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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GRIPAP1
Full Name:
GRIP1-associated protein 1
Alias:
DKFZp434P0630; GRAP1; GRASP1; GRASP-1; GRIP1 associated 1; GRIP1 associated protein 1; KIAA1167; MPMGp800B12492Q3
Type:
Guanine nucleotide exchange factor, Ras
Mass (Da):
95990
Number AA:
841
UniProt ID:
Q4V328
International Prot ID:
IPI00413942
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005769
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y25
L
E
L
R
T
N
N
Y
Q
L
S
D
E
L
R
Site 2
S28
R
T
N
N
Y
Q
L
S
D
E
L
R
K
N
G
Site 3
S40
K
N
G
V
E
L
T
S
L
R
Q
K
V
A
Y
Site 4
Y47
S
L
R
Q
K
V
A
Y
L
D
K
E
F
S
K
Site 5
S53
A
Y
L
D
K
E
F
S
K
A
Q
K
A
L
S
Site 6
S60
S
K
A
Q
K
A
L
S
K
S
K
K
A
Q
E
Site 7
S62
A
Q
K
A
L
S
K
S
K
K
A
Q
E
V
E
Site 8
S73
Q
E
V
E
V
L
L
S
E
N
E
M
L
Q
A
Site 9
T95
D
F
R
L
Q
N
S
T
L
M
A
E
F
S
K
Site 10
S101
S
T
L
M
A
E
F
S
K
L
C
S
Q
M
E
Site 11
S105
A
E
F
S
K
L
C
S
Q
M
E
Q
L
E
Q
Site 12
S166
G
K
E
A
G
K
F
S
A
V
S
E
G
Q
G
Site 13
S169
A
G
K
F
S
A
V
S
E
G
Q
G
D
P
P
Site 14
S215
E
Q
L
Q
G
L
E
S
S
K
Q
A
E
T
S
Site 15
S216
Q
L
Q
G
L
E
S
S
K
Q
A
E
T
S
R
Site 16
S222
S
S
K
Q
A
E
T
S
R
L
Q
E
E
L
A
Site 17
S241
K
L
K
K
K
Q
E
S
F
C
R
L
Q
T
E
Site 18
T247
E
S
F
C
R
L
Q
T
E
K
E
T
L
F
N
Site 19
T251
R
L
Q
T
E
K
E
T
L
F
N
D
S
R
N
Site 20
S256
K
E
T
L
F
N
D
S
R
N
K
I
E
E
L
Site 21
S318
R
A
L
Q
D
Q
V
S
I
Q
S
A
D
A
Q
Site 22
S341
E
N
N
A
L
R
T
S
L
A
A
L
E
Q
I
Site 23
T350
A
A
L
E
Q
I
Q
T
A
K
T
Q
E
L
N
Site 24
T363
L
N
M
L
R
E
Q
T
T
G
L
A
A
E
L
Site 25
Y377
L
Q
Q
Q
Q
A
E
Y
E
D
L
M
G
Q
K
Site 26
S389
G
Q
K
D
D
L
N
S
Q
L
Q
E
S
L
R
Site 27
S394
L
N
S
Q
L
Q
E
S
L
R
A
N
S
R
L
Site 28
S399
Q
E
S
L
R
A
N
S
R
L
L
E
Q
L
Q
Site 29
S425
E
L
Q
E
A
R
K
S
A
E
K
R
K
A
M
Site 30
S445
M
E
T
L
Q
E
K
S
Q
H
K
E
E
L
G
Site 31
Y469
V
L
G
V
R
A
R
Y
E
R
E
L
R
E
L
Site 32
T498
I
R
E
E
K
A
R
T
R
E
L
E
T
L
Q
Site 33
T507
E
L
E
T
L
Q
Q
T
V
E
E
L
Q
A
Q
Site 34
S535
R
L
K
E
A
E
E
S
L
Q
Q
Q
Q
Q
E
Site 35
T585
E
R
D
C
H
L
K
T
I
S
S
L
K
Q
E
Site 36
S588
C
H
L
K
T
I
S
S
L
K
Q
E
V
K
D
Site 37
T596
L
K
Q
E
V
K
D
T
V
D
G
Q
R
I
L
Site 38
S608
R
I
L
E
K
K
G
S
A
A
L
K
D
L
K
Site 39
T637
E
R
L
Q
D
I
L
T
N
S
K
S
R
S
G
Site 40
S639
L
Q
D
I
L
T
N
S
K
S
R
S
G
L
E
Site 41
S641
D
I
L
T
N
S
K
S
R
S
G
L
E
E
L
Site 42
S643
L
T
N
S
K
S
R
S
G
L
E
E
L
V
L
Site 43
S651
G
L
E
E
L
V
L
S
E
M
N
S
P
S
R
Site 44
S655
L
V
L
S
E
M
N
S
P
S
R
T
Q
T
G
Site 45
S657
L
S
E
M
N
S
P
S
R
T
Q
T
G
D
S
Site 46
T659
E
M
N
S
P
S
R
T
Q
T
G
D
S
S
S
Site 47
T661
N
S
P
S
R
T
Q
T
G
D
S
S
S
I
S
Site 48
S664
S
R
T
Q
T
G
D
S
S
S
I
S
S
F
S
Site 49
S665
R
T
Q
T
G
D
S
S
S
I
S
S
F
S
Y
Site 50
S666
T
Q
T
G
D
S
S
S
I
S
S
F
S
Y
R
Site 51
S668
T
G
D
S
S
S
I
S
S
F
S
Y
R
E
I
Site 52
S669
G
D
S
S
S
I
S
S
F
S
Y
R
E
I
L
Site 53
S671
S
S
S
I
S
S
F
S
Y
R
E
I
L
R
E
Site 54
Y672
S
S
I
S
S
F
S
Y
R
E
I
L
R
E
K
Site 55
S681
E
I
L
R
E
K
E
S
S
A
V
P
A
R
S
Site 56
S682
I
L
R
E
K
E
S
S
A
V
P
A
R
S
L
Site 57
S688
S
S
A
V
P
A
R
S
L
S
S
S
P
Q
A
Site 58
S690
A
V
P
A
R
S
L
S
S
S
P
Q
A
Q
P
Site 59
S691
V
P
A
R
S
L
S
S
S
P
Q
A
Q
P
P
Site 60
S692
P
A
R
S
L
S
S
S
P
Q
A
Q
P
P
R
Site 61
S704
P
P
R
P
A
E
L
S
D
E
E
V
A
E
L
Site 62
S738
H
L
E
V
S
S
A
S
M
A
E
D
L
C
R
Site 63
Y753
K
S
A
I
I
E
T
Y
V
M
D
S
R
I
D
Site 64
S762
M
D
S
R
I
D
V
S
V
A
A
G
H
T
D
Site 65
T768
V
S
V
A
A
G
H
T
D
R
S
G
L
G
S
Site 66
S771
A
A
G
H
T
D
R
S
G
L
G
S
V
L
R
Site 67
S775
T
D
R
S
G
L
G
S
V
L
R
D
L
V
K
Site 68
T804
N
M
L
E
E
Q
L
T
K
N
M
H
L
H
K
Site 69
S817
H
K
D
M
E
V
L
S
Q
E
I
V
R
L
S
Site 70
S824
S
Q
E
I
V
R
L
S
K
E
C
V
G
P
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation