KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SVEP1
Full Name:
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1
Alias:
CCP module-containing protein 22;Polydom;Selectin-like osteoblast-derived protein;Serologically defined breast cancer antigen NY-BR-38
Type:
Mass (Da):
390170
Number AA:
3571
UniProt ID:
Q4LDE5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
W
A
T
F
Q
Q
M
S
P
S
R
N
F
S
F
Site 2
S27
T
F
Q
Q
M
S
P
S
R
N
F
S
F
R
L
Site 3
S31
M
S
P
S
R
N
F
S
F
R
L
F
P
E
T
Site 4
T38
S
F
R
L
F
P
E
T
A
P
G
A
P
G
S
Site 5
S45
T
A
P
G
A
P
G
S
I
P
A
P
P
A
P
Site 6
S59
P
G
D
E
A
A
G
S
R
V
E
R
L
G
Q
Site 7
S93
F
L
V
D
D
S
S
S
V
G
E
V
N
F
R
Site 8
Y132
V
T
F
S
S
K
N
Y
V
V
P
R
V
D
Y
Site 9
Y139
Y
V
V
P
R
V
D
Y
I
S
T
R
R
A
R
Site 10
S141
V
P
R
V
D
Y
I
S
T
R
R
A
R
Q
H
Site 11
T142
P
R
V
D
Y
I
S
T
R
R
A
R
Q
H
K
Site 12
S161
L
Q
E
I
P
A
I
S
Y
R
G
G
G
T
Y
Site 13
Y168
S
Y
R
G
G
G
T
Y
T
K
G
A
F
Q
Q
Site 14
Y198
V
F
L
I
T
D
G
Y
S
N
G
G
D
P
R
Site 15
S199
F
L
I
T
D
G
Y
S
N
G
G
D
P
R
P
Site 16
S210
D
P
R
P
I
A
A
S
L
R
D
S
G
V
E
Site 17
S236
R
E
L
N
D
M
A
S
T
P
K
E
E
H
C
Site 18
T237
E
L
N
D
M
A
S
T
P
K
E
E
H
C
Y
Site 19
Y244
T
P
K
E
E
H
C
Y
L
L
H
S
F
E
E
Site 20
S248
E
H
C
Y
L
L
H
S
F
E
E
F
E
A
L
Site 21
S266
A
L
H
E
D
L
P
S
G
S
F
I
Q
D
D
Site 22
S268
H
E
D
L
P
S
G
S
F
I
Q
D
D
M
V
Site 23
Y279
D
D
M
V
H
C
S
Y
L
C
D
E
G
K
D
Site 24
Y311
E
C
I
C
E
K
G
Y
Y
G
K
G
L
Q
Y
Site 25
Y312
C
I
C
E
K
G
Y
Y
G
K
G
L
Q
Y
E
Site 26
Y318
Y
Y
G
K
G
L
Q
Y
E
C
T
A
C
P
S
Site 27
T321
K
G
L
Q
Y
E
C
T
A
C
P
S
G
T
Y
Site 28
T327
C
T
A
C
P
S
G
T
Y
K
P
E
G
S
P
Site 29
S333
G
T
Y
K
P
E
G
S
P
G
G
I
S
S
C
Site 30
S338
E
G
S
P
G
G
I
S
S
C
I
P
C
P
D
Site 31
S339
G
S
P
G
G
I
S
S
C
I
P
C
P
D
E
Site 32
T349
P
C
P
D
E
N
H
T
S
P
P
G
S
T
S
Site 33
S350
C
P
D
E
N
H
T
S
P
P
G
S
T
S
P
Site 34
S354
N
H
T
S
P
P
G
S
T
S
P
E
D
C
V
Site 35
S356
T
S
P
P
G
S
T
S
P
E
D
C
V
C
R
Site 36
Y366
D
C
V
C
R
E
G
Y
R
A
S
G
Q
T
C
Site 37
S369
C
R
E
G
Y
R
A
S
G
Q
T
C
E
L
V
Site 38
T372
G
Y
R
A
S
G
Q
T
C
E
L
V
H
C
P
Site 39
Y388
L
K
P
P
E
N
G
Y
F
I
Q
N
T
C
N
Site 40
S427
C
L
P
N
G
L
W
S
G
S
E
S
Y
C
R
Site 41
S429
P
N
G
L
W
S
G
S
E
S
Y
C
R
V
R
Site 42
S431
G
L
W
S
G
S
E
S
Y
C
R
V
R
T
C
Site 43
Y432
L
W
S
G
S
E
S
Y
C
R
V
R
T
C
P
Site 44
T437
E
S
Y
C
R
V
R
T
C
P
H
L
R
Q
P
Site 45
Y470
L
V
A
C
D
E
G
Y
R
L
E
G
S
D
K
Site 46
S475
E
G
Y
R
L
E
G
S
D
K
L
T
C
Q
G
Site 47
T479
L
E
G
S
D
K
L
T
C
Q
G
N
S
Q
W
Site 48
S484
K
L
T
C
Q
G
N
S
Q
W
D
G
P
E
P
Site 49
T523
K
Q
P
A
K
F
G
T
I
C
Y
V
S
C
R
Site 50
T545
V
K
E
M
L
R
C
T
T
S
G
K
W
N
V
Site 51
T546
K
E
M
L
R
C
T
T
S
G
K
W
N
V
G
Site 52
S547
E
M
L
R
C
T
T
S
G
K
W
N
V
G
V
Site 53
T577
P
K
D
I
E
A
K
T
L
E
Q
Q
D
S
A
Site 54
S583
K
T
L
E
Q
Q
D
S
A
N
V
T
W
Q
I
Site 55
T587
Q
Q
D
S
A
N
V
T
W
Q
I
P
T
A
K
Site 56
S597
I
P
T
A
K
D
N
S
G
E
K
V
S
V
H
Site 57
S602
D
N
S
G
E
K
V
S
V
H
V
H
P
A
F
Site 58
S655
P
V
I
D
W
C
R
S
P
P
P
V
Q
V
S
Site 59
S662
S
P
P
P
V
Q
V
S
E
K
V
H
A
A
S
Site 60
S669
S
E
K
V
H
A
A
S
W
D
E
P
Q
F
S
Site 61
S676
S
W
D
E
P
Q
F
S
D
N
S
G
A
E
L
Site 62
S679
E
P
Q
F
S
D
N
S
G
A
E
L
V
I
T
Site 63
T686
S
G
A
E
L
V
I
T
R
S
H
T
Q
G
D
Site 64
S688
A
E
L
V
I
T
R
S
H
T
Q
G
D
L
F
Site 65
T690
L
V
I
T
R
S
H
T
Q
G
D
L
F
P
Q
Site 66
Y704
Q
G
E
T
I
V
Q
Y
T
A
T
D
P
S
G
Site 67
T741
V
N
G
D
F
I
C
T
P
D
N
T
G
V
N
Site 68
Y757
T
L
T
C
L
E
G
Y
D
F
T
E
G
S
T
Site 69
T760
C
L
E
G
Y
D
F
T
E
G
S
T
D
K
Y
Site 70
Y767
T
E
G
S
T
D
K
Y
Y
C
A
Y
E
D
G
Site 71
Y768
E
G
S
T
D
K
Y
Y
C
A
Y
E
D
G
V
Site 72
T812
K
A
A
R
C
D
D
T
D
L
M
K
K
F
S
Site 73
T824
K
F
S
E
A
F
E
T
T
L
G
K
M
V
P
Site 74
S832
T
L
G
K
M
V
P
S
F
C
S
D
A
E
D
Site 75
T849
C
R
L
E
E
N
L
T
K
K
Y
C
L
E
Y
Site 76
Y852
E
E
N
L
T
K
K
Y
C
L
E
Y
N
Y
D
Site 77
Y856
T
K
K
Y
C
L
E
Y
N
Y
D
Y
E
N
G
Site 78
Y858
K
Y
C
L
E
Y
N
Y
D
Y
E
N
G
F
A
Site 79
Y860
C
L
E
Y
N
Y
D
Y
E
N
G
F
A
I
G
Site 80
Y879
G
A
A
N
R
L
D
Y
S
Y
D
D
F
L
D
Site 81
S880
A
A
N
R
L
D
Y
S
Y
D
D
F
L
D
T
Site 82
Y881
A
N
R
L
D
Y
S
Y
D
D
F
L
D
T
V
Site 83
T887
S
Y
D
D
F
L
D
T
V
Q
E
T
A
T
S
Site 84
S894
T
V
Q
E
T
A
T
S
I
G
N
A
K
S
S
Site 85
S900
T
S
I
G
N
A
K
S
S
R
I
K
R
S
A
Site 86
S901
S
I
G
N
A
K
S
S
R
I
K
R
S
A
P
Site 87
S906
K
S
S
R
I
K
R
S
A
P
L
S
D
Y
K
Site 88
S910
I
K
R
S
A
P
L
S
D
Y
K
I
K
L
I
Site 89
Y912
R
S
A
P
L
S
D
Y
K
I
K
L
I
F
N
Site 90
T933
L
P
D
E
R
N
D
T
L
E
W
E
N
Q
Q
Site 91
T948
R
L
L
Q
T
L
E
T
I
T
N
K
L
K
R
Site 92
T956
I
T
N
K
L
K
R
T
L
N
K
D
P
M
Y
Site 93
Y963
T
L
N
K
D
P
M
Y
S
F
Q
L
A
S
E
Site 94
S964
L
N
K
D
P
M
Y
S
F
Q
L
A
S
E
I
Site 95
S976
S
E
I
L
I
A
D
S
N
S
L
E
T
K
K
Site 96
S978
I
L
I
A
D
S
N
S
L
E
T
K
K
A
S
Site 97
T981
A
D
S
N
S
L
E
T
K
K
A
S
P
F
C
Site 98
S985
S
L
E
T
K
K
A
S
P
F
C
R
P
G
S
Site 99
S992
S
P
F
C
R
P
G
S
V
L
R
G
R
M
C
Site 100
S1022
C
E
S
C
R
I
G
S
Y
Q
D
E
E
G
Q
Site 101
Y1023
E
S
C
R
I
G
S
Y
Q
D
E
E
G
Q
L
Site 102
Y1043
P
S
G
M
Y
T
E
Y
I
H
S
R
N
I
S
Site 103
T1060
K
A
Q
C
K
Q
G
T
Y
S
Y
S
G
L
E
Site 104
S1062
Q
C
K
Q
G
T
Y
S
Y
S
G
L
E
T
C
Site 105
T1068
Y
S
Y
S
G
L
E
T
C
E
S
C
P
L
G
Site 106
S1071
S
G
L
E
T
C
E
S
C
P
L
G
T
Y
Q
Site 107
T1076
C
E
S
C
P
L
G
T
Y
Q
P
K
F
G
S
Site 108
Y1077
E
S
C
P
L
G
T
Y
Q
P
K
F
G
S
R
Site 109
S1083
T
Y
Q
P
K
F
G
S
R
S
C
L
S
C
P
Site 110
S1085
Q
P
K
F
G
S
R
S
C
L
S
C
P
E
N
Site 111
S1088
F
G
S
R
S
C
L
S
C
P
E
N
T
S
T
Site 112
S1094
L
S
C
P
E
N
T
S
T
V
K
R
G
A
V
Site 113
T1095
S
C
P
E
N
T
S
T
V
K
R
G
A
V
N
Site 114
S1116
P
C
P
E
G
K
F
S
R
S
G
L
M
P
C
Site 115
Y1130
C
H
P
C
P
R
D
Y
Y
Q
P
N
A
G
K
Site 116
Y1131
H
P
C
P
R
D
Y
Y
Q
P
N
A
G
K
A
Site 117
T1149
A
C
P
F
Y
G
T
T
P
F
A
G
S
R
S
Site 118
S1154
G
T
T
P
F
A
G
S
R
S
I
T
E
C
S
Site 119
S1156
T
P
F
A
G
S
R
S
I
T
E
C
S
S
F
Site 120
T1158
F
A
G
S
R
S
I
T
E
C
S
S
F
S
S
Site 121
S1161
S
R
S
I
T
E
C
S
S
F
S
S
T
F
S
Site 122
S1162
R
S
I
T
E
C
S
S
F
S
S
T
F
S
A
Site 123
S1164
I
T
E
C
S
S
F
S
S
T
F
S
A
A
E
Site 124
S1165
T
E
C
S
S
F
S
S
T
F
S
A
A
E
E
Site 125
T1166
E
C
S
S
F
S
S
T
F
S
A
A
E
E
S
Site 126
S1168
S
S
F
S
S
T
F
S
A
A
E
E
S
V
V
Site 127
S1179
E
S
V
V
P
P
A
S
L
G
H
I
K
K
R
Site 128
S1236
E
T
D
I
D
E
C
S
P
L
P
C
L
N
N
Site 129
S1276
N
I
N
E
C
S
S
S
P
C
L
N
K
G
I
Site 130
S1351
K
N
V
D
E
C
L
S
Q
P
C
K
N
G
A
Site 131
T1397
N
P
C
R
N
Q
A
T
C
V
D
E
L
N
S
Site 132
Y1405
C
V
D
E
L
N
S
Y
S
C
K
C
Q
P
G
Site 133
T1420
F
S
G
K
R
C
E
T
E
Q
S
T
G
F
N
Site 134
S1423
K
R
C
E
T
E
Q
S
T
G
F
N
L
D
F
Site 135
T1454
S
L
H
A
L
T
C
T
F
W
M
K
S
S
D
Site 136
Y1465
K
S
S
D
D
M
N
Y
G
T
P
I
S
Y
A
Site 137
T1467
S
D
D
M
N
Y
G
T
P
I
S
Y
A
V
D
Site 138
S1470
M
N
Y
G
T
P
I
S
Y
A
V
D
N
G
S
Site 139
Y1471
N
Y
G
T
P
I
S
Y
A
V
D
N
G
S
D
Site 140
S1477
S
Y
A
V
D
N
G
S
D
N
T
L
L
L
T
Site 141
T1480
V
D
N
G
S
D
N
T
L
L
L
T
D
Y
N
Site 142
T1484
S
D
N
T
L
L
L
T
D
Y
N
G
W
V
L
Site 143
Y1492
D
Y
N
G
W
V
L
Y
V
N
G
R
E
K
I
Site 144
T1500
V
N
G
R
E
K
I
T
N
C
P
S
V
N
D
Site 145
Y1527
A
N
G
I
W
K
V
Y
I
D
G
K
L
S
D
Site 146
S1756
V
D
E
C
A
V
G
S
D
C
S
E
H
A
S
Site 147
S1894
E
S
S
C
L
A
N
S
S
W
S
H
S
P
P
Site 148
S2240
Q
C
N
P
G
Y
K
S
V
G
S
P
V
F
V
Site 149
S2602
A
M
Q
T
C
E
E
S
G
W
S
S
S
I
P
Site 150
S2711
E
D
G
T
W
N
G
S
A
P
S
C
I
S
I
Site 151
S2737
F
L
R
F
T
E
T
S
M
G
S
A
V
Q
Y
Site 152
S2767
C
L
E
N
R
K
W
S
G
A
S
P
R
C
E
Site 153
S2994
N
S
S
R
R
C
L
S
N
G
S
W
S
G
S
Site 154
S2999
C
L
S
N
G
S
W
S
G
S
S
P
S
C
L
Site 155
S3001
S
N
G
S
W
S
G
S
S
P
S
C
L
P
C
Site 156
S3079
M
I
P
N
A
F
I
S
E
T
S
S
W
K
E
Site 157
S3127
C
E
P
L
S
C
G
S
P
P
S
V
A
N
A
Site 158
S3235
G
T
W
E
P
P
F
S
D
E
S
C
S
P
V
Site 159
S3240
P
F
S
D
E
S
C
S
P
V
S
C
G
K
P
Site 160
Y3443
Q
Y
G
D
M
I
T
Y
S
C
Y
S
G
Y
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation