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Updated November 2019
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Protein Info
Short Name:
FNDC3B
Full Name:
Fibronectin type III domain-containing protein 3B
Alias:
DKFZp762K137; Factor for adipocyte differentiation 104; FAD104; Fibronectin type III domain containing 3B; FLJ23399; FND3B; HCV NS5A-binding protein 37; PRO4979; YVTM2421
Type:
Membrane, Endoplasmic reticulum, Integral membrane protein
Mass (Da):
132888
Number AA:
1204
UniProt ID:
Q53EP0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T57
T
I
R
A
E
D
G
T
L
Q
C
I
Q
G
P
Site 2
S71
P
A
E
V
P
M
M
S
P
N
G
S
I
P
P
Site 3
S75
P
M
M
S
P
N
G
S
I
P
P
I
H
V
P
Site 4
Y85
P
I
H
V
P
P
G
Y
I
S
Q
V
I
E
D
Site 5
S87
H
V
P
P
G
Y
I
S
Q
V
I
E
D
S
T
Site 6
T102
G
V
R
R
V
V
V
T
P
Q
S
P
E
C
Y
Site 7
S105
R
V
V
V
T
P
Q
S
P
E
C
Y
P
P
S
Site 8
Y109
T
P
Q
S
P
E
C
Y
P
P
S
Y
P
S
A
Site 9
S112
S
P
E
C
Y
P
P
S
Y
P
S
A
M
S
P
Site 10
Y113
P
E
C
Y
P
P
S
Y
P
S
A
M
S
P
T
Site 11
S118
P
S
Y
P
S
A
M
S
P
T
H
H
L
P
P
Site 12
Y141
I
H
N
S
H
T
A
Y
Y
P
P
V
T
G
P
Site 13
Y142
H
N
S
H
T
A
Y
Y
P
P
V
T
G
P
G
Site 14
T164
P
Q
H
H
L
P
H
T
I
Y
G
E
Q
E
I
Site 15
Y166
H
H
L
P
H
T
I
Y
G
E
Q
E
I
I
P
Site 16
Y175
E
Q
E
I
I
P
F
Y
G
M
S
T
Y
I
T
Site 17
Y180
P
F
Y
G
M
S
T
Y
I
T
R
E
D
Q
Y
Site 18
T182
Y
G
M
S
T
Y
I
T
R
E
D
Q
Y
S
K
Site 19
Y187
Y
I
T
R
E
D
Q
Y
S
K
P
P
H
K
K
Site 20
S188
I
T
R
E
D
Q
Y
S
K
P
P
H
K
K
L
Site 21
S208
D
R
Q
N
R
L
N
S
P
P
S
S
I
Y
K
Site 22
S211
N
R
L
N
S
P
P
S
S
I
Y
K
S
S
C
Site 23
S212
R
L
N
S
P
P
S
S
I
Y
K
S
S
C
T
Site 24
Y214
N
S
P
P
S
S
I
Y
K
S
S
C
T
T
V
Site 25
S216
P
P
S
S
I
Y
K
S
S
C
T
T
V
Y
N
Site 26
S217
P
S
S
I
Y
K
S
S
C
T
T
V
Y
N
G
Site 27
T219
S
I
Y
K
S
S
C
T
T
V
Y
N
G
Y
G
Site 28
T220
I
Y
K
S
S
C
T
T
V
Y
N
G
Y
G
K
Site 29
Y222
K
S
S
C
T
T
V
Y
N
G
Y
G
K
G
H
Site 30
S230
N
G
Y
G
K
G
H
S
G
G
S
G
G
G
G
Site 31
S233
G
K
G
H
S
G
G
S
G
G
G
G
S
G
S
Site 32
S238
G
G
S
G
G
G
G
S
G
S
G
P
G
I
K
Site 33
S240
S
G
G
G
G
S
G
S
G
P
G
I
K
K
T
Site 34
T247
S
G
P
G
I
K
K
T
E
R
R
A
R
S
S
Site 35
S253
K
T
E
R
R
A
R
S
S
P
K
S
N
D
S
Site 36
S254
T
E
R
R
A
R
S
S
P
K
S
N
D
S
D
Site 37
S257
R
A
R
S
S
P
K
S
N
D
S
D
L
Q
E
Site 38
S260
S
S
P
K
S
N
D
S
D
L
Q
E
Y
E
L
Site 39
Y265
N
D
S
D
L
Q
E
Y
E
L
E
V
K
R
V
Site 40
S277
K
R
V
Q
D
I
L
S
G
I
E
K
P
Q
V
Site 41
S308
G
L
S
C
G
P
H
S
G
L
S
F
P
Y
S
Site 42
S311
C
G
P
H
S
G
L
S
F
P
Y
S
Y
E
V
Site 43
S315
S
G
L
S
F
P
Y
S
Y
E
V
A
L
S
D
Site 44
Y316
G
L
S
F
P
Y
S
Y
E
V
A
L
S
D
K
Site 45
S321
Y
S
Y
E
V
A
L
S
D
K
G
R
D
G
K
Site 46
Y329
D
K
G
R
D
G
K
Y
K
I
I
Y
S
G
E
Site 47
Y333
D
G
K
Y
K
I
I
Y
S
G
E
E
L
E
C
Site 48
S334
G
K
Y
K
I
I
Y
S
G
E
E
L
E
C
N
Site 49
T349
L
K
D
L
R
P
A
T
D
Y
H
V
R
V
Y
Site 50
Y351
D
L
R
P
A
T
D
Y
H
V
R
V
Y
A
M
Site 51
Y356
T
D
Y
H
V
R
V
Y
A
M
Y
N
S
V
K
Site 52
Y359
H
V
R
V
Y
A
M
Y
N
S
V
K
G
S
C
Site 53
S361
R
V
Y
A
M
Y
N
S
V
K
G
S
C
S
E
Site 54
S365
M
Y
N
S
V
K
G
S
C
S
E
P
V
S
F
Site 55
S367
N
S
V
K
G
S
C
S
E
P
V
S
F
T
T
Site 56
S371
G
S
C
S
E
P
V
S
F
T
T
H
S
C
A
Site 57
T374
S
E
P
V
S
F
T
T
H
S
C
A
P
E
C
Site 58
S376
P
V
S
F
T
T
H
S
C
A
P
E
C
P
F
Site 59
S391
P
P
K
L
A
H
R
S
K
S
S
L
T
L
Q
Site 60
S393
K
L
A
H
R
S
K
S
S
L
T
L
Q
W
K
Site 61
S407
K
A
P
I
D
N
G
S
K
I
T
N
Y
L
L
Site 62
Y412
N
G
S
K
I
T
N
Y
L
L
E
W
D
E
G
Site 63
T459
A
A
R
N
D
I
G
T
S
G
Y
S
Q
E
V
Site 64
S463
D
I
G
T
S
G
Y
S
Q
E
V
V
C
Y
T
Site 65
Y469
Y
S
Q
E
V
V
C
Y
T
L
G
N
I
P
Q
Site 66
T492
R
A
G
I
T
W
V
T
L
Q
W
S
K
P
E
Site 67
S502
W
S
K
P
E
G
C
S
P
E
E
V
I
T
Y
Site 68
T508
C
S
P
E
E
V
I
T
Y
T
L
E
I
Q
E
Site 69
Y509
S
P
E
E
V
I
T
Y
T
L
E
I
Q
E
D
Site 70
Y526
D
N
L
F
H
P
K
Y
T
G
E
D
L
T
C
Site 71
T532
K
Y
T
G
E
D
L
T
C
T
V
K
N
L
K
Site 72
T534
T
G
E
D
L
T
C
T
V
K
N
L
K
R
S
Site 73
T542
V
K
N
L
K
R
S
T
Q
Y
K
F
R
L
T
Site 74
T549
T
Q
Y
K
F
R
L
T
A
S
N
T
E
G
K
Site 75
S551
Y
K
F
R
L
T
A
S
N
T
E
G
K
S
C
Site 76
T553
F
R
L
T
A
S
N
T
E
G
K
S
C
P
S
Site 77
S557
A
S
N
T
E
G
K
S
C
P
S
E
V
L
V
Site 78
T566
P
S
E
V
L
V
C
T
T
S
P
D
R
P
G
Site 79
S568
E
V
L
V
C
T
T
S
P
D
R
P
G
P
P
Site 80
T576
P
D
R
P
G
P
P
T
R
P
L
V
K
G
P
Site 81
T585
P
L
V
K
G
P
V
T
S
H
G
F
S
V
K
Site 82
S590
P
V
T
S
H
G
F
S
V
K
W
D
P
P
K
Site 83
Y607
G
G
S
E
I
L
K
Y
L
L
E
I
T
D
G
Site 84
S616
L
E
I
T
D
G
N
S
E
A
N
Q
W
E
V
Site 85
Y625
A
N
Q
W
E
V
A
Y
S
G
S
A
T
E
Y
Site 86
S626
N
Q
W
E
V
A
Y
S
G
S
A
T
E
Y
T
Site 87
T630
V
A
Y
S
G
S
A
T
E
Y
T
F
T
H
L
Site 88
Y632
Y
S
G
S
A
T
E
Y
T
F
T
H
L
K
P
Site 89
T633
S
G
S
A
T
E
Y
T
F
T
H
L
K
P
G
Site 90
T635
S
A
T
E
Y
T
F
T
H
L
K
P
G
T
L
Site 91
T641
F
T
H
L
K
P
G
T
L
Y
K
L
R
A
C
Site 92
T652
L
R
A
C
C
I
S
T
G
G
H
S
Q
C
S
Site 93
S656
C
I
S
T
G
G
H
S
Q
C
S
E
S
L
P
Site 94
S661
G
H
S
Q
C
S
E
S
L
P
V
R
T
L
S
Site 95
T666
S
E
S
L
P
V
R
T
L
S
I
A
P
G
Q
Site 96
S697
L
E
W
D
V
P
A
S
E
S
G
C
E
V
S
Site 97
S699
W
D
V
P
A
S
E
S
G
C
E
V
S
E
Y
Site 98
S704
S
E
S
G
C
E
V
S
E
Y
S
V
E
M
T
Site 99
Y706
S
G
C
E
V
S
E
Y
S
V
E
M
T
E
P
Site 100
S707
G
C
E
V
S
E
Y
S
V
E
M
T
E
P
E
Site 101
T711
S
E
Y
S
V
E
M
T
E
P
E
D
V
A
S
Site 102
S718
T
E
P
E
D
V
A
S
E
V
Y
H
G
P
E
Site 103
Y721
E
D
V
A
S
E
V
Y
H
G
P
E
L
E
C
Site 104
T729
H
G
P
E
L
E
C
T
V
G
N
L
L
P
G
Site 105
Y751
R
A
L
N
D
G
G
Y
G
P
Y
S
D
V
S
Site 106
Y754
N
D
G
G
Y
G
P
Y
S
D
V
S
E
I
T
Site 107
S755
D
G
G
Y
G
P
Y
S
D
V
S
E
I
T
T
Site 108
S758
Y
G
P
Y
S
D
V
S
E
I
T
T
A
A
G
Site 109
T762
S
D
V
S
E
I
T
T
A
A
G
P
P
G
Q
Site 110
S789
C
V
L
V
G
W
E
S
P
D
S
S
G
A
D
Site 111
S792
V
G
W
E
S
P
D
S
S
G
A
D
I
S
E
Site 112
S793
G
W
E
S
P
D
S
S
G
A
D
I
S
E
Y
Site 113
S798
D
S
S
G
A
D
I
S
E
Y
R
L
E
W
G
Site 114
Y800
S
G
A
D
I
S
E
Y
R
L
E
W
G
E
D
Site 115
S810
E
W
G
E
D
E
E
S
L
E
L
I
Y
H
G
Site 116
T818
L
E
L
I
Y
H
G
T
D
T
R
F
E
I
R
Site 117
T856
S
E
L
V
L
C
Q
T
P
A
S
A
P
D
P
Site 118
T866
S
A
P
D
P
V
S
T
L
C
V
L
E
E
E
Site 119
Y878
E
E
E
P
L
D
A
Y
P
D
S
P
S
A
C
Site 120
S883
D
A
Y
P
D
S
P
S
A
C
L
V
L
N
W
Site 121
Y903
N
G
S
E
I
L
A
Y
T
I
D
L
G
D
T
Site 122
T913
D
L
G
D
T
S
I
T
V
G
N
T
T
M
H
Site 123
T929
M
K
D
L
L
P
E
T
T
Y
R
I
R
I
Q
Site 124
T930
K
D
L
L
P
E
T
T
Y
R
I
R
I
Q
A
Site 125
S947
E
I
G
A
G
P
F
S
Q
F
I
K
A
K
T
Site 126
T954
S
Q
F
I
K
A
K
T
R
P
L
P
P
L
P
Site 127
S973
C
A
A
A
G
P
Q
S
L
K
L
K
W
G
D
Site 128
S981
L
K
L
K
W
G
D
S
N
S
K
T
H
A
A
Site 129
S983
L
K
W
G
D
S
N
S
K
T
H
A
A
E
D
Site 130
T985
W
G
D
S
N
S
K
T
H
A
A
E
D
I
V
Site 131
Y993
H
A
A
E
D
I
V
Y
T
L
Q
L
E
D
R
Site 132
S1006
D
R
N
K
R
F
I
S
I
Y
R
G
P
S
H
Site 133
Y1008
N
K
R
F
I
S
I
Y
R
G
P
S
H
T
Y
Site 134
S1012
I
S
I
Y
R
G
P
S
H
T
Y
K
V
Q
R
Site 135
T1014
I
Y
R
G
P
S
H
T
Y
K
V
Q
R
L
T
Site 136
T1021
T
Y
K
V
Q
R
L
T
E
F
T
C
Y
S
F
Site 137
Y1026
R
L
T
E
F
T
C
Y
S
F
R
I
Q
A
A
Site 138
S1034
S
F
R
I
Q
A
A
S
E
A
G
E
G
P
F
Site 139
S1042
E
A
G
E
G
P
F
S
E
T
Y
T
F
S
T
Site 140
T1044
G
E
G
P
F
S
E
T
Y
T
F
S
T
T
K
Site 141
Y1045
E
G
P
F
S
E
T
Y
T
F
S
T
T
K
S
Site 142
T1046
G
P
F
S
E
T
Y
T
F
S
T
T
K
S
V
Site 143
S1048
F
S
E
T
Y
T
F
S
T
T
K
S
V
P
P
Site 144
S1052
Y
T
F
S
T
T
K
S
V
P
P
T
I
K
A
Site 145
T1056
T
T
K
S
V
P
P
T
I
K
A
P
R
V
T
Site 146
T1063
T
I
K
A
P
R
V
T
Q
L
E
G
N
S
C
Site 147
T1076
S
C
E
I
L
W
E
T
V
P
S
M
K
G
D
Site 148
S1079
I
L
W
E
T
V
P
S
M
K
G
D
P
V
N
Site 149
S1097
Q
V
L
V
G
R
E
S
E
Y
K
Q
V
Y
K
Site 150
Y1103
E
S
E
Y
K
Q
V
Y
K
G
E
E
A
T
F
Site 151
T1109
V
Y
K
G
E
E
A
T
F
Q
I
S
G
L
Q
Site 152
T1117
F
Q
I
S
G
L
Q
T
N
T
D
Y
R
F
R
Site 153
T1119
I
S
G
L
Q
T
N
T
D
Y
R
F
R
V
C
Site 154
Y1121
G
L
Q
T
N
T
D
Y
R
F
R
V
C
A
C
Site 155
T1134
A
C
R
R
C
L
D
T
S
Q
E
L
S
G
A
Site 156
S1135
C
R
R
C
L
D
T
S
Q
E
L
S
G
A
F
Site 157
S1139
L
D
T
S
Q
E
L
S
G
A
F
S
P
S
A
Site 158
S1153
A
A
F
V
L
Q
R
S
E
V
M
L
T
G
D
Site 159
T1158
Q
R
S
E
V
M
L
T
G
D
M
G
S
L
D
Site 160
S1163
M
L
T
G
D
M
G
S
L
D
D
P
K
M
K
Site 161
S1171
L
D
D
P
K
M
K
S
M
M
P
T
D
E
Q
Site 162
T1175
K
M
K
S
M
M
P
T
D
E
Q
F
A
A
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation