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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EPC2
Full Name:
Enhancer of polycomb homolog 2
Alias:
EPC-like
Type:
Mass (Da):
91095
Number AA:
807
UniProt ID:
Q52LR7
International Prot ID:
IPI00141118
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006259
GO:0006281
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
K
L
S
F
R
A
R
Site 2
Y20
A
A
K
P
L
P
I
Y
R
G
K
D
M
P
D
Site 3
S33
P
D
L
N
D
C
V
S
I
N
R
A
V
P
Q
Site 4
S60
H
H
L
Q
R
A
I
S
A
Q
Q
V
F
R
E
Site 5
S71
V
F
R
E
K
K
E
S
M
V
I
P
V
P
E
Site 6
Y85
E
A
E
S
N
V
N
Y
Y
N
R
L
Y
K
G
Site 7
Y86
A
E
S
N
V
N
Y
Y
N
R
L
Y
K
G
E
Site 8
Y90
V
N
Y
Y
N
R
L
Y
K
G
E
F
K
Q
P
Site 9
Y115
L
D
N
E
Q
P
D
Y
D
M
D
S
E
D
E
Site 10
S119
Q
P
D
Y
D
M
D
S
E
D
E
T
L
L
N
Site 11
T123
D
M
D
S
E
D
E
T
L
L
N
R
L
N
R
Site 12
S150
I
D
R
L
E
K
A
S
S
N
Q
L
V
T
L
Site 13
S151
D
R
L
E
K
A
S
S
N
Q
L
V
T
L
Q
Site 14
Y175
D
Y
L
I
K
A
V
Y
D
Y
W
V
R
K
R
Site 15
Y177
L
I
K
A
V
Y
D
Y
W
V
R
K
R
K
N
Site 16
S189
R
K
N
C
R
G
P
S
L
I
P
Q
I
K
Q
Site 17
S202
K
Q
E
K
R
D
G
S
T
N
N
D
P
Y
V
Site 18
Y208
G
S
T
N
N
D
P
Y
V
A
F
R
R
R
T
Site 19
T215
Y
V
A
F
R
R
R
T
E
K
M
Q
T
R
K
Site 20
T220
R
R
T
E
K
M
Q
T
R
K
N
R
K
N
D
Site 21
S230
N
R
K
N
D
E
A
S
Y
E
K
M
L
K
L
Site 22
S242
L
K
L
R
R
E
F
S
R
A
I
T
I
L
E
Site 23
T246
R
E
F
S
R
A
I
T
I
L
E
M
I
K
R
Site 24
T257
M
I
K
R
R
E
K
T
K
R
E
L
L
H
L
Site 25
T265
K
R
E
L
L
H
L
T
L
E
V
V
E
K
R
Site 26
Y278
K
R
Y
H
L
G
D
Y
G
G
E
I
L
N
E
Site 27
S289
I
L
N
E
V
K
I
S
R
S
E
K
E
L
Y
Site 28
Y296
S
R
S
E
K
E
L
Y
A
T
P
A
T
L
H
Site 29
T298
S
E
K
E
L
Y
A
T
P
A
T
L
H
N
G
Site 30
S322
T
K
H
P
H
H
L
S
L
K
E
E
A
S
D
Site 31
S328
L
S
L
K
E
E
A
S
D
V
V
R
Q
K
K
Site 32
Y337
V
V
R
Q
K
K
K
Y
P
K
K
P
K
A
E
Site 33
T348
P
K
A
E
A
L
I
T
S
Q
Q
P
T
P
E
Site 34
S349
K
A
E
A
L
I
T
S
Q
Q
P
T
P
E
T
Site 35
T356
S
Q
Q
P
T
P
E
T
L
P
V
I
N
K
S
Site 36
S363
T
L
P
V
I
N
K
S
D
I
K
Q
Y
D
F
Site 37
Y368
N
K
S
D
I
K
Q
Y
D
F
H
S
S
D
E
Site 38
S372
I
K
Q
Y
D
F
H
S
S
D
E
D
E
F
P
Site 39
S373
K
Q
Y
D
F
H
S
S
D
E
D
E
F
P
Q
Site 40
S383
D
E
F
P
Q
V
L
S
P
V
S
E
P
E
E
Site 41
S386
P
Q
V
L
S
P
V
S
E
P
E
E
E
N
D
Site 42
Y408
R
R
R
A
G
C
Q
Y
Y
A
P
R
L
D
Q
Site 43
Y409
R
R
A
G
C
Q
Y
Y
A
P
R
L
D
Q
A
Site 44
S419
R
L
D
Q
A
N
H
S
C
E
N
S
E
L
A
Site 45
S423
A
N
H
S
C
E
N
S
E
L
A
D
L
D
K
Site 46
T438
L
R
Y
R
H
C
L
T
T
L
T
V
P
R
R
Site 47
T439
R
Y
R
H
C
L
T
T
L
T
V
P
R
R
C
Site 48
T441
R
H
C
L
T
T
L
T
V
P
R
R
C
I
G
Site 49
S466
R
V
I
M
D
R
I
S
T
E
H
D
P
V
L
Site 50
T467
V
I
M
D
R
I
S
T
E
H
D
P
V
L
K
Site 51
S483
I
D
P
E
M
L
N
S
F
S
S
S
S
Q
T
Site 52
S485
P
E
M
L
N
S
F
S
S
S
S
Q
T
I
D
Site 53
S486
E
M
L
N
S
F
S
S
S
S
Q
T
I
D
F
Site 54
S487
M
L
N
S
F
S
S
S
S
Q
T
I
D
F
S
Site 55
S488
L
N
S
F
S
S
S
S
Q
T
I
D
F
S
S
Site 56
T490
S
F
S
S
S
S
Q
T
I
D
F
S
S
N
F
Site 57
S494
S
S
Q
T
I
D
F
S
S
N
F
S
R
T
N
Site 58
S495
S
Q
T
I
D
F
S
S
N
F
S
R
T
N
A
Site 59
S498
I
D
F
S
S
N
F
S
R
T
N
A
S
S
K
Site 60
T500
F
S
S
N
F
S
R
T
N
A
S
S
K
H
C
Site 61
S504
F
S
R
T
N
A
S
S
K
H
C
E
N
R
L
Site 62
S512
K
H
C
E
N
R
L
S
L
S
E
I
L
S
N
Site 63
S514
C
E
N
R
L
S
L
S
E
I
L
S
N
I
R
Site 64
S538
R
L
L
N
L
Q
D
S
D
S
E
E
C
T
S
Site 65
S540
L
N
L
Q
D
S
D
S
E
E
C
T
S
R
K
Site 66
T544
D
S
D
S
E
E
C
T
S
R
K
P
G
Q
T
Site 67
S545
S
D
S
E
E
C
T
S
R
K
P
G
Q
T
V
Site 68
T551
T
S
R
K
P
G
Q
T
V
N
N
K
R
V
S
Site 69
S561
N
K
R
V
S
A
A
S
V
A
L
L
N
T
S
Site 70
T585
I
T
E
E
Q
F
Q
T
H
Q
Q
Q
L
V
Q
Site 71
S607
Q
L
Q
Q
K
Q
Q
S
Q
H
S
S
Q
Q
T
Site 72
S611
K
Q
Q
S
Q
H
S
S
Q
Q
T
H
P
K
A
Site 73
T614
S
Q
H
S
S
Q
Q
T
H
P
K
A
Q
G
S
Site 74
S621
T
H
P
K
A
Q
G
S
S
T
S
D
C
M
S
Site 75
S622
H
P
K
A
Q
G
S
S
T
S
D
C
M
S
K
Site 76
S624
K
A
Q
G
S
S
T
S
D
C
M
S
K
T
L
Site 77
S628
S
S
T
S
D
C
M
S
K
T
L
D
S
A
S
Site 78
T630
T
S
D
C
M
S
K
T
L
D
S
A
S
A
H
Site 79
S635
S
K
T
L
D
S
A
S
A
H
F
A
A
S
A
Site 80
S652
S
A
P
V
P
S
R
S
E
V
A
K
E
Q
N
Site 81
S672
I
N
G
V
V
Q
P
S
G
T
S
K
T
L
Y
Site 82
T677
Q
P
S
G
T
S
K
T
L
Y
S
T
N
M
A
Site 83
Y679
S
G
T
S
K
T
L
Y
S
T
N
M
A
L
S
Site 84
S680
G
T
S
K
T
L
Y
S
T
N
M
A
L
S
S
Site 85
T681
T
S
K
T
L
Y
S
T
N
M
A
L
S
S
S
Site 86
S686
Y
S
T
N
M
A
L
S
S
S
P
G
I
S
A
Site 87
T699
S
A
V
Q
L
V
R
T
V
G
H
T
T
T
N
Site 88
T719
L
C
T
S
S
P
Q
T
L
P
M
N
N
S
C
Site 89
T750
N
V
H
I
N
T
R
T
S
A
P
S
P
T
A
Site 90
S751
V
H
I
N
T
R
T
S
A
P
S
P
T
A
L
Site 91
S754
N
T
R
T
S
A
P
S
P
T
A
L
K
L
A
Site 92
T774
M
D
R
V
P
K
V
T
P
S
S
A
I
S
S
Site 93
S780
V
T
P
S
S
A
I
S
S
I
A
R
E
N
H
Site 94
S781
T
P
S
S
A
I
S
S
I
A
R
E
N
H
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation