Q
E
A
D
T
D
E
N
Q
G
T
L
Site 18
T198
D
T
D
E
N
Q
G
T
L
T
F
E
E
F
C
Site 19
T200
D
E
N
Q
G
T
L
T
F
E
E
F
C
V
F
Site 20
Y208
F
E
E
F
C
V
F
Y
K
M
M
S
L
R
R
Site 21
S223
D
L
Y
L
L
L
L
S
Y
S
D
K
K
D
H
Site 22
Y224
L
Y
L
L
L
L
S
Y
S
D
K
K
D
H
L
Site 23
S225
Y
L
L
L
L
S
Y
S
D
K
K
D
H
L
T
Site 24
T232
S
D
K
K
D
H
L
T
V
E
E
L
A
Q
F
Site 25
Y253
M
N
N
V
T
T
D
Y
C
L
D
I
I
K
K
Site 26
S264
I
I
K
K
F
E
V
S
E
E
N
K
V
K
N
Site 27
Y298
N
P
L
H
H
E
V
Y
Q
D
M
D
Q
P
L
Site 28
Y308
M
D
Q
P
L
C
N
Y
Y
I
A
S
S
H
N
Site 29
Y309
D
Q
P
L
C
N
Y
Y
I
A
S
S
H
N
T
Site 30
Y317
I
A
S
S
H
N
T
Y
L
T
G
D
Q
L
L
Site 31
T319
S
S
H
N
T
Y
L
T
G
D
Q
L
L
S
Q
Site 32
S325
L
T
G
D
Q
L
L
S
Q
S
K
V
D
M
Y
Site 33
S327
G
D
Q
L
L
S
Q
S
K
V
D
M
Y
A
R
Site 34
Y332
S
Q
S
K
V
D
M
Y
A
R
V
L
Q
E
G
Site 35
Y361
E
P
V
V
H
H
G
Y
T
L
T
S
K
I
L
Site 36
Y407
Q
Q
R
K
I
A
Q
Y
L
K
G
I
F
G
D
Site 37
S419
F
G
D
K
L
D
L
S
S
V
D
T
G
E
C
Site 38
S420
G
D
K
L
D
L
S
S
V
D
T
G
E
C
K
Site 39
T423
L
D
L
S
S
V
D
T
G
E
C
K
Q
L
P
Site 40
S431
G
E
C
K
Q
L
P
S
P
Q
S
L
K
G
K
Site 41
S434
K
Q
L
P
S
P
Q
S
L
K
G
K
I
L
V
Site 42
S460
D
A
E
E
G
E
V
S
D
E
D
S
A
D
E
Site 43
S464
G
E
V
S
D
E
D
S
A
D
E
I
E
D
E
Site 44
Y478
E
C
K
F
K
L
H
Y
S
N
G
T
T
E
H
Site 45
T483
L
H
Y
S
N
G
T
T
E
H
Q
V
E
S
F
Site 46
S489
T
T
E
H
Q
V
E
S
F
I
R
K
K
L
E
Site 47
S497
F
I
R
K
K
L
E
S
L
L
K
E
S
Q
I
Site 48
S512
R
D
K
E
D
P
D
S
F
T
V
R
A
L
L
Site 49
T514
K
E
D
P
D
S
F
T
V
R
A
L
L
K
A
Site 50
S533
L
N
A
H
L
K
Q
S
P
D
V
K
E
S
G
Site 51
S539
Q
S
P
D
V
K
E
S
G
K
K
S
H
G
R
Site 52
S543
V
K
E
S
G
K
K
S
H
G
R
S
L
M
T
Site 53
S547
G
K
K
S
H
G
R
S
L
M
T
N
F
G
K
Site 54
T558
N
F
G
K
H
K
K
T
T
K
S
R
S
K
S
Site 55
T559
F
G
K
H
K
K
T
T
K
S
R
S
K
S
Y
Site 56
S561
K
H
K
K
T
T
K
S
R
S
K
S
Y
S
T
Site 57
S563
K
K
T
T
K
S
R
S
K
S
Y
S
T
D
D
Site 58
S565
T
T
K
S
R
S
K
S
Y
S
T
D
D
E
E
Site 59
S567
K
S
R
S
K
S
Y
S
T
D
D
E
E
D
T
Site 60
T574
S
T
D
D
E
E
D
T
Q
Q
S
T
G
K
E
Site 61
Y586
G
K
E
G
G
Q
L
Y
R
L
G
R
R
R
K
Site 62
T594
R
L
G
R
R
R
K
T
M
K
L
C
R
E
L
Site 63
Y607
E
L
S
D
L
V
V
Y
T
N
S
V
A
A
Q
Site 64
T621
Q
D
I
V
D
D
G
T
T
G
N
V
L
S
F
Site 65
T622
D
I
V
D
D
G
T
T
G
N
V
L
S
F
S
Site 66
S627
G
T
T
G
N
V
L
S
F
S
E
T
R
A
H
Site 67
S629
T
G
N
V
L
S
F
S
E
T
R
A
H
Q
V
Site 68
T631
N
V
L
S
F
S
E
T
R
A
H
Q
V
V
Q
Site 69
Y647
K
S
E
Q
F
M
I
Y
N
Q
K
Q
L
T
R
Site 70
Y656
Q
K
Q
L
T
R
I
Y
P
S
A
Y
R
I
D
Site 71
S658
Q
L
T
R
I
Y
P
S
A
Y
R
I
D
S
S
Site 72
Y660
T
R
I
Y
P
S
A
Y
R
I
D
S
S
N
F
Site 73
S664
P
S
A
Y
R
I
D
S
S
N
F
N
P
L
P
Site 74
S665
S
A
Y
R
I
D
S
S
N
F
N
P
L
P
Y
Site 75
Y672
S
N
F
N
P
L
P
Y
W
N
A
G
C
Q
L
Site 76
Y684
C
Q
L
V
A
L
N
Y
Q
S
E
G
R
M
M
Site 77
Y706
K
A
N
G
N
C
G
Y
V
L
K
P
Q
Q
M
Site 78
S722
K
G
T
F
N
P
F
S
G
D
P
L
P
A
N
Site 79
S740
Q
L
I
L
K
V
I
S
G
Q
Q
L
P
K
P
Site 80
S750
Q
L
P
K
P
P
D
S
M
F
G
D
R
G
E
Site 81
T796
P
V
W
E
E
T
L
T
F
T
V
H
M
P
E
Site 82
S830
G
Q
R
T
V
T
F
S
S
L
V
P
G
Y
R
Site 83
S831
Q
R
T
V
T
F
S
S
L
V
P
G
Y
R
H
Site 84
Y836
F
S
S
L
V
P
G
Y
R
H
V
Y
L
E
G
Site 85
Y840
V
P
G
Y
R
H
V
Y
L
E
G
L
T
E
A
Site 86
S863
N
E
I
Y
G
K
W
S
P
L
I
L
N
P
S
Site 87
S899
F
N
K
N
P
R
H
S
S
S
E
N
N
S
H
Site 88
S900
N
K
N
P
R
H
S
S
S
E
N
N
S
H
Y
Site 89
S901
K
N
P
R
H
S
S
S
E
N
N
S
H
Y
V
Site 90
S905
H
S
S
S
E
N
N
S
H
Y
V
R
K
R
S
Site 91
Y907
S
S
E
N
N
S
H
Y
V
R
K
R
S
I
G
Site 92
S912
S
H
Y
V
R
K
R
S
I
G
D
R
I
L
R
Site 93
T921
G
D
R
I
L
R
R
T
A
S
A
P
A
K
G
Site 94
S923
R
I
L
R
R
T
A
S
A
P
A
K
G
R
K
Site 95
S932
P
A
K
G
R
K
K
S
K
M
G
F
Q
E
M
Site 96
S945
E
M
V
E
I
K
D
S
V
S
E
A
T
R
D
Site 97
S947
V
E
I
K
D
S
V
S
E
A
T
R
D
Q
D
Site 98
T960
Q
D
G
V
L
R
R
T
T
R
S
L
Q
A
R
Site 99
T961
D
G
V
L
R
R
T
T
R
S
L
Q
A
R
P
Site 100
S963
V
L
R
R
T
T
R
S
L
Q
A
R
P
V
S
Site 101
S970
S
L
Q
A
R
P
V
S
M
P
V
D
R
N
L
Site 102
S986
G
A
L
S
L
P
V
S
E
T
A
K
D
I
E
Site 103
S998
D
I
E
G
K
E
N
S
L
A
E
D
K
D
G
Site 104
S1012
G
R
R
K
G
K
A
S
I
K
D
P
H
F
L
Site 105
S1026
L
N
F
N
K
K
L
S
S
S
S
S
A
L
L
Site 106
S1027
N
F
N
K
K
L
S
S
S
S
S
A
L
L
H
Site 107
S1028
F
N
K
K
L
S
S
S
S
S
A
L
L
H
K
Site 108
S1029
N
K
K
L
S
S
S
S
S
A
L
L
H
K
D
Site 109
S1030
K
K
L
S
S
S
S
S
A
L
L
H
K
D
T
Site 110
T1037
S
A
L
L
H
K
D
T
S
Q
G
D
T
I
V
Site 111
S1038
A
L
L
H
K
D
T
S
Q
G
D
T
I
V
S
Site 112
T1042
K
D
T
S
Q
G
D
T
I
V
S
T
A
H
M
Site 113
T1046
Q
G
D
T
I
V
S
T
A
H
M
S
V
T
G
Site 114
S1059
T
G
E
Q
L
G
M
S
S
P
R
G
G
R
T
Site 115
S1060
G
E
Q
L
G
M
S
S
P
R
G
G
R
T
T
Site 116
T1066
S
S
P
R
G
G
R
T
T
S
N
A
T
S
N
Site 117
T1067
S
P
R
G
G
R
T
T
S
N
A
T
S
N
C
Site 118
S1068
P
R
G
G
R
T
T
S
N
A
T
S
N
C
Q
Site 119
S1072
R
T
T
S
N
A
T
S
N
C
Q
E
N
P
C
Site 120
S1081
C
Q
E
N
P
C
P
S
K
S
L
S
P
K
Q
Site 121
S1083
E
N
P
C
P
S
K
S
L
S
P
K
Q
H
L
Site 122
S1085
P
C
P
S
K
S
L
S
P
K
Q
H
L
A
P
Site 123
T1099
P
D
P
V
V
N
P
T
Q
D
L
H
G
V
K
Site 124
S1129
I
L
S
G
S
V
L
S
H
S
N
L
E
I
K
Site 125
S1131
S
G
S
V
L
S
H
S
N
L
E
I
K
N
L
Site 126
T1149
R
G
K
G
R
A
A
T
S
F
S
L
S
D
V
Site 127
S1150
G
K
G
R
A
A
T
S
F
S
L
S
D
V
S
Site 128
S1161
S
D
V
S
M
L
C
S
D
I
P
D
L
H
S
Site 129
S1168
S
D
I
P
D
L
H
S
T
A
I
L
Q
E
S
Site 130
T1185
S
H
L
I
D
N
V
T
L
T
N
E
N
E
P
Site 131
T1187
L
I
D
N
V
T
L
T
N
E
N
E
P
G
S
Site 132
S1194
T
N
E
N
E
P
G
S
S
I
S
A
L
I
G
Site 133
S1195
N
E
N
E
P
G
S
S
I
S
A
L
I
G
Q
Site 134
T1206
L
I
G
Q
F
D
E
T
N
N
Q
A
L
T
V
Site 135
T1212
E
T
N
N
Q
A
L
T
V
V
S
H
L
H
N
Site 136
S1247
H
G
F
C
K
G
K
S
K
S
S
F
L
C
S
Site 137
S1249
F
C
K
G
K
S
K
S
S
F
L
C
S
S
P
Site 138
S1250
C
K
G
K
S
K
S
S
F
L
C
S
S
P
E
Site 139
S1262
S
P
E
L
I
A
L
S
S
S
E
T
T
K
H
Site 140
S1263
P
E
L
I
A
L
S
S
S
E
T
T
K
H
A
Site 141
S1264
E
L
I
A
L
S
S
S
E
T
T
K
H
A
T
Site 142
T1266
I
A
L
S
S
S
E
T
T
K
H
A
T
N
T
Site 143
T1273
T
T
K
H
A
T
N
T
V
Y
E
T
T
C
T
Site 144
Y1275
K
H
A
T
N
T
V
Y
E
T
T
C
T
P
I
Site 145
T1280
T
V
Y
E
T
T
C
T
P
I
S
K
T
K
P
Site 146
S1283
E
T
T
C
T
P
I
S
K
T
K
P
D
D
D
Site 147
S1292
T
K
P
D
D
D
L
S
S
K
A
K
T
A
A
Site 148
S1293
K
P
D
D
D
L
S
S
K
A
K
T
A
A
L
Site 149
T1297
D
L
S
S
K
A
K
T
A
A
L
E
S
N
L
Site 150
S1302
A
K
T
A
A
L
E
S
N
L
P
G
S
P
N
Site 151
S1307
L
E
S
N
L
P
G
S
P
N
T
S
R
G
W
Site 152
T1310
N
L
P
G
S
P
N
T
S
R
G
W
L
P
K
Site 153
S1311
L
P
G
S
P
N
T
S
R
G
W
L
P
K
S
Site 154
S1318
S
R
G
W
L
P
K
S
P
T
K
G
E
D
W
Site 155
T1320
G
W
L
P
K
S
P
T
K
G
E
D
W
E
T
Site 156
T1327
T
K
G
E
D
W
E
T
L
K
S
C
S
P
A
Site 157
S1330
E
D
W
E
T
L
K
S
C
S
P
A
S
S
P
Site 158
S1332
W
E
T
L
K
S
C
S
P
A
S
S
P
D
L
Site 159
S1335
L
K
S
C
S
P
A
S
S
P
D
L
T
L
E
Site 160
S1336
K
S
C
S
P
A
S
S
P
D
L
T
L
E
D
Site 161
T1340
P
A
S
S
P
D
L
T
L
E
D
V
I
A
D
Site 162
T1349
E
D
V
I
A
D
P
T
L
C
F
N
S
G
E
Site 163
S1354
D
P
T
L
C
F
N
S
G
E
S
S
L
V
E
Site 164
S1358
C
F
N
S
G
E
S
S
L
V
E
I
D
G
E
Site 165
S1366
L
V
E
I
D
G
E
S
E
N
L
S
L
T
T
Site 166
S1370
D
G
E
S
E
N
L
S
L
T
T
C
E
Y
R
Site 167
T1372
E
S
E
N
L
S
L
T
T
C
E
Y
R
R
E
Site 168
Y1376
L
S
L
T
T
C
E
Y
R
R
E
G
T
S
Q
Site 169
T1381
C
E
Y
R
R
E
G
T
S
Q
L
A
S
P
L
Site 170
S1382
E
Y
R
R
E
G
T
S
Q
L
A
S
P
L
K
Site 171
S1386
E
G
T
S
Q
L
A
S
P
L
K
L
K
Y
N
Site 172
Y1392
A
S
P
L
K
L
K
Y
N
Q
G
V
V
E
H
Site 173
Y1408
Q
R
G
L
R
N
G
Y
C
K
E
T
L
R
P
Site 174
T1412
R
N
G
Y
C
K
E
T
L
R
P
S
V
P
E
Site 175
S1416
C
K
E
T
L
R
P
S
V
P
E
I
F
N
N
Site 176
T1429
N
N
I
Q
D
V
K
T
Q
S
I
S
Y
L
A
Site 177
S1433
D
V
K
T
Q
S
I
S
Y
L
A
Y
Q
G
A
Site 178
Y1434
V
K
T
Q
S
I
S
Y
L
A
Y
Q
G
A
G
Site 179
Y1437
Q
S
I
S
Y
L
A
Y
Q
G
A
G
F
V
H
Site 180
T1457
S
D
A
K
M
F
Q
T
C
V
P
Q
Q
S
S
Site 181
S1488
L
P
A
L
K
L
P
S
P
C
K
S
K
S
L
Site 182
S1492
K
L
P
S
P
C
K
S
K
S
L
G
D
L
T
Site 183
S1494
P
S
P
C
K
S
K
S
L
G
D
L
T
S
E
Site 184
T1499
S
K
S
L
G
D
L
T
S
E
D
I
A
C
N
Site 185
S1500
K
S
L
G
D
L
T
S
E
D
I
A
C
N
F
Site 186
S1509
D
I
A
C
N
F
E
S
K
Y
Q
C
I
S
K
Site 187
Y1511
A
C
N
F
E
S
K
Y
Q
C
I
S
K
S
F
Site 188
S1515
E
S
K
Y
Q
C
I
S
K
S
F
V
T
T
G
Site 189
S1517
K
Y
Q
C
I
S
K
S
F
V
T
T
G
I
R
Site 190
T1520
C
I
S
K
S
F
V
T
T
G
I
R
D
K
K
Site 191
T1521
I
S
K
S
F
V
T
T
G
I
R
D
K
K
G
Site 192
T1533
K
K
G
V
T
V
K
T
K
S
L
E
P
I
D
Site 193
S1551
E
Q
L
R
K
L
V
S
F
D
Q
E
D
N
C
Site 194
Y1562
E
D
N
C
Q
V
L
Y
S
K
Q
D
A
N
Q
Site 195
S1579
R
A
L
V
R
K
L
S
S
R
S
Q
S
R
V
Site 196
S1580
A
L
V
R
K
L
S
S
R
S
Q
S
R
V
R
Site 197
S1582
V
R
K
L
S
S
R
S
Q
S
R
V
R
N
I
Site 198
S1584
K
L
S
S
R
S
Q
S
R
V
R
N
I
A
S
Site 199
T1623
R
N
K
P
S
A
P
T
P
A
V
N
R
H
S
Site 200
S1630
T
P
A
V
N
R
H
S
T
G
S
Y
I
A
G
Site 201
T1631
P
A
V
N
R
H
S
T
G
S
Y
I
A
G
Y
Site 202
S1633
V
N
R
H
S
T
G
S
Y
I
A
G
Y
L
K
Site 203
Y1634
N
R
H
S
T
G
S
Y
I
A
G
Y
L
K
N
Site 204
Y1638
T
G
S
Y
I
A
G
Y
L
K
N
T
K
G
G
Site 205
Y1662
G
A
C
T
A
L
H
Y
G
H
V
D
Q
F
C
Site 206
S1670
G
H
V
D
Q
F
C
S
D
N
S
V
L
Q
T
Site 207
S1673
D
Q
F
C
S
D
N
S
V
L
Q
T
E
P
S
Site 208
T1677
S
D
N
S
V
L
Q
T
E
P
S
S
D
D
K
Site 209
S1680
S
V
L
Q
T
E
P
S
S
D
D
K
P
E
I
Site 210
S1681
V
L
Q
T
E
P
S
S
D
D
K
P
E
I
Y
Site 211
Y1688
S
D
D
K
P
E
I
Y
F
L
L
R
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation