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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZCWPW2
Full Name:
Zinc finger CW-type PWWP domain protein 2
Alias:
Type:
Mass (Da):
41376
Number AA:
356
UniProt ID:
Q504Y3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y12
K
L
D
V
K
I
E
Y
C
N
Y
A
M
D
S
Site 2
Y15
V
K
I
E
Y
C
N
Y
A
M
D
S
S
V
E
Site 3
Y25
D
S
S
V
E
N
M
Y
V
N
K
V
W
V
Q
Site 4
S45
C
L
K
W
R
L
L
S
S
E
D
S
A
K
V
Site 5
S46
L
K
W
R
L
L
S
S
E
D
S
A
K
V
D
Site 6
S49
R
L
L
S
S
E
D
S
A
K
V
D
H
D
E
Site 7
Y59
V
D
H
D
E
P
W
Y
C
F
M
N
T
D
S
Site 8
S66
Y
C
F
M
N
T
D
S
R
Y
N
N
C
S
I
Site 9
Y68
F
M
N
T
D
S
R
Y
N
N
C
S
I
S
E
Site 10
S72
D
S
R
Y
N
N
C
S
I
S
E
E
D
F
P
Site 11
S74
R
Y
N
N
C
S
I
S
E
E
D
F
P
E
E
Site 12
S82
E
E
D
F
P
E
E
S
Q
L
H
Q
C
G
F
Site 13
Y93
Q
C
G
F
K
I
V
Y
S
Q
L
P
L
G
S
Site 14
Y125
P
D
R
F
K
G
K
Y
V
T
Y
D
P
D
G
Site 15
T127
R
F
K
G
K
Y
V
T
Y
D
P
D
G
N
V
Site 16
Y128
F
K
G
K
Y
V
T
Y
D
P
D
G
N
V
E
Site 17
Y137
P
D
G
N
V
E
E
Y
H
I
E
F
L
G
D
Site 18
S147
E
F
L
G
D
P
H
S
R
S
W
I
K
A
T
Site 19
S149
L
G
D
P
H
S
R
S
W
I
K
A
T
F
V
Site 20
T154
S
R
S
W
I
K
A
T
F
V
G
H
Y
S
I
Site 21
S160
A
T
F
V
G
H
Y
S
I
T
L
K
P
E
K
Site 22
T162
F
V
G
H
Y
S
I
T
L
K
P
E
K
C
K
Site 23
Y175
C
K
N
K
K
K
W
Y
K
S
A
L
Q
E
A
Site 24
Y186
L
Q
E
A
C
L
L
Y
G
Y
S
H
E
Q
R
Site 25
S189
A
C
L
L
Y
G
Y
S
H
E
Q
R
L
E
M
Site 26
S200
R
L
E
M
C
C
L
S
K
L
Q
D
K
S
E
Site 27
S206
L
S
K
L
Q
D
K
S
E
T
H
D
K
V
A
Site 28
T222
L
V
K
K
R
K
Q
T
S
K
N
N
I
E
K
Site 29
S246
R
K
A
I
L
K
C
S
F
E
N
V
Y
S
D
Site 30
Y251
K
C
S
F
E
N
V
Y
S
D
D
A
L
S
K
Site 31
S252
C
S
F
E
N
V
Y
S
D
D
A
L
S
K
E
Site 32
S257
V
Y
S
D
D
A
L
S
K
E
N
R
V
V
C
Site 33
T266
E
N
R
V
V
C
E
T
E
V
L
L
K
E
L
Site 34
T286
Q
A
L
Q
P
T
A
T
P
D
E
S
E
E
G
Site 35
S290
P
T
A
T
P
D
E
S
E
E
G
H
G
E
E
Site 36
S305
I
N
M
G
E
K
L
S
K
C
S
P
E
A
P
Site 37
S308
G
E
K
L
S
K
C
S
P
E
A
P
A
G
S
Site 38
Y321
G
S
L
F
E
N
H
Y
E
E
D
Y
L
V
I
Site 39
Y325
E
N
H
Y
E
E
D
Y
L
V
I
D
G
I
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation