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Updated November 2019
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Protein Info
Short Name:
FAM75A4
Full Name:
Protein FAM75A4
Alias:
Type:
Membrane protein
Mass (Da):
148755
Number AA:
1347
UniProt ID:
Q4VX67
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
P
L
K
L
L
S
A
S
S
L
N
A
P
S
S
Site 2
S20
A
S
S
L
N
A
P
S
S
T
P
W
V
L
D
Site 3
S21
S
S
L
N
A
P
S
S
T
P
W
V
L
D
I
Site 4
Y48
V
L
L
P
Y
L
S
Y
F
R
C
D
D
P
P
Site 5
S56
F
R
C
D
D
P
P
S
P
S
P
G
K
R
K
Site 6
S58
C
D
D
P
P
S
P
S
P
G
K
R
K
C
P
Site 7
S80
R
G
R
M
K
N
H
S
L
R
A
G
R
E
C
Site 8
T94
C
R
R
G
L
E
E
T
S
D
L
L
S
Q
L
Site 9
S95
R
R
G
L
E
E
T
S
D
L
L
S
Q
L
Q
Site 10
S99
E
E
T
S
D
L
L
S
Q
L
Q
S
L
L
G
Site 11
S103
D
L
L
S
Q
L
Q
S
L
L
G
P
H
L
D
Site 12
S118
K
G
D
F
G
Q
L
S
G
P
D
P
P
G
E
Site 13
S135
E
R
A
P
D
G
A
S
Q
S
S
H
E
P
M
Site 14
S137
A
P
D
G
A
S
Q
S
S
H
E
P
M
E
D
Site 15
S150
E
D
A
A
P
I
L
S
P
L
A
S
P
D
P
Site 16
S154
P
I
L
S
P
L
A
S
P
D
P
Q
A
K
H
Site 17
S167
K
H
P
Q
D
L
A
S
T
P
S
P
G
P
M
Site 18
T168
H
P
Q
D
L
A
S
T
P
S
P
G
P
M
T
Site 19
S170
Q
D
L
A
S
T
P
S
P
G
P
M
T
T
S
Site 20
T175
T
P
S
P
G
P
M
T
T
S
V
S
S
L
S
Site 21
T176
P
S
P
G
P
M
T
T
S
V
S
S
L
S
A
Site 22
S177
S
P
G
P
M
T
T
S
V
S
S
L
S
A
S
Site 23
S179
G
P
M
T
T
S
V
S
S
L
S
A
S
Q
P
Site 24
S180
P
M
T
T
S
V
S
S
L
S
A
S
Q
P
P
Site 25
S182
T
T
S
V
S
S
L
S
A
S
Q
P
P
E
P
Site 26
S184
S
V
S
S
L
S
A
S
Q
P
P
E
P
S
L
Site 27
S190
A
S
Q
P
P
E
P
S
L
P
L
E
H
P
S
Site 28
S197
S
L
P
L
E
H
P
S
P
E
P
P
A
L
F
Site 29
T210
L
F
P
H
P
P
H
T
P
D
P
L
A
C
S
Site 30
S217
T
P
D
P
L
A
C
S
L
P
P
P
K
G
F
Site 31
S232
T
A
P
P
L
R
D
S
T
L
I
T
P
S
H
Site 32
T233
A
P
P
L
R
D
S
T
L
I
T
P
S
H
C
Site 33
T236
L
R
D
S
T
L
I
T
P
S
H
C
D
S
V
Site 34
S253
P
L
G
T
V
P
Q
S
L
S
P
H
E
D
L
Site 35
S255
G
T
V
P
Q
S
L
S
P
H
E
D
L
V
A
Site 36
S273
A
I
S
G
L
G
G
S
N
S
H
V
S
A
S
Site 37
S275
S
G
L
G
G
S
N
S
H
V
S
A
S
S
R
Site 38
S278
G
G
S
N
S
H
V
S
A
S
S
R
W
Q
E
Site 39
S280
S
N
S
H
V
S
A
S
S
R
W
Q
E
T
A
Site 40
T286
A
S
S
R
W
Q
E
T
A
R
T
S
C
A
F
Site 41
T289
R
W
Q
E
T
A
R
T
S
C
A
F
N
S
S
Site 42
S290
W
Q
E
T
A
R
T
S
C
A
F
N
S
S
V
Site 43
S295
R
T
S
C
A
F
N
S
S
V
Q
Q
D
H
L
Site 44
S296
T
S
C
A
F
N
S
S
V
Q
Q
D
H
L
S
Site 45
S303
S
V
Q
Q
D
H
L
S
R
H
P
P
E
T
C
Site 46
T309
L
S
R
H
P
P
E
T
C
Q
M
E
A
G
S
Site 47
S349
E
E
K
E
N
V
G
S
F
T
N
R
M
T
P
Site 48
T355
G
S
F
T
N
R
M
T
P
E
K
H
L
N
S
Site 49
S362
T
P
E
K
H
L
N
S
L
R
N
L
A
K
S
Site 50
S369
S
L
R
N
L
A
K
S
L
D
A
E
Q
D
T
Site 51
T376
S
L
D
A
E
Q
D
T
T
N
P
K
P
F
W
Site 52
T377
L
D
A
E
Q
D
T
T
N
P
K
P
F
W
N
Site 53
S399
L
P
G
P
Q
K
L
S
D
P
R
L
W
Q
E
Site 54
T434
L
V
A
N
A
W
V
T
D
R
S
Y
T
L
Q
Site 55
S437
N
A
W
V
T
D
R
S
Y
T
L
Q
S
P
P
Site 56
Y438
A
W
V
T
D
R
S
Y
T
L
Q
S
P
P
F
Site 57
T439
W
V
T
D
R
S
Y
T
L
Q
S
P
P
F
L
Site 58
S442
D
R
S
Y
T
L
Q
S
P
P
F
L
F
N
E
Site 59
T461
C
P
I
Q
R
E
T
T
M
S
P
L
L
F
Q
Site 60
S463
I
Q
R
E
T
T
M
S
P
L
L
F
Q
A
Q
Site 61
S473
L
F
Q
A
Q
P
L
S
H
L
G
P
E
C
Q
Site 62
S485
E
C
Q
P
F
I
S
S
T
P
Q
F
R
P
T
Site 63
T486
C
Q
P
F
I
S
S
T
P
Q
F
R
P
T
P
Site 64
T492
S
T
P
Q
F
R
P
T
P
M
A
Q
A
E
A
Site 65
S505
E
A
Q
A
H
L
Q
S
S
F
P
V
L
S
P
Site 66
S536
Q
N
K
V
Q
A
L
S
L
P
E
T
Q
H
P
Site 67
T540
Q
A
L
S
L
P
E
T
Q
H
P
E
W
P
L
Site 68
S560
E
G
R
L
A
L
P
S
R
V
Q
K
S
Q
D
Site 69
S565
L
P
S
R
V
Q
K
S
Q
D
V
F
S
V
S
Site 70
S570
Q
K
S
Q
D
V
F
S
V
S
T
P
N
L
P
Site 71
S572
S
Q
D
V
F
S
V
S
T
P
N
L
P
Q
E
Site 72
T573
Q
D
V
F
S
V
S
T
P
N
L
P
Q
E
S
Site 73
S580
T
P
N
L
P
Q
E
S
L
T
S
I
L
P
E
Site 74
S583
L
P
Q
E
S
L
T
S
I
L
P
E
N
F
P
Site 75
S592
L
P
E
N
F
P
V
S
P
E
L
R
R
Q
L
Site 76
S630
L
M
Q
L
R
D
E
S
P
G
T
S
Q
A
K
Site 77
T633
L
R
D
E
S
P
G
T
S
Q
A
K
G
K
P
Site 78
S634
R
D
E
S
P
G
T
S
Q
A
K
G
K
P
S
Site 79
S641
S
Q
A
K
G
K
P
S
P
W
Q
S
S
M
S
Site 80
S645
G
K
P
S
P
W
Q
S
S
M
S
T
G
E
S
Site 81
S646
K
P
S
P
W
Q
S
S
M
S
T
G
E
S
S
Site 82
S648
S
P
W
Q
S
S
M
S
T
G
E
S
S
K
E
Site 83
T649
P
W
Q
S
S
M
S
T
G
E
S
S
K
E
A
Site 84
S652
S
S
M
S
T
G
E
S
S
K
E
A
Q
K
V
Site 85
S653
S
M
S
T
G
E
S
S
K
E
A
Q
K
V
K
Site 86
T678
L
G
Q
I
L
G
E
T
P
Q
N
L
S
R
D
Site 87
S683
G
E
T
P
Q
N
L
S
R
D
M
K
S
F
P
Site 88
S688
N
L
S
R
D
M
K
S
F
P
R
K
V
L
G
Site 89
S698
R
K
V
L
G
V
T
S
E
E
L
E
R
N
L
Site 90
S711
N
L
R
K
P
L
R
S
D
S
G
S
D
L
L
Site 91
S713
R
K
P
L
R
S
D
S
G
S
D
L
L
R
C
Site 92
S715
P
L
R
S
D
S
G
S
D
L
L
R
C
T
E
Site 93
T721
G
S
D
L
L
R
C
T
E
R
T
H
I
E
N
Site 94
T724
L
L
R
C
T
E
R
T
H
I
E
N
I
L
K
Site 95
T741
M
G
R
N
L
G
Q
T
N
E
G
L
I
P
V
Site 96
S753
I
P
V
R
V
R
R
S
W
L
A
V
N
Q
A
Site 97
S764
V
N
Q
A
L
P
V
S
N
T
H
V
K
T
S
Site 98
T766
Q
A
L
P
V
S
N
T
H
V
K
T
S
N
L
Site 99
S778
S
N
L
A
A
P
K
S
G
K
A
C
V
N
T
Site 100
T796
L
S
F
L
E
P
C
T
Q
Q
G
L
G
A
H
Site 101
T837
K
V
S
S
L
S
L
T
Q
L
A
G
P
S
S
Site 102
S844
T
Q
L
A
G
P
S
S
A
T
C
E
S
G
A
Site 103
S849
P
S
S
A
T
C
E
S
G
A
G
S
E
V
E
Site 104
S853
T
C
E
S
G
A
G
S
E
V
E
V
D
M
F
Site 105
S868
L
R
K
P
P
M
A
S
L
R
K
Q
V
L
T
Site 106
T875
S
L
R
K
Q
V
L
T
K
A
S
D
H
M
P
Site 107
S884
A
S
D
H
M
P
E
S
L
L
A
S
S
P
A
Site 108
S888
M
P
E
S
L
L
A
S
S
P
A
W
K
Q
F
Site 109
S889
P
E
S
L
L
A
S
S
P
A
W
K
Q
F
Q
Site 110
S924
G
Q
E
G
R
W
P
S
K
P
L
T
Y
S
L
Site 111
T928
R
W
P
S
K
P
L
T
Y
S
L
T
G
S
I
Site 112
S930
P
S
K
P
L
T
Y
S
L
T
G
S
I
Q
Q
Site 113
T932
K
P
L
T
Y
S
L
T
G
S
I
Q
Q
S
R
Site 114
S934
L
T
Y
S
L
T
G
S
I
Q
Q
S
R
S
L
Site 115
S938
L
T
G
S
I
Q
Q
S
R
S
L
G
A
Q
S
Site 116
S940
G
S
I
Q
Q
S
R
S
L
G
A
Q
S
S
K
Site 117
S946
R
S
L
G
A
Q
S
S
K
A
G
E
T
R
E
Site 118
T985
H
G
F
E
A
P
G
T
S
K
S
S
L
H
P
Site 119
S986
G
F
E
A
P
G
T
S
K
S
S
L
H
P
R
Site 120
S988
E
A
P
G
T
S
K
S
S
L
H
P
R
V
S
Site 121
S989
A
P
G
T
S
K
S
S
L
H
P
R
V
S
V
Site 122
S995
S
S
L
H
P
R
V
S
V
S
Q
D
P
R
K
Site 123
S997
L
H
P
R
V
S
V
S
Q
D
P
R
K
L
C
Site 124
S1021
E
P
G
M
A
T
K
S
E
T
Q
P
Q
V
C
Site 125
S1040
L
L
P
D
G
Q
A
S
V
V
P
H
A
S
E
Site 126
S1051
H
A
S
E
N
L
V
S
Q
V
P
Q
G
H
L
Site 127
S1060
V
P
Q
G
H
L
Q
S
M
P
T
G
N
M
R
Site 128
S1069
P
T
G
N
M
R
A
S
Q
E
L
H
D
L
M
Site 129
S1081
D
L
M
A
A
R
R
S
K
L
V
H
E
E
P
Site 130
S1110
M
F
P
P
I
H
K
S
E
K
S
R
K
P
N
Site 131
S1113
P
I
H
K
S
E
K
S
R
K
P
N
L
E
K
Site 132
T1130
E
R
L
E
G
L
R
T
P
Q
L
T
P
V
R
Site 133
T1134
G
L
R
T
P
Q
L
T
P
V
R
K
T
E
D
Site 134
T1139
Q
L
T
P
V
R
K
T
E
D
T
H
Q
D
E
Site 135
T1142
P
V
R
K
T
E
D
T
H
Q
D
E
G
V
Q
Site 136
S1153
E
G
V
Q
L
L
P
S
K
K
Q
P
P
S
V
Site 137
S1159
P
S
K
K
Q
P
P
S
V
S
P
F
G
E
N
Site 138
S1161
K
K
Q
P
P
S
V
S
P
F
G
E
N
I
K
Site 139
S1180
W
I
F
S
K
K
K
S
K
P
A
P
V
T
A
Site 140
S1189
P
A
P
V
T
A
E
S
Q
K
T
V
K
N
R
Site 141
T1192
V
T
A
E
S
Q
K
T
V
K
N
R
S
R
V
Site 142
S1197
Q
K
T
V
K
N
R
S
R
V
Y
S
S
S
A
Site 143
Y1200
V
K
N
R
S
R
V
Y
S
S
S
A
E
A
Q
Site 144
S1201
K
N
R
S
R
V
Y
S
S
S
A
E
A
Q
G
Site 145
S1203
R
S
R
V
Y
S
S
S
A
E
A
Q
G
L
M
Site 146
S1256
N
H
R
H
L
F
Y
S
E
H
G
R
I
L
S
Site 147
S1263
S
E
H
G
R
I
L
S
Y
A
A
S
S
Q
Q
Site 148
Y1264
E
H
G
R
I
L
S
Y
A
A
S
S
Q
Q
A
Site 149
S1267
R
I
L
S
Y
A
A
S
S
Q
Q
A
T
L
K
Site 150
S1268
I
L
S
Y
A
A
S
S
Q
Q
A
T
L
K
S
Site 151
T1272
A
A
S
S
Q
Q
A
T
L
K
S
Q
G
C
P
Site 152
S1275
S
Q
Q
A
T
L
K
S
Q
G
C
P
N
R
D
Site 153
S1293
R
N
Q
Q
P
L
K
S
V
R
C
N
N
E
Q
Site 154
S1316
L
H
P
K
K
A
V
S
P
V
S
P
P
Q
H
Site 155
S1319
K
K
A
V
S
P
V
S
P
P
Q
H
W
P
K
Site 156
T1327
P
P
Q
H
W
P
K
T
S
G
A
S
S
H
H
Site 157
S1328
P
Q
H
W
P
K
T
S
G
A
S
S
H
H
H
Site 158
S1332
P
K
T
S
G
A
S
S
H
H
H
H
C
P
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation