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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KLHL22
Full Name:
Kelch-like protein 22
Alias:
Type:
Mass (Da):
71667
Number AA:
634
UniProt ID:
Q53GT1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
A
E
E
Q
E
F
T
Q
L
C
K
L
P
A
Site 2
Y27
P
H
C
V
N
N
T
Y
R
S
A
Q
H
S
Q
Site 3
S33
T
Y
R
S
A
Q
H
S
Q
A
L
L
R
G
L
Site 4
S116
Y
T
S
E
L
E
L
S
L
S
N
V
Q
E
T
Site 5
Y156
E
E
N
I
L
D
V
Y
R
L
A
E
L
F
D
Site 6
T168
L
F
D
L
S
R
L
T
E
Q
L
D
T
Y
I
Site 7
T173
R
L
T
E
Q
L
D
T
Y
I
L
K
N
F
V
Site 8
S183
L
K
N
F
V
A
F
S
R
T
D
K
Y
R
Q
Site 9
Y188
A
F
S
R
T
D
K
Y
R
Q
L
P
L
E
K
Site 10
S198
L
P
L
E
K
V
Y
S
L
L
S
S
N
R
L
Site 11
S201
E
K
V
Y
S
L
L
S
S
N
R
L
E
V
S
Site 12
S202
K
V
Y
S
L
L
S
S
N
R
L
E
V
S
C
Site 13
S208
S
S
N
R
L
E
V
S
C
E
T
E
V
Y
E
Site 14
Y222
E
G
A
L
L
Y
H
Y
S
L
E
Q
V
Q
A
Site 15
S223
G
A
L
L
Y
H
Y
S
L
E
Q
V
Q
A
D
Site 16
T243
E
P
P
K
L
L
E
T
V
R
F
P
L
M
E
Site 17
S264
L
H
D
K
L
D
P
S
P
L
R
D
T
V
A
Site 18
T269
D
P
S
P
L
R
D
T
V
A
S
A
L
M
Y
Site 19
S272
P
L
R
D
T
V
A
S
A
L
M
Y
H
R
N
Site 20
Y276
T
V
A
S
A
L
M
Y
H
R
N
E
S
L
Q
Site 21
S281
L
M
Y
H
R
N
E
S
L
Q
P
S
L
Q
S
Site 22
S285
R
N
E
S
L
Q
P
S
L
Q
S
P
Q
T
E
Site 23
S288
S
L
Q
P
S
L
Q
S
P
Q
T
E
L
R
S
Site 24
T291
P
S
L
Q
S
P
Q
T
E
L
R
S
D
F
Q
Site 25
T309
G
F
G
G
I
H
S
T
P
S
T
V
L
S
D
Site 26
S311
G
G
I
H
S
T
P
S
T
V
L
S
D
Q
A
Site 27
T312
G
I
H
S
T
P
S
T
V
L
S
D
Q
A
K
Site 28
S315
S
T
P
S
T
V
L
S
D
Q
A
K
Y
L
N
Site 29
Y320
V
L
S
D
Q
A
K
Y
L
N
P
L
L
G
E
Site 30
T332
L
G
E
W
K
H
F
T
A
S
L
A
P
R
M
Site 31
S334
E
W
K
H
F
T
A
S
L
A
P
R
M
S
N
Site 32
S393
Q
Q
E
H
A
D
L
S
V
C
V
V
G
R
Y
Site 33
Y409
Y
A
V
A
G
R
D
Y
H
N
D
L
N
A
V
Site 34
T423
V
E
R
Y
D
P
A
T
N
S
W
A
Y
V
A
Site 35
Y428
P
A
T
N
S
W
A
Y
V
A
P
L
K
R
E
Site 36
Y437
A
P
L
K
R
E
V
Y
A
H
A
G
A
T
L
Site 37
Y449
A
T
L
E
G
K
M
Y
I
T
C
G
R
R
G
Site 38
T451
L
E
G
K
M
Y
I
T
C
G
R
R
G
E
D
Site 39
Y459
C
G
R
R
G
E
D
Y
L
K
E
T
H
C
Y
Site 40
T463
G
E
D
Y
L
K
E
T
H
C
Y
D
P
G
S
Site 41
Y466
Y
L
K
E
T
H
C
Y
D
P
G
S
N
T
W
Site 42
T475
P
G
S
N
T
W
H
T
L
A
D
G
P
V
R
Site 43
S501
K
L
Y
V
I
G
G
S
N
N
D
A
G
Y
R
Site 44
Y507
G
S
N
N
D
A
G
Y
R
R
D
V
H
Q
V
Site 45
Y517
D
V
H
Q
V
A
C
Y
S
C
T
S
G
Q
W
Site 46
S525
S
C
T
S
G
Q
W
S
S
V
C
P
L
P
A
Site 47
Y547
A
V
L
D
N
R
I
Y
V
L
G
G
R
S
H
Site 48
S553
I
Y
V
L
G
G
R
S
H
N
R
G
S
R
T
Site 49
S558
G
R
S
H
N
R
G
S
R
T
G
Y
V
H
I
Site 50
T560
S
H
N
R
G
S
R
T
G
Y
V
H
I
Y
D
Site 51
Y562
N
R
G
S
R
T
G
Y
V
H
I
Y
D
V
E
Site 52
Y566
R
T
G
Y
V
H
I
Y
D
V
E
K
D
C
W
Site 53
S582
E
G
P
Q
L
D
N
S
I
S
G
L
A
A
C
Site 54
T605
L
L
E
P
P
R
G
T
P
D
R
S
Q
A
D
Site 55
S609
P
R
G
T
P
D
R
S
Q
A
D
P
D
F
A
Site 56
S617
Q
A
D
P
D
F
A
S
E
V
M
S
V
S
D
Site 57
S621
D
F
A
S
E
V
M
S
V
S
D
W
E
E
F
Site 58
S623
A
S
E
V
M
S
V
S
D
W
E
E
F
D
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation