KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
AASDH
Full Name:
Acyl-CoA synthetase family member 4
Alias:
2-aminoadipic 6-semialdehyde dehydrogenase; ACSF4; Acyl-CoA synthetase 4; Aminoadipate-semialdehyde dehydrogenase; LYS2; Non-ribosomal peptide synthetase 1098; Non-ribosomal peptide synthetase 998; NRPS1098; NRPS998
Type:
EC 1.2.1.31; Oxidoreductase; Amino Acid Metabolism - lysine biosynthesis; Amino Acid Metabolism - lysine degradation; EC 6.2.1.-; Ligase
Mass (Da):
122550
Number AA:
UniProt ID:
Q4L235
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0016878
GO:0000036
PhosphoSite+
KinaseNET
Biological Process:
GO:0006631
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y32
C
N
N
Q
L
P
V
Y
Y
T
Y
K
T
V
V
Site 2
T37
P
V
Y
Y
T
Y
K
T
V
V
N
A
A
S
E
Site 3
S92
Y
V
P
I
E
P
D
S
P
P
S
L
S
T
H
Site 4
S95
I
E
P
D
S
P
P
S
L
S
T
H
F
M
K
Site 5
S97
P
D
S
P
P
S
L
S
T
H
F
M
K
K
C
Site 6
Y108
M
K
K
C
N
L
K
Y
I
L
V
E
K
K
Q
Site 7
S121
K
Q
I
N
K
F
K
S
F
H
E
T
L
L
N
Site 8
T125
K
F
K
S
F
H
E
T
L
L
N
Y
D
T
F
Site 9
Y129
F
H
E
T
L
L
N
Y
D
T
F
T
V
E
H
Site 10
T131
E
T
L
L
N
Y
D
T
F
T
V
E
H
N
D
Site 11
T133
L
L
N
Y
D
T
F
T
V
E
H
N
D
L
V
Site 12
Y162
L
N
D
G
K
E
K
Y
E
K
E
K
I
K
S
Site 13
S169
Y
E
K
E
K
I
K
S
I
S
S
E
H
V
N
Site 14
Y194
R
L
K
H
C
L
A
Y
V
L
H
T
S
G
T
Site 15
T326
G
E
A
F
P
S
L
T
V
L
R
S
W
R
G
Site 16
S330
P
S
L
T
V
L
R
S
W
R
G
E
G
N
K
Site 17
T338
W
R
G
E
G
N
K
T
Q
I
F
N
V
Y
G
Site 18
T354
T
E
V
S
S
W
A
T
I
Y
R
I
P
E
K
Site 19
Y356
V
S
S
W
A
T
I
Y
R
I
P
E
K
T
L
Site 20
T362
I
Y
R
I
P
E
K
T
L
N
S
T
L
K
C
Site 21
T389
T
V
V
E
V
R
D
T
N
G
F
T
I
Q
E
Site 22
T431
R
A
T
G
D
F
V
T
V
K
D
G
E
I
F
Site 23
S445
F
F
L
G
R
K
D
S
Q
I
K
R
H
G
K
Site 24
Y477
E
S
C
A
V
T
W
Y
N
Q
E
K
L
I
L
Site 25
S492
F
M
V
S
K
D
A
S
V
K
E
Y
I
F
K
Site 26
Y496
K
D
A
S
V
K
E
Y
I
F
K
E
L
Q
K
Site 27
Y504
I
F
K
E
L
Q
K
Y
L
P
S
H
A
V
P
Site 28
S531
S
H
G
K
I
D
V
S
E
L
N
K
I
Y
L
Site 29
Y537
V
S
E
L
N
K
I
Y
L
N
Y
I
N
L
K
Site 30
S545
L
N
Y
I
N
L
K
S
E
N
K
L
S
G
K
Site 31
S550
L
K
S
E
N
K
L
S
G
K
E
D
L
W
E
Site 32
Y561
D
L
W
E
K
L
Q
Y
L
W
K
S
T
L
N
Site 33
S565
K
L
Q
Y
L
W
K
S
T
L
N
L
P
E
D
Site 34
S585
D
E
S
L
F
L
N
S
G
G
D
S
L
K
S
Site 35
S592
S
G
G
D
S
L
K
S
I
R
L
L
S
E
I
Site 36
T637
V
V
P
D
E
D
V
T
F
R
K
S
C
A
T
Site 37
S641
E
D
V
T
F
R
K
S
C
A
T
K
R
K
L
Site 38
T644
T
F
R
K
S
C
A
T
K
R
K
L
S
D
I
Site 39
S649
C
A
T
K
R
K
L
S
D
I
N
Q
E
E
A
Site 40
S689
S
R
G
S
Q
I
L
S
L
N
S
T
R
F
L
Site 41
T697
L
N
S
T
R
F
L
T
K
L
G
H
C
S
S
Site 42
S703
L
T
K
L
G
H
C
S
S
A
C
P
S
D
S
Site 43
S704
T
K
L
G
H
C
S
S
A
C
P
S
D
S
V
Site 44
S708
H
C
S
S
A
C
P
S
D
S
V
S
Q
T
N
Site 45
S710
S
S
A
C
P
S
D
S
V
S
Q
T
N
I
Q
Site 46
S712
A
C
P
S
D
S
V
S
Q
T
N
I
Q
N
L
Site 47
T714
P
S
D
S
V
S
Q
T
N
I
Q
N
L
K
G
Site 48
S724
Q
N
L
K
G
L
N
S
P
V
L
I
G
K
S
Site 49
S735
I
G
K
S
K
D
P
S
C
V
A
K
V
S
E
Site 50
S741
P
S
C
V
A
K
V
S
E
E
G
K
P
A
I
Site 51
T750
E
G
K
P
A
I
G
T
Q
K
M
E
L
H
V
Site 52
S761
E
L
H
V
R
W
R
S
D
T
G
K
C
V
D
Site 53
T763
H
V
R
W
R
S
D
T
G
K
C
V
D
A
S
Site 54
T783
P
T
F
D
K
S
S
T
T
V
Y
I
G
S
H
Site 55
T784
T
F
D
K
S
S
T
T
V
Y
I
G
S
H
S
Site 56
Y786
D
K
S
S
T
T
V
Y
I
G
S
H
S
H
R
Site 57
Y800
R
M
K
A
V
D
F
Y
S
G
K
V
K
W
E
Site 58
S817
L
G
D
R
I
E
S
S
A
C
V
S
K
C
G
Site 59
S841
G
L
V
Y
V
L
K
S
N
S
G
E
K
Y
W
Site 60
Y847
K
S
N
S
G
E
K
Y
W
M
F
T
T
E
D
Site 61
Y870
D
P
T
T
G
L
I
Y
I
G
S
H
D
Q
H
Site 62
Y884
H
A
Y
A
L
D
I
Y
R
K
K
C
V
W
K
Site 63
T897
W
K
S
K
C
G
G
T
V
F
S
S
P
C
L
Site 64
S942
S
C
G
K
P
L
F
S
S
P
Q
C
C
S
Q
Site 65
S943
C
G
K
P
L
F
S
S
P
Q
C
C
S
Q
Y
Site 66
S974
G
E
Q
V
W
Q
F
S
T
S
G
P
I
F
S
Site 67
S976
Q
V
W
Q
F
S
T
S
G
P
I
F
S
S
P
Site 68
S981
S
T
S
G
P
I
F
S
S
P
C
T
S
P
S
Site 69
S982
T
S
G
P
I
F
S
S
P
C
T
S
P
S
E
Site 70
T985
P
I
F
S
S
P
C
T
S
P
S
E
Q
K
I
Site 71
S986
I
F
S
S
P
C
T
S
P
S
E
Q
K
I
F
Site 72
S988
S
S
P
C
T
S
P
S
E
Q
K
I
F
F
G
Site 73
Y1021
F
E
T
T
S
R
V
Y
A
T
P
F
A
F
H
Site 74
T1023
T
T
S
R
V
Y
A
T
P
F
A
F
H
N
D
Site 75
S1033
A
F
H
N
D
N
G
S
N
E
M
L
L
A
A
Site 76
S1052
G
K
V
W
I
L
E
S
Q
S
G
Q
L
Q
S
Site 77
S1054
V
W
I
L
E
S
Q
S
G
Q
L
Q
S
V
Y
Site 78
S1059
S
Q
S
G
Q
L
Q
S
V
Y
E
L
P
G
E
Site 79
Y1061
S
G
Q
L
Q
S
V
Y
E
L
P
G
E
V
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation