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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGAP29
Full Name:
Rho GTPase-activating protein 29
Alias:
PARG1; PTPL1-associated RhoGAP protein 1; RHG29; Rho GTPase activating protein 29
Type:
GTPase activating protein, Rac/Rho
Mass (Da):
142064
Number AA:
1261
UniProt ID:
Q52LW3
International Prot ID:
IPI00152011
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005100
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007266
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
K
K
K
R
A
W
A
S
G
Q
L
S
T
D
I
Site 2
S21
A
W
A
S
G
Q
L
S
T
D
I
T
T
S
E
Site 3
T25
G
Q
L
S
T
D
I
T
T
S
E
M
G
L
K
Site 4
S27
L
S
T
D
I
T
T
S
E
M
G
L
K
S
L
Site 5
S33
T
S
E
M
G
L
K
S
L
S
S
N
S
I
F
Site 6
S35
E
M
G
L
K
S
L
S
S
N
S
I
F
D
P
Site 7
S36
M
G
L
K
S
L
S
S
N
S
I
F
D
P
D
Site 8
Y44
N
S
I
F
D
P
D
Y
I
K
E
L
V
N
D
Site 9
S88
E
L
L
R
V
L
K
S
I
M
N
K
H
Q
N
Site 10
S98
N
K
H
Q
N
L
N
S
V
D
L
Q
N
A
A
Site 11
S166
S
L
L
R
L
P
V
S
R
E
T
K
S
F
E
Site 12
T169
R
L
P
V
S
R
E
T
K
S
F
E
N
V
S
Site 13
S171
P
V
S
R
E
T
K
S
F
E
N
V
S
V
E
Site 14
S176
T
K
S
F
E
N
V
S
V
E
S
V
D
S
S
Site 15
S179
F
E
N
V
S
V
E
S
V
D
S
S
S
E
K
Site 16
S182
V
S
V
E
S
V
D
S
S
S
E
K
G
N
F
Site 17
S183
S
V
E
S
V
D
S
S
S
E
K
G
N
F
S
Site 18
S184
V
E
S
V
D
S
S
S
E
K
G
N
F
S
P
Site 19
S190
S
S
E
K
G
N
F
S
P
L
E
L
D
N
V
Site 20
S210
D
S
I
E
L
A
L
S
Y
A
K
T
W
S
K
Site 21
Y211
S
I
E
L
A
L
S
Y
A
K
T
W
S
K
Y
Site 22
T214
L
A
L
S
Y
A
K
T
W
S
K
Y
T
K
N
Site 23
Y218
Y
A
K
T
W
S
K
Y
T
K
N
I
V
S
W
Site 24
S236
K
L
N
L
E
L
E
S
T
R
N
M
V
K
L
Site 25
T237
L
N
L
E
L
E
S
T
R
N
M
V
K
L
A
Site 26
T249
K
L
A
E
A
T
R
T
N
I
G
I
Q
E
F
Site 27
S273
A
L
L
N
D
I
E
S
S
H
L
L
Q
Q
T
Site 28
Y339
C
M
Q
R
Q
D
E
Y
E
K
A
K
S
S
M
Site 29
S344
D
E
Y
E
K
A
K
S
S
M
F
R
A
E
E
Site 30
S345
E
Y
E
K
A
K
S
S
M
F
R
A
E
E
E
Site 31
S355
R
A
E
E
E
H
L
S
S
S
G
G
L
A
K
Site 32
S357
E
E
E
H
L
S
S
S
G
G
L
A
K
N
L
Site 33
Y389
V
E
E
A
N
E
L
Y
K
V
C
V
T
N
V
Site 34
T406
R
R
N
D
L
E
N
T
K
R
E
I
L
A
Q
Site 35
S442
M
Q
H
L
Q
A
A
S
L
A
D
S
L
Q
S
Site 36
S446
Q
A
A
S
L
A
D
S
L
Q
S
L
C
D
S
Site 37
S449
S
L
A
D
S
L
Q
S
L
C
D
S
A
K
L
Site 38
S453
S
L
Q
S
L
C
D
S
A
K
L
Y
D
P
G
Site 39
Y457
L
C
D
S
A
K
L
Y
D
P
G
Q
E
Y
S
Site 40
S464
Y
D
P
G
Q
E
Y
S
E
F
V
K
A
T
N
Site 41
S472
E
F
V
K
A
T
N
S
T
E
E
E
K
V
D
Site 42
S488
N
V
N
K
H
L
N
S
S
Q
P
S
G
F
G
Site 43
S489
V
N
K
H
L
N
S
S
Q
P
S
G
F
G
P
Site 44
S492
H
L
N
S
S
Q
P
S
G
F
G
P
A
N
S
Site 45
S499
S
G
F
G
P
A
N
S
L
E
D
V
V
R
L
Site 46
S509
D
V
V
R
L
P
D
S
S
N
K
I
E
E
D
Site 47
S510
V
V
R
L
P
D
S
S
N
K
I
E
E
D
R
Site 48
S519
K
I
E
E
D
R
C
S
N
S
A
D
I
T
G
Site 49
S521
E
E
D
R
C
S
N
S
A
D
I
T
G
P
S
Site 50
T525
C
S
N
S
A
D
I
T
G
P
S
F
I
R
S
Site 51
S528
S
A
D
I
T
G
P
S
F
I
R
S
W
T
F
Site 52
S532
T
G
P
S
F
I
R
S
W
T
F
G
M
F
S
Site 53
T534
P
S
F
I
R
S
W
T
F
G
M
F
S
D
S
Site 54
S539
S
W
T
F
G
M
F
S
D
S
E
S
T
G
G
Site 55
S541
T
F
G
M
F
S
D
S
E
S
T
G
G
S
S
Site 56
S543
G
M
F
S
D
S
E
S
T
G
G
S
S
E
S
Site 57
S547
D
S
E
S
T
G
G
S
S
E
S
R
S
L
D
Site 58
S548
S
E
S
T
G
G
S
S
E
S
R
S
L
D
S
Site 59
S550
S
T
G
G
S
S
E
S
R
S
L
D
S
E
S
Site 60
S552
G
G
S
S
E
S
R
S
L
D
S
E
S
I
S
Site 61
S555
S
E
S
R
S
L
D
S
E
S
I
S
P
G
D
Site 62
S557
S
R
S
L
D
S
E
S
I
S
P
G
D
F
H
Site 63
S559
S
L
D
S
E
S
I
S
P
G
D
F
H
R
K
Site 64
T570
F
H
R
K
L
P
R
T
P
S
S
G
T
M
S
Site 65
S572
R
K
L
P
R
T
P
S
S
G
T
M
S
S
A
Site 66
S573
K
L
P
R
T
P
S
S
G
T
M
S
S
A
D
Site 67
S577
T
P
S
S
G
T
M
S
S
A
D
D
L
D
E
Site 68
S578
P
S
S
G
T
M
S
S
A
D
D
L
D
E
R
Site 69
S589
L
D
E
R
E
P
P
S
P
S
E
T
G
P
N
Site 70
S591
E
R
E
P
P
S
P
S
E
T
G
P
N
S
L
Site 71
T593
E
P
P
S
P
S
E
T
G
P
N
S
L
G
T
Site 72
S597
P
S
E
T
G
P
N
S
L
G
T
F
K
K
T
Site 73
T600
T
G
P
N
S
L
G
T
F
K
K
T
L
M
S
Site 74
S607
T
F
K
K
T
L
M
S
K
A
A
L
T
H
K
Site 75
S620
H
K
F
R
K
L
R
S
P
T
K
C
R
D
C
Site 76
T622
F
R
K
L
R
S
P
T
K
C
R
D
C
E
G
Site 77
S732
G
M
H
L
V
D
I
S
E
F
S
S
H
D
I
Site 78
T779
H
V
N
E
E
Q
E
T
K
K
N
S
L
E
D
Site 79
S803
I
N
R
I
L
L
K
S
K
D
L
L
R
Q
L
Site 80
S813
L
L
R
Q
L
P
A
S
N
F
N
S
L
H
F
Site 81
T856
S
L
I
R
P
R
P
T
T
A
P
I
T
I
S
Site 82
T857
L
I
R
P
R
P
T
T
A
P
I
T
I
S
S
Site 83
T861
R
P
T
T
A
P
I
T
I
S
S
L
A
E
Y
Site 84
S863
T
T
A
P
I
T
I
S
S
L
A
E
Y
S
N
Site 85
S864
T
A
P
I
T
I
S
S
L
A
E
Y
S
N
Q
Site 86
Y868
T
I
S
S
L
A
E
Y
S
N
Q
A
R
L
V
Site 87
S889
S
Q
K
I
F
D
G
S
L
Q
P
Q
D
V
M
Site 88
S913
C
F
P
K
P
L
L
S
P
E
E
R
D
I
E
Site 89
S922
E
E
R
D
I
E
R
S
M
K
S
L
F
F
S
Site 90
S925
D
I
E
R
S
M
K
S
L
F
F
S
S
K
E
Site 91
S929
S
M
K
S
L
F
F
S
S
K
E
D
I
H
T
Site 92
S930
M
K
S
L
F
F
S
S
K
E
D
I
H
T
S
Site 93
T936
S
S
K
E
D
I
H
T
S
E
S
E
S
K
I
Site 94
S937
S
K
E
D
I
H
T
S
E
S
E
S
K
I
F
Site 95
S939
E
D
I
H
T
S
E
S
E
S
K
I
F
E
R
Site 96
S941
I
H
T
S
E
S
E
S
K
I
F
E
R
A
T
Site 97
T948
S
K
I
F
E
R
A
T
S
F
E
E
S
E
R
Site 98
S949
K
I
F
E
R
A
T
S
F
E
E
S
E
R
K
Site 99
S953
R
A
T
S
F
E
E
S
E
R
K
Q
N
A
L
Site 100
S981
L
L
D
Q
E
A
E
S
A
S
Q
K
I
E
D
Site 101
T991
Q
K
I
E
D
G
K
T
P
K
P
L
S
L
K
Site 102
S996
G
K
T
P
K
P
L
S
L
K
S
D
R
S
T
Site 103
S999
P
K
P
L
S
L
K
S
D
R
S
T
N
N
V
Site 104
S1002
L
S
L
K
S
D
R
S
T
N
N
V
E
R
H
Site 105
T1003
S
L
K
S
D
R
S
T
N
N
V
E
R
H
T
Site 106
T1010
T
N
N
V
E
R
H
T
P
R
T
K
I
R
P
Site 107
T1013
V
E
R
H
T
P
R
T
K
I
R
P
V
S
L
Site 108
S1019
R
T
K
I
R
P
V
S
L
P
V
D
R
L
L
Site 109
S1029
V
D
R
L
L
L
A
S
P
P
N
E
R
N
G
Site 110
T1063
V
N
R
K
D
A
A
T
T
V
C
S
K
F
N
Site 111
T1076
F
N
G
F
D
Q
Q
T
L
Q
K
I
Q
D
K
Site 112
Y1085
Q
K
I
Q
D
K
Q
Y
E
Q
N
S
L
T
A
Site 113
S1089
D
K
Q
Y
E
Q
N
S
L
T
A
K
T
T
M
Site 114
T1108
A
L
Q
E
K
G
V
T
T
S
L
Q
I
S
G
Site 115
S1110
Q
E
K
G
V
T
T
S
L
Q
I
S
G
D
H
Site 116
S1114
V
T
T
S
L
Q
I
S
G
D
H
S
I
N
A
Site 117
S1118
L
Q
I
S
G
D
H
S
I
N
A
T
Q
P
S
Site 118
T1122
G
D
H
S
I
N
A
T
Q
P
S
K
P
Y
A
Site 119
S1125
S
I
N
A
T
Q
P
S
K
P
Y
A
E
P
V
Site 120
Y1128
A
T
Q
P
S
K
P
Y
A
E
P
V
R
S
V
Site 121
S1134
P
Y
A
E
P
V
R
S
V
R
E
A
S
E
R
Site 122
S1139
V
R
S
V
R
E
A
S
E
R
R
S
S
D
S
Site 123
S1143
R
E
A
S
E
R
R
S
S
D
S
Y
P
L
A
Site 124
S1144
E
A
S
E
R
R
S
S
D
S
Y
P
L
A
P
Site 125
S1146
S
E
R
R
S
S
D
S
Y
P
L
A
P
V
R
Site 126
Y1147
E
R
R
S
S
D
S
Y
P
L
A
P
V
R
A
Site 127
T1157
A
P
V
R
A
P
R
T
L
Q
P
Q
H
W
T
Site 128
T1165
L
Q
P
Q
H
W
T
T
F
Y
K
P
H
A
P
Site 129
S1175
K
P
H
A
P
I
I
S
I
R
G
N
E
E
K
Site 130
S1185
G
N
E
E
K
P
A
S
P
S
A
A
V
P
P
Site 131
S1187
E
E
K
P
A
S
P
S
A
A
V
P
P
G
T
Site 132
T1194
S
A
A
V
P
P
G
T
D
H
D
P
H
G
L
Site 133
S1205
P
H
G
L
V
V
K
S
M
P
D
P
D
K
A
Site 134
S1213
M
P
D
P
D
K
A
S
A
C
P
G
Q
A
T
Site 135
S1227
T
G
Q
P
K
E
D
S
E
E
L
G
L
P
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation