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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HSP90AA4P
Full Name:
Putative heat shock protein HSP 90-alpha A4
Alias:
Heat shock 90 kDa protein 1 alpha-like 2;Heat shock protein 90-alpha D
Type:
Mass (Da):
47712
Number AA:
418
UniProt ID:
Q58FG1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T5
_
_
_
M
E
S
L
T
D
P
S
K
L
D
S
Site 2
S8
M
E
S
L
T
D
P
S
K
L
D
S
G
K
E
Site 3
S12
T
D
P
S
K
L
D
S
G
K
E
P
H
I
S
Site 4
S19
S
G
K
E
P
H
I
S
L
I
P
N
K
Q
D
Site 5
T28
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
Site 6
T30
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
Site 7
T34
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
Site 8
S53
N
L
G
T
I
T
K
S
E
T
K
V
F
M
E
Site 9
Y100
K
H
N
N
D
E
Q
Y
A
W
E
S
S
L
R
Site 10
S104
D
E
Q
Y
A
W
E
S
S
L
R
G
S
F
T
Site 11
S105
E
Q
Y
A
W
E
S
S
L
R
G
S
F
T
E
Site 12
S109
W
E
S
S
L
R
G
S
F
T
E
Y
R
E
F
Site 13
T111
S
S
L
R
G
S
F
T
E
Y
R
E
F
Y
K
Site 14
Y113
L
R
G
S
F
T
E
Y
R
E
F
Y
K
S
L
Site 15
Y117
F
T
E
Y
R
E
F
Y
K
S
L
T
I
N
W
Site 16
T121
R
E
F
Y
K
S
L
T
I
N
W
E
D
Y
L
Site 17
Y127
L
T
I
N
W
E
D
Y
L
A
V
K
H
F
S
Site 18
S168
K
K
N
K
I
K
L
S
A
R
R
D
L
I
M
Site 19
T206
P
L
N
I
F
R
E
T
K
D
Q
V
A
N
S
Site 20
T229
H
G
L
E
V
I
Y
T
I
E
P
I
D
E
Y
Site 21
Y236
T
I
E
P
I
D
E
Y
C
V
Q
Q
L
K
E
Site 22
T248
L
K
E
F
E
G
K
T
L
V
S
V
T
K
E
Site 23
T253
G
K
T
L
V
S
V
T
K
E
D
L
E
L
P
Site 24
S283
T
K
Q
K
K
N
Q
S
L
R
T
S
A
K
S
Site 25
T286
K
K
N
Q
S
L
R
T
S
A
K
S
T
Y
G
Site 26
S287
K
N
Q
S
L
R
T
S
A
K
S
T
Y
G
W
Site 27
S290
S
L
R
T
S
A
K
S
T
Y
G
W
T
A
N
Site 28
T291
L
R
T
S
A
K
S
T
Y
G
W
T
A
N
M
Site 29
Y292
R
T
S
A
K
S
T
Y
G
W
T
A
N
M
E
Site 30
S311
A
Q
A
L
R
D
N
S
T
T
G
Y
M
A
A
Site 31
T312
Q
A
L
R
D
N
S
T
T
G
Y
M
A
A
K
Site 32
T313
A
L
R
D
N
S
T
T
G
Y
M
A
A
K
K
Site 33
Y315
R
D
N
S
T
T
G
Y
M
A
A
K
K
H
L
Site 34
S329
L
E
I
N
P
D
H
S
F
I
D
T
L
R
Q
Site 35
T333
P
D
H
S
F
I
D
T
L
R
Q
K
A
E
T
Site 36
T340
T
L
R
Q
K
A
E
T
D
K
N
D
K
S
V
Site 37
S346
E
T
D
K
N
D
K
S
V
K
D
L
V
I
L
Site 38
T371
F
G
L
E
G
P
Q
T
H
A
N
R
I
Y
R
Site 39
Y377
Q
T
H
A
N
R
I
Y
R
M
N
K
L
G
L
Site 40
T392
G
T
D
E
D
D
P
T
A
D
D
T
S
A
A
Site 41
T396
D
D
P
T
A
D
D
T
S
A
A
V
T
E
E
Site 42
S397
D
P
T
A
D
D
T
S
A
A
V
T
E
E
M
Site 43
T401
D
D
T
S
A
A
V
T
E
E
M
P
P
L
E
Site 44
T413
P
L
E
G
D
D
D
T
S
R
M
E
K
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation