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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLEKHG4
Full Name:
Puratrophin-1
Alias:
DKFZP434I216; PKHG4; Pleckstrin homology domain containing, family G (with RhoGef domain) member 4; Pleckstrin homology domain-containing family G member 4; Pleckstriny domain containing, family G (with RhoGef domain) member 4; PRTPHN1; Puratrophin1; Purkinje cell atrophy-associated protein 1; SCA4
Type:
Mass (Da):
130803
Number AA:
1191
UniProt ID:
Q58EX7
International Prot ID:
IPI00025442
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0044464
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005083
GO:0005085
GO:0005088
PhosphoSite+
KinaseNET
Biological Process:
GO:0008219
GO:0009966
GO:0009987
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
P
L
E
N
G
D
E
S
P
D
S
Q
G
H
A
Site 2
S14
N
G
D
E
S
P
D
S
Q
G
H
A
T
D
W
Site 3
T19
P
D
S
Q
G
H
A
T
D
W
R
F
A
V
C
Site 4
S39
W
E
E
E
E
P
A
S
Q
M
H
V
K
D
P
Site 5
S64
Q
D
E
E
L
Q
G
S
P
L
S
R
K
F
Q
Site 6
S67
E
L
Q
G
S
P
L
S
R
K
F
Q
L
P
P
Site 7
T86
S
G
D
A
Q
R
G
T
V
E
S
S
S
V
L
Site 8
S89
A
Q
R
G
T
V
E
S
S
S
V
L
S
E
G
Site 9
S90
Q
R
G
T
V
E
S
S
S
V
L
S
E
G
P
Site 10
S91
R
G
T
V
E
S
S
S
V
L
S
E
G
P
G
Site 11
S94
V
E
S
S
S
V
L
S
E
G
P
G
P
S
G
Site 12
S114
C
P
M
S
S
H
L
S
L
A
Q
G
E
S
D
Site 13
S120
L
S
L
A
Q
G
E
S
D
T
P
G
V
G
L
Site 14
S134
L
V
G
D
P
G
P
S
R
A
M
P
S
G
L
Site 15
S139
G
P
S
R
A
M
P
S
G
L
S
P
G
A
L
Site 16
S142
R
A
M
P
S
G
L
S
P
G
A
L
D
S
D
Site 17
S148
L
S
P
G
A
L
D
S
D
P
V
G
L
G
D
Site 18
S169
K
L
L
E
A
A
P
S
G
S
G
L
P
K
P
Site 19
S171
L
E
A
A
P
S
G
S
G
L
P
K
P
A
D
Site 20
S221
H
S
P
A
W
L
Q
S
E
C
S
S
Q
E
L
Site 21
S224
A
W
L
Q
S
E
C
S
S
Q
E
L
I
R
L
Site 22
S225
W
L
Q
S
E
C
S
S
Q
E
L
I
R
L
L
Site 23
S237
R
L
L
L
Y
L
R
S
I
P
R
P
E
V
Q
Site 24
S265
A
P
S
S
S
L
F
S
G
L
S
Q
L
Q
E
Site 25
S268
S
S
L
F
S
G
L
S
Q
L
Q
E
A
A
P
Site 26
Y325
S
L
G
G
G
L
P
Y
C
H
Q
A
W
L
D
Site 27
T402
C
Q
G
G
R
E
L
T
W
L
K
Q
E
V
P
Site 28
S414
E
V
P
E
V
T
L
S
P
D
Y
R
T
A
M
Site 29
Y417
E
V
T
L
S
P
D
Y
R
T
A
M
D
K
A
Site 30
Y428
M
D
K
A
D
E
L
Y
D
R
V
D
G
L
L
Site 31
T439
D
G
L
L
H
Q
L
T
L
Q
S
N
Q
R
I
Site 32
T454
Q
A
L
E
L
V
Q
T
L
E
A
R
E
S
G
Site 33
S460
Q
T
L
E
A
R
E
S
G
L
H
Q
I
E
V
Site 34
S484
L
E
E
A
G
E
P
S
L
D
M
L
L
Q
A
Site 35
Y499
Q
G
S
F
Q
E
L
Y
Q
V
A
Q
E
Q
V
Site 36
T596
Q
Q
L
Q
L
H
W
T
R
H
P
D
L
P
P
Site 37
Y676
H
P
P
L
R
K
A
Y
S
F
D
R
N
L
G
Site 38
S677
P
P
L
R
K
A
Y
S
F
D
R
N
L
G
Q
Site 39
S685
F
D
R
N
L
G
Q
S
L
S
E
P
A
C
H
Site 40
S687
R
N
L
G
Q
S
L
S
E
P
A
C
H
C
H
Site 41
S716
G
G
A
L
P
Q
A
S
P
T
V
P
P
P
G
Site 42
T718
A
L
P
Q
A
S
P
T
V
P
P
P
G
S
S
Site 43
S724
P
T
V
P
P
P
G
S
S
D
P
R
S
L
N
Site 44
S725
T
V
P
P
P
G
S
S
D
P
R
S
L
N
R
Site 45
S729
P
G
S
S
D
P
R
S
L
N
R
L
Q
L
V
Site 46
Y747
M
V
A
T
E
R
E
Y
V
R
A
L
E
Y
T
Site 47
T754
Y
V
R
A
L
E
Y
T
M
E
N
Y
F
P
E
Site 48
Y758
L
E
Y
T
M
E
N
Y
F
P
E
L
D
R
P
Site 49
Y809
R
H
P
P
R
V
A
Y
A
F
L
R
H
R
V
Site 50
Y821
H
R
V
Q
F
G
M
Y
A
L
Y
S
K
N
K
Site 51
Y824
Q
F
G
M
Y
A
L
Y
S
K
N
K
P
R
S
Site 52
S825
F
G
M
Y
A
L
Y
S
K
N
K
P
R
S
D
Site 53
S831
Y
S
K
N
K
P
R
S
D
A
L
M
S
S
Y
Site 54
S837
R
S
D
A
L
M
S
S
Y
G
H
T
F
F
K
Site 55
Y838
S
D
A
L
M
S
S
Y
G
H
T
F
F
K
D
Site 56
T841
L
M
S
S
Y
G
H
T
F
F
K
D
K
Q
Q
Site 57
S858
G
D
H
L
D
L
A
S
Y
L
L
K
P
I
Q
Site 58
Y859
D
H
L
D
L
A
S
Y
L
L
K
P
I
Q
R
Site 59
S889
G
G
P
T
Q
E
L
S
A
L
R
E
A
Q
S
Site 60
S896
S
A
L
R
E
A
Q
S
L
V
H
F
Q
L
R
Site 61
T937
Q
D
E
F
V
V
R
T
G
R
H
K
S
V
R
Site 62
S942
V
R
T
G
R
H
K
S
V
R
R
I
F
L
F
Site 63
T963
S
K
P
R
H
G
P
T
G
V
D
T
F
A
Y
Site 64
T967
H
G
P
T
G
V
D
T
F
A
Y
K
R
S
F
Site 65
Y970
T
G
V
D
T
F
A
Y
K
R
S
F
K
M
A
Site 66
S973
D
T
F
A
Y
K
R
S
F
K
M
A
D
L
G
Site 67
T1004
R
R
R
K
A
R
D
T
F
V
L
Q
A
S
S
Site 68
S1057
A
F
R
D
I
A
P
S
E
E
A
I
N
D
R
Site 69
T1065
E
E
A
I
N
D
R
T
V
N
Y
V
L
K
C
Site 70
Y1068
I
N
D
R
T
V
N
Y
V
L
K
C
R
E
V
Site 71
S1080
R
E
V
R
S
R
A
S
I
A
V
A
P
F
D
Site 72
S1090
V
A
P
F
D
H
D
S
L
Y
L
G
A
S
N
Site 73
Y1092
P
F
D
H
D
S
L
Y
L
G
A
S
N
S
L
Site 74
S1096
D
S
L
Y
L
G
A
S
N
S
L
P
G
D
P
Site 75
S1098
L
Y
L
G
A
S
N
S
L
P
G
D
P
A
S
Site 76
Y1130
L
G
L
R
C
P
L
Y
P
S
F
P
E
E
A
Site 77
S1150
A
E
L
G
G
Q
P
S
L
T
A
E
D
S
E
Site 78
T1152
L
G
G
Q
P
S
L
T
A
E
D
S
E
I
S
Site 79
S1156
P
S
L
T
A
E
D
S
E
I
S
S
Q
C
P
Site 80
S1160
A
E
D
S
E
I
S
S
Q
C
P
S
A
S
G
Site 81
S1164
E
I
S
S
Q
C
P
S
A
S
G
S
S
G
S
Site 82
S1166
S
S
Q
C
P
S
A
S
G
S
S
G
S
D
S
Site 83
S1168
Q
C
P
S
A
S
G
S
S
G
S
D
S
S
C
Site 84
S1169
C
P
S
A
S
G
S
S
G
S
D
S
S
C
V
Site 85
S1171
S
A
S
G
S
S
G
S
D
S
S
C
V
S
G
Site 86
S1173
S
G
S
S
G
S
D
S
S
C
V
S
G
Q
A
Site 87
S1174
G
S
S
G
S
D
S
S
C
V
S
G
Q
A
L
Site 88
S1177
G
S
D
S
S
C
V
S
G
Q
A
L
G
R
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation