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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZC3H12A
Full Name:
Ribonuclease ZC3H12A
Alias:
MCP-induced protein 1;Zinc finger CCCH domain-containing protein 12A
Type:
Mass (Da):
65699
Number AA:
599
UniProt ID:
Q5D1E8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
E
K
P
V
L
E
A
S
P
T
M
S
L
W
E
Site 2
T16
P
V
L
E
A
S
P
T
M
S
L
W
E
F
E
Site 3
S18
L
E
A
S
P
T
M
S
L
W
E
F
E
D
S
Site 4
S25
S
L
W
E
F
E
D
S
H
S
R
Q
G
T
P
Site 5
S27
W
E
F
E
D
S
H
S
R
Q
G
T
P
R
P
Site 6
T31
D
S
H
S
R
Q
G
T
P
R
P
G
Q
E
L
Site 7
Y60
D
F
F
R
K
L
G
Y
S
S
T
E
I
H
S
Site 8
S61
F
F
R
K
L
G
Y
S
S
T
E
I
H
S
V
Site 9
S62
F
R
K
L
G
Y
S
S
T
E
I
H
S
V
L
Site 10
T63
R
K
L
G
Y
S
S
T
E
I
H
S
V
L
Q
Site 11
T92
L
V
K
H
G
T
A
T
E
R
E
R
Q
T
S
Site 12
T98
A
T
E
R
E
R
Q
T
S
P
D
P
C
P
Q
Site 13
S99
T
E
R
E
R
Q
T
S
P
D
P
C
P
Q
L
Site 14
T115
L
V
P
R
G
G
G
T
P
K
A
P
N
L
E
Site 15
S133
P
E
E
E
K
E
G
S
D
L
R
P
V
V
I
Site 16
S143
R
P
V
V
I
D
G
S
N
V
A
M
S
H
G
Site 17
S148
D
G
S
N
V
A
M
S
H
G
N
K
E
V
F
Site 18
T176
E
R
G
H
T
D
I
T
V
F
V
P
S
W
R
Site 19
S181
D
I
T
V
F
V
P
S
W
R
K
E
Q
P
R
Site 20
T194
P
R
P
D
V
P
I
T
D
Q
H
I
L
R
E
Site 21
T211
K
K
K
I
L
V
F
T
P
S
R
R
V
G
G
Site 22
S213
K
I
L
V
F
T
P
S
R
R
V
G
G
K
R
Site 23
Y224
G
G
K
R
V
V
C
Y
D
D
R
F
I
V
K
Site 24
S242
E
S
D
G
I
V
V
S
N
D
T
Y
R
D
L
Site 25
T245
G
I
V
V
S
N
D
T
Y
R
D
L
Q
G
E
Site 26
Y246
I
V
V
S
N
D
T
Y
R
D
L
Q
G
E
R
Site 27
S268
E
E
R
L
L
M
Y
S
F
V
N
D
K
F
M
Site 28
S287
P
L
G
R
H
G
P
S
L
D
N
F
L
R
K
Site 29
T298
F
L
R
K
K
P
L
T
L
E
H
R
K
Q
P
Site 30
Y308
H
R
K
Q
P
C
P
Y
G
R
K
C
T
Y
G
Site 31
Y314
P
Y
G
R
K
C
T
Y
G
I
K
C
R
F
F
Site 32
S327
F
F
H
P
E
R
P
S
C
P
Q
R
S
V
A
Site 33
S332
R
P
S
C
P
Q
R
S
V
A
D
E
L
R
A
Site 34
S344
L
R
A
N
A
L
L
S
P
P
R
A
P
S
K
Site 35
S350
L
S
P
P
R
A
P
S
K
D
K
N
G
R
R
Site 36
S359
D
K
N
G
R
R
P
S
P
S
S
Q
S
S
S
Site 37
S361
N
G
R
R
P
S
P
S
S
Q
S
S
S
L
L
Site 38
S362
G
R
R
P
S
P
S
S
Q
S
S
S
L
L
T
Site 39
S364
R
P
S
P
S
S
Q
S
S
S
L
L
T
E
S
Site 40
S365
P
S
P
S
S
Q
S
S
S
L
L
T
E
S
E
Site 41
S366
S
P
S
S
Q
S
S
S
L
L
T
E
S
E
Q
Site 42
T369
S
Q
S
S
S
L
L
T
E
S
E
Q
C
S
L
Site 43
S371
S
S
S
L
L
T
E
S
E
Q
C
S
L
D
G
Site 44
S375
L
T
E
S
E
Q
C
S
L
D
G
K
K
L
G
Site 45
S386
K
K
L
G
A
Q
A
S
P
G
S
R
Q
E
G
Site 46
S389
G
A
Q
A
S
P
G
S
R
Q
E
G
L
T
Q
Site 47
T395
G
S
R
Q
E
G
L
T
Q
T
Y
A
P
S
G
Site 48
T397
R
Q
E
G
L
T
Q
T
Y
A
P
S
G
R
S
Site 49
Y398
Q
E
G
L
T
Q
T
Y
A
P
S
G
R
S
L
Site 50
S401
L
T
Q
T
Y
A
P
S
G
R
S
L
A
P
S
Site 51
S404
T
Y
A
P
S
G
R
S
L
A
P
S
G
G
S
Site 52
S408
S
G
R
S
L
A
P
S
G
G
S
G
S
S
F
Site 53
S411
S
L
A
P
S
G
G
S
G
S
S
F
G
P
T
Site 54
S413
A
P
S
G
G
S
G
S
S
F
G
P
T
D
W
Site 55
S414
P
S
G
G
S
G
S
S
F
G
P
T
D
W
L
Site 56
T418
S
G
S
S
F
G
P
T
D
W
L
P
Q
T
L
Site 57
T424
P
T
D
W
L
P
Q
T
L
D
S
L
P
Y
V
Site 58
S427
W
L
P
Q
T
L
D
S
L
P
Y
V
S
Q
D
Site 59
Y430
Q
T
L
D
S
L
P
Y
V
S
Q
D
C
L
D
Site 60
S432
L
D
S
L
P
Y
V
S
Q
D
C
L
D
S
G
Site 61
S438
V
S
Q
D
C
L
D
S
G
I
G
S
L
E
S
Site 62
S442
C
L
D
S
G
I
G
S
L
E
S
Q
M
S
E
Site 63
S445
S
G
I
G
S
L
E
S
Q
M
S
E
L
W
G
Site 64
S448
G
S
L
E
S
Q
M
S
E
L
W
G
V
R
G
Site 65
Y468
P
G
P
P
R
A
P
Y
T
G
Y
S
P
Y
G
Site 66
T469
G
P
P
R
A
P
Y
T
G
Y
S
P
Y
G
S
Site 67
Y471
P
R
A
P
Y
T
G
Y
S
P
Y
G
S
E
L
Site 68
S472
R
A
P
Y
T
G
Y
S
P
Y
G
S
E
L
P
Site 69
Y474
P
Y
T
G
Y
S
P
Y
G
S
E
L
P
A
T
Site 70
S476
T
G
Y
S
P
Y
G
S
E
L
P
A
T
A
A
Site 71
S497
A
M
G
A
G
H
F
S
V
P
A
D
Y
P
P
Site 72
Y502
H
F
S
V
P
A
D
Y
P
P
A
P
P
A
F
Site 73
Y514
P
A
F
P
P
R
E
Y
W
S
E
P
Y
P
L
Site 74
S516
F
P
P
R
E
Y
W
S
E
P
Y
P
L
P
P
Site 75
Y519
R
E
Y
W
S
E
P
Y
P
L
P
P
P
T
S
Site 76
S526
Y
P
L
P
P
P
T
S
V
L
Q
E
P
P
V
Site 77
S535
L
Q
E
P
P
V
Q
S
P
G
A
G
R
S
P
Site 78
S541
Q
S
P
G
A
G
R
S
P
W
G
R
A
G
S
Site 79
S548
S
P
W
G
R
A
G
S
L
A
K
E
Q
A
S
Site 80
S555
S
L
A
K
E
Q
A
S
V
Y
T
K
L
C
G
Site 81
S591
Q
L
A
A
E
I
L
S
Y
K
S
Q
H
P
S
Site 82
Y592
L
A
A
E
I
L
S
Y
K
S
Q
H
P
S
E
Site 83
S594
A
E
I
L
S
Y
K
S
Q
H
P
S
E
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation