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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IQWD1
Full Name:
DDB1- and CUL4-associated factor 6
Alias:
Androgen receptor complex-associated protein; ARCAP; NRIP; nuclear receptor interaction protein
Type:
Nuclear receptor co-regulator
Mass (Da):
96292
Number AA:
860
UniProt ID:
Q58WW2
International Prot ID:
IPI00290516
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0030374
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
L
W
D
V
R
K
R
S
L
G
L
E
D
P
S
Site 2
S25
S
L
G
L
E
D
P
S
R
L
R
S
R
Y
L
Site 3
S29
E
D
P
S
R
L
R
S
R
Y
L
G
R
R
E
Site 4
Y31
P
S
R
L
R
S
R
Y
L
G
R
R
E
F
I
Site 5
T46
Q
R
L
K
L
E
A
T
L
N
V
H
D
G
C
Site 6
S68
D
T
G
E
Y
I
L
S
G
S
D
D
T
K
L
Site 7
S70
G
E
Y
I
L
S
G
S
D
D
T
K
L
V
I
Site 8
T73
I
L
S
G
S
D
D
T
K
L
V
I
S
N
P
Site 9
S78
D
D
T
K
L
V
I
S
N
P
Y
S
R
K
V
Site 10
T87
P
Y
S
R
K
V
L
T
T
I
R
S
G
H
R
Site 11
T88
Y
S
R
K
V
L
T
T
I
R
S
G
H
R
A
Site 12
S91
K
V
L
T
T
I
R
S
G
H
R
A
N
I
F
Site 13
T106
S
A
K
F
L
P
C
T
N
D
K
Q
I
V
S
Site 14
Y122
S
G
D
G
V
I
F
Y
T
N
V
E
Q
D
A
Site 15
Y145
T
C
H
Y
G
T
T
Y
E
I
M
T
V
P
N
Site 16
T149
G
T
T
Y
E
I
M
T
V
P
N
D
P
Y
T
Site 17
Y155
M
T
V
P
N
D
P
Y
T
F
L
S
C
G
E
Site 18
T156
T
V
P
N
D
P
Y
T
F
L
S
C
G
E
D
Site 19
S159
N
D
P
Y
T
F
L
S
C
G
E
D
G
T
V
Site 20
T165
L
S
C
G
E
D
G
T
V
R
W
F
D
T
R
Site 21
T175
W
F
D
T
R
I
K
T
S
C
T
K
E
D
C
Site 22
S214
L
A
V
G
C
S
D
S
S
V
R
I
Y
D
R
Site 23
S215
A
V
G
C
S
D
S
S
V
R
I
Y
D
R
R
Site 24
Y219
S
D
S
S
V
R
I
Y
D
R
R
M
L
G
T
Site 25
T226
Y
D
R
R
M
L
G
T
R
A
T
G
N
Y
A
Site 26
T229
R
M
L
G
T
R
A
T
G
N
Y
A
G
R
G
Site 27
Y232
G
T
R
A
T
G
N
Y
A
G
R
G
T
T
G
Site 28
T237
G
N
Y
A
G
R
G
T
T
G
M
V
A
R
F
Site 29
S253
P
S
H
L
N
N
K
S
C
R
V
T
S
L
C
Site 30
T257
N
N
K
S
C
R
V
T
S
L
C
Y
S
E
D
Site 31
S258
N
K
S
C
R
V
T
S
L
C
Y
S
E
D
G
Site 32
S262
R
V
T
S
L
C
Y
S
E
D
G
Q
E
I
L
Site 33
S271
D
G
Q
E
I
L
V
S
Y
S
S
D
Y
I
Y
Site 34
Y276
L
V
S
Y
S
S
D
Y
I
Y
L
F
D
P
K
Site 35
Y278
S
Y
S
S
D
Y
I
Y
L
F
D
P
K
D
D
Site 36
T286
L
F
D
P
K
D
D
T
A
R
E
L
K
T
P
Site 37
T292
D
T
A
R
E
L
K
T
P
S
A
E
E
R
R
Site 38
S317
L
R
L
R
G
D
W
S
D
T
G
P
R
A
R
Site 39
T319
L
R
G
D
W
S
D
T
G
P
R
A
R
P
E
Site 40
S327
G
P
R
A
R
P
E
S
E
R
E
R
D
G
E
Site 41
S336
R
E
R
D
G
E
Q
S
P
N
V
S
L
M
Q
Site 42
S340
G
E
Q
S
P
N
V
S
L
M
Q
R
M
S
D
Site 43
S350
Q
R
M
S
D
M
L
S
R
W
F
E
E
A
S
Site 44
S357
S
R
W
F
E
E
A
S
E
V
A
Q
S
N
R
Site 45
S362
E
A
S
E
V
A
Q
S
N
R
G
R
G
R
S
Site 46
S369
S
N
R
G
R
G
R
S
R
P
R
G
G
T
S
Site 47
T375
R
S
R
P
R
G
G
T
S
Q
S
D
I
S
T
Site 48
S376
S
R
P
R
G
G
T
S
Q
S
D
I
S
T
L
Site 49
S378
P
R
G
G
T
S
Q
S
D
I
S
T
L
P
T
Site 50
S381
G
T
S
Q
S
D
I
S
T
L
P
T
V
P
S
Site 51
T382
T
S
Q
S
D
I
S
T
L
P
T
V
P
S
S
Site 52
T385
S
D
I
S
T
L
P
T
V
P
S
S
P
D
L
Site 53
S388
S
T
L
P
T
V
P
S
S
P
D
L
E
V
S
Site 54
S389
T
L
P
T
V
P
S
S
P
D
L
E
V
S
E
Site 55
S395
S
S
P
D
L
E
V
S
E
T
A
M
E
V
D
Site 56
T397
P
D
L
E
V
S
E
T
A
M
E
V
D
T
P
Site 57
T403
E
T
A
M
E
V
D
T
P
A
E
Q
F
L
Q
Site 58
S412
A
E
Q
F
L
Q
P
S
T
S
S
T
M
S
A
Site 59
T413
E
Q
F
L
Q
P
S
T
S
S
T
M
S
A
Q
Site 60
S414
Q
F
L
Q
P
S
T
S
S
T
M
S
A
Q
A
Site 61
T416
L
Q
P
S
T
S
S
T
M
S
A
Q
A
H
S
Site 62
S418
P
S
T
S
S
T
M
S
A
Q
A
H
S
T
S
Site 63
S423
T
M
S
A
Q
A
H
S
T
S
S
P
T
E
S
Site 64
T424
M
S
A
Q
A
H
S
T
S
S
P
T
E
S
P
Site 65
S425
S
A
Q
A
H
S
T
S
S
P
T
E
S
P
H
Site 66
S426
A
Q
A
H
S
T
S
S
P
T
E
S
P
H
S
Site 67
T428
A
H
S
T
S
S
P
T
E
S
P
H
S
T
P
Site 68
S430
S
T
S
S
P
T
E
S
P
H
S
T
P
L
L
Site 69
S433
S
P
T
E
S
P
H
S
T
P
L
L
S
S
P
Site 70
T434
P
T
E
S
P
H
S
T
P
L
L
S
S
P
D
Site 71
S438
P
H
S
T
P
L
L
S
S
P
D
S
E
Q
R
Site 72
S439
H
S
T
P
L
L
S
S
P
D
S
E
Q
R
Q
Site 73
S442
P
L
L
S
S
P
D
S
E
Q
R
Q
S
V
E
Site 74
S447
P
D
S
E
Q
R
Q
S
V
E
A
S
G
H
H
Site 75
S451
Q
R
Q
S
V
E
A
S
G
H
H
T
H
H
Q
Site 76
T455
V
E
A
S
G
H
H
T
H
H
Q
S
D
N
N
Site 77
S467
D
N
N
N
E
K
L
S
P
K
P
G
T
G
E
Site 78
T472
K
L
S
P
K
P
G
T
G
E
P
V
L
S
L
Site 79
S478
G
T
G
E
P
V
L
S
L
H
Y
S
T
E
G
Site 80
S482
P
V
L
S
L
H
Y
S
T
E
G
T
T
T
S
Site 81
T486
L
H
Y
S
T
E
G
T
T
T
S
T
I
K
L
Site 82
T488
Y
S
T
E
G
T
T
T
S
T
I
K
L
N
F
Site 83
S489
S
T
E
G
T
T
T
S
T
I
K
L
N
F
T
Site 84
T496
S
T
I
K
L
N
F
T
D
E
W
S
S
I
A
Site 85
S500
L
N
F
T
D
E
W
S
S
I
A
S
S
S
R
Site 86
S501
N
F
T
D
E
W
S
S
I
A
S
S
S
R
G
Site 87
S504
D
E
W
S
S
I
A
S
S
S
R
G
I
G
S
Site 88
S505
E
W
S
S
I
A
S
S
S
R
G
I
G
S
H
Site 89
S506
W
S
S
I
A
S
S
S
R
G
I
G
S
H
C
Site 90
S511
S
S
S
R
G
I
G
S
H
C
K
S
E
G
Q
Site 91
S515
G
I
G
S
H
C
K
S
E
G
Q
E
E
S
F
Site 92
S521
K
S
E
G
Q
E
E
S
F
V
P
Q
S
S
V
Site 93
S526
E
E
S
F
V
P
Q
S
S
V
Q
P
P
E
G
Site 94
S527
E
S
F
V
P
Q
S
S
V
Q
P
P
E
G
D
Site 95
T537
P
P
E
G
D
S
E
T
K
A
P
E
E
S
S
Site 96
T548
E
E
S
S
E
D
V
T
K
Y
Q
E
G
V
S
Site 97
Y550
S
S
E
D
V
T
K
Y
Q
E
G
V
S
A
E
Site 98
T573
I
T
Q
S
D
K
F
T
A
K
P
L
D
S
N
Site 99
S579
F
T
A
K
P
L
D
S
N
S
G
E
R
N
D
Site 100
S581
A
K
P
L
D
S
N
S
G
E
R
N
D
L
N
Site 101
S592
N
D
L
N
L
D
R
S
C
G
V
P
E
E
S
Site 102
S599
S
C
G
V
P
E
E
S
A
S
S
E
K
A
K
Site 103
S601
G
V
P
E
E
S
A
S
S
E
K
A
K
E
P
Site 104
S602
V
P
E
E
S
A
S
S
E
K
A
K
E
P
E
Site 105
S611
K
A
K
E
P
E
T
S
D
Q
T
S
T
E
S
Site 106
S615
P
E
T
S
D
Q
T
S
T
E
S
A
T
N
E
Site 107
S645
P
S
A
H
E
E
T
S
T
R
D
S
A
L
Q
Site 108
T646
S
A
H
E
E
T
S
T
R
D
S
A
L
Q
D
Site 109
S649
E
E
T
S
T
R
D
S
A
L
Q
D
T
D
D
Site 110
T654
R
D
S
A
L
Q
D
T
D
D
S
D
D
D
P
Site 111
S657
A
L
Q
D
T
D
D
S
D
D
D
P
V
L
I
Site 112
S678
A
G
P
G
D
R
R
S
A
V
A
R
I
Q
E
Site 113
T701
K
E
M
E
E
L
D
T
L
N
I
R
R
P
L
Site 114
Y713
R
P
L
V
K
M
V
Y
K
G
H
R
N
S
R
Site 115
S719
V
Y
K
G
H
R
N
S
R
T
M
I
K
E
A
Site 116
T721
K
G
H
R
N
S
R
T
M
I
K
E
A
N
F
Site 117
Y783
L
A
S
S
G
I
D
Y
D
I
K
I
W
S
P
Site 118
S789
D
Y
D
I
K
I
W
S
P
L
E
E
S
R
I
Site 119
T819
M
L
E
E
T
R
N
T
I
T
V
P
A
S
F
Site 120
T821
E
E
T
R
N
T
I
T
V
P
A
S
F
M
L
Site 121
S847
D
R
L
E
G
D
R
S
E
G
S
G
Q
E
N
Site 122
S850
E
G
D
R
S
E
G
S
G
Q
E
N
E
N
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation