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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FLYWCH1
Full Name:
FLYWCH-type zinc finger-containing protein 1
Alias:
DKFZp761A132; FLYWCH-type zinc finger 1; FLYWCH-type zinc finger-containing 1; FWCH1
Type:
Mass (Da):
80108
Number AA:
716
UniProt ID:
Q4VC44
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
V
K
A
G
Q
E
P
S
P
K
P
G
T
D
V
Site 2
S40
P
R
K
P
R
E
F
S
K
L
V
L
L
T
A
Site 3
S48
K
L
V
L
L
T
A
S
D
Q
D
E
D
G
V
Site 4
S113
L
D
A
A
A
P
Q
S
L
E
F
L
R
T
P
Site 5
T119
Q
S
L
E
F
L
R
T
P
F
G
G
R
L
L
Site 6
S130
G
R
L
L
V
L
E
S
F
L
Y
K
Q
E
K
Site 7
Y144
K
A
V
G
D
K
V
Y
W
K
C
R
Q
H
A
Site 8
T161
G
C
R
G
R
A
I
T
R
G
L
R
A
T
V
Site 9
S192
R
Q
R
E
K
L
P
S
L
A
L
P
E
G
L
Site 10
T231
C
P
E
E
P
E
P
T
P
G
L
V
L
S
K
Site 11
S237
P
T
P
G
L
V
L
S
K
P
A
L
E
E
E
Site 12
S251
E
E
A
P
R
A
L
S
L
L
S
L
P
P
K
Site 13
S254
P
R
A
L
S
L
L
S
L
P
P
K
K
R
S
Site 14
S261
S
L
P
P
K
K
R
S
I
L
G
L
G
Q
A
Site 15
S287
G
S
F
L
V
H
E
S
F
L
Y
K
R
E
K
Site 16
Y290
L
V
H
E
S
F
L
Y
K
R
E
K
A
V
G
Site 17
Y301
K
A
V
G
D
K
V
Y
W
T
C
R
D
H
A
Site 18
T318
G
C
R
S
R
A
I
T
Q
G
Q
R
V
T
V
Site 19
S360
A
G
Q
D
G
P
G
S
Q
V
D
T
L
L
R
Site 20
T364
G
P
G
S
Q
V
D
T
L
L
R
G
V
D
S
Site 21
S371
T
L
L
R
G
V
D
S
L
L
Y
R
R
G
P
Site 22
Y374
R
G
V
D
S
L
L
Y
R
R
G
P
G
P
L
Site 23
T382
R
R
G
P
G
P
L
T
L
T
R
P
R
P
R
Site 24
T384
G
P
G
P
L
T
L
T
R
P
R
P
R
K
R
Site 25
S435
G
S
F
L
V
Y
E
S
F
L
Y
R
R
E
K
Site 26
Y438
L
V
Y
E
S
F
L
Y
R
R
E
K
A
A
G
Site 27
S462
Q
A
R
M
G
C
R
S
R
A
I
T
Q
G
R
Site 28
T466
G
C
R
S
R
A
I
T
Q
G
R
R
V
T
V
Site 29
T498
Q
R
E
K
R
P
N
T
A
Q
R
G
S
P
G
Site 30
S503
P
N
T
A
Q
R
G
S
P
G
G
P
E
F
L
Site 31
T554
G
C
R
S
R
A
I
T
Q
G
R
R
V
M
V
Site 32
S591
P
N
L
A
Q
W
D
S
P
D
P
L
R
P
L
Site 33
T603
R
P
L
E
F
L
R
T
S
L
G
G
R
F
L
Site 34
S614
G
R
F
L
V
H
E
S
F
L
Y
R
K
E
K
Site 35
Y617
L
V
H
E
S
F
L
Y
R
K
E
K
A
A
G
Site 36
S641
Q
A
R
L
G
C
R
S
R
A
I
T
Q
G
H
Site 37
T645
G
C
R
S
R
A
I
T
Q
G
H
R
I
M
V
Site 38
T676
R
Q
R
E
R
L
P
T
T
A
Q
Q
E
D
P
Site 39
T694
Q
V
Q
L
C
F
K
T
C
S
P
E
S
Q
Q
Site 40
S696
Q
L
C
F
K
T
C
S
P
E
S
Q
Q
I
Y
Site 41
Y703
S
P
E
S
Q
Q
I
Y
G
D
I
K
D
V
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation