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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HSP90AB4P
Full Name:
Putative heat shock protein HSP 90-beta 4
Alias:
Type:
Mass (Da):
58264
Number AA:
505
UniProt ID:
Q58FF6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y32
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
Site 2
S34
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
L
Site 3
T36
K
I
R
Y
E
S
L
T
D
P
S
K
L
D
G
Site 4
Y130
K
H
N
D
E
E
Q
Y
S
W
V
S
S
A
G
Site 5
S131
H
N
D
E
E
Q
Y
S
W
V
S
S
A
G
S
Site 6
S134
E
E
Q
Y
S
W
V
S
S
A
G
S
S
F
T
Site 7
S135
E
Q
Y
S
W
V
S
S
A
G
S
S
F
T
L
Site 8
S138
S
W
V
S
S
A
G
S
S
F
T
L
H
V
D
Site 9
S139
W
V
S
S
A
G
S
S
F
T
L
H
V
D
H
Site 10
T154
G
E
P
I
D
R
D
T
K
V
I
L
H
L
K
Site 11
T165
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
W
Site 12
Y167
L
K
E
D
Q
T
E
Y
L
E
E
R
W
V
K
Site 13
S201
K
E
P
E
K
E
I
S
D
D
E
E
E
K
G
Site 14
T223
D
D
K
E
K
P
K
T
E
D
V
G
S
D
E
Site 15
S228
P
K
T
E
D
V
G
S
D
E
E
D
D
T
D
Site 16
T234
G
S
D
E
E
D
D
T
D
K
N
N
K
K
K
Site 17
Y249
T
K
K
I
K
E
K
Y
T
D
R
E
E
L
N
Site 18
T250
K
K
I
K
E
K
Y
T
D
R
E
E
L
N
Q
Site 19
T258
D
R
E
E
L
N
Q
T
K
P
I
W
T
R
N
Site 20
T270
T
R
N
P
D
D
I
T
Q
E
E
C
G
E
F
Site 21
Y278
Q
E
E
C
G
E
F
Y
K
S
L
T
S
A
W
Site 22
S280
E
C
G
E
F
Y
K
S
L
T
S
A
W
E
D
Site 23
T282
G
E
F
Y
K
S
L
T
S
A
W
E
D
H
L
Site 24
Y323
F
D
D
L
M
P
E
Y
V
G
F
V
R
E
D
Site 25
S342
K
K
L
D
E
V
F
S
K
I
S
W
L
G
I
Site 26
S365
H
L
S
E
L
L
W
S
H
T
F
Q
S
G
D
Site 27
T367
S
E
L
L
W
S
H
T
F
Q
S
G
D
E
M
Site 28
S370
L
W
S
H
T
F
Q
S
G
D
E
M
T
S
L
Site 29
S376
Q
S
G
D
E
M
T
S
L
S
E
Y
V
S
C
Site 30
S378
G
D
E
M
T
S
L
S
E
Y
V
S
C
M
K
Site 31
Y380
E
M
T
S
L
S
E
Y
V
S
C
M
K
E
A
Site 32
S382
T
S
L
S
E
Y
V
S
C
M
K
E
A
Q
K
Site 33
Y420
K
K
G
F
E
V
I
Y
M
S
E
P
I
D
E
Site 34
Y428
M
S
E
P
I
D
E
Y
C
V
Q
Q
L
K
E
Site 35
S440
L
K
E
F
D
G
K
S
L
L
S
V
T
K
E
Site 36
S443
F
D
G
K
S
L
L
S
V
T
K
E
G
L
E
Site 37
T487
D
K
K
V
E
R
V
T
I
S
S
R
L
V
S
Site 38
S489
K
V
E
R
V
T
I
S
S
R
L
V
S
S
P
Site 39
T501
S
S
P
C
R
I
V
T
S
T
Y
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation