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Updated November 2019
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Protein Info
Short Name:
COBLL1
Full Name:
Cordon-bleu protein-like 1
Alias:
COBL1; COBL-like 1; KIAA0977
Type:
Cell development/differentiation
Mass (Da):
131787
Number AA:
1204
UniProt ID:
Q53SF7
International Prot ID:
IPI00007133
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
R
A
A
E
A
A
A
S
S
R
T
P
G
R
E
Site 2
S12
A
A
E
A
A
A
S
S
R
T
P
G
R
E
M
Site 3
T14
E
A
A
A
S
S
R
T
P
G
R
E
M
G
Q
Site 4
T43
R
R
A
M
D
G
R
T
P
R
P
Q
D
A
P
Site 5
Y68
L
P
P
A
E
T
K
Y
T
D
V
S
S
A
A
Site 6
T69
P
P
A
E
T
K
Y
T
D
V
S
S
A
A
D
Site 7
S73
T
K
Y
T
D
V
S
S
A
A
D
S
V
E
S
Site 8
T81
A
A
D
S
V
E
S
T
A
F
I
M
E
Q
K
Site 9
S109
L
P
G
D
I
I
K
S
T
T
V
H
G
S
K
Site 10
T110
P
G
D
I
I
K
S
T
T
V
H
G
S
K
P
Site 11
T111
G
D
I
I
K
S
T
T
V
H
G
S
K
P
M
Site 12
S135
Q
Y
H
L
N
P
S
S
Y
T
I
D
L
L
S
Site 13
S142
S
Y
T
I
D
L
L
S
A
E
Q
N
H
I
K
Site 14
T154
H
I
K
F
K
P
N
T
P
I
G
M
L
E
V
Site 15
T177
M
L
D
K
K
K
P
T
P
I
I
P
E
K
T
Site 16
T197
N
F
K
K
T
Q
K
T
I
V
R
V
S
P
H
Site 17
S202
Q
K
T
I
V
R
V
S
P
H
A
S
L
Q
E
Site 18
Y231
H
T
L
L
L
K
D
Y
Q
S
Q
E
P
L
D
Site 19
S233
L
L
L
K
D
Y
Q
S
Q
E
P
L
D
L
T
Site 20
T240
S
Q
E
P
L
D
L
T
K
S
L
N
D
L
G
Site 21
S242
E
P
L
D
L
T
K
S
L
N
D
L
G
L
R
Site 22
Y252
D
L
G
L
R
E
L
Y
A
M
D
V
N
R
E
Site 23
S260
A
M
D
V
N
R
E
S
C
Q
I
S
Q
N
L
Site 24
S264
N
R
E
S
C
Q
I
S
Q
N
L
D
I
M
K
Site 25
S280
K
E
N
K
G
F
F
S
F
F
Q
R
S
K
K
Site 26
T292
S
K
K
K
R
D
Q
T
A
S
A
P
A
T
P
Site 27
S294
K
K
R
D
Q
T
A
S
A
P
A
T
P
L
V
Site 28
T298
Q
T
A
S
A
P
A
T
P
L
V
N
K
H
R
Site 29
T307
L
V
N
K
H
R
P
T
F
T
R
S
N
T
I
Site 30
S311
H
R
P
T
F
T
R
S
N
T
I
S
K
P
Y
Site 31
T313
P
T
F
T
R
S
N
T
I
S
K
P
Y
I
S
Site 32
S315
F
T
R
S
N
T
I
S
K
P
Y
I
S
N
T
Site 33
Y318
S
N
T
I
S
K
P
Y
I
S
N
T
L
P
S
Site 34
S320
T
I
S
K
P
Y
I
S
N
T
L
P
S
D
A
Site 35
T322
S
K
P
Y
I
S
N
T
L
P
S
D
A
P
K
Site 36
S325
Y
I
S
N
T
L
P
S
D
A
P
K
K
R
R
Site 37
S341
P
L
P
P
M
P
A
S
Q
S
V
P
Q
D
L
Site 38
S343
P
P
M
P
A
S
Q
S
V
P
Q
D
L
A
H
Site 39
S357
H
I
Q
E
R
P
A
S
C
I
V
K
S
M
S
Site 40
S362
P
A
S
C
I
V
K
S
M
S
V
D
E
T
D
Site 41
S364
S
C
I
V
K
S
M
S
V
D
E
T
D
K
S
Site 42
T368
K
S
M
S
V
D
E
T
D
K
S
P
C
E
A
Site 43
S371
S
V
D
E
T
D
K
S
P
C
E
A
G
R
V
Site 44
S382
A
G
R
V
R
A
G
S
L
Q
L
S
S
M
S
Site 45
S386
R
A
G
S
L
Q
L
S
S
M
S
A
G
N
S
Site 46
S387
A
G
S
L
Q
L
S
S
M
S
A
G
N
S
S
Site 47
S389
S
L
Q
L
S
S
M
S
A
G
N
S
S
L
R
Site 48
S393
S
S
M
S
A
G
N
S
S
L
R
R
T
K
R
Site 49
S394
S
M
S
A
G
N
S
S
L
R
R
T
K
R
K
Site 50
T398
G
N
S
S
L
R
R
T
K
R
K
A
P
S
P
Site 51
S404
R
T
K
R
K
A
P
S
P
P
S
K
I
P
P
Site 52
S407
R
K
A
P
S
P
P
S
K
I
P
P
H
Q
S
Site 53
S414
S
K
I
P
P
H
Q
S
D
E
N
S
R
V
T
Site 54
S418
P
H
Q
S
D
E
N
S
R
V
T
A
L
Q
P
Site 55
T421
S
D
E
N
S
R
V
T
A
L
Q
P
V
D
G
Site 56
S433
V
D
G
V
P
P
D
S
A
S
E
A
N
S
P
Site 57
S435
G
V
P
P
D
S
A
S
E
A
N
S
P
E
E
Site 58
S439
D
S
A
S
E
A
N
S
P
E
E
L
S
S
P
Site 59
S444
A
N
S
P
E
E
L
S
S
P
E
T
F
H
P
Site 60
S445
N
S
P
E
E
L
S
S
P
E
T
F
H
P
G
Site 61
T448
E
E
L
S
S
P
E
T
F
H
P
G
L
S
S
Site 62
S455
T
F
H
P
G
L
S
S
Q
E
Q
C
T
A
P
Site 63
S469
P
K
L
M
E
E
T
S
V
F
E
C
P
G
T
Site 64
T485
E
A
A
I
T
S
L
T
S
G
I
S
S
D
Y
Site 65
S489
T
S
L
T
S
G
I
S
S
D
Y
S
L
E
E
Site 66
S490
S
L
T
S
G
I
S
S
D
Y
S
L
E
E
I
Site 67
Y492
T
S
G
I
S
S
D
Y
S
L
E
E
I
D
E
Site 68
S493
S
G
I
S
S
D
Y
S
L
E
E
I
D
E
K
Site 69
S504
I
D
E
K
E
E
L
S
E
V
P
K
V
E
A
Site 70
S515
K
V
E
A
E
N
I
S
P
K
S
Q
D
I
P
Site 71
S518
K
V
E
A
E
N
I
S
P
K
S
Q
D
I
P
Site 72
S538
T
L
K
N
D
P
D
S
A
L
G
N
G
S
G
Site 73
S544
D
S
A
L
G
N
G
S
G
E
F
S
Q
N
S
Site 74
S548
G
N
G
S
G
E
F
S
Q
N
S
M
E
E
K
Site 75
S551
G
N
G
S
G
E
F
S
Q
N
S
M
E
E
K
Site 76
T558
S
M
E
E
K
Q
E
T
K
S
T
D
G
Q
E
Site 77
S560
E
E
K
Q
E
T
K
S
T
D
G
Q
E
P
H
Site 78
T561
E
K
Q
E
T
K
S
T
D
G
Q
E
P
H
S
Site 79
S568
T
D
G
Q
E
P
H
S
V
V
Y
D
T
S
N
Site 80
Y571
Q
E
P
H
S
V
V
Y
D
T
S
N
G
K
K
Site 81
S574
H
S
V
V
Y
D
T
S
N
G
K
K
V
V
D
Site 82
S582
N
G
K
K
V
V
D
S
I
R
N
L
K
S
L
Site 83
S588
D
S
I
R
N
L
K
S
L
G
P
N
Q
E
N
Site 84
Y603
V
Q
N
E
I
I
V
Y
P
E
N
T
E
D
N
Site 85
T618
M
K
N
G
V
K
K
T
E
I
N
V
E
G
V
Site 86
S639
D
M
E
V
E
R
P
S
N
S
E
A
H
E
T
Site 87
S641
E
V
E
R
P
S
N
S
E
A
H
E
T
D
T
Site 88
T646
S
N
S
E
A
H
E
T
D
T
A
I
S
Y
K
Site 89
S660
K
E
N
H
L
A
A
S
S
V
P
D
Q
K
L
Site 90
T675
N
Q
P
S
A
E
K
T
K
D
A
A
I
Q
T
Site 91
T683
K
D
A
A
I
Q
T
T
P
S
C
N
S
F
D
Site 92
S688
Q
T
T
P
S
C
N
S
F
D
G
K
H
Q
D
Site 93
S699
K
H
Q
D
H
N
L
S
D
S
K
V
E
E
C
Site 94
S701
Q
D
H
N
L
S
D
S
K
V
E
E
C
V
Q
Site 95
T709
K
V
E
E
C
V
Q
T
S
N
N
N
I
S
T
Site 96
S715
Q
T
S
N
N
N
I
S
T
Q
H
S
C
L
S
Site 97
T716
T
S
N
N
N
I
S
T
Q
H
S
C
L
S
S
Site 98
S719
N
N
I
S
T
Q
H
S
C
L
S
S
Q
D
S
Site 99
S722
S
T
Q
H
S
C
L
S
S
Q
D
S
V
N
T
Site 100
S723
T
Q
H
S
C
L
S
S
Q
D
S
V
N
T
S
Site 101
S726
S
C
L
S
S
Q
D
S
V
N
T
S
R
E
F
Site 102
S730
S
Q
D
S
V
N
T
S
R
E
F
R
S
Q
G
Site 103
S735
N
T
S
R
E
F
R
S
Q
G
T
L
I
I
H
Site 104
S743
Q
G
T
L
I
I
H
S
E
D
P
L
T
V
K
Site 105
T748
I
H
S
E
D
P
L
T
V
K
D
P
I
C
A
Site 106
S772
V
D
R
I
D
K
N
S
T
A
S
Y
L
K
N
Site 107
Y776
D
K
N
S
T
A
S
Y
L
K
N
Y
P
L
Y
Site 108
Y780
T
A
S
Y
L
K
N
Y
P
L
Y
R
Q
D
Y
Site 109
Y783
T
A
S
Y
L
K
N
Y
P
L
Y
R
Q
D
Y
Site 110
Y787
Y
P
L
Y
R
Q
D
Y
N
P
K
P
K
P
S
Site 111
T798
P
K
P
S
N
E
I
T
R
E
Y
I
P
K
I
Site 112
Y801
S
N
E
I
T
R
E
Y
I
P
K
I
G
M
T
Site 113
Y810
P
K
I
G
M
T
T
Y
K
I
V
P
P
K
S
Site 114
S817
Y
K
I
V
P
P
K
S
L
E
I
S
K
D
W
Site 115
S821
P
P
K
S
L
E
I
S
K
D
W
Q
S
E
T
Site 116
S826
E
I
S
K
D
W
Q
S
E
T
I
E
Y
K
D
Site 117
Y831
W
Q
S
E
T
I
E
Y
K
D
D
Q
D
M
H
Site 118
S859
T
A
I
Q
T
E
D
S
A
I
S
E
S
P
E
Site 119
S864
E
D
S
A
I
S
E
S
P
E
E
P
L
P
N
Site 120
T880
K
P
K
P
N
L
R
T
E
H
Q
V
P
S
S
Site 121
S886
R
T
E
H
Q
V
P
S
S
V
S
S
P
D
D
Site 122
S887
T
E
H
Q
V
P
S
S
V
S
S
P
D
D
A
Site 123
S889
H
Q
V
P
S
S
V
S
S
P
D
D
A
M
V
Site 124
S890
T
E
H
Q
V
P
S
S
V
S
S
P
D
D
A
Site 125
S897
S
P
D
D
A
M
V
S
P
L
K
P
A
P
K
Site 126
T909
A
P
K
M
T
R
D
T
G
T
A
P
F
A
P
Site 127
T911
K
M
T
R
D
T
G
T
A
P
F
A
P
N
L
Site 128
S927
E
I
N
N
I
L
E
S
K
F
K
S
R
A
S
Site 129
S931
I
L
E
S
K
F
K
S
R
A
S
N
A
Q
A
Site 130
S934
S
K
F
K
S
R
A
S
N
A
Q
A
K
P
S
Site 131
S941
S
N
A
Q
A
K
P
S
S
F
F
L
Q
M
Q
Site 132
S942
N
A
Q
A
K
P
S
S
F
F
L
Q
M
Q
K
Site 133
S952
L
Q
M
Q
K
R
V
S
G
H
Y
V
T
S
A
Site 134
Y955
Q
K
R
V
S
G
H
Y
V
T
S
A
A
A
K
Site 135
S958
V
S
G
H
Y
V
T
S
A
A
A
K
S
V
H
Site 136
S963
V
T
S
A
A
A
K
S
V
H
A
A
P
N
P
Site 137
S987
A
E
R
D
M
L
P
S
P
E
Q
T
L
S
P
Site 138
T991
M
L
P
S
P
E
Q
T
L
S
P
L
S
K
M
Site 139
S993
P
S
P
E
Q
T
L
S
P
L
S
K
M
P
H
Site 140
S996
P
S
P
E
Q
T
L
S
P
L
S
K
M
P
H
Site 141
S1001
P
L
S
K
M
P
H
S
V
P
Q
P
L
V
E
Site 142
T1010
P
Q
P
L
V
E
K
T
D
D
D
V
I
G
Q
Site 143
S1023
G
Q
A
P
A
E
A
S
P
P
P
I
A
P
K
Site 144
S1037
K
P
V
T
I
P
A
S
Q
V
S
T
Q
N
L
Site 145
T1041
I
P
A
S
Q
V
S
T
Q
N
L
K
T
L
K
Site 146
T1046
V
S
T
Q
N
L
K
T
L
K
T
F
G
A
P
Site 147
T1049
Q
N
L
K
T
L
K
T
F
G
A
P
R
P
Y
Site 148
Y1056
T
F
G
A
P
R
P
Y
S
S
S
G
P
S
P
Site 149
S1057
F
G
A
P
R
P
Y
S
S
S
G
P
S
P
F
Site 150
S1058
G
A
P
R
P
Y
S
S
S
G
P
S
P
F
A
Site 151
S1059
A
P
R
P
Y
S
S
S
G
P
S
P
F
A
L
Site 152
S1072
A
L
A
V
V
K
R
S
Q
S
F
S
K
E
R
Site 153
S1074
A
V
V
K
R
S
Q
S
F
S
K
E
R
T
E
Site 154
S1076
V
K
R
S
Q
S
F
S
K
E
R
T
E
S
P
Site 155
T1080
Q
S
F
S
K
E
R
T
E
S
P
S
A
S
A
Site 156
S1082
F
S
K
E
R
T
E
S
P
S
A
S
A
L
V
Site 157
S1084
K
E
R
T
E
S
P
S
A
S
A
L
V
Q
P
Site 158
S1086
R
T
E
S
P
S
A
S
A
L
V
Q
P
P
A
Site 159
T1100
A
N
T
E
E
G
K
T
H
S
V
N
K
F
V
Site 160
S1102
T
E
E
G
K
T
H
S
V
N
K
F
V
D
I
Site 161
S1115
D
I
P
Q
L
G
V
S
D
K
E
N
N
S
A
Site 162
S1128
S
A
H
N
E
Q
N
S
Q
I
P
T
P
T
D
Site 163
T1132
E
Q
N
S
Q
I
P
T
P
T
D
G
P
S
F
Site 164
T1134
N
S
Q
I
P
T
P
T
D
G
P
S
F
T
V
Site 165
S1138
P
T
P
T
D
G
P
S
F
T
V
M
R
Q
S
Site 166
T1140
P
T
D
G
P
S
F
T
V
M
R
Q
S
S
L
Site 167
S1145
S
F
T
V
M
R
Q
S
S
L
T
F
Q
S
S
Site 168
S1146
F
T
V
M
R
Q
S
S
L
T
F
Q
S
S
D
Site 169
T1148
V
M
R
Q
S
S
L
T
F
Q
S
S
D
P
E
Site 170
S1152
S
S
L
T
F
Q
S
S
D
P
E
Q
M
R
Q
Site 171
S1160
D
P
E
Q
M
R
Q
S
L
L
T
A
I
R
S
Site 172
T1163
Q
M
R
Q
S
L
L
T
A
I
R
S
G
E
A
Site 173
T1178
A
A
K
L
K
R
V
T
I
P
S
N
T
I
S
Site 174
S1181
L
K
R
V
T
I
P
S
N
T
I
S
V
N
G
Site 175
S1185
T
I
P
S
N
T
I
S
V
N
G
R
S
R
L
Site 176
S1193
V
N
G
R
S
R
L
S
H
S
M
S
P
D
A
Site 177
S1195
G
R
S
R
L
S
H
S
M
S
P
D
A
Q
D
Site 178
S1197
S
R
L
S
H
S
M
S
P
D
A
Q
D
G
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation