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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ESCO2
Full Name:
N-acetyltransferase ESCO2
Alias:
ECO1 homolog 2; EFO2; Establishment of cohesion 1 2; Establishment of cohesion 1 homolog 2; Establishment of cohesion 1 homologue 2; RBS
Type:
DNA replication; Acetyltransferase; EC 2.3.1.-
Mass (Da):
68307
Number AA:
601
UniProt ID:
Q56NI9
International Prot ID:
IPI00087498
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0005488
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006259
GO:0006281
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T5
_
_
_
M
A
A
L
T
P
R
K
R
K
Q
D
Site 2
S13
P
R
K
R
K
Q
D
S
L
K
C
D
S
L
L
Site 3
S18
Q
D
S
L
K
C
D
S
L
L
H
F
T
E
N
Site 4
S29
F
T
E
N
L
F
P
S
P
N
K
K
H
C
F
Site 5
S58
Q
Q
E
H
F
V
L
S
A
L
K
T
T
E
I
Site 6
S70
T
E
I
N
R
L
P
S
A
N
Q
G
S
P
F
Site 7
S75
L
P
S
A
N
Q
G
S
P
F
K
S
A
L
S
Site 8
S79
N
Q
G
S
P
F
K
S
A
L
S
T
V
S
F
Site 9
S82
S
P
F
K
S
A
L
S
T
V
S
F
Y
N
Q
Site 10
T83
P
F
K
S
A
L
S
T
V
S
F
Y
N
Q
N
Site 11
S85
K
S
A
L
S
T
V
S
F
Y
N
Q
N
K
W
Site 12
Y93
F
Y
N
Q
N
K
W
Y
L
N
P
L
E
R
K
Site 13
S107
K
L
I
K
E
S
R
S
T
C
L
K
T
N
D
Site 14
T108
L
I
K
E
S
R
S
T
C
L
K
T
N
D
E
Site 15
T112
S
R
S
T
C
L
K
T
N
D
E
D
K
S
F
Site 16
S118
K
T
N
D
E
D
K
S
F
P
I
V
T
E
K
Site 17
S143
N
N
K
K
P
Q
K
S
L
T
A
K
Y
Q
P
Site 18
T145
K
K
P
Q
K
S
L
T
A
K
Y
Q
P
K
Y
Site 19
Y148
Q
K
S
L
T
A
K
Y
Q
P
K
Y
R
H
I
Site 20
Y152
T
A
K
Y
Q
P
K
Y
R
H
I
K
P
V
S
Site 21
S159
Y
R
H
I
K
P
V
S
R
N
S
R
N
S
K
Site 22
S162
I
K
P
V
S
R
N
S
R
N
S
K
Q
N
R
Site 23
S165
V
S
R
N
S
R
N
S
K
Q
N
R
V
I
Y
Site 24
Y172
S
K
Q
N
R
V
I
Y
K
P
I
V
E
K
E
Site 25
S184
E
K
E
N
N
C
H
S
A
E
N
N
S
N
A
Site 26
S196
S
N
A
P
R
V
L
S
Q
K
I
K
P
Q
V
Site 27
S217
A
F
F
V
R
K
K
S
S
L
R
K
S
S
L
Site 28
S218
F
F
V
R
K
K
S
S
L
R
K
S
S
L
E
Site 29
S222
K
K
S
S
L
R
K
S
S
L
E
N
E
P
S
Site 30
S223
K
S
S
L
R
K
S
S
L
E
N
E
P
S
L
Site 31
S229
S
S
L
E
N
E
P
S
L
G
R
T
Q
K
S
Site 32
T233
N
E
P
S
L
G
R
T
Q
K
S
K
S
E
V
Site 33
S236
S
L
G
R
T
Q
K
S
K
S
E
V
I
E
D
Site 34
S238
G
R
T
Q
K
S
K
S
E
V
I
E
D
S
D
Site 35
S244
K
S
E
V
I
E
D
S
D
V
E
T
V
S
E
Site 36
T248
I
E
D
S
D
V
E
T
V
S
E
K
K
T
F
Site 37
S250
D
S
D
V
E
T
V
S
E
K
K
T
F
A
T
Site 38
T254
E
T
V
S
E
K
K
T
F
A
T
R
Q
V
P
Site 39
S276
K
L
K
I
G
L
L
S
A
S
S
K
N
K
E
Site 40
S278
K
I
G
L
L
S
A
S
S
K
N
K
E
K
L
Site 41
S279
I
G
L
L
S
A
S
S
K
N
K
E
K
L
I
Site 42
S289
K
E
K
L
I
K
D
S
S
D
D
R
V
S
S
Site 43
S290
E
K
L
I
K
D
S
S
D
D
R
V
S
S
K
Site 44
S295
D
S
S
D
D
R
V
S
S
K
E
H
K
V
D
Site 45
S296
S
S
D
D
R
V
S
S
K
E
H
K
V
D
K
Site 46
S308
V
D
K
N
E
A
F
S
S
E
D
S
L
G
E
Site 47
S309
D
K
N
E
A
F
S
S
E
D
S
L
G
E
N
Site 48
S312
E
A
F
S
S
E
D
S
L
G
E
N
K
T
I
Site 49
T318
D
S
L
G
E
N
K
T
I
S
P
K
S
T
V
Site 50
S320
L
G
E
N
K
T
I
S
P
K
S
T
V
Y
P
Site 51
S323
N
K
T
I
S
P
K
S
T
V
Y
P
I
F
S
Site 52
T324
K
T
I
S
P
K
S
T
V
Y
P
I
F
S
A
Site 53
S330
S
T
V
Y
P
I
F
S
A
S
S
V
N
S
K
Site 54
S332
V
Y
P
I
F
S
A
S
S
V
N
S
K
R
S
Site 55
S333
Y
P
I
F
S
A
S
S
V
N
S
K
R
S
L
Site 56
S336
F
S
A
S
S
V
N
S
K
R
S
L
G
E
E
Site 57
S339
S
S
V
N
S
K
R
S
L
G
E
E
Q
F
S
Site 58
S346
S
L
G
E
E
Q
F
S
V
G
S
V
N
F
M
Site 59
T367
K
N
T
N
T
R
D
T
S
K
K
T
K
D
Q
Site 60
S368
N
T
N
T
R
D
T
S
K
K
T
K
D
Q
L
Site 61
Y396
C
K
S
C
G
M
I
Y
T
A
S
N
P
E
D
Site 62
Y420
R
F
L
E
G
I
K
Y
V
G
W
K
K
E
R
Site 63
T478
K
C
P
N
K
I
K
T
F
L
F
I
S
D
E
Site 64
S505
K
Q
A
F
R
V
L
S
E
P
I
G
P
E
S
Site 65
S512
S
E
P
I
G
P
E
S
P
S
S
T
E
C
P
Site 66
S515
I
G
P
E
S
P
S
S
T
E
C
P
R
A
W
Site 67
T516
G
P
E
S
P
S
S
T
E
C
P
R
A
W
Q
Site 68
S525
C
P
R
A
W
Q
C
S
D
V
P
E
P
A
V
Site 69
S575
S
T
D
E
I
A
F
S
D
P
T
P
D
G
K
Site 70
T578
E
I
A
F
S
D
P
T
P
D
G
K
L
F
A
Site 71
Y588
G
K
L
F
A
T
K
Y
C
N
T
P
N
F
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation