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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KLHL12
Full Name:
Kelch-like protein 12
Alias:
C3ip1; CUL3-interacting protein 1; Kelch-like 12; Klhl12
Type:
Ubiquitin conjugating system
Mass (Da):
63280
Number AA:
UniProt ID:
Q53G59
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0016055
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T14
P
K
D
I
M
T
N
T
H
A
K
S
I
L
N
Site 2
S18
M
T
N
T
H
A
K
S
I
L
N
S
M
N
S
Site 3
S22
H
A
K
S
I
L
N
S
M
N
S
L
R
K
S
Site 4
S25
S
I
L
N
S
M
N
S
L
R
K
S
N
T
L
Site 5
S29
S
M
N
S
L
R
K
S
N
T
L
C
D
V
T
Site 6
T31
N
S
L
R
K
S
N
T
L
C
D
V
T
L
R
Site 7
T36
S
N
T
L
C
D
V
T
L
R
V
E
Q
K
D
Site 8
S67
A
M
F
T
S
E
L
S
E
K
G
K
P
Y
V
Site 9
Y73
L
S
E
K
G
K
P
Y
V
D
I
Q
G
L
T
Site 10
S133
L
E
S
Q
L
D
P
S
N
C
L
G
I
R
D
Site 11
S158
M
Q
A
A
E
V
F
S
Q
K
H
F
P
E
V
Site 12
S175
H
E
E
F
I
L
L
S
Q
G
E
V
E
K
L
Site 13
S192
C
D
E
I
Q
V
D
S
E
E
P
V
F
E
A
Site 14
S214
A
K
K
E
R
E
E
S
L
P
N
L
L
Q
Y
Site 15
S266
H
L
R
P
E
L
R
S
Q
M
Q
G
P
R
T
Site 16
T273
S
Q
M
Q
G
P
R
T
R
A
R
L
G
A
N
Site 17
S294
G
G
F
G
S
Q
Q
S
P
I
D
V
V
E
K
Site 18
Y302
P
I
D
V
V
E
K
Y
D
P
K
T
Q
E
W
Site 19
T306
V
E
K
Y
D
P
K
T
Q
E
W
S
F
L
P
Site 20
S310
D
P
K
T
Q
E
W
S
F
L
P
S
I
T
R
Site 21
S314
Q
E
W
S
F
L
P
S
I
T
R
K
R
R
Y
Site 22
Y321
S
I
T
R
K
R
R
Y
V
A
S
V
S
L
H
Site 23
S324
R
K
R
R
Y
V
A
S
V
S
L
H
D
R
I
Site 24
S326
R
R
Y
V
A
S
V
S
L
H
D
R
I
Y
V
Site 25
Y337
R
I
Y
V
I
G
G
Y
D
G
R
S
R
L
S
Site 26
S341
I
G
G
Y
D
G
R
S
R
L
S
S
V
E
C
Site 27
S344
Y
D
G
R
S
R
L
S
S
V
E
C
L
D
Y
Site 28
S345
D
G
R
S
R
L
S
S
V
E
C
L
D
Y
T
Site 29
Y351
S
S
V
E
C
L
D
Y
T
A
D
E
D
G
V
Site 30
T352
S
V
E
C
L
D
Y
T
A
D
E
D
G
V
W
Site 31
S384
L
G
D
M
I
Y
V
S
G
G
F
D
G
S
R
Site 32
S390
V
S
G
G
F
D
G
S
R
R
H
T
S
M
E
Site 33
T394
F
D
G
S
R
R
H
T
S
M
E
R
Y
D
P
Site 34
S395
D
G
S
R
R
H
T
S
M
E
R
Y
D
P
N
Site 35
Y399
R
H
T
S
M
E
R
Y
D
P
N
I
D
Q
W
Site 36
T414
S
M
L
G
D
M
Q
T
A
R
E
G
A
G
L
Site 37
S442
D
G
L
N
I
L
N
S
V
E
K
Y
D
P
H
Site 38
Y446
I
L
N
S
V
E
K
Y
D
P
H
T
G
H
W
Site 39
T450
V
E
K
Y
D
P
H
T
G
H
W
T
N
V
T
Site 40
T457
T
G
H
W
T
N
V
T
P
M
A
T
K
R
S
Site 41
S488
F
D
G
T
A
H
L
S
S
V
E
A
Y
N
I
Site 42
S489
D
G
T
A
H
L
S
S
V
E
A
Y
N
I
R
Site 43
Y493
H
L
S
S
V
E
A
Y
N
I
R
T
D
S
W
Site 44
S499
A
Y
N
I
R
T
D
S
W
T
T
V
T
S
M
Site 45
T501
N
I
R
T
D
S
W
T
T
V
T
S
M
T
T
Site 46
S536
D
G
N
S
L
L
S
S
I
E
C
Y
D
P
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation