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Updated November 2019
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Protein Info
Short Name:
GREB1
Full Name:
Protein GREB1
Alias:
Gene regulated in breast cancer 1 protein
Type:
Mass (Da):
216467
Number AA:
1949
UniProt ID:
Q4ZG55
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T11
S
Y
A
G
Q
L
K
T
T
R
F
E
E
V
L
Site 2
S21
F
E
E
V
L
H
N
S
I
E
A
S
L
R
S
Site 3
S25
L
H
N
S
I
E
A
S
L
R
S
N
N
L
V
Site 4
Y41
R
P
I
F
S
Q
L
Y
L
E
A
E
Q
Q
L
Site 5
T72
E
G
E
G
G
L
E
T
N
G
P
P
N
P
F
Site 6
S105
G
K
D
L
R
L
V
S
I
S
N
E
P
M
D
Site 7
S107
D
L
R
L
V
S
I
S
N
E
P
M
D
V
P
Site 8
T180
N
H
I
N
L
K
L
T
T
Q
P
K
K
Q
K
Site 9
Y191
K
K
Q
K
H
L
K
Y
Y
L
V
R
N
A
Q
Site 10
Y192
K
Q
K
H
L
K
Y
Y
L
V
R
N
A
Q
G
Site 11
T202
R
N
A
Q
G
T
L
T
K
G
P
L
I
C
W
Site 12
S212
P
L
I
C
W
K
G
S
E
F
R
S
R
Q
I
Site 13
S216
W
K
G
S
E
F
R
S
R
Q
I
P
A
S
T
Site 14
S222
R
S
R
Q
I
P
A
S
T
C
S
S
S
L
F
Site 15
T223
S
R
Q
I
P
A
S
T
C
S
S
S
L
F
P
Site 16
S240
E
S
T
A
A
F
P
S
E
P
V
P
G
T
N
Site 17
T246
P
S
E
P
V
P
G
T
N
P
S
I
L
M
G
Site 18
S249
P
V
P
G
T
N
P
S
I
L
M
G
A
Q
Q
Site 19
S261
A
Q
Q
A
G
P
A
S
D
H
P
S
L
N
A
Site 20
S265
G
P
A
S
D
H
P
S
L
N
A
A
M
G
P
Site 21
S280
A
V
F
N
G
K
D
S
P
K
C
Q
Q
L
A
Site 22
S304
P
S
A
L
G
I
L
S
N
S
G
P
P
K
K
Site 23
S306
A
L
G
I
L
S
N
S
G
P
P
K
K
R
H
Site 24
S317
K
K
R
H
K
G
W
S
P
E
S
P
S
A
P
Site 25
S320
H
K
G
W
S
P
E
S
P
S
A
P
D
G
G
Site 26
S322
G
W
S
P
E
S
P
S
A
P
D
G
G
C
P
Site 27
Y338
G
G
G
N
R
A
K
Y
E
S
A
G
M
S
C
Site 28
S340
G
N
R
A
K
Y
E
S
A
G
M
S
C
V
P
Site 29
Y393
K
G
H
G
N
F
P
Y
L
C
G
N
L
N
D
Site 30
Y411
S
P
L
L
Y
T
C
Y
Q
N
S
Q
S
V
S
Site 31
S414
L
Y
T
C
Y
Q
N
S
Q
S
V
S
R
A
Y
Site 32
S416
T
C
Y
Q
N
S
Q
S
V
S
R
A
Y
E
Q
Site 33
S418
Y
Q
N
S
Q
S
V
S
R
A
Y
E
Q
Y
G
Site 34
Y421
S
Q
S
V
S
R
A
Y
E
Q
Y
G
A
S
A
Site 35
Y424
V
S
R
A
Y
E
Q
Y
G
A
S
A
I
Q
P
Site 36
S466
L
E
Q
I
F
L
R
S
W
R
E
S
H
L
T
Site 37
S470
F
L
R
S
W
R
E
S
H
L
T
E
I
R
Q
Site 38
T473
S
W
R
E
S
H
L
T
E
I
R
Q
Y
Q
Q
Site 39
Y478
H
L
T
E
I
R
Q
Y
Q
Q
A
P
P
Q
P
Site 40
S574
K
Y
Q
A
R
I
L
S
E
S
L
L
T
P
A
Site 41
S576
Q
A
R
I
L
S
E
S
L
L
T
P
A
E
Y
Site 42
T579
I
L
S
E
S
L
L
T
P
A
E
Y
Q
K
E
Site 43
Y589
E
Y
Q
K
E
V
N
Y
E
L
V
T
G
K
V
Site 44
S628
Q
E
N
Q
G
H
I
S
S
S
L
A
A
S
S
Site 45
S629
E
N
Q
G
H
I
S
S
S
L
A
A
S
S
V
Site 46
S630
N
Q
G
H
I
S
S
S
L
A
A
S
S
V
T
Site 47
S641
S
S
V
T
K
A
A
S
L
D
V
S
G
T
P
Site 48
T647
A
S
L
D
V
S
G
T
P
V
C
T
S
Y
N
Site 49
S652
S
G
T
P
V
C
T
S
Y
N
L
E
P
H
S
Site 50
S659
S
Y
N
L
E
P
H
S
I
R
P
F
Q
L
A
Site 51
S677
K
L
L
S
H
V
C
S
I
A
D
S
S
T
Q
Site 52
S681
H
V
C
S
I
A
D
S
S
T
Q
N
L
D
L
Site 53
T683
C
S
I
A
D
S
S
T
Q
N
L
D
L
G
S
Site 54
S690
T
Q
N
L
D
L
G
S
F
E
K
V
D
F
L
Site 55
Y707
I
P
P
S
E
V
T
Y
Q
Q
T
L
L
H
V
Site 56
Y738
T
K
Q
R
V
E
Q
Y
V
L
K
L
D
T
E
Site 57
S757
F
K
A
F
L
Q
N
S
F
Q
N
P
H
T
L
Site 58
T763
N
S
F
Q
N
P
H
T
L
F
V
L
I
H
D
Site 59
T780
H
W
D
L
V
S
S
T
V
H
N
L
Y
S
Q
Site 60
Y785
S
S
T
V
H
N
L
Y
S
Q
S
D
P
S
V
Site 61
S786
S
T
V
H
N
L
Y
S
Q
S
D
P
S
V
G
Site 62
S788
V
H
N
L
Y
S
Q
S
D
P
S
V
G
L
V
Site 63
S791
L
Y
S
Q
S
D
P
S
V
G
L
V
D
R
L
Site 64
T824
S
F
P
Y
A
L
Q
T
Q
H
T
L
I
S
P
Site 65
Y848
C
S
N
G
V
D
L
Y
H
E
N
K
K
Y
F
Site 66
Y854
L
Y
H
E
N
K
K
Y
F
G
L
S
E
F
I
Site 67
S858
N
K
K
Y
F
G
L
S
E
F
I
E
S
T
L
Site 68
T864
L
S
E
F
I
E
S
T
L
S
G
H
S
L
P
Site 69
S869
E
S
T
L
S
G
H
S
L
P
L
L
R
Y
D
Site 70
Y875
H
S
L
P
L
L
R
Y
D
S
S
F
E
A
M
Site 71
S895
K
R
F
P
R
L
H
S
A
V
I
R
T
F
V
Site 72
Y923
G
L
P
Q
M
K
N
Y
T
S
V
E
T
L
E
Site 73
S925
P
Q
M
K
N
Y
T
S
V
E
T
L
E
I
T
Site 74
S938
I
T
Q
N
L
L
N
S
P
K
Q
C
P
C
G
Site 75
T992
G
S
P
S
S
G
V
T
V
G
K
H
F
V
K
Site 76
T1016
D
V
E
W
R
P
Q
T
Y
L
E
L
E
G
L
Site 77
Y1017
V
E
W
R
P
Q
T
Y
L
E
L
E
G
L
P
Site 78
S1038
G
M
D
P
H
G
E
S
L
P
R
S
L
R
Y
Site 79
S1042
H
G
E
S
L
P
R
S
L
R
Y
C
D
L
R
Site 80
S1089
A
R
N
E
A
L
E
S
D
A
E
K
L
S
S
Site 81
S1096
S
D
A
E
K
L
S
S
T
D
N
E
D
E
E
Site 82
T1106
N
E
D
E
E
L
G
T
E
G
S
T
S
E
K
Site 83
S1109
E
E
L
G
T
E
G
S
T
S
E
K
R
S
P
Site 84
S1111
L
G
T
E
G
S
T
S
E
K
R
S
P
M
K
Site 85
S1115
G
S
T
S
E
K
R
S
P
M
K
R
E
R
S
Site 86
S1122
S
P
M
K
R
E
R
S
R
S
H
D
S
A
S
Site 87
S1124
M
K
R
E
R
S
R
S
H
D
S
A
S
S
S
Site 88
S1127
E
R
S
R
S
H
D
S
A
S
S
S
L
S
S
Site 89
S1129
S
R
S
H
D
S
A
S
S
S
L
S
S
K
A
Site 90
S1130
R
S
H
D
S
A
S
S
S
L
S
S
K
A
S
Site 91
S1131
S
H
D
S
A
S
S
S
L
S
S
K
A
S
G
Site 92
S1133
D
S
A
S
S
S
L
S
S
K
A
S
G
S
A
Site 93
S1134
S
A
S
S
S
L
S
S
K
A
S
G
S
A
L
Site 94
S1137
S
S
L
S
S
K
A
S
G
S
A
L
G
G
E
Site 95
S1139
L
S
S
K
A
S
G
S
A
L
G
G
E
S
S
Site 96
S1146
S
A
L
G
G
E
S
S
A
Q
P
T
A
L
P
Site 97
T1150
G
E
S
S
A
Q
P
T
A
L
P
Q
G
E
H
Site 98
S1160
P
Q
G
E
H
A
R
S
P
Q
P
R
G
P
A
Site 99
S1182
E
K
Q
R
P
R
A
S
Q
G
P
P
S
A
I
Site 100
S1187
R
A
S
Q
G
P
P
S
A
I
S
R
H
S
P
Site 101
S1190
Q
G
P
P
S
A
I
S
R
H
S
P
G
P
T
Site 102
S1193
P
S
A
I
S
R
H
S
P
G
P
T
P
Q
P
Site 103
T1197
S
R
H
S
P
G
P
T
P
Q
P
D
C
S
L
Site 104
S1203
P
T
P
Q
P
D
C
S
L
R
T
G
Q
R
S
Site 105
T1206
Q
P
D
C
S
L
R
T
G
Q
R
S
V
Q
V
Site 106
S1210
S
L
R
T
G
Q
R
S
V
Q
V
S
V
T
S
Site 107
S1214
G
Q
R
S
V
Q
V
S
V
T
S
S
C
S
Q
Site 108
T1216
R
S
V
Q
V
S
V
T
S
S
C
S
Q
L
S
Site 109
S1217
S
V
Q
V
S
V
T
S
S
C
S
Q
L
S
S
Site 110
S1218
V
Q
V
S
V
T
S
S
C
S
Q
L
S
S
S
Site 111
S1220
V
S
V
T
S
S
C
S
Q
L
S
S
S
S
G
Site 112
S1223
T
S
S
C
S
Q
L
S
S
S
S
G
S
S
S
Site 113
S1224
S
S
C
S
Q
L
S
S
S
S
G
S
S
S
S
Site 114
S1225
S
C
S
Q
L
S
S
S
S
G
S
S
S
S
S
Site 115
S1226
C
S
Q
L
S
S
S
S
G
S
S
S
S
S
V
Site 116
S1228
Q
L
S
S
S
S
G
S
S
S
S
S
V
A
P
Site 117
S1229
L
S
S
S
S
G
S
S
S
S
S
V
A
P
A
Site 118
S1230
S
S
S
S
G
S
S
S
S
S
V
A
P
A
A
Site 119
S1231
S
S
S
G
S
S
S
S
S
V
A
P
A
A
G
Site 120
S1232
S
S
G
S
S
S
S
S
V
A
P
A
A
G
T
Site 121
T1272
V
Y
D
M
V
V
S
T
D
S
S
G
L
P
K
Site 122
S1288
A
S
L
L
P
S
P
S
V
M
W
A
S
S
F
Site 123
S1294
P
S
V
M
W
A
S
S
F
R
P
L
L
S
K
Site 124
S1300
S
S
F
R
P
L
L
S
K
T
M
T
S
T
E
Site 125
T1302
F
R
P
L
L
S
K
T
M
T
S
T
E
Q
S
Site 126
T1304
P
L
L
S
K
T
M
T
S
T
E
Q
S
L
Y
Site 127
S1305
L
L
S
K
T
M
T
S
T
E
Q
S
L
Y
Y
Site 128
Y1311
T
S
T
E
Q
S
L
Y
Y
R
Q
W
T
V
P
Site 129
T1316
S
L
Y
Y
R
Q
W
T
V
P
R
P
S
H
M
Site 130
Y1325
P
R
P
S
H
M
D
Y
G
N
R
A
E
G
R
Site 131
S1344
H
P
R
R
L
L
L
S
G
P
P
Q
I
G
K
Site 132
T1370
S
R
M
L
V
R
L
T
E
V
D
V
Y
D
E
Site 133
Y1375
R
L
T
E
V
D
V
Y
D
E
E
E
I
N
I
Site 134
Y1392
R
E
E
S
D
W
H
Y
L
Q
L
S
D
P
W
Site 135
Y1412
F
K
K
L
P
F
D
Y
I
I
H
D
P
K
Y
Site 136
Y1419
Y
I
I
H
D
P
K
Y
E
D
A
S
L
I
C
Site 137
S1423
D
P
K
Y
E
D
A
S
L
I
C
S
H
Y
Q
Site 138
S1427
E
D
A
S
L
I
C
S
H
Y
Q
G
I
K
S
Site 139
Y1429
A
S
L
I
C
S
H
Y
Q
G
I
K
S
E
D
Site 140
S1434
S
H
Y
Q
G
I
K
S
E
D
R
G
M
S
R
Site 141
S1440
K
S
E
D
R
G
M
S
R
K
P
E
D
L
Y
Site 142
Y1447
S
R
K
P
E
D
L
Y
V
R
R
Q
T
A
R
Site 143
T1452
D
L
Y
V
R
R
Q
T
A
R
M
R
L
S
K
Site 144
S1458
Q
T
A
R
M
R
L
S
K
Y
A
A
Y
N
T
Site 145
Y1460
A
R
M
R
L
S
K
Y
A
A
Y
N
T
Y
H
Site 146
Y1482
Y
M
G
F
H
P
R
Y
Q
L
Y
E
S
T
L
Site 147
Y1485
F
H
P
R
Y
Q
L
Y
E
S
T
L
H
A
F
Site 148
T1488
R
Y
Q
L
Y
E
S
T
L
H
A
F
A
F
S
Site 149
S1520
K
E
H
H
F
V
F
S
Q
P
G
G
Q
L
E
Site 150
S1528
Q
P
G
G
Q
L
E
S
M
R
L
P
L
V
T
Site 151
T1535
S
M
R
L
P
L
V
T
D
K
S
H
E
Y
I
Site 152
S1538
L
P
L
V
T
D
K
S
H
E
Y
I
K
S
P
Site 153
S1544
K
S
H
E
Y
I
K
S
P
T
F
T
P
T
T
Site 154
T1546
H
E
Y
I
K
S
P
T
F
T
P
T
T
G
R
Site 155
T1548
Y
I
K
S
P
T
F
T
P
T
T
G
R
H
E
Site 156
T1550
K
S
P
T
F
T
P
T
T
G
R
H
E
H
G
Site 157
T1551
S
P
T
F
T
P
T
T
G
R
H
E
H
G
L
Site 158
Y1562
E
H
G
L
F
N
L
Y
H
A
M
D
G
A
S
Site 159
Y1579
H
V
L
V
V
K
E
Y
E
M
A
I
Y
K
K
Site 160
Y1584
K
E
Y
E
M
A
I
Y
K
K
Y
W
P
N
H
Site 161
S1616
H
F
L
I
K
E
L
S
Y
H
N
L
E
L
E
Site 162
S1658
W
N
V
V
D
V
N
S
A
G
E
R
S
R
E
Site 163
S1663
V
N
S
A
G
E
R
S
R
E
F
S
W
S
E
Site 164
S1667
G
E
R
S
R
E
F
S
W
S
E
R
N
V
S
Site 165
S1669
R
S
R
E
F
S
W
S
E
R
N
V
S
L
K
Site 166
S1700
L
L
G
L
R
K
W
S
S
K
T
R
A
S
E
Site 167
S1701
L
G
L
R
K
W
S
S
K
T
R
A
S
E
V
Site 168
S1706
W
S
S
K
T
R
A
S
E
V
Q
E
P
F
S
Site 169
T1728
I
I
L
N
V
D
L
T
Q
N
V
Q
Y
N
Q
Site 170
T1780
G
H
R
S
F
H
I
T
S
K
V
S
D
N
S
Site 171
S1781
H
R
S
F
H
I
T
S
K
V
S
D
N
S
A
Site 172
S1787
T
S
K
V
S
D
N
S
A
A
V
V
P
A
Q
Site 173
S1822
E
K
F
L
Q
H
H
S
H
L
F
F
P
L
S
Site 174
S1829
S
H
L
F
F
P
L
S
L
K
N
H
D
H
P
Site 175
Y1854
G
S
Q
I
S
V
C
Y
V
S
S
R
P
H
S
Site 176
S1856
Q
I
S
V
C
Y
V
S
S
R
P
H
S
L
N
Site 177
S1861
Y
V
S
S
R
P
H
S
L
N
I
S
C
S
D
Site 178
S1865
R
P
H
S
L
N
I
S
C
S
D
L
L
F
S
Site 179
S1908
V
I
C
Q
D
R
S
S
L
R
Q
T
V
V
R
Site 180
T1912
D
R
S
S
L
R
Q
T
V
V
R
L
E
L
E
Site 181
T1932
R
L
R
D
E
F
Q
T
A
N
A
R
E
D
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation