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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PAN3
Full Name:
PAB-dependent poly(A)-specific ribonuclease subunit 3
Alias:
PAB-dependent poly(A)-specific ribonuclease 3; PAN3 poly (A) specific ribonuclease subunit; PAN3 polyA specific ribonuclease
Type:
Mass (Da):
82181
Number AA:
741
UniProt ID:
Q58A45
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004672
PhosphoSite+
KinaseNET
Biological Process:
GO:0000184
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
D
G
G
A
L
T
D
T
S
L
T
D
S
Y
F
Site 2
S10
G
G
A
L
T
D
T
S
L
T
D
S
Y
F
S
Site 3
T12
A
L
T
D
T
S
L
T
D
S
Y
F
S
T
S
Site 4
S14
T
D
T
S
L
T
D
S
Y
F
S
T
S
F
I
Site 5
Y15
D
T
S
L
T
D
S
Y
F
S
T
S
F
I
G
Site 6
S28
I
G
V
N
G
F
G
S
P
V
E
T
K
Y
P
Site 7
T32
G
F
G
S
P
V
E
T
K
Y
P
L
M
Q
R
Site 8
Y34
G
S
P
V
E
T
K
Y
P
L
M
Q
R
M
T
Site 9
T41
Y
P
L
M
Q
R
M
T
N
S
S
S
S
P
S
Site 10
S43
L
M
Q
R
M
T
N
S
S
S
S
P
S
L
L
Site 11
S44
M
Q
R
M
T
N
S
S
S
S
P
S
L
L
N
Site 12
S45
Q
R
M
T
N
S
S
S
S
P
S
L
L
N
D
Site 13
S46
R
M
T
N
S
S
S
S
P
S
L
L
N
D
S
Site 14
S48
T
N
S
S
S
S
P
S
L
L
N
D
S
A
K
Site 15
S53
S
P
S
L
L
N
D
S
A
K
P
Y
S
A
H
Site 16
Y57
L
N
D
S
A
K
P
Y
S
A
H
D
P
L
T
Site 17
S58
N
D
S
A
K
P
Y
S
A
H
D
P
L
T
S
Site 18
T64
Y
S
A
H
D
P
L
T
S
P
A
S
S
L
F
Site 19
S65
S
A
H
D
P
L
T
S
P
A
S
S
L
F
N
Site 20
S68
D
P
L
T
S
P
A
S
S
L
F
N
D
F
G
Site 21
S80
D
F
G
A
L
N
I
S
Q
R
R
K
P
R
K
Site 22
Y88
Q
R
R
K
P
R
K
Y
R
L
G
M
L
E
E
Site 23
S102
E
R
L
V
P
M
G
S
K
A
R
K
A
K
N
Site 24
T139
V
T
E
N
N
L
Q
T
P
N
P
T
A
S
E
Site 25
S145
Q
T
P
N
P
T
A
S
E
F
I
P
K
G
G
Site 26
S153
E
F
I
P
K
G
G
S
T
S
R
L
S
N
V
Site 27
T154
F
I
P
K
G
G
S
T
S
R
L
S
N
V
S
Site 28
S158
G
G
S
T
S
R
L
S
N
V
S
Q
S
N
M
Site 29
S161
T
S
R
L
S
N
V
S
Q
S
N
M
S
A
F
Site 30
S163
R
L
S
N
V
S
Q
S
N
M
S
A
F
S
Q
Site 31
S169
Q
S
N
M
S
A
F
S
Q
V
F
S
H
P
S
Site 32
S173
S
A
F
S
Q
V
F
S
H
P
S
M
G
S
P
Site 33
S176
S
Q
V
F
S
H
P
S
M
G
S
P
A
T
A
Site 34
S196
M
S
L
S
A
G
S
S
P
L
H
S
P
K
I
Site 35
S200
A
G
S
S
P
L
H
S
P
K
I
T
P
H
T
Site 36
T204
P
L
H
S
P
K
I
T
P
H
T
S
P
A
P
Site 37
S208
P
K
I
T
P
H
T
S
P
A
P
R
R
R
S
Site 38
S215
S
P
A
P
R
R
R
S
H
T
P
N
P
A
S
Site 39
T217
A
P
R
R
R
S
H
T
P
N
P
A
S
Y
M
Site 40
S222
S
H
T
P
N
P
A
S
Y
M
V
P
S
S
A
Site 41
Y223
H
T
P
N
P
A
S
Y
M
V
P
S
S
A
S
Site 42
S227
P
A
S
Y
M
V
P
S
S
A
S
T
S
V
N
Site 43
S228
A
S
Y
M
V
P
S
S
A
S
T
S
V
N
N
Site 44
T231
M
V
P
S
S
A
S
T
S
V
N
N
P
V
S
Site 45
S232
V
P
S
S
A
S
T
S
V
N
N
P
V
S
Q
Site 46
S238
T
S
V
N
N
P
V
S
Q
T
P
S
S
G
Q
Site 47
T240
V
N
N
P
V
S
Q
T
P
S
S
G
Q
V
I
Site 48
S242
N
P
V
S
Q
T
P
S
S
G
Q
V
I
Q
K
Site 49
S243
P
V
S
Q
T
P
S
S
G
Q
V
I
Q
K
E
Site 50
T251
G
Q
V
I
Q
K
E
T
V
G
G
T
T
Y
F
Site 51
Y257
E
T
V
G
G
T
T
Y
F
Y
T
D
T
T
P
Site 52
Y259
V
G
G
T
T
Y
F
Y
T
D
T
T
P
A
P
Site 53
T262
T
T
Y
F
Y
T
D
T
T
P
A
P
L
T
G
Site 54
T263
T
Y
F
Y
T
D
T
T
P
A
P
L
T
G
M
Site 55
T268
D
T
T
P
A
P
L
T
G
M
V
F
P
N
Y
Site 56
Y275
T
G
M
V
F
P
N
Y
H
I
Y
P
P
T
A
Site 57
Y278
V
F
P
N
Y
H
I
Y
P
P
T
A
P
H
V
Site 58
Y287
P
T
A
P
H
V
A
Y
M
Q
P
K
A
N
A
Site 59
S296
Q
P
K
A
N
A
P
S
F
F
M
A
D
E
L
Site 60
T328
A
D
M
P
A
V
P
T
E
V
D
S
Y
H
S
Site 61
Y333
V
P
T
E
V
D
S
Y
H
S
L
F
P
L
E
Site 62
S335
T
E
V
D
S
Y
H
S
L
F
P
L
E
P
L
Site 63
S351
P
P
N
R
I
Q
K
S
S
N
F
G
Y
I
T
Site 64
S352
P
N
R
I
Q
K
S
S
N
F
G
Y
I
T
S
Site 65
Y356
Q
K
S
S
N
F
G
Y
I
T
S
C
Y
K
A
Site 66
Y361
F
G
Y
I
T
S
C
Y
K
A
V
N
S
K
D
Site 67
Y372
N
S
K
D
D
L
P
Y
C
L
R
R
I
H
G
Site 68
T411
T
L
R
E
V
F
T
T
K
A
F
A
E
P
S
Site 69
Y423
E
P
S
L
V
F
A
Y
D
F
H
A
G
G
E
Site 70
Y445
N
D
P
N
A
D
A
Y
F
T
K
R
K
W
G
Site 71
T520
V
G
V
F
D
V
L
T
F
D
N
S
Q
N
N
Site 72
S524
D
V
L
T
F
D
N
S
Q
N
N
N
P
L
A
Site 73
T572
Q
K
A
M
E
L
V
T
I
N
Y
S
S
D
L
Site 74
Y575
M
E
L
V
T
I
N
Y
S
S
D
L
K
N
L
Site 75
Y585
D
L
K
N
L
I
L
Y
L
L
T
D
Q
N
R
Site 76
Y608
P
M
I
G
A
R
F
Y
T
Q
L
D
A
A
Q
Site 77
T643
R
L
L
A
K
L
G
T
I
N
E
R
P
E
F
Site 78
T655
P
E
F
Q
K
D
P
T
W
S
E
T
G
D
R
Site 79
S657
F
Q
K
D
P
T
W
S
E
T
G
D
R
Y
L
Site 80
Y663
W
S
E
T
G
D
R
Y
L
L
K
L
F
R
D
Site 81
S705
A
G
V
P
E
K
I
S
L
I
S
R
D
E
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation