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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PAN2
Full Name:
PAB-dependent poly(A)-specific ribonuclease subunit 2
Alias:
EC=3.1.13.4; Inactive ubiquitin carboxyl-terminal hydrolase 52; KIAA0710; USP52
Type:
Nuclease
Mass (Da):
135368
Number AA:
1202
UniProt ID:
Q504Q3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0004535
GO:0004221
PhosphoSite+
KinaseNET
Biological Process:
GO:0000184
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S99
S
H
G
G
H
A
T
S
F
F
G
P
A
L
E
Site 2
Y108
F
G
P
A
L
E
R
Y
S
S
F
Q
V
N
G
Site 3
S109
G
P
A
L
E
R
Y
S
S
F
Q
V
N
G
S
Site 4
S110
P
A
L
E
R
Y
S
S
F
Q
V
N
G
S
D
Site 5
S116
S
S
F
Q
V
N
G
S
D
D
I
R
Q
I
Q
Site 6
T133
E
N
G
I
L
F
L
T
K
N
N
L
K
Y
M
Site 7
Y139
L
T
K
N
N
L
K
Y
M
A
R
G
G
L
I
Site 8
Y150
G
G
L
I
I
F
D
Y
L
L
D
E
N
E
D
Site 9
S160
D
E
N
E
D
M
H
S
L
L
L
T
D
S
S
Site 10
T185
I
L
E
I
D
L
N
T
V
Q
E
T
Q
K
Y
Site 11
Y192
T
V
Q
E
T
Q
K
Y
A
V
E
T
P
G
V
Site 12
T196
T
Q
K
Y
A
V
E
T
P
G
V
T
I
M
R
Site 13
S219
G
H
T
S
G
K
V
S
L
R
D
L
R
T
F
Site 14
T225
V
S
L
R
D
L
R
T
F
K
V
E
H
E
F
Site 15
S236
E
H
E
F
D
A
F
S
G
S
L
S
D
F
D
Site 16
S238
E
F
D
A
F
S
G
S
L
S
D
F
D
V
H
Site 17
S240
D
A
F
S
G
S
L
S
D
F
D
V
H
G
N
Site 18
Y270
C
D
R
F
L
K
V
Y
D
L
R
M
M
R
A
Site 19
S304
T
S
R
L
A
I
I
S
Q
S
G
Q
C
Q
F
Site 20
T358
E
G
C
V
H
L
W
T
D
S
P
E
P
S
F
Site 21
S360
C
V
H
L
W
T
D
S
P
E
P
S
F
N
P
Site 22
S364
W
T
D
S
P
E
P
S
F
N
P
Y
S
R
E
Site 23
Y368
P
E
P
S
F
N
P
Y
S
R
E
T
E
F
A
Site 24
S369
E
P
S
F
N
P
Y
S
R
E
T
E
F
A
L
Site 25
T372
F
N
P
Y
S
R
E
T
E
F
A
L
P
C
L
Site 26
S389
S
L
P
P
L
D
W
S
Q
D
L
L
P
L
S
Site 27
S409
L
T
T
D
T
L
L
S
D
W
P
A
A
N
S
Site 28
Y456
R
L
R
N
Q
I
P
Y
R
L
K
E
S
D
S
Site 29
S461
I
P
Y
R
L
K
E
S
D
S
E
F
D
S
F
Site 30
S463
Y
R
L
K
E
S
D
S
E
F
D
S
F
S
Q
Site 31
S467
E
S
D
S
E
F
D
S
F
S
Q
V
T
E
S
Site 32
S469
D
S
E
F
D
S
F
S
Q
V
T
E
S
P
V
Site 33
T472
F
D
S
F
S
Q
V
T
E
S
P
V
G
R
E
Site 34
S474
S
F
S
Q
V
T
E
S
P
V
G
R
E
E
E
Site 35
S488
E
P
H
L
H
M
V
S
K
K
Y
R
K
V
T
Site 36
Y491
L
H
M
V
S
K
K
Y
R
K
V
T
I
K
Y
Site 37
T495
S
K
K
Y
R
K
V
T
I
K
Y
S
K
L
G
Site 38
Y498
Y
R
K
V
T
I
K
Y
S
K
L
G
L
E
D
Site 39
T514
D
F
K
H
Y
N
K
T
L
F
A
G
L
E
P
Site 40
S570
L
F
H
M
L
D
L
S
R
G
D
P
C
Q
G
Site 41
S604
L
A
D
S
D
E
A
S
G
K
G
N
L
A
R
Site 42
Y637
E
L
E
I
P
Q
A
Y
R
G
A
G
G
S
S
Site 43
S643
A
Y
R
G
A
G
G
S
S
F
C
S
S
G
D
Site 44
S644
Y
R
G
A
G
G
S
S
F
C
S
S
G
D
S
Site 45
S648
G
G
S
S
F
C
S
S
G
D
S
V
I
G
Q
Site 46
S671
C
S
L
C
R
C
G
S
E
T
V
R
A
S
S
Site 47
T673
L
C
R
C
G
S
E
T
V
R
A
S
S
T
L
Site 48
S677
G
S
E
T
V
R
A
S
S
T
L
L
F
T
L
Site 49
S685
S
T
L
L
F
T
L
S
Y
P
D
G
S
K
S
Site 50
Y686
T
L
L
F
T
L
S
Y
P
D
G
S
K
S
D
Site 51
S690
T
L
S
Y
P
D
G
S
K
S
D
K
T
G
K
Site 52
S692
S
Y
P
D
G
S
K
S
D
K
T
G
K
N
Y
Site 53
T695
D
G
S
K
S
D
K
T
G
K
N
Y
D
F
A
Site 54
Y699
S
D
K
T
G
K
N
Y
D
F
A
Q
V
L
K
Site 55
T728
T
C
E
K
Y
Q
P
T
I
Q
T
R
N
I
R
Site 56
T731
K
Y
Q
P
T
I
Q
T
R
N
I
R
H
L
P
Site 57
S776
K
K
H
G
G
E
I
S
K
N
K
E
F
A
L
Site 58
S791
A
D
W
K
E
L
G
S
P
E
G
V
L
V
C
Site 59
Y848
A
E
E
E
H
G
V
Y
V
Y
D
L
M
A
T
Site 60
Y878
H
I
K
V
G
E
T
Y
H
Q
R
K
E
G
V
Site 61
Y920
W
K
V
P
A
I
L
Y
Y
V
K
R
N
L
N
Site 62
Y921
K
V
P
A
I
L
Y
Y
V
K
R
N
L
N
S
Site 63
S928
Y
V
K
R
N
L
N
S
R
Y
N
L
N
I
K
Site 64
S948
S
V
L
L
A
E
A
S
L
A
R
K
Q
R
K
Site 65
T956
L
A
R
K
Q
R
K
T
H
T
T
F
I
P
L
Site 66
T959
K
Q
R
K
T
H
T
T
F
I
P
L
M
L
N
Site 67
S993
E
E
E
A
E
L
R
S
D
G
T
K
S
T
I
Site 68
S998
L
R
S
D
G
T
K
S
T
I
K
P
S
Q
M
Site 69
T999
R
S
D
G
T
K
S
T
I
K
P
S
Q
M
S
Site 70
S1003
T
K
S
T
I
K
P
S
Q
M
S
V
A
R
I
Site 71
T1011
Q
M
S
V
A
R
I
T
C
V
R
G
Q
G
P
Site 72
Y1028
G
I
P
F
I
D
D
Y
I
S
T
Q
E
Q
V
Site 73
S1030
P
F
I
D
D
Y
I
S
T
Q
E
Q
V
V
D
Site 74
Y1038
T
Q
E
Q
V
V
D
Y
L
T
Q
Y
S
G
I
Site 75
T1040
E
Q
V
V
D
Y
L
T
Q
Y
S
G
I
K
P
Site 76
Y1042
V
V
D
Y
L
T
Q
Y
S
G
I
K
P
G
D
Site 77
S1055
G
D
L
D
A
K
I
S
S
K
H
L
T
T
L
Site 78
T1060
K
I
S
S
K
H
L
T
T
L
K
S
T
Y
L
Site 79
S1064
K
H
L
T
T
L
K
S
T
Y
L
K
L
R
F
Site 80
T1103
P
K
D
Q
V
L
D
T
V
Y
L
F
H
M
P
Site 81
Y1105
D
Q
V
L
D
T
V
Y
L
F
H
M
P
R
K
Site 82
S1136
I
Q
G
E
T
H
D
S
I
E
D
A
R
T
A
Site 83
T1142
D
S
I
E
D
A
R
T
A
L
Q
L
Y
R
K
Site 84
Y1150
A
L
Q
L
Y
R
K
Y
L
E
L
S
K
N
G
Site 85
T1158
L
E
L
S
K
N
G
T
E
P
E
S
F
H
K
Site 86
S1162
K
N
G
T
E
P
E
S
F
H
K
V
L
K
G
Site 87
Y1171
H
K
V
L
K
G
L
Y
E
K
G
R
K
M
D
Site 88
S1189
P
E
P
E
G
Q
T
S
P
K
N
A
A
V
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation