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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HSD17B12
Full Name:
Estradiol 17-beta-dehydrogenase 12
Alias:
17-beta-HSD 12
Type:
Mass (Da):
34306
Number AA:
312
UniProt ID:
Q53GQ0
International Prot ID:
IPI00007676
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0005789
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004303
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006629
GO:0006694
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y12
L
P
A
A
G
F
L
Y
W
V
G
A
G
T
V
Site 2
S58
E
W
A
V
V
T
G
S
T
D
G
I
G
K
S
Site 3
S65
S
T
D
G
I
G
K
S
Y
A
E
E
L
A
K
Site 4
S83
K
V
V
L
I
S
R
S
K
D
K
L
D
Q
V
Site 5
S91
K
D
K
L
D
Q
V
S
S
E
I
K
E
K
F
Site 6
S92
D
K
L
D
Q
V
S
S
E
I
K
E
K
F
K
Site 7
Y115
D
F
A
S
E
D
I
Y
D
K
I
K
T
G
L
Site 8
Y138
V
N
N
V
G
M
S
Y
E
Y
P
E
Y
F
L
Site 9
Y140
N
V
G
M
S
Y
E
Y
P
E
Y
F
L
D
V
Site 10
Y143
M
S
Y
E
Y
P
E
Y
F
L
D
V
P
D
L
Site 11
S164
M
I
N
I
N
I
L
S
V
C
K
M
T
Q
L
Site 12
Y220
S
Q
C
L
H
E
E
Y
R
S
K
G
V
F
V
Site 13
S222
C
L
H
E
E
Y
R
S
K
G
V
F
V
Q
S
Site 14
T246
L
A
K
I
R
K
P
T
L
D
K
P
S
P
E
Site 15
S251
K
P
T
L
D
K
P
S
P
E
T
F
V
K
S
Site 16
T254
L
D
K
P
S
P
E
T
F
V
K
S
A
I
K
Site 17
T262
F
V
K
S
A
I
K
T
V
G
L
Q
S
R
T
Site 18
Y272
L
Q
S
R
T
N
G
Y
L
I
H
A
L
M
G
Site 19
Y305
N
K
S
T
R
A
H
Y
L
K
K
T
K
K
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation